Laryngo-rhino-otologiePub Date : 2024-09-01Epub Date: 2024-02-12DOI: 10.1055/a-2249-2239
Tim Brandenburg, Yara Maria Machlah, Dagmar Führer-Sakel
{"title":"[Systemic therapies for advanced thyroid cancer - an update].","authors":"Tim Brandenburg, Yara Maria Machlah, Dagmar Führer-Sakel","doi":"10.1055/a-2249-2239","DOIUrl":"10.1055/a-2249-2239","url":null,"abstract":"<p><p>Based on phase III clinical studies, four multi-kinase inhibitors (MKI) are approved for the treatment of progressive radioiodine-refractory differentiated thyroid carcinoma (rrDTC) and medullary thyroid carcinoma (MTC) in Germany. Only recently, based on the randomized trial COSMIC-311, Cabozantinib has been approved as a second-line treatment option in advanced rrDTC. As first in-label selective RET-Inhibitor, Selpercatinib showed promising efficacy in advanced MTC (first line) with RET mutations and rrDTC (second line) with RET fusions along with fewer side effects. Changes and new approaches for the treatment of ATC have been summarised in the current ATA guidelines.</p>","PeriodicalId":17965,"journal":{"name":"Laryngo-rhino-otologie","volume":" ","pages":"637-642"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laryngo-rhino-otologiePub Date : 2024-09-01Epub Date: 2024-04-02DOI: 10.1055/a-2246-2793
Eric Deuss, Sven Becker, Moritz Meyer, Timon Hussain, Jonas Eckrich, Stephan Lang, Ludger Klimek, Benjamin Ernst
{"title":"[Results of a survey on the current management of chronic rhinosinusitis with nasal polyps in Germany].","authors":"Eric Deuss, Sven Becker, Moritz Meyer, Timon Hussain, Jonas Eckrich, Stephan Lang, Ludger Klimek, Benjamin Ernst","doi":"10.1055/a-2246-2793","DOIUrl":"10.1055/a-2246-2793","url":null,"abstract":"<p><strong>Introduction: </strong>With a prevalence of 0.55% to 4%, chronic rhinosinusitis with nasal polyps (CRSwNP) is a relevant part of the daily work of German otolaryngologists. The aim of the questionnaire-based data collection was to assess the current treatment status of CRSwNP in Germany.</p><p><strong>Material and methods: </strong>For this purpose, 24 questions within an anonymized online questionnaire were sent to all German ENT departments.</p><p><strong>Results: </strong>Of 160 contacted ENT departments, 50 participated in the survey (31.3%). Among these, 76% performed more than 100 sinus surgeries annually and 38% treated more than 50 patients with biologics. Saline irrigations (80%) and intranasal glucocorticoids (GCS, 96%) were the most common conservative therapies. Systemic GCSs (52%) and intranasal GCS irrigation (20%) were less common. 80% of departments used biologics in the therapy of CRSwNP with an overall preference for dupilumab (70%). For therapy of aspirin intolerance, biologics (52%) were preferred to aspirin desensitization (26%). Prior to treatment with biologics clinical workup included the nasal polyp score (90%), the SNOT-22 questionnaire (84%), surrogate markers of type 2 inflammation (60%-72%), and computer tomography (50%). Final treatment success was assessed after 24 weeks (50%).</p><p><strong>Conclusion: </strong>Mostly, the responding departments followed German and European recommendations for diagnosis and therapy of CRSwNP. Therapy with biologics is widely used. The value of preoperative systemic GCS and the frequent performance of CT before initiation of therapy with a biologic should be debated in regard to its currently widespread use.</p>","PeriodicalId":17965,"journal":{"name":"Laryngo-rhino-otologie","volume":" ","pages":"646-654"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laryngo-rhino-otologiePub Date : 2024-09-01Epub Date: 2024-02-26DOI: 10.1055/a-2249-3796
Reiner Hanewinkel, Julia Hansen
{"title":"[Use of tobacco cigarettes, e-cigarettes, and shishas among children and adolescents: Results of the \"Präventionsradar\" from 2016 to 2023].","authors":"Reiner Hanewinkel, Julia Hansen","doi":"10.1055/a-2249-3796","DOIUrl":"10.1055/a-2249-3796","url":null,"abstract":"<p><strong>Aim: </strong>To measure trends in the use of various smoking products among children and adolescents from 2016 to 2023.</p><p><strong>Method: </strong>The data is based on seven waves of the \"Präventionsradar\", a school-based epidemiological study in grades 5 to 10. The primary endpoints of the study were the lifetime and monthly prevalence of the use of tobacco cigarettes, e-cigarettes, shisha and the use of at least two of these smoking products (combined use). Prevalence estimates are based on logistic regression models.</p><p><strong>Results: </strong>The analysis was based on 94,127 questionnaires. The sex ratio was balanced (49% female), mean age was 13 years (SD=1.8). In 2022/2023, the lifetime prevalence of smoking tobacco cigarettes was 18.8% (95% CI 18.1-19.5), of e-cigarettes 23.5% (95% CI 22.8-24.3), of shisha 14.0% (95% CI 13.4-14.7) and combined use 19.0% (95% CI 18.3-19.7). The monthly prevalence of smoking tobacco cigarettes was 5.9% (95% CI 5.5-6.4), of e-cigarettes 7.0% (95% CI 6.5-7.4), of shisha 3.2% (95% CI 2.8-3.5) and combined use 4.8% (95% CI 4.4-5.2). The following trends in lifetime prevalence have emerged since 2016: tobacco cigarettes (-3.0 percentage points), e-cigarettes (+1.8 percentage points), shisha (-9.2 percentage points), combined use (-2.7 percentage points). In the years of the COVID-19 pandemic, youth smoking decreased and rose again post-COVID with the exception of shisha.</p><p><strong>Discussion: </strong>The use of smoking products in adolescence occurs frequently. Over the observational period, a trend reversal towards e-cigarettes as the most popular product among children and young people is most likely. In addition, the combined use of several smoking products has become a common pattern of consumption. Consistent preventive measures are required in order to achieve the goal of a smoke-free society in 2040.</p>","PeriodicalId":17965,"journal":{"name":"Laryngo-rhino-otologie","volume":" ","pages":"655-662"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139972516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laryngo-rhino-otologiePub Date : 2024-09-01Epub Date: 2024-09-02DOI: 10.1055/a-2331-4536
{"title":"Direktes Feedback während der Insertion der Elektrode des Cochlea-Implantats.","authors":"","doi":"10.1055/a-2331-4536","DOIUrl":"https://doi.org/10.1055/a-2331-4536","url":null,"abstract":"","PeriodicalId":17965,"journal":{"name":"Laryngo-rhino-otologie","volume":"103 9","pages":"629-630"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laryngo-rhino-otologiePub Date : 2024-09-01Epub Date: 2024-09-02DOI: 10.1055/a-2316-2983
J A Werner, J P Windfuhr
{"title":"Eingriffe an Larynx, Hypopharynx und Trachea.","authors":"J A Werner, J P Windfuhr","doi":"10.1055/a-2316-2983","DOIUrl":"10.1055/a-2316-2983","url":null,"abstract":"","PeriodicalId":17965,"journal":{"name":"Laryngo-rhino-otologie","volume":"103 9","pages":"685-687"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laryngo-rhino-otologiePub Date : 2024-09-01Epub Date: 2024-07-16DOI: 10.1055/a-2338-1070
Shachi Jenny Sharma, Nicole Rotter, Denise Lundershausen, Anna Messerschmid, Andrea Kreuder, Jan Hagemann, Jan Löhler, Thomas Deitmer, Chia-Jung Busch
{"title":"Gemeinsame Stellungnahme der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie (DGHNO-KHC) und des Deutschen Berufsverbandes der HNO-Ärzte (BVHNO) für ärztliches Personal in der Hals-, Nasen- und Ohrenheilkunde/Kopf- und Hals-Chirurgie zum Arbeiten in der Schwangerschaft und Stillzeit.","authors":"Shachi Jenny Sharma, Nicole Rotter, Denise Lundershausen, Anna Messerschmid, Andrea Kreuder, Jan Hagemann, Jan Löhler, Thomas Deitmer, Chia-Jung Busch","doi":"10.1055/a-2338-1070","DOIUrl":"10.1055/a-2338-1070","url":null,"abstract":"<p><p>Working during pregnancy and breastfeeding is a special situation for both the employee and the employer/supervisor. The amended version of the Maternity Protection Act (MuSchG), which came into force on January 1st, 2018, protects the health of women and their children while working, training or studying during pregnancy, after giving birth and while breastfeeding. Women should be able to continue their employment or related activities during this time without jeopardising their health or that of their child. This law was furthermore reformed to prevent discrimination against the working mother during this time. In order to create the best and safest possible framework conditions for employment during pregnancy and breastfeeding, the DGHNO-KHC and the BVHNO would like to present a \"general positive list\" and a \"positive list for surgical activities\" as part of this statement, which should serve as a guideline for all relevant parties. This agreed positive list is intended to enable pregnant and breastfeeding doctors to carry out patient-related activities as well as head and neck surgeries in accordance with the MuSchG of 2018. Hereby, affected colleagues should have the opportunity to continue working self-determined.</p>","PeriodicalId":17965,"journal":{"name":"Laryngo-rhino-otologie","volume":" ","pages":"643-645"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}