Journal of VitreoRetinal Diseases最新文献

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From the Editor-in-Chief. 主编的话
IF 0.6
Journal of VitreoRetinal Diseases Pub Date : 2024-01-10 eCollection Date: 2024-01-01 DOI: 10.1177/24741264231222514
Timothy G Murray
{"title":"From the Editor-in-Chief.","authors":"Timothy G Murray","doi":"10.1177/24741264231222514","DOIUrl":"https://doi.org/10.1177/24741264231222514","url":null,"abstract":"","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10786075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Race and Insurance Status on Treatment and Outcomes in Diabetic Retinopathy: Analysis of 43 274 Eyes Using the IRIS Registry 种族和保险状况对糖尿病视网膜病变治疗和结果的影响:利用 IRIS 登记对 43 274 只眼睛进行分析
IF 0.6
Journal of VitreoRetinal Diseases Pub Date : 2024-01-04 DOI: 10.1177/24741264231221607
Jay Maturi, V. Maturi, Adrienne W. Scott, Kathryn A. Carson, Thomas Ciulla, Raj Maturi
{"title":"Effect of Race and Insurance Status on Treatment and Outcomes in Diabetic Retinopathy: Analysis of 43 274 Eyes Using the IRIS Registry","authors":"Jay Maturi, V. Maturi, Adrienne W. Scott, Kathryn A. Carson, Thomas Ciulla, Raj Maturi","doi":"10.1177/24741264231221607","DOIUrl":"https://doi.org/10.1177/24741264231221607","url":null,"abstract":"Purpose: To examine disparities in visual acuity (VA) outcomes 1 year and 2 years after initiation of diabetic retinopathy (DR) or diabetic macular edema (DME) treatment in patients based on race/ethnicity and insurance status, accounting for disease severity. Methods: This retrospective analysis used the IRIS Registry and included DR patients older than 18 years with documented antivascular endothelial growth factor (anti-VEGF) treatment and VA data for at least 2 years. International Classification of Diseases, Tenth Revision, Clinical Modification codes were used to determine the severity of DR and DME presence. VA outcomes were assessed using multivariable linear regressions and anti-VEGF drug use by multivariable logistic regressions, with race and insurance status as independent variables. Main outcome measures comprised the mean VA change at 1 year and 2 years and percentage of patients treated with bevacizumab. Results: Among 43 274 eyes, White patients presented with a higher mean VA and lower mean DR severity than Black and Hispanic patients. Multivariable logistic regression showed Hispanic patients were significantly more likely to be treated with bevacizumab than White patients across all insurance types, controlling for disease severity and VA. After 1 year, the letter improvement was 1.73, 1.33, and 1.13 in White, Black, and Hispanic patients, respectively. Multivariable linear regression suggested that across races, Medicaid-insured patients had significantly smaller gains in VA than privately insured patients. Conclusion: Race-based and insurance-based differences in 1-year and 2-year outcomes after anti-VEGF treatment for DR and anti-VEGF treatment patterns suggest a need to ensure earlier and more effective treatment of minority and underserved patients nationally.","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139384395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics and Risk Factors for Rhegmatogenous Retinal Detachment Related to Endophthalmitis 与眼底病相关的流泪性视网膜脱离的特征和风险因素
IF 0.6
Journal of VitreoRetinal Diseases Pub Date : 2024-01-02 DOI: 10.1177/24741264231218509
Cary R. Baxter, Martin G. Mccandless, Albert L. Lin
{"title":"Characteristics and Risk Factors for Rhegmatogenous Retinal Detachment Related to Endophthalmitis","authors":"Cary R. Baxter, Martin G. Mccandless, Albert L. Lin","doi":"10.1177/24741264231218509","DOIUrl":"https://doi.org/10.1177/24741264231218509","url":null,"abstract":"Purpose: To evaluate the risk factors for the development of concurrent or delayed-onset rhegmatogenous retinal detachment (RRD) related to endophthalmitis as well as the anatomic and visual outcomes with subsequent RRD repair. Methods: In this retrospective case study, a 2-tailed t test (continuous) and Fisher exact test were used to determine statistical significance of the observed findings. The relative risk (RR) and 95% confidence intervals (CIs) were calculated to assess statistical significance. Results: Of the 170 patients included, 22 were found to have a concurrent or subsequent RRD. Initial treatment with pars plana vitrectomy (PPV) (RR, 3.544; 95% CI, 1.650-7.614), aphakia (RR, 4.150; 95% CI, 1.434-12.011), endogenous endophthalmitis (RR, 2.684; 95% CI, 1.065-6.764), and posterior synechiae (RR, 3.026; 95% CI, 1.408-6.505) were statistically significant risk factors for RRD. Anatomically successful repair was achieved in 77.7% of patients. Conclusions: In addition to preexisting risk factors, the initial treatment of endophthalmitis may be a significant risk factor for RRD development, with a higher incidence of subsequent RRD in patients who have PPV as the initial treatment of endophthalmitis.","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139452619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subfoveal Choroidal Neovascular Membrane Secondary to Idiopathic Intracranial Hypertension 特发性颅内高压继发的眼底脉络膜新生血管膜
IF 0.6
Journal of VitreoRetinal Diseases Pub Date : 2024-01-02 DOI: 10.1177/24741264231218539
Austin Pereira, Prem A H Nichani, Peng Yan, J. Micieli
{"title":"Subfoveal Choroidal Neovascular Membrane Secondary to Idiopathic Intracranial Hypertension","authors":"Austin Pereira, Prem A H Nichani, Peng Yan, J. Micieli","doi":"10.1177/24741264231218539","DOIUrl":"https://doi.org/10.1177/24741264231218539","url":null,"abstract":"Purpose: To present a rare case of subfoveal choroidal neovascular membrane (CNVM) secondary to idiopathic intracranial hypertension. Methods: A case was evaluated. Results: A 21-year-old woman presented with a 2-week history of painless blurred vision in the right eye. She described initial metamorphopsia and intermittent bitemporal headaches lasting 30 minutes. She denied pain with eye movements and a history of trauma. Her body mass index was 49 kg/m2. The visual acuity (VA) was 20/320 OD and 20/20 OS; there was no relative afferent pupillary defect. A dilated fundus examination showed bilateral optic disc edema and a subfoveal CNVM in the right eye. The patient was started on oral acetazolamide 500 mg twice daily and treated with 2 intravitreal antivascular endothelial growth factor (anti-VEGF) injections. Three months later, the VA was 20/30 in the right eye and the disc edema had improved. Conclusions: CNVMs in the setting of idiopathic intracranial hypertension–related papilledema may be subfoveal and have an excellent response to anti-VEGF agents.","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139390685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical Approaches to Serous Retinal Detachment With Retina-Lens Touch in Eyes With Nanophthalmos. 南眼球视网膜触及浆液性视网膜脱离的手术方法。
IF 0.6
Journal of VitreoRetinal Diseases Pub Date : 2023-12-27 eCollection Date: 2024-03-01 DOI: 10.1177/24741264231220157
Ahmad M Mansour, Lorenzo López-Guajardo, Şengül Özdek, Ivajlo Popov, Maurizio Parodi Battaglia
{"title":"Surgical Approaches to Serous Retinal Detachment With Retina-Lens Touch in Eyes With Nanophthalmos.","authors":"Ahmad M Mansour, Lorenzo López-Guajardo, Şengül Özdek, Ivajlo Popov, Maurizio Parodi Battaglia","doi":"10.1177/24741264231220157","DOIUrl":"10.1177/24741264231220157","url":null,"abstract":"<p><p><b>Purpose:</b>To describe the visual outcomes and problems that resulted from surgical treatment of nanophthalmic complete retinal detachment (RD) with retina-lens contact. <b>Methods:</b> A multicenter retrospective case series with deep sclerectomy as a treatment was performed. <b>Results:</b> Five cases had extensive deep sclerectomies, 3 with intended drainage of subretinal fluid (SRF). The RD resolved 1 week postoperatively in 4 cases and within 1 month in 1 case. The visual acuity improved from light perception to a median of 20/100. Three cases had longstanding lens touch beyond 1 year and improved VA to 20/100, 20/150, and hand motions, respectively. Complications included focal lens dialysis in 2 cases (passive drainage of SRF) and lens or intraocular lens dislocation in 1 case each (active drainage of SRF). Ultrasound biomicroscopy and anterior optical coherence tomography showed a very narrow angle and short zonules. <b>Conclusions:</b> Deep sclerectomy results in good anatomic and functional improvements in advanced cases of nanophthalmos exudative detachment, which is often considered to be incurable.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10924594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140094345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytomegalovirus Retinitis Associated With Intravitreal Dexamethasone Implant Injection. 与玻璃体内注射地塞米松有关的巨细胞病毒视网膜炎
IF 0.6
Journal of VitreoRetinal Diseases Pub Date : 2023-12-27 eCollection Date: 2024-03-01 DOI: 10.1177/24741264231221325
Marissa K Shoji, Jesse D Sengillo, Akaanksh Shetty, Joshua Uhr, Jayanth Sridhar
{"title":"Cytomegalovirus Retinitis Associated With Intravitreal Dexamethasone Implant Injection.","authors":"Marissa K Shoji, Jesse D Sengillo, Akaanksh Shetty, Joshua Uhr, Jayanth Sridhar","doi":"10.1177/24741264231221325","DOIUrl":"10.1177/24741264231221325","url":null,"abstract":"<p><p><b>Purpose:</b> To describe an immunocompetent patient with cytomegalovirus (CMV) retinitis after dexamethasone implant injection and review previously documented cases. <b>Methods:</b> A review of case reports and literature was performed. <b>Results:</b> A 75-year-old man presented with acute decreased vision in the left eye. He had a vitrectomy and membrane peeling for an epiretinal membrane with recurrent cystoid macular edema and was receiving intravitreal dexamethasone implant injections at an outside hospital. The visual acuity in the left eye was hand motions, and an examination found patchy retinal whitening with hemorrhages. Aqueous polymerase chain reaction was positive for CMV. The laboratory evaluation was negative for immunodeficiencies. He was treated successfully with intravitreal and oral antivirals; however, his vision remained poor at most recent follow-up. A literature review found 8 previous cases of CMV retinitis after dexamethasone implant injection, although most had underlying immune dysregulation. <b>Conclusions:</b> CMV retinitis after intravitreal dexamethasone implant injection is rare. Awareness of this complication is essential because of the risk for devastating blindness.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10924599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140094341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of Pars Plana Vitrectomy With Membrane Peel for Lamellar Macular Holes and Related Conditions Using a New Optical Coherence Tomography Consensus Definition 使用新的光学相干断层扫描共识定义进行带膜剥离的玻璃体旁切术治疗鳞状黄斑孔及相关病症的结果
IF 0.6
Journal of VitreoRetinal Diseases Pub Date : 2023-12-24 DOI: 10.1177/24741264231218054
Taariq K. Mohammed, John T. Thompson
{"title":"Outcomes of Pars Plana Vitrectomy With Membrane Peel for Lamellar Macular Holes and Related Conditions Using a New Optical Coherence Tomography Consensus Definition","authors":"Taariq K. Mohammed, John T. Thompson","doi":"10.1177/24741264231218054","DOIUrl":"https://doi.org/10.1177/24741264231218054","url":null,"abstract":"Purpose: To characterize the change in visual acuity (VA) in eyes treated with vitrectomy using the 2020 international consensus-based optical coherence tomography (OCT) definition of lamellar macular hole (LMH), macular pseudohole (MPH), and epiretinal membrane with foveoschisis (ERMF). Methods: A retrospective chart review was performed from 2000 to 2022 of patients who had vitrectomy for symptomatic decreased VA from LMH, MPH, or ERMF performed by the same surgeon at a community hospital. Preoperative spectral domain (SD-OCT) was reviewed to classify patients using the consensus guidelines. Primary outcomes were the mean change in best-corrected VA at 3 months, 1 year, and the final postoperative examination. Results: Fifty-one patients were included, 30 with LMH, 14 with MPH, and 7 with ERMF. The VA was 20/63 at baseline, 20/62 ( P = .79) 3 months postoperatively, 20/40 ( P = .003) at 1 year, and 20/52 ( P = .10) at the final examination for LMH; 20/64, 20/50 ( P = .16), 20/40 ( P = .040), and 20/40 ( P = .02), respectively, for MPH; and 20/53, 20/50 ( P = .42), 20/30 ( P = .03), and 20/38 ( P = .04), respectively, for ERMF. Subgroup analysis showed that eyes with LMH without ellipsoid zone disruption on SD-OCT improved from 20/57 at baseline to 20/39 ( P = .01) at the final examination. Conclusions: There was no significant improvement in VA at the final postvitrectomy examination in eyes with LMH, while there was significant improvement in eyes with MPH and ERMF. This supports surgery in selected eyes with MPH and ERMF but possibly not in eyes with LMH, unless OCT shows no ellipsoid zone disruption.","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disparity in Medicare Reimbursement Between Female and Male Vitreoretinal Surgeons 女性和男性玻璃体视网膜外科医生在医疗保险报销方面的差异
IF 0.6
Journal of VitreoRetinal Diseases Pub Date : 2023-12-23 DOI: 10.1177/24741264231215532
Aidan S. Gilson, Ron A. Adelman
{"title":"Disparity in Medicare Reimbursement Between Female and Male Vitreoretinal Surgeons","authors":"Aidan S. Gilson, Ron A. Adelman","doi":"10.1177/24741264231215532","DOIUrl":"https://doi.org/10.1177/24741264231215532","url":null,"abstract":"Purpose: To quantify the Medicare reimbursement disparity between female and male vitreoretinal surgeons. Methods: Reimbursement reports were obtained from the US Center for Medicare and Medicaid Services from 2013 through 2020, which detail all Medicare Part B services. A vitreoretinal surgeon was defined as any provider with at least 10 charges of a Healthcare Common Procedure Coding System code related to vitrectomy or retinal detachment repair. Providers were grouped by sex, and the average total reimbursement rate and additional secondary statistics to quantify the reimbursement disparity were identified. Results: On average, female vitreoretinal surgeons were reimbursed 65% that of their male counterparts in 2020, $1.66 million to $2.56 million. The percentage of the average male vitreoretinal specialist’s total reimbursement that the average female vitreoretinal specialist received decreased 8.8% from 2013 to 2020, from 73.8% to 65.0%. Conclusions: The reimbursement that the average female vitreoretinal surgeon receives from Medicare is only two thirds that of the average male vitreoretinal surgeon. In addition, there was no identifiable improvement in this disparity over the study period. Further efforts must be taken to establish concerted efforts to improve the reimbursement disparity and to identify the systematic inequities that led to its presence in the first place.","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139161134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of Scleral Buckling After Failed Pneumatic Retinopexy 气动视网膜成形术失败后的巩膜扣带术后效果
IF 0.6
Journal of VitreoRetinal Diseases Pub Date : 2023-12-23 DOI: 10.1177/24741264231216795
Tuan Tran, Henry Chen, Bonnie He, D. Albiani, A. Kirker, A. Merkur, David Maberley, Zaid N Mammo
{"title":"Outcomes of Scleral Buckling After Failed Pneumatic Retinopexy","authors":"Tuan Tran, Henry Chen, Bonnie He, D. Albiani, A. Kirker, A. Merkur, David Maberley, Zaid N Mammo","doi":"10.1177/24741264231216795","DOIUrl":"https://doi.org/10.1177/24741264231216795","url":null,"abstract":"Purpose: To assess the visual and anatomic outcomes of eyes that had secondary scleral buckle (SB) surgery after unsuccessful pneumatic retinopexy (PR) for rhegmatogenous retinal detachment (RRD). Methods: A retrospective study, performed over a 12-year period, comprised patients who had secondary SB procedures after failed primary PR. Clinical parameters (eg, best-corrected visual acuity [BCVA], lens status, macula status, details of RRD and subretinal fluid) were assessed at presentation, before additional procedures, and at follow-up (6 months, 1 year, and last visit). Statistical comparisons were made using Brown-Forsythe and Welch analysis of variance tests, with significance levels set at P < .05. Results: Fifty-four eyes with adequate follow-up were included. Forty-four (81.5%) of 54 eyes had successful retinal reattachment with secondary SB alone. The remaining eyes had subsequent pars plana vitrectomy (PPV). Patients presenting with macula-on RRD who had successful secondary SB had no statistically significant change in BCVA from baseline (mean final logMAR 0.23 ± 0.25 [Snellen 20/34]; P = .999). There was a statistically significant improvement in BCVA in patients presenting with macula-off RRD who had successful secondary SB (mean final logMAR 0.32 ± 0.36 [20/42]; P < .001 and mean change in logMAR −1.06 ± 0.85). Ten patients presenting with macula-off RRD who had failed secondary SB had a significant improvement in the final BCVA (mean final logMAR 0.22 ± 0.28 [20/33]; P = .044), despite the need for an additional PPV to achieve reattachment. Conclusions: Secondary SB remains a good option for RRD repair after unsuccessful PR and may avoid the need for PPV.","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139162886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinal Vasculitis After Intravitreal Pegcetacoplan: Report From the ASRS Research and Safety in Therapeutics (ReST) Committee 玻璃体内注射 Pegcetacoplan 后的视网膜血管炎:ASRS 治疗研究与安全(ReST)委员会的报告
IF 0.6
Journal of VitreoRetinal Diseases Pub Date : 2023-12-21 DOI: 10.1177/24741264231220224
A. Witkin, Glenn J. Jaffe, Sunil K. Srivastava, Janet L. Davis, Judy E. Kim
{"title":"Retinal Vasculitis After Intravitreal Pegcetacoplan: Report From the ASRS Research and Safety in Therapeutics (ReST) Committee","authors":"A. Witkin, Glenn J. Jaffe, Sunil K. Srivastava, Janet L. Davis, Judy E. Kim","doi":"10.1177/24741264231220224","DOIUrl":"https://doi.org/10.1177/24741264231220224","url":null,"abstract":"Purpose: To analyze post-marketing cases of retinal vasculitis after intravitreal pegcetacoplan. Methods: The American Society of Retina Specialists (ASRS) Research and Safety in Therapeutics (ReST) Committee as well as an expert panel performed a retrospective review of cases of retinal vasculitis reported to the ASRS. Clinical and imaging characteristics were reviewed for evidence of retinal vasculitis and analyzed. Results: Fourteen eyes of 13 patients were confirmed to have retinal vasculitis by review of imaging studies. All cases occurred after the first pegcetacoplan injection. Occlusive retinal vasculopathy was confirmed in 11 eyes (79%). Patients presented a median of 10.5 days (range, 8-23 days) after pegcetacoplan injection. All eyes had anterior chamber inflammation, and 12 eyes (86%) had vitritis. Vasculopathy involved retinal veins (100%) more than arteries (73%), and 12 eyes (86%) had retinal hemorrhages. The median visual acuity (VA) was 20/60 (range, 20/30-5/200) at baseline, 20/300 (range, 20/100-no light perception [NLP]) at vasculitis presentation, and 20/200 (range 20/70-NLP) at the last follow-up. Eight eyes (57%) had more than a 3-line decrease in VA, and 6 eyes (43%) had more than a 6-line decrease in VA from baseline to the final follow-up, including 2 eyes that were enucleated. Six eyes (43%) developed signs of anterior segment neovascularization. Conclusions: There is currently no known etiology for vasculitis in this series. Optimum treatment strategies remain unknown. Infectious etiologies should be considered, and corticosteroid treatments may hasten resolution of inflammatory findings. Continued treatment of affected patients with pegcetacoplan should be avoided.","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138949718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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