Macedonian Journal of Chemistry and Chemical Engineering最新文献_第4页

Voltammetric examination of hydroquinone at ordinary and nano-architecture platinum electrodes 对苯二酚在普通和纳米结构铂电极上的伏安测定

IF 1 4区化学

Macedonian Journal of Chemistry and Chemical Engineering Pub Date : 2023-05-29 DOI: 10.20450/mjcce.2023.2677

A. Al-Owais, I. El-Hallag, Elsayed El-Mossalamy

引用次数: 0

Antibacterial and antibiofilm activities of sodium ibuprofen- and paracetamol-loaded nanofibers 布洛芬钠和对乙酰氨基酚负载纳米纤维的抗菌和抗生物膜活性

IF 1 4区化学

Macedonian Journal of Chemistry and Chemical Engineering Pub Date : 2023-05-15 DOI: 10.20450/mjcce.2023.2584

Gürkan Alkan, S. Ulusoy, M. Akgün, A. Oral

{"title":"Antibacterial and antibiofilm activities of sodium ibuprofen- and paracetamol-loaded nanofibers","authors":"Gürkan Alkan, S. Ulusoy, M. Akgün, A. Oral","doi":"10.20450/mjcce.2023.2584","DOIUrl":"https://doi.org/10.20450/mjcce.2023.2584","url":null,"abstract":"Nanofibers loaded with pharmaceutical agents for various medical purposes have become more important in recent years because of their advantages, such as control on release, gas permeability, high surface area, and lightweight matrices. In the present study, polylactic acid (PLA)-gelatin (Gel) nanofibers were successfully loaded with Ibuprofen-Na/Paracetamol (henceforth Ibu-Na and Par, respectively) by electrospinning. The nanofibers were characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The Ibu-Na/Par content of the nanofibers was determined by using high-performance liquid chromatography (HPLC). Their antibacterial activities were tested against Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa PA01, opportunistic pathogenic bacteria which are frequently associated with infections. Moreover, their antibiofilm activities against P. aeruginosa and E. faecalis were also investigated.\u0000The Ibu-Na-containing nanofibers exhibited antibacterial activity against S. aureus, E. coli, and E. faecalis. The inhibition zone diameters of PLA-Gel-Ibu-Na 300 against E. faecalis, S. aureus, and E. coli were calculated to be 23.0 ± 2.1 mm, 18.0 ± 1.5 mm, and 12.0 ± 1.2 mm, respectively. It was found that PLA-Gel-Ibu-Na 300 and PLA-Gel-Par 300 nanofibers’ capacity to show biofilm formation inhibition originated remarkable effects on P. aeruginosa, which were found to be 48 % and 50.4 %, respectively.\u0000This study indicated that Ibu-Na/Par-loaded nanofibers are promising materials for wound healing applications.","PeriodicalId":18088,"journal":{"name":"Macedonian Journal of Chemistry and Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67570577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactivity and quantum chemical calculations оf a new coumarine derivative as a strong antioxidant, antimicrobial and anti-cancer substance 一种新型香豆素衍生物的生物活性和量子化学计算

IF 1 4区化学

Macedonian Journal of Chemistry and Chemical Engineering Pub Date : 2023-05-11 DOI: 10.20450/mjcce.2023.2554

P. Koparir

{"title":"Bioactivity and quantum chemical calculations оf a new coumarine derivative as a strong antioxidant, antimicrobial and anti-cancer substance","authors":"P. Koparir","doi":"10.20450/mjcce.2023.2554","DOIUrl":"https://doi.org/10.20450/mjcce.2023.2554","url":null,"abstract":"4-(((4-Ethyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl)thio)methyl)-7-methyl-coumarin was synthesized, and its characterization was done with quantum chemical calculations and spectral techniques. The density functional method (B3LYP) with the 6-311G(d,p) basis set was used to calculate the molecular geometry, vibrational frequencies, and gauge, including atomic orbital (GIAO) 1H and 13C-NMR chemical shift values of the title compound in the ground state. The theoretical vibrational frequencies and chemical shift values agree well with the experimental results. DFT calculations of the density of states (DOS) and frontier molecular orbitals of the title compound were carried out at the B3LYP/6-311G(d,p) level of theory. In the present study, biological activities and molecular docking studies of this triazole ring containing coumarin derivative compound were carried out. Interactions with important residues in active sites were detected in molecular docking studies. In addition, in vitro analysis has shown that anti-microorganism activity is especially effective against bacterial organisms such as E. coli, S. aureus, B. cereus, and fungal organisms such as C. albicans, C. tropicalis. Also, the antioxidant capacity of the test compound was investigated by oxidative stress index (OSI) and radical scavenging power (DPPH.), and its antioxidant potential was found. In addition, it was determined by in vitro anticancer and SDS-PAGE analysis that the test compound does not cause a detrimental cytotoxic effect on healthy cell cultures such as HUVEC and has the potential for anticarcinogenic activity on MCF-7 and MKN-45 cancerous cell cultures.","PeriodicalId":18088,"journal":{"name":"Macedonian Journal of Chemistry and Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49453111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, characterization, and biological activity of 1,3-disubstitued benzimidazolium salt and its Ag-NHC complex 1,3-二取代苯并咪唑盐及其Ag-NHC配合物的合成、表征和生物活性

IF 1 4区化学

Macedonian Journal of Chemistry and Chemical Engineering Pub Date : 2023-04-28 DOI: 10.20450/mjcce.2023.2589

Öznur Doğan Ulu

引用次数: 0

Novel tyrosinase-based bisphenol-A biosensor for the determination of bisphenol-A in bracket adhesive in orthodontics 基于酪氨酸酶的新型双酚a生物传感器用于正畸支架粘接剂中双酚a的测定

IF 1 4区化学

Macedonian Journal of Chemistry and Chemical Engineering Pub Date : 2022-12-31 DOI: 10.20450/mjcce.2022.2585

F. Arslan, Hasan Koçak, O. Bodur, E. Hasanoğlu Özkan, B. Arslan, N. Sarı

引用次数: 0

Превод/препев на хумористичниот Периоден систем на македонски

IF 1 4区化学

Macedonian Journal of Chemistry and Chemical Engineering Pub Date : 2022-12-31 DOI: 10.20450/mjcce.2022.2633

Владимир Петрушевски

{"title":"Превод/препев на хумористичниот Периоден систем на македонски","authors":"Владимир Петрушевски","doi":"10.20450/mjcce.2022.2633","DOIUrl":"https://doi.org/10.20450/mjcce.2022.2633","url":null,"abstract":"Бев поканет и го прифатив предизвикот, по што се обидов да го преведам/препеам текстот од хумористичниот Периоден систем на елементите, даден на англиски јазик1. При ова си поставив неколку императиви од самиот почеток: 1) Текстот на секоја слика да биде во стихови (најдобро дистих или скриен дистих), при што двата стиха да бидат со еднаква стапка. 2) Предност да имаат римувани стихови (секаде каде што тоа е возможно). 3) Кога тоа може да се стори, да не се отстапува од оригиналот во однос на клучните зборови/поими (последново се покажа како речиси невозможна мисија, па отстапено е во определен број случаи, нудејќи решенија што се во непосредна врска со својствата на дадениот елемент, а држејќи се до императивите 1) и 2). 4) Во еден мал број случаи (в. го четвртиот пример во овој труд) препевот е даден со моностихови, ценејќи дека со непотребно инсистирање врз римата и стапката би се изгубила „пораката“ од оригиналот.\u0000Даден е (споредбено/табеларно) англискиот оригинал и препевот на текстот за десетина елементи, со кратки коментари. Таму каде што постои позначително отстапување на текстот од оригиналот е коментирано и која била мотивацијата за таквото решение.","PeriodicalId":18088,"journal":{"name":"Macedonian Journal of Chemistry and Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43307839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and characterization of silver nanoparticles using Sphaerophysa kotschyana fruit and the assessment of their antioxidant activity 利用大叶藻果实制备纳米银及其抗氧化活性评价

IF 1 4区化学

Macedonian Journal of Chemistry and Chemical Engineering Pub Date : 2022-12-31 DOI: 10.20450/mjcce.2022.2579

N. Genc

{"title":"Synthesis and characterization of silver nanoparticles using Sphaerophysa kotschyana fruit and the assessment of their antioxidant activity","authors":"N. Genc","doi":"10.20450/mjcce.2022.2579","DOIUrl":"https://doi.org/10.20450/mjcce.2022.2579","url":null,"abstract":"Nanoparticles have attracted great interest recently due to their application in many fields. In this study, an eco-friendly, scalable, cost-effective method was used for the synthesis of silver nanoparticles (s-AgNPs) using the fruit extract of Sphaerophysa kotschyana as a reducing agent, and their structure was elucidated by extensive spectroscopic techniques. The color change from yellow to dark brown indicated the formation of s-AgNPs. In the UV-Vis spectrum, the maximum absorption was observed at 437 nm. Fourier transform infrared (FTIR) spectroscopy displayed the functional group of the natural compounds in the extract that capped and stabilized the s-AgNPs. The characteristic hydroxyl vibrational signal appeared at 3168 cm–1. The X-ray diffraction (XRD) pattern indicated that the s-AgNPs were face-centered cubic crystalline structures. Scanning electron microscopy (SEM) exhibited the spherical-shaped nanoparticles with an average size of 67.37 nm. The antioxidant activity of the extract and s-AgNPs was established using the DPPH, ABTS, and FRAP assays. In the DPPH test, the effect of s-AgNPs was observed to be significantly higher than that of the extract, and the activity of s-AgNPs in the FRAP test was also reported to be higher than the extract. In the ABTS assay, the s-AgNPs displayed outstanding activity, which was even better than the standards. Consequently, s-AgNPs synthesized from S. kotschyana are promising drug products for diseases caused by oxidative stress.","PeriodicalId":18088,"journal":{"name":"Macedonian Journal of Chemistry and Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42131883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Voltammetric determination of anti-malarial drug amodiaquine at a boron-doped diamond electrode surface in an anionic surfactant media 阴离子表面活性剂介质中硼掺杂金刚石电极表面伏安法测定抗疟药物阿莫地喹

IF 1 4区化学

Macedonian Journal of Chemistry and Chemical Engineering Pub Date : 2022-12-30 DOI: 10.20450/mjcce.2022.2565

Sara Kurdo Kamal, Yavuz Yardım

{"title":"Voltammetric determination of anti-malarial drug amodiaquine at a boron-doped diamond electrode surface in an anionic surfactant media","authors":"Sara Kurdo Kamal, Yavuz Yardım","doi":"10.20450/mjcce.2022.2565","DOIUrl":"https://doi.org/10.20450/mjcce.2022.2565","url":null,"abstract":"In this study, the electrochemical determination of the amodiaquine (ADQ) drug was evaluated using an electrochemically pretreated boron-doped diamond (BDD) electrode due to the enhanced surface activity. The cyclic voltammogram results of ADQ were given as single reversible and diffusion-controlled peaks at +0.48 V for the oxidation peak and +0.05 V for the reduction peak (vs. Ag/AgCl) in Britton-Robinson (BR) buffer at pH 8.0. The peak potential and current signals of ADQ were evaluated at the surface of the BDD electrode using instrumental parameters to develop a simple method for ADQ detection. Also, the effect of an anionic surfactant, sodium dodecyl sulfate (SDS), on the adsorption applicability of the BDD electrode significantly increased the stripping voltammetric determination of ADQ. Under the optimal conditions chosen and employing square-wave adsorptive stripping voltammetry at the BDD electrode, ADQ was determined at + 0.34 V (vs. Ag/AgCl) at the open-circuit condition in BR buffer at pH 8.0 in the presence of 2·10–4 mol l–1 SDS. Furthermore, analytical parameters showed the linear relationship for ADQ determination in the concentration range of 0.1–20.0 μg ml–1 (2.2·10–7 – 4.3·10–5 mol l–1), with a detection limit of 0.03 μg ml–1 (6.5·10–8 mol l–1). The proposed approach can be applied to determine ADQ in water samples.","PeriodicalId":18088,"journal":{"name":"Macedonian Journal of Chemistry and Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47012804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, microwave-assisted synthesis, biological evaluation, molecular docking and ADME studies of pyrrole-based hydrazide-hydrazones as potential antioxidant agents 吡咯基酰肼腙作为潜在抗氧化剂的设计、微波辅助合成、生物评价、分子对接和ADME研究

IF 1 4区化学

Macedonian Journal of Chemistry and Chemical Engineering Pub Date : 2022-12-30 DOI: 10.20450/mjcce.2022.2494

E. Mateev, M. Georgieva, A. Zlatkov

{"title":"Design, microwave-assisted synthesis, biological evaluation, molecular docking and ADME studies of pyrrole-based hydrazide-hydrazones as potential antioxidant agents","authors":"E. Mateev, M. Georgieva, A. Zlatkov","doi":"10.20450/mjcce.2022.2494","DOIUrl":"https://doi.org/10.20450/mjcce.2022.2494","url":null,"abstract":"In this study, one novel N-pyrrolyl carboxylic acid (3), the corresponding N-pyrrolyl hydrazide (5), and four new hydrazide-hydrazones (5a-d) bearing electron donating moieties were designed, synthesized, and fully elucidated by 1H NMR, FT-IR, and HRMS. The hydrazide-hydrazones were produced in five steps, which were optimized by applying microwave heating. The microwave-assisted synthesis significantly decreased the reaction times and increased the yields of the title molecules. In addition, all novel compounds were assessed for their radical scavenging properties by employing DPPH and ABTS assays. The most promising agent was obtained after condensation of the title hydrazide (5) with a 3,5-dimetoxy-4-hydroxybenzaldehyde (5d). The latter compound showed better antioxidant properties than Trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) and could serve as a prominent lead structure for future optimization as an antioxidant agent. A possible binding conformation of 5d in the active site of NADPH oxidase was also identified through molecular docking simulations. Analysis of the major interactions showed the importance of the hydroxyl moiety for the antioxidant activity. Finally, the virtual calculations of the ADME properties of the synthesized compounds displayed good drug-like properties. Overall, an optimized synthetic protocol through MW irradiation was employed. The newly synthesized ethyl (E)-5-(4-bromophenyl)-1-(1-(2-(4-hydroxy-3,5-dimethoxybenzylidene)hydrazineyl)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-2-methyl-1H-pyrrole-3-carboxylate (5d) was found to possess the most prominent radical-scavenging capacity, which identifies it as a promising lead compound for the development of novel antioxidants.","PeriodicalId":18088,"journal":{"name":"Macedonian Journal of Chemistry and Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44715153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A simple and efficient method for constructing azocino[4,3-b]indole 一种简单有效的偶氮[4,3-b]吲哚的构建方法

IF 1 4区化学

Macedonian Journal of Chemistry and Chemical Engineering Pub Date : 2022-12-30 DOI: 10.20450/mjcce.2022.2471

N. Uludağ

引用次数: 0