Nicolas Owlya, Mickael Barbosa, Anna Chiara Nascimbeni, Yannic Pannatier-Schuetz, Daniela Gallo Castro, Aude Ambresin
{"title":"Torpedo Maculopathy: Case Series of an Underdiagnosed and Rare Condition Using Multimodal Imaging.","authors":"Nicolas Owlya, Mickael Barbosa, Anna Chiara Nascimbeni, Yannic Pannatier-Schuetz, Daniela Gallo Castro, Aude Ambresin","doi":"10.1055/a-2238-7245","DOIUrl":"10.1055/a-2238-7245","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":"759-763"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139098090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Beckers, Florian Kretz, Karen Glandorf, Salah Abdassalam, Fabian Höhn, Mohamed Amer, Detlev R H Breyer, Lena Beckers
{"title":"AREDS2 Under Scrutiny: Advocating Unified Regulations.","authors":"David Beckers, Florian Kretz, Karen Glandorf, Salah Abdassalam, Fabian Höhn, Mohamed Amer, Detlev R H Breyer, Lena Beckers","doi":"10.1055/a-2611-2310","DOIUrl":"10.1055/a-2611-2310","url":null,"abstract":"<p><strong>Background: </strong>Age-related macular degeneration (AMD) is one of the leading causes of blindness in older adults. Dietary supplements based on the AREDS2 formulation are considered an evidence-based intervention to slow disease progression in intermediate AMD.</p><p><strong>Objective: </strong>This study aimed to systematically compare the composition of over-the-counter dietary supplements marketed for AMD support with the original AREDS2 formula and to quantify any deviations.</p><p><strong>Methods: </strong>As part of a market analysis, products available in Germany claiming a supportive effect in AMD were identified. The ingredients and dosages declared on the packaging were compared with the reference values used in the AREDS2 study.</p><p><strong>Results: </strong>The majority of analysed supplements exhibited substantial deviations from the AREDS2 formulation. On average, the concentrations of vitamin C were 52.3% lower, vitamin E 61.2% lower, and zinc 40.1% lower than the recommended amounts. Only a minority of products matched the reference formulation in both composition and dosage.</p><p><strong>Conclusion: </strong>There are significant discrepancies in the composition of commercially available AREDS2-based supplements. The implementation of standardised labelling requirements and regulatory guidelines appears necessary to enhance comparability and support evidence-based use in clinical practice.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":"242 7","pages":"735-740"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julia Prinz, Kathi Hartmann, Peter Walter, Tibor Lohmann, Matthias Fuest, David Kuerten
{"title":"Tendon Elongation with Fascia Lata Grafts in Strabismus Surgery - Multiple Indications Apart from Graves' Orbitopathy.","authors":"Julia Prinz, Kathi Hartmann, Peter Walter, Tibor Lohmann, Matthias Fuest, David Kuerten","doi":"10.1055/a-2611-2250","DOIUrl":"https://doi.org/10.1055/a-2611-2250","url":null,"abstract":"<p><strong>Background: </strong>To investigate the use of fascia lata (FL) grafts for eye muscle tendon elongation in patients with complex and residual strabismus types apart from Graves' orbitopathy.</p><p><strong>Methods and materials: </strong>In this retrospective study, a heterogeneous group of 27 eyes of 21 patients with complex and residual strabismus types who underwent elongation of the eye muscle tendon with FL were included. Orthoptic and ophthalmological examinations including measurement of the head posture, the extent of deviation in primary position (PP), and monocular excursion were conducted preoperatively and after a mean postoperative time of 12.2 (6.0 - 37.0, median 7.0) months in all patients.</p><p><strong>Results: </strong>Eight patients (12 eyes) with residual exotropia, 4 patients (4 eyes) with residual esotropia, 4 patients (6 eyes) with partial abducens nerve palsy, 4 patients (4 eyes) with vertical deviation, and 1 patient (1 eye) with Duane's retraction syndrome (DRS) type I were included. A residual squint angle of 10Δ or less was achieved in 57.1% of the patients at the last follow-up. The head posture was significantly reduced at the last follow-up compared to preoperatively in patients with residual exotropia (p = 0.002), esotropia (p = 0.040), abducens nerve palsy (p = 0.005), and vertical deviation (p = 0.005). At the last follow-up, a significant reduction in the squint angle occurred in patients with residual exotropia (p = 0.001), abducens nerve palsy (p = 0.046), and vertical deviation (p = 0.033).</p><p><strong>Conclusion: </strong>FL grafts may offer safe and effective surgical options for complex and residual strabismus types. No significant reduction in the excursion into the fields of action of the affected muscles was witnessed.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dimitrios Kalogeropoulos, Samir Khandhadia, Fatima Shawkat, Andrew John Lotery
{"title":"A Rare Case of CLN3-associated Isolated Retinal Degeneration with Macular Oedema.","authors":"Dimitrios Kalogeropoulos, Samir Khandhadia, Fatima Shawkat, Andrew John Lotery","doi":"10.1055/a-2577-9808","DOIUrl":"https://doi.org/10.1055/a-2577-9808","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Niklas Schön, Patrick K Peschke, Warda Darwisch, Clara Eileen Englisch, Annekatrin Rickmann
{"title":"[Foveal Red Spot Syndrome - Diagnosis on Sight?]","authors":"Niklas Schön, Patrick K Peschke, Warda Darwisch, Clara Eileen Englisch, Annekatrin Rickmann","doi":"10.1055/a-2604-4288","DOIUrl":"https://doi.org/10.1055/a-2604-4288","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carsten Heinz, David J Fink, Jennifer Dell, Moritz Berger, Matthias Schmid, Robert P Finger
{"title":"Prospective International Registry for Treatment Exit Options in Uveitis (TOFU) - the First Five Years.","authors":"Carsten Heinz, David J Fink, Jennifer Dell, Moritz Berger, Matthias Schmid, Robert P Finger","doi":"10.1055/a-2529-0057","DOIUrl":"10.1055/a-2529-0057","url":null,"abstract":"<p><p>Uveitis diseases are generally rare and therefore often pose a significant challenge in treatment. In developed countries, non-infectious uveitis is one of the most common causes of severe functional impairment and even blindness. The current guidelines provide information on when and how to initiate treatment, but do not include recommendations on when and how to reduce or discontinue treatment. The Treatment Exit Options for Uveitis Register (TOFU) was initiated over five years ago, with the aim of improving the evidence for therapy reduction and termination. Over the past five years, the register has been established nationally with funding from the German Federal Ministry of Education and Research (BMBF), the Eye Foundation and industry partners and has since been expanded in individual European countries. The registry is under the auspices of the Uveitis Section of the German Ophthalmological Society (DOG). The analysis of baseline data from around 1000 patients shows that, in the prospectively documented patient population, intermediate uveitis is most common, followed by posterior uveitis, panuveitis and retinal vasculitis. The disease was bilateral in 75.9% of cases. The mean visual acuity was 0.22 ± 0.36 logMAR. Patients with panuveitis had the worst visual acuity, with 0.27 ± 0.39 logMAR. Severe visual impairment (> 1.0 logMAR) was observed in only 1% of patients at baseline. The continuation and European expansion will ensure the continuous generation of high-quality data in the coming years and thus help to develop recommendations on the end of therapy.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Dietrich Beckers, Lena Beckers, Ulrich Schaudig, Birthe Stemplewitz
{"title":"[21-Year-old Patient with Paracentral Scotoma after Drug Abuse].","authors":"David Dietrich Beckers, Lena Beckers, Ulrich Schaudig, Birthe Stemplewitz","doi":"10.1055/a-2570-2993","DOIUrl":"10.1055/a-2570-2993","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":"671-673"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ocular Mucosal Pemphigoid: Diagnosis, Clinic and Therapy.","authors":"Uwe Pleyer","doi":"10.1055/a-2566-3860","DOIUrl":"https://doi.org/10.1055/a-2566-3860","url":null,"abstract":"<p><p>Ocular mucosal pemphigoid is a rare, chronically progressive autoimmune disease of the ocular surface. It belongs to a group of diseases whose common clinical correlate is the disruption of cohesion at the basement membrane. Recurrent inflammation with progressive fibrosis of the conjunctiva and damage to limbal stem cells are characteristic. If the course remains uncontrolled, severe morphological and functional damage can occur, up to blindness. Therefore, the critical perception of initially subtle findings and early diagnostic are of great importance. The aim of immune modulative therapy is to control the underlying inflammation and prevent the progression of fibrosis, in order to avoid serious complications.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":"242 6","pages":"653-659"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}