LGBT healthPub Date : 2024-11-01Epub Date: 2024-07-05DOI: 10.1089/lgbt.2023.0469
Thomas W Gaither, Tara Shahrvini, Nathan W Vincent, Marcia Russell, Mark S Litwin
{"title":"Receptive Anal Intercourse: Impact on Colorectal and Urologic Diagnoses.","authors":"Thomas W Gaither, Tara Shahrvini, Nathan W Vincent, Marcia Russell, Mark S Litwin","doi":"10.1089/lgbt.2023.0469","DOIUrl":"10.1089/lgbt.2023.0469","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> We evaluated the relationship between lifetime receptive anal intercourse (RAI) and the risk of common colorectal and urologic diagnoses. <b><i>Methods:</i></b> We conducted an internet-based survey on sensations during RAI between July 2022 and March 2023. We used multivariable logistic regression to assess the independent impact of lifetime RAI exposure on the diagnosis of common urologic and colorectal conditions. Participants completed a main survey and were invited to complete randomly assigned patient-reported outcome measures (PROMs), which measured pelvic symptoms, mental health symptoms, and sexual satisfaction. <b><i>Results:</i></b> In total, 1100 participants completed the main survey and 416 completed the PROMs. Participants of the main survey ranged from 18 to 78 years old and the median age of the sample was 32 years. There was no significant association between lifetime RAI exposure and any medical diagnosis, except for anal fissures, which increased linearly with additional RAI exposure. Both sexual satisfaction and mental health symptoms improved with RAI exposure. <b><i>Conclusions:</i></b> RAI was not associated with most of the colorectal and urologic diagnoses tested and was associated with fewer mental symptoms and increased sexual satisfaction. Development of anal fissures may be directly related to trauma of the anal canal from penetration.</p>","PeriodicalId":18062,"journal":{"name":"LGBT health","volume":" ","pages":"633-638"},"PeriodicalIF":3.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
LGBT healthPub Date : 2024-11-01Epub Date: 2024-05-27DOI: 10.1089/lgbt.2023.0253
Manuel A Ocasio, Ahnalee M Brincks, M Isabel Fernandez
{"title":"Examining the Performance of the Sexual Minority Adolescent Stress Inventory with Transgender and Gender-Diverse Youth and Sexual Minority Emerging Adults: A Methodological Study.","authors":"Manuel A Ocasio, Ahnalee M Brincks, M Isabel Fernandez","doi":"10.1089/lgbt.2023.0253","DOIUrl":"10.1089/lgbt.2023.0253","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> We examined the psychometric properties and criterion validity of the Sexual Minority Adolescent Stress Inventory (SMASI) among 730 sexual minority (SM) and transgender and gender-diverse (TGD) youth aged 14 to 24 years who participated in a human immunodeficiency virus study. <b><i>Methods:</i></b> We tested the factor structure of the global scale and subscales and measurement invariance across age, gender identity, sex assigned at birth, sexual identity, ethnoracial identity, and city. For criterion validity, we regressed mental health and substance use measures on the global scale. <b><i>Results:</i></b> The global scale had excellent fit (comparative fit index = 0.95) and high reliability (omega = 0.89). Subscale model fit was adequate. We confirmed invariance by gender identity and age and established criterion validity. <b><i>Conclusion:</i></b> The SMASI exhibits strong psychometric properties among SM emerging adults and TGD youth. Modifications could enhance the SMASI to better capture both sexual and gender minority stress among ethnoracial minority youth.</p>","PeriodicalId":18062,"journal":{"name":"LGBT health","volume":" ","pages":"639-644"},"PeriodicalIF":3.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
LGBT healthPub Date : 2024-11-01Epub Date: 2024-05-09DOI: 10.1089/lgbt.2023.0419
Christina M Roberts, Wendy Funk, Veronika Pav, Kevin W Sunderland, Jennifer A Thornton, David A Klein
{"title":"Health Care Utilization During the First 5½ Years of Authorized Service by Transgender U.S. Service Members (2016-2021).","authors":"Christina M Roberts, Wendy Funk, Veronika Pav, Kevin W Sunderland, Jennifer A Thornton, David A Klein","doi":"10.1089/lgbt.2023.0419","DOIUrl":"10.1089/lgbt.2023.0419","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> This study examined the utilization of gender-affirming health care by active-duty service members during the initial 5½ years that transgender and gender-diverse (TGD) individuals were authorized to serve in the U.S. military. The aim of this study was to inform policy discussions regarding inclusion of TGD individuals in the military. <b><i>Methods:</i></b> We conducted a retrospective cohort study using administrative health care data from the Military Data Repository (MDR). We assessed the association of demographic factors with the utilization of gender-affirming medical and surgical care. We calculated the incidence rate of initial TGD-related encounters and new prescriptions for gender-affirming hormones among Defense Department Service members between July 2016 and December 2021. <b><i>Results:</i></b> We identified 2481 service members with an initial health care encounter with an associated TGD-related diagnosis. More than half (53%) of these service members started gender-affirming hormones, and 14% underwent gender-affirming surgery. Mastectomies and hysterectomies accounted for more than 70% of surgeries. Service members made 3.22 initial encounters with a TGD-related diagnosis per 10,000 service members per year, with an overrepresentation of service members who were designated female in the MDR (8.62), junior enlisted (4.98), and young (4.64). Individuals designated female in the MDR comprised 17% of all service members but accounted for 46% of initial encounters, 51% of new prescriptions, and 73% of surgeries. <b><i>Conclusion:</i></b> The study revealed a higher-than-expected number of service members seeking gender-affirming care, particularly among service members designated female in the MDR. Military Health System clinicians provided most of this care, which may mitigate the cost of delivering this essential medical care.</p>","PeriodicalId":18062,"journal":{"name":"LGBT health","volume":" ","pages":"625-632"},"PeriodicalIF":3.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140898017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
LGBT healthPub Date : 2024-11-01Epub Date: 2024-04-01DOI: 10.1089/lgbt.2023.0294
Elsie Yan, Iris Po Yee Lo, Rongwei Sun, Alex Siu Wing Chan, Haze Ka Lai Ng, Anise Wu
{"title":"Intimate Partner Violence Among Lesbian, Gay, and Bisexual Adults: A Cross-Sectional Survey in Hong Kong.","authors":"Elsie Yan, Iris Po Yee Lo, Rongwei Sun, Alex Siu Wing Chan, Haze Ka Lai Ng, Anise Wu","doi":"10.1089/lgbt.2023.0294","DOIUrl":"10.1089/lgbt.2023.0294","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> This study investigated the prevalence rates of various types of intimate partner violence (IPV) among lesbian, gay, and bisexual (LGB) adults in Hong Kong and examined the associations between IPV and different addictive behavior and mental health problems. <b><i>Methods:</i></b> A total of 759 LGB adults completed an online cross-sectional survey between November 2021 and February 2022. Data on past-year IPV and LGB-specific tactics (whether perpetrated or experienced by participants), addictive behavior, anxiety, depression, and demographics were collected and analyzed with descriptive statistics and logistic regressions. <b><i>Results:</i></b> Psychological aggression was the most common type of IPV within an LGB relationship (22.1%), followed by physical assault (10.8%) and IPV-related injury (4.1%). LGB-specific tactics were experienced by 39.0% of the LGB adults. Depression, anxiety, and frequent gambling were significantly associated with specific types of IPV and LGB-specific tactics. <b><i>Conclusion:</i></b> IPV was prevalent in the LGB population. Findings on correlates provided insights for future development of IPV detection and intervention.</p>","PeriodicalId":18062,"journal":{"name":"LGBT health","volume":" ","pages":"645-650"},"PeriodicalIF":3.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
LGBT healthPub Date : 2024-11-01Epub Date: 2024-08-27DOI: 10.1089/lgbt.2024.0103
Ziad Saade, Brady D Hanshaw, Alex S Keuroghlian
{"title":"Including Sexually and Gender Diverse Populations in 3,4-Methylenedioxymethamphetamine-Assisted Psychotherapy Trial Research.","authors":"Ziad Saade, Brady D Hanshaw, Alex S Keuroghlian","doi":"10.1089/lgbt.2024.0103","DOIUrl":"10.1089/lgbt.2024.0103","url":null,"abstract":"<p><p>Sexually and gender diverse (SGD) populations experience an increased prevalence and severity of posttraumatic stress disorder (PTSD) compared with the general population. Minority stress theory contextualizes this increased disease burden by outlining how stigma and discrimination (e.g., homophobia and transphobia) contribute to worse mental health outcomes. The standard-of-care pharmacotherapy for PTSD is associated with significant treatment resistance. 3,4-Methylenedioxymethamphetamine (MDMA)-assisted psychotherapy (MDMA-AP) has emerged as an investigational treatment for PTSD but has lacked consideration for SGD populations. This article explores next steps in clinical trial design and implementation for the study of MDMA-AP with SGD populations who have PTSD.</p>","PeriodicalId":18062,"journal":{"name":"LGBT health","volume":" ","pages":"577-582"},"PeriodicalIF":3.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
LGBT healthPub Date : 2024-10-28DOI: 10.1089/lgbt.2024.0135
Charlie Giraud, Michael E Newcomb, Sarah W Whitton
{"title":"An Evaluation of Resilience as a Protective Factor for Mental Health Among Sexual and Gender Minority Young People.","authors":"Charlie Giraud, Michael E Newcomb, Sarah W Whitton","doi":"10.1089/lgbt.2024.0135","DOIUrl":"10.1089/lgbt.2024.0135","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> Sexual and gender minority (SGM) individuals often face minority stressors that negatively affect their mental health, making it important to identify protective factors against the adverse psychological effects of minority stress. We investigated the potential protective effect of trait resilience in SGM individuals assigned female at birth (SGM-AFAB), who are understudied despite being at particularly high risk for mental health problems. <b><i>Methods:</i></b> As part of an ongoing longitudinal cohort study, 452 SGM-AFAB young people (age 16-31 years) completed measures of resilience, minority stressors (victimization, microaggressions, internalized heterosexism, and cisgenderism), and mental health (depression, anxiety, suicidal ideation) in 2017-2018. Moderating effects of resilience on associations between the minority stressors and mental health outcomes were tested using regression analyses. <b><i>Results:</i></b> Resilience attenuated the positive associations of microaggressions with both depression and anxiety and of internalized cisgenderism with depression (in transgender and gender-diverse participants), suggesting protective effects. Resilience did not moderate any other associations. <b><i>Conclusion:</i></b> These findings suggest that resilience serves as a protective factor against depressive and anxiety symptoms following experiences of microaggressions and against depressive symptoms following internalized cisgenderism among diverse SGM-AFAB individuals. These results underscore the importance of identifying factors that bolster resilience and developing intervention strategies aimed at promoting resilience within SGM-AFAB individuals, especially following experiences of microaggressions and internalized cisgenderism.</p>","PeriodicalId":18062,"journal":{"name":"LGBT health","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
LGBT healthPub Date : 2024-10-28DOI: 10.1089/lgbt.2024.0059
Brian C Thoma, Candice L Biernesser, Emma Win
{"title":"Gender Nonconformity, Minority Stress, and Psychological Distress Among Sexual Minority Adolescents.","authors":"Brian C Thoma, Candice L Biernesser, Emma Win","doi":"10.1089/lgbt.2024.0059","DOIUrl":"https://doi.org/10.1089/lgbt.2024.0059","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> Sexual minority adolescents (SMAs) have disproportionate experiences of mental health symptoms during adolescence, and minority stress contributes to mental health inequities among SMAs. Gender nonconformity (GNC) could place SMAs at higher risk for minority stress and subsequent mental health symptoms. The current study was designed to examine associations between GNC, minority stress, and psychological distress among SMAs. <b><i>Method:</i></b> SMAs ages 12-17 years (<i>n</i> = 455; mean age = 15.52 years) in the United States completed a cross-sectional online survey from February to July 2022, including measures of GNC, peer victimization, family rejection, negative expectations, negative disclosure experiences, internalized homonegativity, and psychological distress. We conducted path analysis to examine associations between GNC, minority stressors, and psychological distress, including indirect effects of GNC on psychological distress via minority stress. <b><i>Results:</i></b> In multivariable path analysis adjusted for demographic characteristics, GNC was associated with higher levels of peer victimization and negative expectations and lower internalized homonegativity among SMAs. Higher levels of peer victimization and negative expectations were associated with higher psychological distress. GNC was indirectly related to higher levels of psychological distress via higher peer victimization. <b><i>Conclusions:</i></b> The current study is the first to document associations between GNC and multiple minority stress experiences among SMAs, and GNC was indirectly related to psychological distress among SMAs via peer victimization. Although all SMAs would benefit from interventions designed to reduce peer victimization and increase their capacity to cope with minority stress, such interventions may be particularly beneficial for SMAs who are gender nonconforming.</p>","PeriodicalId":18062,"journal":{"name":"LGBT health","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
LGBT healthPub Date : 2024-10-10DOI: 10.1089/lgbt.2023.0373
Alison R Walsh, Devon E Spiars, Charisse Loder, Emily Dove-Medows, Claire Kalpakjian, Andrea Hess, Kelsey Postler, Michelle L Munro-Kramer, Susan Ernst
{"title":"Sexual and Gender Identity-Associated Disparities in University Students' Experiences with Inappropriate, Disrespectful, and Coercive Health Care.","authors":"Alison R Walsh, Devon E Spiars, Charisse Loder, Emily Dove-Medows, Claire Kalpakjian, Andrea Hess, Kelsey Postler, Michelle L Munro-Kramer, Susan Ernst","doi":"10.1089/lgbt.2023.0373","DOIUrl":"https://doi.org/10.1089/lgbt.2023.0373","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> Inappropriate, disrespectful, or coercive health care (IDCH) is associated with patient age and sexual orientation and gender identity (SOGI) and can impact healthcare engagement and outcomes. Emerging adulthood is a critical period for establishing trust in health care, yet little is known about university students' IDCH experiences. This study assessed the IDCH prevalence and identified IDCH-SOGI associations in a university student sample. <b><i>Methods:</i></b> Using data from the cross-sectional IDC Survey (2021), we quantified the lifetime prevalence of 18 IDCH items in a sample of 3403 university students. Chi-squared and Kruskal-Wallis tests were used to assess bivariate associations between IDCH items and SOGI. We modeled associations between demographic characteristics and two types of provider-sexual misconduct using logistic regression. <b><i>Results:</i></b> Statistically significant associations between SOGI and 17 of the analyzed IDCH items were identified. Self-reported IDCH experiences were more prevalent among minoritized SOGI students than heterosexual cisgender students, including receiving inappropriate/harmful treatment and dismissive or biased provider communication. Gender minority and sexual minority cisgender male and female students had significantly higher odds of ever being touched inappropriately during an exam, compared with heterosexual cisgender males (adjusted odds ratios [95% confidence interval]: 3.07 [1.59-5.93], 2.34 [1.24-4.41], and 1.85 [1.16-2.90], respectively). SOGI was not significantly associated with experiencing a provider's sexual advances. <b><i>Conclusion:</i></b> University students with historically minoritized SOGIs may be particularly vulnerable to IDCH experiences; research is needed to understand differential experiences within minoritized sexual and gender subpopulations. Patient and provider education about healthcare norms and trauma-centered care could potentially reduce IDCH and its harms.</p>","PeriodicalId":18062,"journal":{"name":"LGBT health","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
LGBT healthPub Date : 2024-10-04DOI: 10.1089/lgbt.2023.0230
Allen B Mallory, Jared K Martin, Margaret M Fitzpatrick, Tansel Yilmazer, Laura Chavez, Natasha Slesnick
{"title":"Differences in Mental Health Between Female Sexual Minority and Heterosexual Youth with a Substance Use Disorder Who Are Experiencing Homelessness.","authors":"Allen B Mallory, Jared K Martin, Margaret M Fitzpatrick, Tansel Yilmazer, Laura Chavez, Natasha Slesnick","doi":"10.1089/lgbt.2023.0230","DOIUrl":"https://doi.org/10.1089/lgbt.2023.0230","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> The purpose of this study was to examine differences in mental health outcomes of two groups within youth experiencing homelessness (YEH) and who have a substance use disorder (SUD): sexual minority (SM) and heterosexual females. <b><i>Methods:</i></b> This study used baseline data from four randomized clinical trials of substance use interventions for YEH with a SUD to examine differences in depression and suicidality between SM and heterosexual female youth. Participants were between 12 and 24 years of age. Meta-analytic methods were used to aggregate data across studies to estimate differences in mental health. <b><i>Results:</i></b> Results indicated that female SM-YEH had higher depression symptoms (Hedge's <i>g</i> [<i>g</i>]<i>=</i>0.20; 95% confidence interval [CI] 0.01-0.39), higher risk of a history of suicide behavior (risk ratio <i>=</i> 1.63; 95% CI: 1.17-2.27), and a greater number of suicide behaviors (<i>g =</i> 0.31; 95% CI: 0.09-0.54) compared to their heterosexual peers. These effect sizes were not moderated by age. <b><i>Conclusion:</i></b> Female SM-YEH had elevated levels of depression and suicidality compared to their heterosexual peers. The findings of this study align with research on mental health disparities between SM and heterosexual youth generally, which underscores the unique struggles and risks associated with identifying as a female SM-YEH with a SUD.</p>","PeriodicalId":18062,"journal":{"name":"LGBT health","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
LGBT healthPub Date : 2024-10-03DOI: 10.1089/lgbt.2023.0296
Phillip W Schnarrs, Armin A Dorri, Stephen T Russell, Timothy J Grigsby, Ruby Charak, Hayden Dawes, Amy L Stone, R Andrew Yockey, Joshua G Rosenberger
{"title":"Adverse Childhood Experiences, Perceived Discrimination, and Mental Health in Sexual and Gender Minoritized Adults: Comparing Stress Accumulation and Stress Sensitization Models.","authors":"Phillip W Schnarrs, Armin A Dorri, Stephen T Russell, Timothy J Grigsby, Ruby Charak, Hayden Dawes, Amy L Stone, R Andrew Yockey, Joshua G Rosenberger","doi":"10.1089/lgbt.2023.0296","DOIUrl":"https://doi.org/10.1089/lgbt.2023.0296","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> The purpose of this study was to assess the relationship between adverse childhood experiences (ACEs) exposure, perceived discrimination, and anxiety and depressive symptoms in sexual and gender minoritized (SGM) adults in the United States. <b><i>Methods:</i></b> Respondents (<i>n</i> = 4445) from a national Qualtrics research panel completed a web-based survey. Guided by the stress proliferation (mediation model) and stress sensitization (moderation model) models, we examined the relationships between ACEs and perceived discrimination and the severity of anxiety and depressive symptoms in adulthood. <b><i>Results:</i></b> Cumulative ACEs exposure was positively associated with everyday discrimination scale (EDS) scores. ACEs and EDS scores had a significant direct association with anxiety and depressive symptoms. We found support for EDS as a mediator for anxiety (<i>β</i> = 0.12, <i>p</i> < 0.001) and depressive symptoms (<i>β</i> = 0.14, <i>p</i> < 0.001) and for ACEs as a moderator of the relationship between EDS and anxiety (<i>β</i> = -0.04, <i>p</i> = 0.004) and depressive (<i>β</i> = -0.05, <i>p</i> = 0.001) symptoms. <b><i>Conclusions:</i></b> These findings suggest that both stress proliferation and stress sensitization likely contribute to disparities in anxiety and depressive symptoms in SGM adults. This finding supports the integration of social safety and minority stress perspectives regarding health disparities in SGM populations. Exposure to early life adversity likely alters neurodevelopment, which in turn increases awareness of the lack of social safety in adulthood, reduces capacity to cope with minority stress exposure, and ultimately contributes to increased anxiety and depressive symptoms. Prevention efforts should focus on building positive and compensatory childhood experiences.</p>","PeriodicalId":18062,"journal":{"name":"LGBT health","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}