Diagnostic Performance of 10 Mathematical Formulae for Identifying Blood Donors with Thalassemia Trait.

Laboratory medicine Pub Date : 2023-11-02 DOI:10.1093/labmed/lmad011

Egarit Noulsri, Surada Lerdwana, Duangdao Palasuwan, Attakorn Palasuwan

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Abstract

Objective: To compare the diagnostic performance of 10 mathematical formulae for identifying thalassemia trait in blood donors.

Methods: Compete blood counts were conducted on peripheral blood specimens using the UniCel DxH 800 hematology analyzer. Receiver operating characteristic curves were used to evaluate the diagnostic performance of each mathematical formula.

Results: In the 66 donors with thalassemia and 288 subjects with no thalassemia analyzed, donors with thalassemia trait had lower values for mean corpuscular volume and mean corpuscular hemoglobin than subjects without thalassemia donors (77 fL vs 86 fL [P < .001]; 25 pg vs 28 pg [P < .001]). The formula developed by Shine and Lal in 1977 showed the highest area under the curve value, namely, 0.9. At the cutoff value of <1812, this formula had maximum specificity of 82.35% and sensitivity of 89.58%.

Conclusions: Our data indicate that the Shine and Lal formula has remarkable diagnostic performance in identifying donors with underlying thalassemia trait.

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10个确定献血者地中海贫血特征的数学公式的诊断性能。

目的：比较10个用于识别献血者地中海贫血特征的数学公式的诊断性能。方法：使用UniCel DxH 800血液分析仪对外周血标本进行竞争性血液计数。受试者工作特性曲线用于评估每个数学公式的诊断性能。结果：在分析的66例地中海贫血捐献者和288例非地中海贫血受试者中，具有地中海贫血特征的供体的平均红细胞体积和平均红细胞血红蛋白值低于没有地中海贫血供体的受试者（77fLvs 86fL[P结论：我们的数据表明，Shine和Lal公式在识别具有潜在地中海贫血特征的供体方面具有显著的诊断性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Laboratory medicine

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