Langenbeck's Archives of Surgery最新文献

{"title":"Transversalis fascia collagen content and the risk of surgical complications: results of a prospective study.","authors":"Marcin Morawski, Maciej Krasnodębski, Jakub Rochoń, Hubert Kubiszewski, Mikołaj Staszewski, Mikołaj Kuncewicz, Piotr Krawczyk, Paweł Rykowski, Adam Bołtuć, Zbigniew Lewandowski, Wojciech Figiel, Marek Krawczyk, Michał Grąt","doi":"10.1007/s00423-025-03706-8","DOIUrl":"https://doi.org/10.1007/s00423-025-03706-8","url":null,"abstract":"<p><strong>Background: </strong>Collagen is the major protein of the extracellular matrix that provides mechanical strength to the tissues. The relationship between the development of complications and the quality and quantity of collagen fibres has not been investigated in the literature, yet.</p><p><strong>Methods: </strong>This was a prospective study of 392 patients who underwent subcostal laparotomy for confirmed or suspected gastrointestinal malignancy. Prior to abdominal closure a sample of transversalis fascia was collected. The area covered by collagen (ACC) was measured as the mean area covered by Picosirius stained fibres in three areas of the fascia. The primary endpoint of the study was the occurrence of complications, graded according to the Clavien-Dindo over a 90-day follow-up period.</p><p><strong>Results: </strong>392 patients were included in the study. A transversalis fascia sample was obtained in 354 patients (90.3%) and image assessment yielded a group of 259 specimens that were included in the analysis (66.1%). Predicting the development of complications of at least CD III based on ACC was associated with an AUC of 0.606 (p = 0.027) and an optimal threshold of 0.771. There were significantly fewer complications of at least CD III in the group of patients with ACC ≥ 0.771 (6/125) than in the group below the threshold (25/134) (p < 0.01).</p><p><strong>Conclusions: </strong>Collagen content may serve as an adjunct predictor of surgical risk, although its clinical utility requires further validation. There is a need for further studies on the causal nature of this relationship and modifiable risk factors related to body collagen quality.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"130"},"PeriodicalIF":2.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spleen volume after stage-I associated liver partition and portal vein ligation for staged hepatectomy predicts future liver remnant.","authors":"Wei Wang, Zhi Qin, Ji-Long Wang, Ling Zhang, Bang-Hao Xu, Hai Zhu, Ya Guo, Zhang Wen","doi":"10.1007/s00423-025-03698-5","DOIUrl":"https://doi.org/10.1007/s00423-025-03698-5","url":null,"abstract":"<p><strong>Background: </strong>The spleen has been reported to inhibit liver regeneration following hepatectomy; however, the underlying mechanisms remain poorly understood. In particular, its role in future liver remnant (FLR) regeneration after associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) warrants investigation.</p><p><strong>Aim: </strong>To evaluate the relationship between splenic volume changes and FLR regeneration following ALPPS-stage I in patients with massive hepatocellular carcinoma (HCC).</p><p><strong>Methods: </strong>Clinical data from 65 HCC patients who underwent ALPPS between 2018 and 2021 were retrospectively analyzed. Liver and spleen volumes were measured pre- and post-ALPPS-stage I use the IQQA-Liver system. The kinetic growth rate (KGR) of the FLR was calculated. Pearson correlation and logistic regression were used to identify predictors of FLR hypertrophy. Receiver operating characteristic (ROC) curves were constructed to determine cutoff values for splenic predictors.</p><p><strong>Results: </strong>Following ALPPS-stage I, FLR volume significantly increased from 35.57%±8.51-54.31%±11.19% of standard liver volume (SLV) (P < 0.001), with a median KGR of 4.65%/day. Splenic volume also increased (218.65 ± 84.77 cm³ vs. 252.69 cm³, P < 0.001). Preoperative splenic volume and spleen volume/SLV ratio negatively correlated with KGR (r = -0.240, P = 0.027; r = -0.218, P = 0.041). Multivariate analysis identified splenic volume (OR = 0.991, P = 0.043), platelet count (OR = 1.014, P = 0.013), Indocyanine Green Retention Rate at 15 min (ICG-R15) (OR = 0.670, P = 0.010), and CNLC stage (P = 0.001) as independent predictors of FLR regeneration. ROC analysis showed that splenic volume > 265.29 cm³ (AUC = 0.645) and spleen volume/SLV ratio > 0.1997 (AUC = 0.646) predicted poor FLR hypertrophy. One- and two-year survival rates were 80.77% and 68.18%, respectively.</p><p><strong>Conclusion: </strong>Preoperative splenic volume is an independent predictor of FLR regeneration after ALPPS. Combined evaluation of splenic volume, platelet count, and liver function may improve patient selection, reduce the risk of postoperative liver failure, and optimize surgical outcomes.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"128"},"PeriodicalIF":2.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Who do you trust?\" - levels of evidence in the era of artificial intelligence.","authors":"Pascal Probst, Martin Wagner","doi":"10.1007/s00423-025-03705-9","DOIUrl":"https://doi.org/10.1007/s00423-025-03705-9","url":null,"abstract":"","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"127"},"PeriodicalIF":2.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term patient-centered outcomes following carpal tunnel release surgery: a 10-year follow-up.","authors":"Moh'd S Dawod, Mohammad N Alswerki, Ahmad F Alelaumi, Israa Alasfoor, Omar F Alelaumi, Abdulaziz Aldoseri, Shahad W Khalid, Ali M Sharadga, Joud M Sharadga, Hamzeh M Alsamarah, Fatimah Alshadeedi, Aws Khanfar","doi":"10.1007/s00423-025-03664-1","DOIUrl":"https://doi.org/10.1007/s00423-025-03664-1","url":null,"abstract":"<p><strong>Introduction: </strong>Carpal Tunnel Syndrome (CTS) is a painful orthopedic hand condition caused by compression of the median nerve at the wrist. Diagnosis is typically clinical, relying on patient's symptoms and physical examination findings, but confirmation often requires electrodiagnostic studies. Previous research on CTS has explored the relationship between median nerve compression severity and various outcomes. However, these studies have been limited by short follow-up durations, small to modest patient cohorts, and a narrow focus on patient-reported outcomes. The objective of this study was to provide a long-term, 10-year follow-up with a relatively large patient cohort, focusing on new patient-reported outcomes and their association with the severity of nerve compression.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on a total of 581 patients who underwent open carpal tunnel release surgery between 2013 and 2023 at a major teaching hospital in Jordan. Severity was categorized based on nerve conduction study results into three groups: mild, moderate, and severe and Six distinct outcomes of interest were examined.</p><p><strong>Results: </strong>No significant differences in age, health profiles, comorbidities, or disease presentation were observed among the severity groups. However, significant variations were found across the six outcomes. Patients with severe disease had longer recovery times (p < 0.01), less pain relief (p = 0.03), reduced satisfaction (p = 0.04), diminished functional improvement (p < 0.01), lower ADL improvement (p < 0.01), yet experienced better sleep quality improvement (p < 0.01).</p><p><strong>Conclusion: </strong>Long-term follow-up post-open carpal tunnel release surgery revealed that severe cases experienced longer recovery times, less pain relief, reduced satisfaction, diminished functionality improvement, and lower ADL improvement, but better sleep quality.</p><p><strong>Level of evidence: </strong>Level III, Retrospective cohort study.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"126"},"PeriodicalIF":2.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The concept of dynamic frailty: an exploratory study of the trajectory to postoperative mortality.","authors":"Raegan Mahler, Richard Rivera, Nicholas Alford, Sunny Kahlon, Vic Velanovich","doi":"10.1007/s00423-025-03696-7","DOIUrl":"https://doi.org/10.1007/s00423-025-03696-7","url":null,"abstract":"<p><strong>Background: </strong>Frailty is a heightened vulnerability to stress due to decreased physical and mental abilities. Preoperative frailty has been associated with poorer outcomes. However, frailty is not static, and those patients who eventually die appear to become more frail. Our hypothesis is in-patient, postoperative changes in frailty after major operations predicts the trajectory to postoperative discharge alive or in-hospital mortality.</p><p><strong>Study design: </strong>The accumulating deficit model of frailty was used. Data from the medical records of patients who have undergone major operations were used to determine the mFI preoperatively, postoperative day 1, and day before discharge or death. Of the 1063 patients who met inclusion criteria, 50 patients with in-hospital postoperative death and 50 patients discharged alive were randomly selected.</p><p><strong>Results: </strong>Patients in the in-hospital mortality group had significantly greater median preoperative mFI scores than those in the discharged alive (0.178 vs. 0.115 p = 0.00009). This significant difference was present on postoperative day 1, while also increasing in margin (0.240 vs. 0.143, p < 0.00001). Median Pre-Post mFI differences were also significant between the two groups, with operations leading to in-hospital mortality experiencing a greater increase in mFI (0.06 vs. 0.01 p = 0.00019), and the day before death or discharge (0.276 vs. 0.014, p < 0.00001).</p><p><strong>Conclusion: </strong>Preoperative mFI is a useful predictor of postoperative mortality. Moreover, worsening mFI score as early as day 1 and continued worsening scores throughout hospitalization are associated with a postoperative trajectory toward mortality. Recognition of worsening frailty may be helpful in identifying patients in need of early intervention.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"125"},"PeriodicalIF":2.1,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11985595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does very high alpha-fetoprotein affect very early hepatocellular carcinoma receiving hepatectomy?","authors":"Hong-Shiue Chou, Chen-Fang Lee, Hao-Chien Hung, Yin Lai, Jin-Chiao Lee, Yu-Chao Wang, Chih-Hsien Cheng, Tsung-Han Wu, Ting-Jung Wu, Kun-Ming Chan, Wei-Chen Lee","doi":"10.1007/s00423-025-03675-y","DOIUrl":"https://doi.org/10.1007/s00423-025-03675-y","url":null,"abstract":"<p><strong>Background: </strong>Following liver resection (LR), recurrence is critical to the prognosis of hepatocellular carcinoma (HCC). A higher level of alpha-fetoprotein (AFP) is typically associated with poor prognosis and recurrence concerns. Specifically, we attempted to determine whether high AFP (> 1,000ng/ml) and other potentially relevant factors affect survivals of patients with BCLC stage 0 HCC after LR.</p><p><strong>Methods: </strong>This retrospective study focused on 223 patients who received LR for stage 0 HCC of BCLC between 2004 and 2012. In patients with a low AFP (n = 200) and a high AFP (n = 23), we conducted chi-squares, independent t-test, Cox regression, and Kaplan-Meier survival analyses to investigate the relationship between clinicopathologic variables and outcomes.</p><p><strong>Results: </strong>The long-term disease-free survival (DFS) (p = 0.799) and the overall survival (OS) (p = 0.942) between the low and high AFP groups were comparable. The two groups' clinicopathologic features-tumor size, presence of a tumor capsule, cirrhosis, histology activity index (HAI), and microvascular invasion-appear to be similar. Additionally, we observed significant associations between HCC recurrence and ICG R15, HAI score, and cirrhosis, but not AFP.</p><p><strong>Conclusions: </strong>In stage 0 HCC, the consideration of curative-intent therapy in these patients should begin as soon as possible, irrespective of AFP levels.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"124"},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative hemodynamic management during pancreatoduodenectomy - an analysis of 525 patients.","authors":"Maximilian Dietrich, Tobias Hölle, Mattia Piredda, Manuel Feißt, Patrick Rehn, Maik von der Forst, Dania Fischer, Thilo Hackert, Jan Larmann, Christoph W Michalski, Markus A Weigand, Martin Loos, Felix C F Schmitt","doi":"10.1007/s00423-025-03669-w","DOIUrl":"10.1007/s00423-025-03669-w","url":null,"abstract":"<p><strong>Importance: </strong>Optimization of perioperative hemodynamic management during major pancreatic surgery can reduce postoperative complications.</p><p><strong>Objective: </strong>In this study, we aimed to investigate the effect of intraoperative hemodynamic management, in consideration of both anesthesiologic and surgery-related aspects on major short-term complications following partial pancreatoduodenectomy (PD).</p><p><strong>Design, setting and participants: </strong>Data of 525 patients undergoing PD between January 2017 and December 2018 at the Heidelberg University Hospital were retrospectively analyzed.</p><p><strong>Main outcomes and measures: </strong>Primary outcome was a composite of 90-day mortality, pancreatic fistula and completion pancreatectomy. Logistic regression was performed to estimate the impact of anesthesiologic and surgical factors. Furthermore, patients were stratified by the amount of fluid administered intraoperatively and the maximum catecholamine dose to examine the impact on the primary endpoint.</p><p><strong>Results: </strong>Using logistic regression analysis we demonstrated that epidural anesthesia was associated with a reduction in the occurrence of the combined endpoint (OR 0.568; CI 0.331-0.973), this effect was primarily driven by a lower rate of completion pancreatectomy. The intraoperative administration of fresh frozen plasma (FFP) doubled the odds of the occurrence of the primary endpoint (OR 2.238; CI 1.290-3.882). The comparison of patients with and without FFP transfusion showed that all components of the primary endpoint were more frequent in the FFP group. Complication rates in the stratified fluid groups showed a U-shaped curve with the least amount of complications in patients who received 6.5 to 8 ml/kg/h of intraoperative fluid. The comparison of maximum norepinephrine doses revealed the same pattern with the least complication rate in the low-intermediate dose range (0.05-0.08 µg/kg/min and 0.08-0.11 µg/kg/min).</p><p><strong>Conclusions and relevance: </strong>Epidural anesthesia had a beneficial effect on the rate of major surgical complications following PD, whereas intraoperative FFP transfusion showed a negative association. Intraoperative hemodynamic management appears to have a major impact on perioperative mortality and morbidity with a U-shaped relation for both fluid and vasopressor dose.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"123"},"PeriodicalIF":2.1,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11978697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of arthroscopic cartilage transplantation combined with platelet-rich plasma in the treatment of early knee osteoarthritis: a retrospective cohort study.","authors":"Xin Li, Yuefu Dong, Jian Liu, Weidong He, Chen Yan, Jian Zhang","doi":"10.1007/s00423-025-03690-z","DOIUrl":"10.1007/s00423-025-03690-z","url":null,"abstract":"<p><strong>Background: </strong>Knee osteoarthritis (KOA) is a common degenerative disease that leads to functional decline in the knee joint and a significant reduction in quality of life. Arthroscopic cartilage transplantation combined with platelet-rich plasma (ACT-PRP) has emerged as a novel treatment method and is gradually being applied to patients with early KOA. This study aimed to evaluate the therapeutic efficacy of ACT-PRP compared to conventional conservative treatment.</p><p><strong>Methods: </strong>Patients diagnosed with KOA who were treated in the Department of Orthopedics at the First People's Hospital of Lianyungang from January 2020 to January 2022 were included in the study. Patients were divided into two groups: the ACT-PRP group, receiving arthroscopic cartilage transplantation combined with PRP, and the conservative treatment group, receiving standard conservative treatment. All patients were followed for six months, and knee function and pain relief were assessed using the Lysholm score, IKDC score, KOOS, and VAS.</p><p><strong>Results: </strong>A total of 113 patients were enrolled, with 43 in the ACT-PRP group and 70 in the conservative treatment group. Baseline characteristics showed no significant differences (P > 0.05). At the final follow-up, the ACT-PRP group showed greater improvements in knee function and pain relief compared to the conservative treatment group, with significantly higher Lysholm score (P < 0.001), IKDC score (P < 0.001), and KOOS (P < 0.001), and lower VAS (P < 0.001). These findings suggest the ACT-PRP approach is more effective for early knee osteoarthritis.</p><p><strong>Conclusions: </strong>Arthroscopic cartilage transplantation combined with platelet-rich plasma is significantly superior to conventional conservative treatment in improving knee function, alleviating pain, and enhancing patient satisfaction, making it a recommended option for early KOA.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"122"},"PeriodicalIF":2.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The optimal number of lymph node dissections in three-field lymphadenectomy for esophageal squamous cell carcinoma: a large retrospective study.","authors":"Huaiyuan Zhang, Jun-Peng Lin, Xiao-Feng Chen, Feng Wang","doi":"10.1007/s00423-025-03686-9","DOIUrl":"10.1007/s00423-025-03686-9","url":null,"abstract":"<p><strong>Background: </strong>Currently, there is no consensus on the optimal number of lymph node dissections (LNDs) in three-field lymphadenectomy for esophageal squamous cell carcinoma (ESCC). This study aimed to explore the relationship between the LND count and overall survival (OS) in ESCC patients to determine the optimal number of LNDs that confer a survival benefit.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on ESCC patients who underwent three-field lymphadenectomy at Fujian Cancer Hospital from February 2004 to January 2018. The optimal LND number was determined using X-Tile software. Kaplan‒Meier survival curves and Cox regression analyses were used to evaluate the relationship between LND count and OS.</p><p><strong>Results: </strong>A total of 1053 ESCC patients who underwent three-field lymphadenectomy were included in this study (median age 58 years [IQR: 52-65], 781 males [74.2%]). Using X-Tile software, 27 was identified as the optimal cutoff value for the number of LNDs. The 5-year OS for the > 27 LNDs group was significantly better than that for the ≤ 27 LNDs group (67.8% vs. 59.8%, P = 0.042). Multivariate Cox regression analysis confirmed that LND count (≤ 27 and > 27) was an independent protective factor for OS (HR = 0.724; P = 0.004). Stratified analysis on the basis of TNM stage revealed that in patients with T3-4N0M0 disease (HR = 0.412; P = 0.001) and T1-2 N + M0 disease (HR = 0.503; P = 0.025), a greater number of dissected lymph nodes was closely associated with a survival benefit.</p><p><strong>Conclusion: </strong>For ESCC patients undergoing three-field lymphadenectomy, dissecting more than 27 lymph nodes is associated with better prognosis, especially for patients with T3-4N0M0 and T1-2 N + M0 stages.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"121"},"PeriodicalIF":2.1,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of pre-operative MRI on the in-breast tumor recurrence rate of patients with breast cancer: a meta-analysis.","authors":"Mahdieh Khoshzaban Banisi, Hani Ghadri, Behnaz Soltani, Amirali Farshid, Bahar Behnam, Amir Abbas Rhouholamini, Amirhossein Mohammadi, Seyedeh Fatemeh Hamzavi, Ashkan Azizi, Niloofar Deravi, Masoud Noroozi, Amin Magsudy, Sina Seyedipour, Shima Behzad, Yaser Khakpour","doi":"10.1007/s00423-025-03691-y","DOIUrl":"10.1007/s00423-025-03691-y","url":null,"abstract":"<p><strong>Purpose: </strong>The impact of preoperative MRI on breast cancer recurrence and long-term outcomes remains undefined. Therefore, this study aims at determining the influence of preoperative MRI on in-breast tumor recurrence rates in cases of surgical treatment for breast cancer.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were performed. Literature searches of PubMed, Scopus, and Google Scholar were conducted for studies up to February 2024. Two authors assessed the quality of the eligible studies and extracted their data.</p><p><strong>Results: </strong>The meta-analysis included 14 studies (2 RCTs, 12 cohort studies) with 12,889 patients with 5,451 undergoing preoperative MRI. Pooled hazard ratio for in-breast tumor recurrence was 0.95, using fixed effects and 0.94 using random effects models with 95% confidence intervals of 0.80-1.14 and 0.77-1.14, respectively. A trend towards lower recurrence rates in the MRI group was seen, but the reduction was not statistically significant.</p><p><strong>Conclusion: </strong>This meta-analysis found no significant reduction in in-breast tumor recurrence rates associated with preoperative MRI use in breast cancer patients, consistent with previous findings.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"120"},"PeriodicalIF":2.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}