LUTS: Lower Urinary Tract Symptoms最新文献

{"title":"Is Vaginal Prosthetic Surgery Always to Be Avoided? Analysis of the Efficacy and Safety of Vaginal Mesh With 3 Levels-De Lancey Attachment in Women With Recurrent Vaginal Vault Prolapse","authors":"Lorenzo Campanella,&nbsp;Giovanni Grossi,&nbsp;Passarello Alessandra,&nbsp;Pietro Cignini,&nbsp;Fabio Manganelli,&nbsp;Pierluigi Palazzetti,&nbsp;M. A. Zullo,&nbsp;Andrea Morciano,&nbsp;Carlo Rappa,&nbsp;Francesco Deltetto,&nbsp;M. C. Schiavi","doi":"10.1111/luts.70021","DOIUrl":"https://doi.org/10.1111/luts.70021","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The purpose of this research is to determine the effectiveness and safety of a vaginal mesh intended to resolve multicompartmental prolapse in individuals with substantial vaginal vault prolapse.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>From 2015 to 2020, 67 patients with recurrent apical prolapse ≥ III stage (POP-Q grading) underwent transvaginal vault repair using the isoelastic mesh InGYNious. Operative time, blood transfusions, spontaneous voiding, perioperative issues, postoperative hospital stay, and postoperative complications (early within 30 days and late after 30 days) were also investigated. Following the first preoperative examination, clinical and QoL questionnaires were examined both before and after surgery at the long-term follow-up (&gt; 60 months).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The average surgery duration was 41 ± 21 min, with an estimated blood loss of 50 ± 21 mL. The total number of surgical complications was eight (11.9%). The study discovered significant reductions in the apical (from 1.88 ± 2.59 to −6.73 ± 1.77) and anterior (from 1.34 ± 1.67 to −2.25 ± 0.95) deficiencies, as well as improvements in PQOL (from 67.72 ± 19.25 to 33.74 ± 7.48), PISQ-12 (from 29 to 36), FSFI (from 20 to 29), and FSDS (from 21 to 8). Finally, we identified three cases of full recurrence and only two occurrences needed reoperation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Transvaginal mesh repair is a safe and effective surgical technique that can treat multi-compartment prolapse, improve anatomical success, and reduce the risk of recurrence in certain patient populations, such as those with significant comorbidities, elderly patients, patients with recurrent POP, or patients with very challenging cases of POP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 4","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Repeatability Study of Measurement of Micturition With Voiding Sonography and Uroflowmetry of Asymptomatic Women","authors":"Bernadette Dellar,&nbsp;Ryan Stafford,&nbsp;Eric Chung,&nbsp;Gabriel Schaer,&nbsp;Margret Sherburn,&nbsp;Roxanna Turner,&nbsp;Handoo Rhee,&nbsp;Anna Page,&nbsp;Paul W. Hodges","doi":"10.1111/luts.70020","DOIUrl":"https://doi.org/10.1111/luts.70020","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study aimed to assess the intra- and inter-tester repeatability of voiding sonography measures in asymptomatic women and to examine the effect of perineal transducer placement on uroflowmetry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A prospective observational study of 32 asymptomatic women was conducted using ultrasound with simultaneous uroflowmetry. Participants completed four voids (two per day). The ultrasound transducer placed on the perineum assessed bladder neck and urethral displacement during micturition. On Day 1, a void with ultrasound and uroflow recorded by a sonographer was compared to a void recorded with uroflowmetry only to determine whether the transducer placement affected voiding. On Day 2, two sonographers evaluated the voids with ultrasound and uroflowmetry. Each sonographer measured their own images. One sonographer also made measures on the images recorded by the second sonographer. Uroflowmetry measures and void patterns were evaluated. The repeatability of ultrasound measures was analyzed using intraclass correlation coefficient (ICC 2,1) and Bland–Altman analysis, and <i>t</i> tests examined the transducer's impact on uroflowmetry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Some changes in flow rate and flow pattern (20% of participants) were observed with placement of the transducer. Most sonographic measures showed good to excellent inter- and intra-tester repeatability, and between measures made by the different testers on the same image. During void, bladder neck and urethral diameter were more repeatable if measures were made at the time of maximum flow estimated from the simultaneous uroflowmetry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Voiding sonography is both feasible and repeatable. Perineal transducer placement affected micturition for some individuals. Voiding sonography combined with uroflowmetry shows promise for a noninvasive urogynecology functional assessment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 4","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/luts.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Urinary Incontinence Occurrence Among Patients With Advanced Pelvic Organ Prolapse After Single Incision Mesh (SIM) and Anterior Mesh (A-Mesh) With Sacrospinous Ligament Fixation (SSF) Surgery at 1 Year Follow-Up Study","authors":"Tsia-Shu Lo,&nbsp;Maherah Kamarudin,&nbsp;Huan-Ka Chiung,&nbsp;Eyal Rom,&nbsp;Louiza Erika Rellora,&nbsp;Wu-Chiao Hsieh","doi":"10.1111/luts.70017","DOIUrl":"https://doi.org/10.1111/luts.70017","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We aimed to study the incidence of de novo and persistent stress urinary incontinence (SUI), urodynamic stress incontinence (USI) for single incision mesh (SIM) using Calistar-S and anterior mesh (A-mesh) using Surelift-A with sacrospinous fixation (SSF).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with Stage III or IV POP who underwent Surelift-A + SSF (A-mesh + SSF) or Calistar-S (SIM) were evaluated at 1 year post-operative and compared. The primary outcome was the emergence of post-operative de novo and persistent SUI. Secondary outcomes included the rate of POP recurrence, quality of life, sexual function, and complications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>One hundred and seven patients underwent SIM and 122 patients with A-mesh + SSF. 12/58 (20.7%) had de novo USI, 15/58 (25.9%) de novo SUI in SIM, while in the A-mesh + SSF group, de novo USI developed in 3/43 (7%) and de novo SUI in 4/43 (9.3%), significantly higher with <i>p</i> = 0.048 and <i>p</i> = 0.035 respectively. Rates of persistent USI and SUI were comparable between groups. Objective cure was comparable between the two groups (96.3% vs. 97.5%, <i>p</i> = 0.428), subjective cure 99/107 (92%) vs. 114/122 (93.8%) for SIM vs. A-mesh + SSF. Quality-of-life measures improved significantly in both groups, with greater perceived improvement in the A-mesh + SSF group. One case of bladder injury occurred in SIM and one mesh erosion was seen in both groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Risk of de novo SUI and de novo USI were three-fold higher in the SIM (Calistar-S), however risk of persistent USI and SUI was similar. Both SIM and A-mesh + SSF confer comparable high objective and subjective cure.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 4","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Serotonin Levels as a Potential Risk Factor for Overactive Bladder in a Community-Dwelling Population: A Four-Year Longitudinal Study","authors":"Takafumi Fukushima,&nbsp;Teppei Okamoto,&nbsp;Tomoko Hamaya,&nbsp;Hirotake Kodama,&nbsp;Naoki Fujita,&nbsp;Hayato Yamamoto,&nbsp;Atsushi Imai,&nbsp;Shigeyuki Nakaji,&nbsp;Shingo Hatakeyama","doi":"10.1111/luts.70019","DOIUrl":"https://doi.org/10.1111/luts.70019","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>This study aims to investigate the potential influence of serum serotonin (5-HT) levels on the development of overactive bladder (OAB) in a community-dwelling population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A four-year longitudinal study was conducted involving 615 subjects who participated in the Iwaki Health Promotion Project in Hirosaki, Japan, in both 2015 and 2019. OAB was defined as experiencing urinary urgency at least once a week with an Overactive Bladder Symptom Score (OABSS) of ≥ 3. Baseline data from 2015, including serum 5-HT levels, other laboratory data, and comorbidity information, were used for the analysis. The association between serum 5-HT levels and incident OAB in 2019 (OAB-2019) was examined using multivariate logistic regression analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study included 250 men and 365 women, of whom 74 individuals (29 men and 45 women) met the diagnostic criteria for OAB in 2019. Significant differences were observed between the OAB-2019 and non-OAB-2019 groups, including age, chronic kidney disease, irritable bowel syndrome, hypertension, glycemic status, mental status, and OAB in 2015. Participants in the OAB-2019 group had significantly lower serum 5-HT levels compared to the non-OAB-2019 group (100 vs. 129 ng/mL, <i>p</i> &lt; 0.001). After adjusting for confounders, multivariable analysis revealed that serum 5-HT levels &lt; 134 ng/mL (odds ratio: 2.48, 95% confidence interval: 1.39–5.83, <i>p</i> = 0.004), age, mental status, and OAB in 2015 independently served as risk factors for OAB-2019.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Low serum 5-HT levels may be associated with an increased risk of OAB. Further research is needed to elucidate the underlying mechanisms responsible for this association.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 4","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/luts.70019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overactive Bladder is Positively Associated With the Prevalence and Mortality of Cancer Among US Adults","authors":"Jianing Liu,&nbsp;Kai Wang","doi":"10.1111/luts.70018","DOIUrl":"https://doi.org/10.1111/luts.70018","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Overactive bladder (OAB) is a prevalent urological condition often perceived as negligible or non-threatening, leading to its potential links with severe health conditions being overlooked. Notably, the relationship between OAB and cancer remains unexplored. This study endeavors to elucidate the association of OAB with cancer prevalence and mortality risks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study utilized data from the 2007 to 2016 cycles of the National Health and Nutrition Examination Survey (NHANES), incorporating linked mortality data up to December 31, 2019. OAB symptoms were quantified using the modified overactive bladder symptom score (OABSS), with scores ≥ 3 confirming diagnosis. Cancer status was self-reported and further clarified for cancer type. We employed multivariate weighted logistic regression to examine the association between OAB and cancer prevalence, and subgroup analysis to identify variations across demographic and clinical characteristics. Cumulative mortality incidence curves, adjusted via inverse probability weighting, and multivariate Cox regression analysis were utilized to investigate the relationship between OAB and cancer-related mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 20 468 adults aged 20 and older were involved in this study. After adjusting for potential confounders, OAB was positively associated with the risk of cancer (OR = 1.36, 95% CI: 1.18, 1.57). Subgroup analysis revealed significant interactions between OAB and age (<i>P</i>_interaction = 0.001). Survival analysis suggests that OAB was linked to higher all-cause mortality risks exclusively among cancer patients (HR 1.39, 95% CI: 1.17, 1.65) and elevated cancer-specific mortality across the overall population (HR 1.33, 95% CI: 1.03, 1.73).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>OAB is associated with the prevalence and mortality of cancer among US adults.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 4","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonography and Clinical Outcomes Following Single-Incision Mid-Urethral Tape Procedure (I-Stop-Mini) for Urodynamic Stress Incontinence at 1 Year","authors":"Tsia-Shu Lo,&nbsp;Maherah Kamarudin,&nbsp;Lan-Sin Jhang,&nbsp;Huan-Ka Chiung,&nbsp;Wu-Chiao Hsieh,&nbsp;Louiza Erika Rellora","doi":"10.1111/luts.70016","DOIUrl":"https://doi.org/10.1111/luts.70016","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate I-Stop-Mini surgery outcomes in urodynamic stress incontinence (USI) patients and its sonographic features at 1 year.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>One hundred one patients with confirmed USI who underwent I-Stop-Mini surgery from March 2019 to February 2023 were recruited. Inclusion criteria include confirmed USI. Pelvic organ prolapse ≥ stage 2, detrusor overactivity, neurogenic bladder, high residual urine, or concomitant prolapse surgery were excluded. Primary outcomes were objective and subjective continence cure. Secondary outcomes were sonography findings of sling mobility (T), bladder neck (BN), sling to urethra percentile, and the presence of dynamic urethral kinking.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Objective cure and subjective cure were 85/92 (92.4%) and 83/92 (90.2%). Significant improvement in UDS diagnosis of USI was seen pre- versus postoperatively 92/92 (100%) versus 7/92 (7.85%) <i>p</i> &lt; 0.001 and change in pad weight from 22.4 ± 29.1 to 1.5 ± 3.8 g, <i>p</i> &lt; 0.001. As for secondary outcome, no change in resting tape position (xt, yt), at 6months and 1 year; (18.2 ± 2.8, 17.3 ± 2.6 mm) versus (18.8 ± 2.2, 17.8 ± 2.8 mm), (<i>p</i> = 0.208, <i>p</i> = 0.237) respectively. During Valsalva (22.4 ± 3.3, 7.0 ± 2.9 mm) versus (22.8 ± 3.7, 7.5 ± 2.4 mm) (<i>p</i> = 0.251, <i>p</i> = 0.135) at 6 months and 1 year. Tape mobility unchanged, 11.3 ± 2.5 versus 11.4 ± 3.0 mm, <i>p</i> = 0.693. Dynamic kinking was maintained at 60% versus 59%, <i>p</i> = 0.877. No major complication was observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>I-Stop-Mini SIS has high objective and subjective cure. Dynamic kinking, BN position (at rest and Valsalva) and mobility between 6 months and 1 year were maintained, thus promoting its continence effect.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 4","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144206755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saw Palmetto Extract Ameliorates Benign Prostatic Hyperplasia by Regulating 5α-Reductase and Apoptosis In Vitro and In Vivo","authors":"Bo Zhang,&nbsp;Hui Wang,&nbsp;Tianyu Ma,&nbsp;Jiangang Yang","doi":"10.1111/luts.70015","DOIUrl":"https://doi.org/10.1111/luts.70015","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The therapeutic effect of saw palmetto extract (SPE) in benign prostatic hyperplasia (BPH) has been evaluated in clinical trials. However, the molecular mechanisms of SPE in BPH development are not fully understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>LNCap cell line treated with dihydrotestosterone (DHT) and SD rats induced with testosterone were used, respectively. TUNEL and Muse Cell Analyzer for apoptosis and CCK8 assay for cell viability were performed to investigate the effects of SPE against BPH. Histological changes were examined by HE staining. Protein expression was analyzed for AR, PSA, SRC-1, and 5AR2 by Western blot, and the levels of DHT and testosterone in rat serum were quantified by ELISA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>SPE treatment could accelerate the apoptosis of cells and decrease the expressions of TNF-α, IL-1β and IL-18. TUNEL staining revealed an increase in positive staining after SPE treatment. Rats treated with SPE exhibited a reduction in prostate weight. SPE treatment led to a decrease in serum DHT and testosterone levels. SPE treatment significantly reduced the protein levels of AR, PSA, SRC-1, and 5AR2 in vitro and in vivo.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>SPE possesses anti-proliferative and pro-apoptotic effects by inhibiting 5α-reductase and DHT expression in vitro and in vivo, thereby mitigating the progression of BPH.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life After Augmentation Enterocystoplasty in Children","authors":"Alicia Gómez Sánchez,&nbsp;Lara Merino Mateo,&nbsp;Cristina Tordable Ojeda,&nbsp;Sara M. Proaño Landázuri,&nbsp;Daniel Cabezalí Barbacho,&nbsp;Andrés Gómez Fraile","doi":"10.1111/luts.70014","DOIUrl":"https://doi.org/10.1111/luts.70014","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate outcomes following bladder augmentation in children at a specialized third-level center concerning quality of life (QoL), continence status, and sexual function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study population included bladder augmented patients treated over the last 25 years. We established contact with them and emailed an online survey with three validated questionnaires: QoL (EQ-5D-5L), incontinence (ICIQ-SF) and sexual function (FSH/FSM2).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-four patients, aged between 9 and 44, answered the questionnaire. Among respondents, 54.2% declared experiencing some problem in one or more of the five evaluated dimensions. The mean EQ-VAS score was 80 out of 100, while the mean EQ-5D-5L index was 0,845 out of 1. Based on the ICIQ-SF questionnaire, 58.3% of patients were classified as incontinent. Regarding the bother scale (0–10), the mean score was 4.7 ± 3. Among the 18 patients old enough to answer the sexual function questionnaire, 11 (61.1%) described a low or nonexistent level of sexual satisfaction. Among the male cluster, the average score on the FSH questionnaire was 10.95 ± 6.78 (scale 2–24), while in the female cohort the average score on the FSM-2 questionnaire was 21.5 ± 9.64 (scale 2–32).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Despite the high complication rate and the presence of some degree of incontinence or sexual dysfunction in nearly 60% of patients undergoing bladder augmentation in childhood, our cohort exhibits relatively good QoL scores when compared to those reported for the general population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of Urethral Pressure Profile Using Air-Charged Catheters in the Diagnosis of Female Bladder Neck Obstruction","authors":"Yan Qin,&nbsp;Fei Wang,&nbsp;Chaohua Zhang,&nbsp;Liyang Wu","doi":"10.1111/luts.70013","DOIUrl":"https://doi.org/10.1111/luts.70013","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Rarely have studies focused on the utilization of urethral pressure profile (UPP) in bladder neck obstruction (BNO). This study aimed to evaluate the parameters of UPP in urodynamic testing (UDS) using air-charged catheters (ACC) and to investigate the value of UPP as a diagnostic tool for female BNO.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients and Methods</h3>\u0000 \u0000 <p>We retrospectively collected records of 165 female patients with lower urinary tract symptoms (LUTS) who received UDS at our center from September 2020 to September 2022. The whole patient group was divided into BNO group (<i>n</i> = 92) and non-BNO group (<i>n</i> = 73). The urodynamic data were evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The UPP includes urethral pressures at the bladder neck (b-UP) and urethral sphincter (s-UP). The b-UP was higher in the BNO group than in the non-BNO group [104.50 (40.50) cmH2O vs. 58.00 (33.50) cmH2O, <i>p</i> &lt; 0.001]. According to multivariable logistic regression analysis, b-UP and bladder voiding efficiency (BVE) were independently associated with BNO. The area under the curve (AUC) of the b-UP had the best value for predicting BNO [AUC: 0.878, sensitivity: 88.04%, specificity: 76.71%, 95% confidence interval (CI): 0.819–0.924]; its cut-off value was 72 cmH2O. Meanwhile, Cohen's kappa was 0.65 (95% CI: 0.537–0.770), indicating that UPP as a diagnostic tool was highly consistent with the video-urodynamic study (VUDS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>UPP by air-charged urodynamic catheters can show the pressure of the bladder neck, with predictive value for identifying BNO in women. The predictive method based on UPP and pressure-flow study (PFS) without fluoroscopy will improve the diagnostic accuracy of BNO, which could help urologists in making better clinical decisions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Thulium Laser Vaporization of the Prostate: A Transurethral Procedure for Benign Prostatic Hyperplasia","authors":"Daisuke Gotoh,&nbsp;Kazumasa Torimoto,&nbsp;Akira Tachibana,&nbsp;Nobutaka Nishimura,&nbsp;Mitsuru Tomizawa,&nbsp;Kenta Onishi,&nbsp;Yosuke Morizawa,&nbsp;Shunta Hori,&nbsp;Yasushi Nakai,&nbsp;Makito Miyake,&nbsp;Kiyohide Fujimoto","doi":"10.1111/luts.70012","DOIUrl":"https://doi.org/10.1111/luts.70012","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To explore the efficacy and safety of thulium laser vaporization of the prostate (ThuVAP) for benign prostatic hyperplasia (BPH) at Nara Medical University from 2022 to 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with BPH who underwent ThuVAP at the Department of Urology, Nara Medical University, between January 01, 2022 and April 30, 2024, were enrolled. Patient background, presurgical pressure flow study results, treatment efficacy, and safety were retrospectively evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study included 32 patients; the median age was 74.5 years at surgery. The total International Prostate Symptom Score and quality of life were significantly lower at 4 weeks after surgery than at baseline. They continued to decrease at 12 and 24 weeks. The maximum flow rate was significantly higher at 4 weeks after surgery than at baseline; it continued to increase for 12 and 24 weeks. The postvoid residual (PVR) was significantly lower at 4 weeks after surgery than at baseline and continued to decrease at 12 and 24 weeks.</p>\u0000 \u0000 <p>Intravesical prostatic protrusion and prostate volume were positively correlated with the surgery and laser usage times. Two patients experienced temporary urinary retention, and two underwent transurethral electrocoagulation for postoperative bleeding.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our data confirm ThuVAP as an effective and safe treatment for BPH.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}