Association of lower urinary tract symptoms and diuretic adherence

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY

LUTS: Lower Urinary Tract Symptoms Pub Date : 2022-06-23 DOI:10.1111/luts.12452

Matthew L. Miller, Brent N. Reed, Rena D. Malik

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引用次数: 1

Abstract

Objective

To assess whether more severe urinary symptoms and poorer quality of life among patients on diuretic therapy are associated with decreased adherence to the diuretic regimen.

Methods

Participants were recruited via ResearchMatch.org and sent a REDCap survey. The Overactive Bladder Questionnaire-Short Form (OAB-q SF) was used to assess urinary symptom bother and health-related quality of life (HRQL). Participants were asked if they skip diuretic doses due to urinary symptoms with a bivariate (yes or no) outcome. Subgroup analyses of loop vs non-loop diuretic and those taking the diuretic for a cardiovascular indication (hypertension or heart failure) were performed.

Results

A total of 4029 surveys were sent, 285 were returned (7.1% response rate), and 279 were included in the study. Fifty-three participants admitted to skipping diuretic doses due to urinary symptoms. Lower HRQL scores were significantly associated with poorer adherence scores among all participants (P < .001), among participants taking a loop diuretic (P < .001), and among participants with hypertension and heart failure (P < .039). Association between symptoms and adherence remained significant after adjustment in the multivariate model for the whole cohort and loop diuretic subgroup but lost significance in the hypertension and heart failure subgroup.

Conclusions

Worsening quality of life due to urinary symptoms may be associated with poorer adherence to diuretics, particularly loop diuretics.

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下尿路症状与利尿剂依从性的关系

目的评估利尿剂治疗患者更严重的泌尿系统症状和较差的生活质量是否与利尿剂治疗方案依从性降低有关。方法通过ResearchMatch.org招募参与者，并发送REDCap调查问卷。膀胱过度活动问卷(OAB-q SF)用于评估泌尿症状困扰和健康相关生活质量(HRQL)。参与者被问及是否因为泌尿系统症状(是或否)的双变量结果而跳过利尿剂剂量。对环状与非环状利尿剂以及因心血管适应症(高血压或心力衰竭)而服用利尿剂的患者进行亚组分析。结果共发放问卷4029份，回收问卷285份，回复率为7.1%，其中279份被纳入研究。53名参与者承认，由于泌尿系统症状，他们没有服用利尿剂。在所有参与者中，较低的HRQL评分与较差的依从性评分显著相关(P < .001)，在服用利尿剂的参与者中(P < .001)，在高血压和心力衰竭的参与者中(P < .039)。在整个队列和利尿剂循环亚组的多变量模型调整后，症状与依从性之间的相关性仍然显著，但在高血压和心力衰竭亚组中失去了显著性。结论泌尿系统症状导致的生活质量恶化可能与较差的利尿剂依从性有关，特别是循环利尿剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

LUTS: Lower Urinary Tract Symptoms UROLOGY & NEPHROLOGY-

CiteScore

3.00

自引率

7.70%

发文量

审稿时长

>12 weeks

期刊介绍： LUTS is designed for the timely communication of peer-reviewed studies which provides new clinical and basic science information to physicians and researchers in the field of neurourology, urodynamics and urogynecology. Contributions are reviewed and selected by a group of distinguished referees from around the world, some of whom constitute the journal''s Editorial Board. The journal covers both basic and clinical research on lower urinary tract dysfunctions (LUTD), such as overactive bladder (OAB), detrusor underactivity, benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), urinary incontinence, pelvic organ prolapse (POP), painful bladder syndrome (PBS), as well as on other relevant conditions. Case reports are published only if new findings are provided. LUTS is an official journal of the Japanese Continence Society, the Korean Continence Society, and the Taiwanese Continence Society. Submission of papers from all countries are welcome. LUTS has been accepted into Science Citation Index Expanded (SCIE) with a 2011 Impact Factor.