Laboratory medicine最新文献_第7页

Serum aspartate aminotransferase is an adverse prognostic indicator for patients with resectable pancreatic ductal adenocarcinoma. 血清天冬氨酸转氨酶是可切除胰导管腺癌患者的不良预后指标。

Laboratory medicine Pub Date : 2023-11-02 DOI: 10.1093/labmed/lmad014

Meifang He, Yin Liu, Hefei Huang, Jiali Wu, Juehui Wu, Ruizhi Wang, Dong Wang

{"title":"Serum aspartate aminotransferase is an adverse prognostic indicator for patients with resectable pancreatic ductal adenocarcinoma.","authors":"Meifang He, Yin Liu, Hefei Huang, Jiali Wu, Juehui Wu, Ruizhi Wang, Dong Wang","doi":"10.1093/labmed/lmad014","DOIUrl":"10.1093/labmed/lmad014","url":null,"abstract":"Objective: In this study, the association between preoperative levels of serum liver enzymes and overall survival (OS) was evaluated in patients with resectable pancreatic cancer.Methods: Preoperative serum levels of alanine aminotransferase (ALT), aspartate aminotransferases (AST), γ-glutamyltransferase, alkaline phosphatase, and lactate dehydrogenase of 101 patients with pancreatic ductal adenocarcinoma (PDAC) were collected. Univariate and multivariate Cox hazard models were used to identify independent variables associated with OS in this cohort.Results: Patients with elevated AST levels had significantly worse OS than patients with lower AST levels. A nomogram was created using TNM staging and AST levels and was shown to be more accurate in prediction than the American Joint Committee on Cancer 8th edition standard method.Conclusion: Preoperative AST levels could be a novel independent prognostic biomarker for patients with PDAC. The incorporation of AST levels into a nomogram with TNM staging can be an accurate predictive model for OS in patients with resectable PDAC.","PeriodicalId":17951,"journal":{"name":"Laboratory medicine","volume":" ","pages":"608-612"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9312441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Interprofessional Education in NAACLS MLT and MLS Programs: Results of a National Survey. NAACLS MLT和MLS项目的跨专业教育:一项全国调查的结果。

Laboratory medicine Pub Date : 2023-11-02 DOI: 10.1093/labmed/lmad006

Shafisha Bamfield-Cummings, Kendra Bufkin, Stephanie Jones, Giti Bayhaghi, Hari Kashyap, Gianluca De Leo

{"title":"Interprofessional Education in NAACLS MLT and MLS Programs: Results of a National Survey.","authors":"Shafisha Bamfield-Cummings, Kendra Bufkin, Stephanie Jones, Giti Bayhaghi, Hari Kashyap, Gianluca De Leo","doi":"10.1093/labmed/lmad006","DOIUrl":"10.1093/labmed/lmad006","url":null,"abstract":"Background: Interprofessional education is essential for students enrolled in health care professional programs.Objectives: We assessed the attitudes towards and the beliefs about interprofessional education (IPE) among program directors of medical laboratory science (MLS) and medical laboratory technician (MLT) programs accredited by the National Accrediting Agency for Clinical Laboratory Sciences (NAACLS). We also investigated the inclusion of IPE in the curricula of such programs.Methods: We emailed the link to an anonymous 22-item cross-sectional survey to 468 program directors and tabulated the responses.Results: Program directors who support the need to include IPE within the curricula of MLT and MLS programs showed a generally positive attitude towards IPE. The beliefs about IPE among our respondents were not homogeneous. Program directors who have not yet implemented IPE in the curriculum may not have had an opportunity to experience the practical benefits of IPE.Conclusion: Although barriers to IPE implementation exist, half of the respondents reported having already implemented IPE within their curricula.","PeriodicalId":17951,"journal":{"name":"Laboratory medicine","volume":" ","pages":"555-561"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9137785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluation of Serum Creatinine Levels with Reference Change Value in Patients Receiving Colistin Treatment. 粘菌素治疗患者血清肌酐水平与参考变化值的评价。

Laboratory medicine Pub Date : 2023-11-02 DOI: 10.1093/labmed/lmad009

Havva Yasemin Cinpolat, Sevil Alkan, Hatice Betul Altinisik, Dilek Ulker Cakir, Hamdi Oguzman

引用次数: 0

Is very high platelet count always associated with essential thrombocythemia? An unusual presentation in a child. 非常高的血小板计数是否总是与原发性血小板增多症相关?孩子的不寻常表现。

Laboratory medicine Pub Date : 2023-11-02 DOI: 10.1093/labmed/lmad053

Elif Habibe Aktekin, Nalan Yazici, İlknur Kozanoğlu, Ayşe Erbay

引用次数: 0

Clinical role of serum tumor markers SCC, NSE, CA 125, CA 19-9, and CYFRA 21-1 in patients with lung cancer. 血清肿瘤标志物SCC、NSE、CA 125、CA 19-9和CYFRA 21-1在肺癌患者中的临床作用

Laboratory medicine Pub Date : 2023-11-02 DOI: 10.1093/labmed/lmad020

Aiwen Sun

引用次数: 0

Correction to: A meta-analysis of the accuracy of Xpert MTB/RIF in diagnosing intestinal tuberculosis. 更正:对专家MTB/RIF诊断肠结核准确性的荟萃分析。

Laboratory medicine Pub Date : 2023-11-02 DOI: 10.1093/labmed/lmad095

引用次数: 0

Evusheld, a SARS-CoV-2 spike protein-directed attachment inhibitor, appears in serum protein electrophoresis and immunofixation: a case study. Evusheld是一种SARS-CoV-2刺突蛋白定向附着抑制剂，出现在血清蛋白电泳和免疫固定中:一个案例研究。

Laboratory medicine Pub Date : 2023-11-02 DOI: 10.1093/labmed/lmad085

Sumit K Shah, Hoda A Hagrass

{"title":"Evusheld, a SARS-CoV-2 spike protein-directed attachment inhibitor, appears in serum protein electrophoresis and immunofixation: a case study.","authors":"Sumit K Shah, Hoda A Hagrass","doi":"10.1093/labmed/lmad085","DOIUrl":"10.1093/labmed/lmad085","url":null,"abstract":"Serum protein electrophoresis (SPE) and immunofixation (IFE) assays are commonly used to diagnose and monitor patients with multiple myeloma (MM). Identifying analytical interferences in SPE and IFE caused by therapeutic monoclonal antibodies (tmAbs) can be challenging. Here we report the case of a 72-year-old male with a long history of relapsed immunoglobulin (Ig)G kappa MM. A follow-up SPE showed the original peak plus 2 additional cathode peaks. Immunofixation was ordered as a reflex test to investigate the new peaks that showed initial patient monoclonal IgG kappa in addition to 2 restricted bands of the IgG kappa type. Therapeutic monoclonal antibody interference was suspected and the patient's chart was reviewed. The patient was not on any antimyeloma monoclonal antibody therapy. However, preexposure prophylaxis therapeutic monoclonal antibodies tixagevimab plus cilgavimab (Evusheld) for severe acute SARS-CoV-2 was administered approximately 45 minutes before sample collection, which led to the identifiable spikes and correlated bands. After 2 days, the IgG kappa bands disappeared, confirming this therapy's effect on SPE and IFE. Therefore, clinical pathologists should be aware of when providers prescribe new monoclonal antibody therapy and become familiar with the position of commonly prescribed (tmAbs) therapies at their institutions.","PeriodicalId":17951,"journal":{"name":"Laboratory medicine","volume":" ","pages":"e201-e203"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10234460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Performance of 10 Mathematical Formulae for Identifying Blood Donors with Thalassemia Trait. 10个确定献血者地中海贫血特征的数学公式的诊断性能。

Laboratory medicine Pub Date : 2023-11-02 DOI: 10.1093/labmed/lmad011

Egarit Noulsri, Surada Lerdwana, Duangdao Palasuwan, Attakorn Palasuwan

引用次数: 0

Identification of Differential Metabolites Between  Type 2 Diabetes and Postchronic Pancreatitis Diabetes (Type 3c) Based on an Untargeted Metabolomics Approach. 基于非靶向代谢组学方法鉴定 2型糖尿病和慢性胰腺炎后糖尿病(3c型)之间的差异代谢物

Laboratory medicine Pub Date : 2023-11-02 DOI: 10.1093/labmed/lmad004

Liang Qi, Zheng Ye, Hao Lin

{"title":"Identification of Differential Metabolites Between \u2028Type 2 Diabetes and Postchronic Pancreatitis Diabetes (Type 3c) Based on an Untargeted Metabolomics Approach.","authors":"Liang Qi, Zheng Ye, Hao Lin","doi":"10.1093/labmed/lmad004","DOIUrl":"10.1093/labmed/lmad004","url":null,"abstract":"Objective: A nontargeted metabolomics approach was established to characterize serum metabolic profile in type 3c diabetes mellitus (T3cDM) secondary to chronic pancreatitis and compare with T2DM.Methods: Forty patients were recruited for metabolite analysis based on liquid chromatography-mass spectrometry. Cluster heatmap and KEGG metabolic pathway enrichment analysis were used to analyze the specific and differential metabolites. The receiver operating characteristics (ROCs) were generated and correlation analysis with clinical data was conducted.Results: Metabolites including sphingosine, lipids, carnitine, bile acid, and hippuric acid were found to be different between T2DM and T3cDM, mainly enriched in bile acid biosynthesis, fatty acid biosynthesis, and sphingolipid metabolic pathways. The ROCs were generated with an area under the curve of 0.907 (95% confidence interval, 0.726-1) for the model with 15 metabolites.Conclusion: T3cDM is characterized by increased sphingosine, carnitine, bile acid, and most lipids, providing novel biomarkers for clinical diagnosis and a future direction in research on pathophysiological mechanisms.","PeriodicalId":17951,"journal":{"name":"Laboratory medicine","volume":" ","pages":"562-573"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10821322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between apolipoprotein B/A1 ratio, lipoprotein(a), and the risk of metabolic-associated fatty liver diseases in a Korean population. 韩国人群载脂蛋白B/A1比值、脂蛋白(a)与代谢性脂肪肝疾病风险之间的关系

Laboratory medicine Pub Date : 2023-11-02 DOI: 10.1093/labmed/lmad021

Kyoung-Jin Park

引用次数: 0