Klinische Monatsblatter fur Augenheilkunde最新文献_第6页

[Inherited retinal disorders: Current therapeutic options and future perspectives]. [遗传性视网膜疾病：当前的治疗选择和未来的展望]。

IF 0.8 4区医学

Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-07-23 DOI: 10.1055/a-2521-4616

Kristina Pfau, Ulrich Kellner

{"title":"[Inherited retinal disorders: Current therapeutic options and future perspectives].","authors":"Kristina Pfau, Ulrich Kellner","doi":"10.1055/a-2521-4616","DOIUrl":"https://doi.org/10.1055/a-2521-4616","url":null,"abstract":"Inherited retinal diseases (IRDs) represent a heterogeneous group of genetically driven conditions that frequently lead to progressive vision loss. Due to their complexity and the limited therapeutic options available, they pose a significant challenge for ophthalmology. This article provides a comprehensive overview of current evidence-based therapeutic approaches, including pharmacological strategies, gene therapy, and stem cell therapy, as well as innovative developments such as optogenetics and retinal implants. While gene therapies like Luxturna for RPE65-associated retinitis pigmentosa have paved the way for causal treatments, initial successes are also being observed in other retinal dystrophies, such as Stargardt disease and Usher syndrome. Rehabilitative measures and interdisciplinary care remain essential to improving the quality of life for affected individuals. Future research efforts focus on enhancing the efficacy and accessibility of therapies while addressing challenges such as inflammatory reactions, high costs, and genetic variability. The perspectives outlined highlight promising advancements in the treatment of genetic retinal diseases.","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world Efficacy, Safety, and the Impact of Spherical Equivalent on Intravitreal Anti-VEGF Therapy in Patients Affected by Myopic Choroidal Neovascularisation. 在近视脉络膜新生血管患者中，球形等效物对玻璃体内抗vegf治疗的实际疗效、安全性和影响。

IF 0.7 4区医学

Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-07-01 Epub Date: 2025-06-11 DOI: 10.1055/a-2561-2847

Peter Wolfrum, Anna Maria Voigt, Katrin Lorenz, Bernhard M Stoffelns, Christina A Korb

{"title":"Real-world Efficacy, Safety, and the Impact of Spherical Equivalent on Intravitreal Anti-VEGF Therapy in Patients Affected by Myopic Choroidal Neovascularisation.","authors":"Peter Wolfrum, Anna Maria Voigt, Katrin Lorenz, Bernhard M Stoffelns, Christina A Korb","doi":"10.1055/a-2561-2847","DOIUrl":"10.1055/a-2561-2847","url":null,"abstract":"Purpose: To analyse real-world clinical outcomes and influence of the spherical equivalent (SE) on anti-vascular endothelial growth factor (VEGF) therapy in patients affected by myopic choroidal neovascularisation (mCNV).Patients and methods: A retrospective investigation was conducted on treatment-naïve mCNV patients receiving anti-VEGF therapy at the Department of Ophthalmology, University Medical Center Mainz, Germany, between January 2018 and March 2024. Safety, functional and morphological changes in visual acuity (VA), central retinal thickness (CRT), and central retinal volume (CRV) were evaluated over a two-year period. Further, we analysed how baseline VA and CRT relate to it's final outcome measures. Finally, a subgroup analysis assessed the impact of SE above and below - 10 D.Results: Significant improvements in VA, CRT, and CRV were observed. VA improved from 0.5 ± 0.27 logMAR to 0.38 ± 0.31 logMAR (p = 0.005) at 6 months and remained stable at 2 years. CRT and CRV decreased from 344.4 ± 115.0 µm to 284.2 ± 45.2 µm (p < 0.001) and 0.27 ± 0.09 mm³ to 0.22 ± 0.04 mm³ (p < 0.001), respectively, four weeks after the initial injection, with stability maintained thereafter. Baseline VA correlated strongly with final VA, whereas CRT did not. No adverse events were reported. The subgroup analysis showed no significant outcome differences based on SE.Conclusion: Anti-VEGF therapy in mCNV patients proved to be safe and effective in our study with sustained improvement in functional and anatomical measures. Baseline VA strongly predicted final VA, whereas baseline and final CRT showed no association. No differences in treatment outcomes were observed as based on a varying SE.","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":"745-751"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal Nerve Fibre Layer OCT for Glaucoma Diagnosis - Gold Standard or Just a Piece of the Puzzle? 视网膜神经纤维层OCT诊断青光眼-金标准还是只是一块拼图？

IF 0.7 4区医学

Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-07-01 Epub Date: 2025-07-24 DOI: 10.1055/a-2501-8538

Leonie Bourauel, Karl Mercieca

{"title":"Retinal Nerve Fibre Layer OCT for Glaucoma Diagnosis - Gold Standard or Just a Piece of the Puzzle?","authors":"Leonie Bourauel, Karl Mercieca","doi":"10.1055/a-2501-8538","DOIUrl":"10.1055/a-2501-8538","url":null,"abstract":"Early diagnosis and accurate monitoring are essential in treating glaucoma effectively and avoiding further irreversible loss of retinal ganglion cells. Glaucoma is a complex disease; initial progression is usually asymptomatic, and regular clinical and imaging examinations are extremely important. Imaging the retinal nerve fibre layer (RNFL) using spectral domain optical coherence tomography (SD-OCT) has established itself in recent years as an easy-to-perform and reproducible diagnostic method. This imaging technique allows precise analysis of the RNFL in monitoring retinal nerve fibre thickness. The present article will discuss the anatomical principles, changes to be expected in the RNFL with glaucoma compared to normal control scans, and options in analysing disease progression. We will also be discussing limitations to the method as well as additional OCT imaging techniques available. Awareness of potential sources of error makes it easier to achieve an accurate analysis of RNFL scans. Tips on interpreting RNFL scans should help ophthalmologists using the available data effectively towards reaching informed decisions on disease treatment and management in glaucoma patients.","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":"242 7","pages":"726-734"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Patient selection for multifocal intraocular lenses]. [多焦人工晶体的患者选择]。

IF 0.7 4区医学

Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-07-01 Epub Date: 2025-05-19 DOI: 10.1055/a-2519-4324

Ramin Khoramnia, Tadas Naujokaitis

引用次数: 0

Früherkennung des Glaukoms als eine der häufigsten Erblindungsursachen – Fortschritte durch moderne Diagnostik mit OCT. 青光眼作为最常见的失明原因之一的早期发现-现代近距离CT诊断的进展。

IF 0.7 4区医学

Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-07-01 Epub Date: 2025-07-24 DOI: 10.1055/a-2579-7419

Verena Prokosch, Carl Erb

引用次数: 0

Patient Reported Outcomes of Retrobulbar versus Topical Anaesthesia in Cataract Surgery - a Prospective Observational Trial. [患者报告的后球囊与局部麻醉的结果]。

IF 0.7 4区医学

Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-07-01 Epub Date: 2025-05-19 DOI: 10.1055/a-2616-2773

Vera Kanlic, Andreas Guttmann, Andreas Wedrich, Domagoj Ivastinovic

{"title":"Patient Reported Outcomes of Retrobulbar versus Topical Anaesthesia in Cataract Surgery - a Prospective Observational Trial.","authors":"Vera Kanlic, Andreas Guttmann, Andreas Wedrich, Domagoj Ivastinovic","doi":"10.1055/a-2616-2773","DOIUrl":"10.1055/a-2616-2773","url":null,"abstract":"Objective: The aim of this prospective clinical, monocentric observational study was to assess the pain perception of patients during cataract surgery.Methodology: Patients undergoing cataract surgery at the Department of Ophthalmology at the Medical University of Graz were recruited. Patients who received retrobulbar anaesthesia (RBA) were compared to those who received topical drop anaesthesia (TA) with (TAG) or without an anaesthetic gel. Exclusion criteria were complications during the cataract surgery requiring additional steps including anterior vitrectomy and the placement of a Malyugin ring. The patients were interviewed postoperatively regarding their perceived pain experience during cataract surgery, using the Numeric Rating Scale. Additionally, the mean intraoperative blood pressure was recorded for correlation with the subjective assessment of pain.Results: Overall, 201 patients could be enrolled. Among them, 105 patients underwent cataract surgery under RBA, 50 patients under TA and 46 patients under TAG. The average pain score under RBA was 0.35 ± 0.87, under TA 1.32 ± 1.22, and under TAG 0.89 ± 0.97. Statistical analysis revealed a significant difference between RBA and the two topical anaesthesia methods (p < 0.01). However, no significant difference was found between the two topically applied methods, TA and TAG (p = 0.64). The mean intraoperative blood pressure could be obtained for a total of 32 patients. The average difference in values before and during the operation was + 1.88 mmHg under RBA and + 3.33 mmHg under TAG (p > 0.05).Conclusion: Our results indicate that patients receiving RBA have significantly less pain intraoperatively than those with TA and TAG. The addition of an anaesthetic gel to TA showed a slight, but not significant, reduction in pain.","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":"741-744"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glaucoma Diagnosis of the Optic Nerve Head Using Optical Coherence Tomography - Significance of Bruch's Membrane Opening and Derived OCT Parameters. 光学相干断层扫描诊断视神经头青光眼-布鲁赫膜开口及衍生OCT参数的意义。

IF 0.7 4区医学

Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-07-01 Epub Date: 2025-07-24 DOI: 10.1055/a-2558-8721

Philip Enders

{"title":"Glaucoma Diagnosis of the Optic Nerve Head Using Optical Coherence Tomography - Significance of Bruch's Membrane Opening and Derived OCT Parameters.","authors":"Philip Enders","doi":"10.1055/a-2558-8721","DOIUrl":"10.1055/a-2558-8721","url":null,"abstract":"Background: With the introduction of optical coherence tomography (OCT) in glaucoma imaging, the neuroretinal tissue of the retina and optic nerve head can be measured and quantified at different measuring points, much more accurately than with previous imaging techniques. In addition to macular parameters such as the macular and peripapillary thickness of the retinal nerve fibre thickness and the macular ganglion cell layer thickness, parameters close to the papillary were also defined, as based on the Bruch's membrane opening (BMO), and examined with regard to their suitability for glaucoma diagnostics. This overview presents the advantages and disadvantages of these parameters in glaucoma diagnostics.Materials and methods: Review of current literature in PubMed as well as synopsis of relevant guidelines.Results and conclusion: The minimum marginal width of the Bruch's membrane opening (BMO-MRW) is the most frequently used OCT parameter for measuring the neuroretinal marginal width of the optic nerve head. There are also area parameters. Compared to peripapillary RNFL thickness and macular parameters, BMO-MRW has equivalent to superior sensitivity in glaucoma detection. In the longitudinal view, effects such as changes in the eye pressure level lead to fluctuations in BMO-MRW, which limits the usefulness of this parameter with regard to morphometric progression analysis. Numerous studies have shown that peripapillary nerve fibre layer thickness (pRNFL) is better suited for progression analysis. Checking the automatic segmentation of OCT images is relevant for all OCT parameters in glaucoma diagnostics.","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":"242 7","pages":"718-725"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lamellar Macular Hole-Associated Epiretinal Proliferation with Cystoid Changes: Long-term Follow-up. 片状黄斑空洞相关视网膜上增生伴囊样改变：长期随访。

IF 0.7 4区医学

Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-07-01 Epub Date: 2023-06-21 DOI: 10.1055/a-2114-4953

Ayse Guzin Taslipinar Uzel, Jonas Neubauer, Faik Gelisken

引用次数: 0

[Subconjuctival Dexamethasone Implantation]. [龈下地塞米松植入]。

IF 0.7 4区医学

Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-07-01 Epub Date: 2024-03-26 DOI: 10.1055/a-2243-4507

Louise Massia Menkene, Clara Eileen Englisch, Warda Darwisch, Peter Szurman, Annekatrin Rickmann

引用次数: 0

Understanding Glaucoma: Why it Remains a Leading Cause of Blindness Worldwide. 了解青光眼：为什么它仍然是全球失明的主要原因。

IF 0.7 4区医学

Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-07-01 Epub Date: 2025-07-24 DOI: 10.1055/a-2617-1575

Tienan Qi, Hanhan Liu, Layla Frühn, Katrin Löw, Claus Cursiefen, Verena Prokosch

{"title":"Understanding Glaucoma: Why it Remains a Leading Cause of Blindness Worldwide.","authors":"Tienan Qi, Hanhan Liu, Layla Frühn, Katrin Löw, Claus Cursiefen, Verena Prokosch","doi":"10.1055/a-2617-1575","DOIUrl":"10.1055/a-2617-1575","url":null,"abstract":"Glaucoma is one of the leading causes of irreversible blindness worldwide and is often referred to as the \"silent thief of sight\", because it often progresses without noticeable symptoms until significant vision loss occurs. With an estimated 76 million patients affected in 2020 and a forecast of over 111 million by 2040, the global situation requires urgent attention. Vision loss caused by glaucoma is irreversible but largely preventable, highlighting the importance of early detection and treatment. Diagnosis presents significant challenges, particularly due to the asymptomatic nature of the disease and age-related risk factors. Inequalities in care and access to appropriate treatments are other barriers leading to delayed diagnoses. Early diagnosis and interventions are critical to slow disease progression, protect remaining vision and improve the quality of life of those affected. These measures are particularly important to minimise the psychological impact and impairment in daily activities. The use of innovative technologies and targeted interventions could help improve the early detection and treatment of glaucoma and thus reduce the risk of irreversible vision loss.","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":"242 7","pages":"712-717"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0