Korean Journal of Ophthalmology : KJO最新文献

{"title":"The First Korean Child of Jalili Syndrome with a Novel Missense Mutation in Cation Transport Mediator 4 (CNNM4): A Case Report.","authors":"Ji Hye Lee, Ji Sook Yim, Myung Shin Kim, Sin-Young Kim, Shin Hae Park","doi":"10.3341/kjo.2022.0144","DOIUrl":"https://doi.org/10.3341/kjo.2022.0144","url":null,"abstract":"Dear Editor, Jalili syndrome is an extremely rare autosomal recessive disorder with two major ocular and dental features: conerod dystrophy and amelogenesis imperfecta [1]. Patients often have poor visual acuity, photophobia, nystagmus, and absent color vision. Since the first case report in 1988, the metal cation transport mediator 4 (CNNM4) gene residing at chromosome locus 2q11.2 is discovered to be a causative gene of Jalili syndrome in 2009 [2,3]. We report the first Korean case of Jalili syndrome carrying compound heterozygous causative variants with a novel missense variant in CNNM4. A 7-year-old boy visited Seoul St. Mary’s Hospital with uncorrected vision. He was the first baby of nonconsanguineous parents and was born at 38 weeks gestation with a birth weight of 3.35 kg. There was no previous family history of ocular, systemic, or chromosomal disorders. He had a mild hyperopic refractive error of +1.5 diopters. He had been wearing glasses for several years, but his best-corrected visual acuity was 20 / 200 in both eyes. Photophobia and slow pendular nystagmus were also observed. Fundus examination revealed a normal-looking optic disc and macula (Fig. 1A, 1B). Whereas widefield fundus photography and fundus autofluorescence did not reveal any definite abnormalities, the blurring of ellipsoid zone was noted on optical coherence tomography (Fig. 1C–1F). A full-field electroretinogram (RETI-scan, Roland Consult) showed severely reduced responses in the cone and rod systems in both eyes (Fig. 1G). After obtaining written informed consent from his parents, next-generation sequencing (NGS) was performed for the genetic analysis. Targeted panel sequencing was done with 439 genes, which were reported as being related to inherited retinal dystrophy. Subsequently, compound heterozygous missense variants of c.1511T>G, p.(Ile504Ser), and c.344T>C, p.(Leu115Pro) in the CNNM4 (reference sequence, NM_020184.4) were identified. The c.1511T>G, p.(Ile504Ser), is in the cystathionine-β-synthase domain which is evolutionarily conserved and known to play essential roles in the regulation of the activities of numerous proteins (PMID: 31347285, 16275737, 14722619). Population frequencies were extremely low (0.0000544 in East Asian populations and 0.00000398 in all ethnicities, according to gnomAD exome), and the variant was predicted to have a deleterious effect by multiple line in silico tools, including MutationTaster [4], PolyPhen-2 [5], and SIFT [6]. Based on these facts, we classified the mutation as likely pathogenic according to the American College of Medical Genetics and Genomics guidelines. A c.344T>C variant has never been reported in a population database. It causes a p.(Leu115Pro) amino acid change, and this position is conserved (phyloP100way, 6.03); multiple in silico tools such as FATHMM-MKL [7], MutationTaster [4], and PolyPhen-2 [5] predicted a deleterious effect by affecting the protein synthetic process. A parental testing, which was perfor","PeriodicalId":17883,"journal":{"name":"Korean Journal of Ophthalmology : KJO","volume":"37 2","pages":"195-197"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/54/68/kjo-2022-0144.PMC10151169.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9395636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scleral Lens Applications Focused on Korean Patients with Various Corneal Disorders.","authors":"Ko Eun Lee,&nbsp;Su Young Moon,&nbsp;Sanghyu Nam,&nbsp;Joon Hyuck Jang,&nbsp;Jae Yong Kim,&nbsp;Hungwon Tchah,&nbsp;Hun Lee","doi":"10.3341/kjo.2022.0164","DOIUrl":"https://doi.org/10.3341/kjo.2022.0164","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to report on the clinical outcomes of scleral lens applications in Korean patients with various corneal disorders.</p><p><strong>Methods: </strong>This retrospective review was conducted for 62 eyes of 47 patients who had been fitted with scleral lenses for various corneal disorders. The patients were referred for inadequate spectacle-corrected visual acuity and rigid gas permeable (RGP) or soft contact lens intolerance. Uncorrected visual acuity, habitually corrected visual acuity, best lens-corrected visual acuity, topographic indices, keratometry indices, and lens parameters were evaluated.</p><p><strong>Results: </strong>Twenty-six eyes of 19 patients with keratoconus were enrolled. Other conditions included corneal scar (13 eyes of 12 patients), phlyctenules (three eyes), laceration (four eyes), chemical burn (one eye), keratitis (one eye), Peters' anomaly (one eye), fibrous dysplasia (one eye), ocular graft-versus-host disease (two eyes of one patient), irregular astigmatism (18 eyes of 12 patients), and corneal transplant status (five eyes of four patients). The mean topographic values of the eyes include flat keratometric value (43.0 ± 6.1 diopters [D]), steep keratometric value (48.0 ± 7.4 D), and astigmatism (4.9 ± 3.6 D). Of the eyes fitted with scleral lenses, best lens-corrected visual acuity (0.10 ± 0.22 logarithm of the minimum angle of resolution [logMAR]) was significantly better than the habitually corrected visual acuity (0.59 ± 0.62 logMAR, p < 0.001).</p><p><strong>Conclusions: </strong>Scleral contact lenses are a good alternative for patients with corneal abnormalities and those who are intolerable to RGP contact lenses, resulting in both successful visual outcomes and patient satisfaction, especially concerning keratoconus, corneal scar, and corneal transplant status.</p>","PeriodicalId":17883,"journal":{"name":"Korean Journal of Ophthalmology : KJO","volume":"37 2","pages":"157-165"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0d/0a/kjo-2022-0164.PMC10151163.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9766826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possibility of Neurological Diseases Associated with Acute Acquired Comitant Esotropia.","authors":"Mayuree Montriwet","doi":"10.3341/kjo.2022.0112","DOIUrl":"https://doi.org/10.3341/kjo.2022.0112","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the possibility of neurological etiologies causing acute acquired comitant esotropia (AACE) and to evaluate the differences in clinical features between younger children, older children, and adults.</p><p><strong>Methods: </strong>In this retrospective analysis, patients who had been diagnosed with AACE between July 2017 and June 2021 were included. Data on clinical findings, medical history, brain or orbital imaging, and ophthalmological and orthoptic examinations were retrieved from medical records and analyzed. Patients were divided into three groups based on their age: younger children (<10 years), older children (10-18 years), and adults (>18 years).</p><p><strong>Results: </strong>Overall, 41 patients with AACE (15 females and 26 males) were examined. Most patients were children. Mild hyperopia was observed in children, while adults had moderate to high myopia. The mean angle of esotropia at a distance fixation was 43.57 ± 9.77, 51.54 ± 8.75, and 30.14 ± 12.39 prism diopters (PD) in younger children, older children, and adult groups, respectively. The mean angle of esotropia at a near fixation was 43.57 ± 9.37, 51.15 ± 9.39, and 31.43 ± 12.15 PD in younger children, older children, and adult groups, respectively. Significant differences were found in the mean angles of esotropia in patients with AACE at both near and far distances according to their age (all p < 0.001). Among 36 patients with previous neuroimaging data, none had AACE secondary to intracranial lesions. Over 2 years, five patients who were under continuous observation did not develop any neurological abnormalities.</p><p><strong>Conclusions: </strong>AACE was more common in children than in adults. The angle of deviation was larger in children than in adults. Coexisting or underlying neurological diseases were not present in patients with isolated AACE, which eliminated the need for neuroimaging. Continuous follow-up evaluations are warranted when signs of intracranial disease are observed in patients who have not undergone an imaging investigation.</p>","PeriodicalId":17883,"journal":{"name":"Korean Journal of Ophthalmology : KJO","volume":"37 2","pages":"120-127"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/eb/c4/kjo-2022-0112.PMC10151165.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9402747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyrotropin Receptor Autoantibody Assessment in Thyroid Eye Disease: Does the Assay Type Matter?","authors":"Malik Moledina,&nbsp;Jonathan Roos,&nbsp;Rachna Murthy","doi":"10.3341/kjo.2022.0131","DOIUrl":"https://doi.org/10.3341/kjo.2022.0131","url":null,"abstract":"<p><strong>Purpose: </strong>Thyroid receptor antibodies can quantify thyroid eye disease activity, predict outcomes and aid timing of interventions. The type and generation of assay is frequently unspecified, complicating meta-analyses. To determine the clinical and biochemical relationships between a second-generation thyrotropin receptor-binding inhibition antibody (TRAb) immunoassay, detecting stimulatory and blocking antibodies, with the thyroid stimulating immunoglobulin (TSI) bridging immunoassay detecting the stimulatory component only.</p><p><strong>Methods: </strong>Retrospective review of 100 consecutive patients attending a regional specialist service. For each patient and visit, both a TRAb and TSI were performed, and a clinical activity score (CAS) recorded.</p><p><strong>Results: </strong>A significant positive correlation between TRAb and TSI (rho = 0.828, p < 0.01) but a weaker correlation between the assays and CAS (TRAb: rho = 0.439, p < 0.01; TSI: r = 0.357, p < 0.01) were found. In 10% of the episodic data, patients had a TRAb level that was disproportionately high (39.41 ± 52.84 IU/L), compared to their TSI levels (9.53 ± 12.10 IU/L) with a higher-than-average CAS (2.47 ± 1.78; range, 0-5). Within 12 months of diagnosis, a significant positive correlation between CAS and TRAb (rho = 0.503, p < 0.01) as well as between CAS and TSI (rho = 0.329, p < 0.01) were found. In patients with a diagnosis over 12 months, the correlation with CAS for both TSI and TRAb were Spearman rank correlation coefficient of 0.347 (p < 0.01) and 0.327 (p < 0.01), respectively.</p><p><strong>Conclusions: </strong>TRAb and TSI correlate strongly and to a lesser extent with the CAS. For most patients, TRAb can be replaced with the more economical TSI. TRAb also correlates better with newly diagnosed, more active patients than TSI. In a subset of patients, blocking antibodies may play a significant pathogenic role, requiring different treatment and monitoring. Further studies are required to investigate this relationship.</p>","PeriodicalId":17883,"journal":{"name":"Korean Journal of Ophthalmology : KJO","volume":"37 2","pages":"147-156"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4c/7d/kjo-2022-0131.PMC10151161.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9420951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between Interocular Asymmetry of Corneal Hysteresis and Visual Field Defect in Glaucoma.","authors":"Eun Jung Choi,&nbsp;Kyung Nam Kim,&nbsp;Mi Yeon Song,&nbsp;Young Hoon Hwang","doi":"10.3341/kjo.2022.0120","DOIUrl":"https://doi.org/10.3341/kjo.2022.0120","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the relationship between interocular asymmetries of corneal hysteresis (CH) and visual field defects in Korean patients with glaucoma.</p><p><strong>Methods: </strong>A total of 444 eyes from 222 participants with glaucoma in at least one eye were enrolled. CH was measured using an ocular response analyzer (Reichert Technologies Inc). Eyes of each participant were classified into \"better eye\" and \"worse eye\" based on the mean deviation (MD) value of visual field test. The correlation between interocular differences in intraocular pressure, axial length, central corneal thickness, CH, and MD values was evaluated using Spearman correlation analysis. To exclude the possible effect of antiglaucoma medication on corneal properties, additional analyses were performed on eyes without any glaucoma treatment at the time of CH measurement (treatment-naive group).</p><p><strong>Results: </strong>Median (interquartile range) MD value was -3.71 dB (-6.87 to -1.30 dB) in the better eye and -10.20 dB (-16.32 to -5.62 dB) in the worse eye. When the correlation between the asymmetry of the MD value and asymmetry of intraocular pressure, axial length, central corneal thickness, and CH were evaluated, only interocular differences in CH were significantly associated with interocular differences in MD values (rho = 0.214, p = 0.001). Among the 222 participants, 60 (27.0%) were treatment-naive group. In these eyes, interocular differences in CH were also significantly associated with interocular differences in the MD values (rho = 0.285, p = 0.029).</p><p><strong>Conclusions: </strong>The interocular asymmetry of CH was significantly correlated with the interocular asymmetry of visual field defects in glaucoma.</p>","PeriodicalId":17883,"journal":{"name":"Korean Journal of Ophthalmology : KJO","volume":"37 2","pages":"112-119"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/78/0c/kjo-2022-0120.PMC10151164.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9402750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Intrascleral Fixation of Intraocular Lens Compared to Ciliary Sulcus Implantation and Transscleral Fixation.","authors":"Eun Gyu Yoon,&nbsp;Youngsub Eom,&nbsp;Minji Woo,&nbsp;Hyun Sun Jeon,&nbsp;Seong-Jae Kim,&nbsp;Jong Suk Song,&nbsp;Hyo Myung Kim","doi":"10.3341/kjo.2022.0093","DOIUrl":"https://doi.org/10.3341/kjo.2022.0093","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the clinical outcomes of intrascleral fixation of the three-piece intraocular lenses (IOLs) 2.5 mm posterior to the limbus with ciliary sulcus implantation and transscleral fixation 2.5 mm posterior to the limbus.</p><p><strong>Methods: </strong>Sixty-five eyes of 65 patients who underwent ciliary sulcus implantation or transscleral or intrascleral fixation of the AMO Sensar AR40e IOL were retrospectively reviewed. The postoperative refractive prediction error, back-calculated effective lens position (ELP), corrected distance visual acuity (CDVA), and postoperative residual cylinder were compared.</p><p><strong>Results: </strong>There were significant differences in the median (interquartile range) postoperative refractive prediction error (diopters [D]) among the three groups (p < 0.001): for ciliary sulcus implantation (33 eyes), -0.89 D (-1.21 to -0.56 D); for transscleral fixation (10 eyes), -0.40 D (-0.78 to -0.22 D); and for intrascleral fixation (22 eyes), 0.01 D (-0.28 to 0.34 D). Significant differences (p < 0.001) were observed in the median back-calculated ELP: for ciliary sulcus implantation, 4.35 mm (3.95 to 4.55 mm); for transscleral fixation, 4.51 mm (4.34 to 4.76 mm); and for intrascleral fixation, 4.90 mm (4.56 to 5.35 mm). There were no differences in the median postoperative CDVA (0, 0.10, and 0 logarithm of the minimum angle of resolution, respectively; p = 0.083) and the residual cylinder (-0.75, -1.50, and -0.63 D, respectively; p = 0.074) among three groups.</p><p><strong>Conclusions: </strong>Intrascleral fixation showed no myopic shift and the most posterior lens position, while ciliary sulcus implantation induced the greatest myopic shift and the most anterior lens position. However, there was no significant difference in the postoperative CDVA or astigmatism among the eyes with different IOL insertion methods, demonstrating good IOL stability and vision outcomes.</p>","PeriodicalId":17883,"journal":{"name":"Korean Journal of Ophthalmology : KJO","volume":"37 2","pages":"128-136"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d5/93/kjo-2022-0093.PMC10151168.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9402748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inverted Mucoepidermoid Papilloma: A Case Report.","authors":"Hyunchul Jeong,&nbsp;Namju Kim","doi":"10.3341/kjo.2022.0121","DOIUrl":"https://doi.org/10.3341/kjo.2022.0121","url":null,"abstract":"Dear Editor, Inverted mucoepidermoid papilloma is a rare benign epithelial tumor. There have been six cases reported worldwide and here, we would like to introduce the first case of the inverted mucoepidermoid papilloma of conjunctiva in Korea. Written informed consent for publication of the clinical images was obtained from the patient. A 56-year-old man presented with right conjunctival mass found 2 months ago. He had no other underlying diseases except hypertension. His corrected visual acuity was 20 / 16 in both eyes. About 0.5 × 0.3-cm-sized pigmented and vascularized pedunculated mass was seen over the right inferior palpebral conjunctiva (Fig. 1A). The mass was soft and painless in nature. An excisional biopsy was performed, and the brownish sample was measured 0.5 × 0.3 × 0.2 cm. Histopathologic examination showed a single fragment lined by stratified squamous cells, with downward extension of conjunctival epithelium (Fig. 1B, 1C). Cystic components were visible in the lobules of nonkeratinizing squamous epithelium. Many goblet cells were found. No definite evidence of inflammation, dysplasia, and necrosis was found. Heuring et al. [1] reported peripheral carcinomatous foci within the lesion in their case of inverted transitional cell papilloma, whereas there was no evidence of malignancy in this case. On follow-up examination, his tarsal conjunctiva of the right lower lid was clear without remaining pigmented lesion (Fig. 1D). No recurrence was reported in up to 6 months of follow-up. Inverted papilloma is less common compared to exophytic papilloma in conjunctiva, with epithelium invaginating into the substantia propria endophytically. It is usually found in nasal cavity or paranasal sinuses, and there have been some case reports regarding local recurrence and malignant transformation of the tumor [2]. On histopathologic examination, inverted papilloma involving conjunctiva quite differ from inverted papilloma of other sites, featuring distinct cystic components within acanthotic lobules. Based on this finding, Jakobiec et al. [3] recommended the term inverted mucoepidermoid papilloma. Since inverted mucoepidermoid papilloma can be misdiagnosed as conjunctival nevus or malignant melanoma, definitive diagnosis should be made by histopathologic examination. There is no report on local recurrence or malignant transformation of inverted mucoepidermoid papilloma in conjunctiva, though there is no data on long-term follow-up of inverted mucoepidermoid papilloma over 5 years due to the rarity of the subtype [4]. In conclusion, we present a first case of inverted mucoepidermoid papilloma of conjunctiva in South Korea, which is an exceedingly rare neoplasm. Although inverted mucoepidermoid papilloma is extremely rare, it should be considered as a differential diagnosis of pigmented conjunctival mass.","PeriodicalId":17883,"journal":{"name":"Korean Journal of Ophthalmology : KJO","volume":"37 2","pages":"190-191"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4a/02/kjo-2022-0121.PMC10151175.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9401655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Learning-based Prediction of Axial Length Using Ultra-widefield Fundus Photography.","authors":"Richul Oh,&nbsp;Eun Kyoung Lee,&nbsp;Kunho Bae,&nbsp;Un Chul Park,&nbsp;Hyeong Gon Yu,&nbsp;Chang Ki Yoon","doi":"10.3341/kjo.2022.0059","DOIUrl":"https://doi.org/10.3341/kjo.2022.0059","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a deep learning model that can predict the axial lengths of eyes using ultra-widefield (UWF) fundus photography.</p><p><strong>Methods: </strong>We retrospectively enrolled patients who visited the ophthalmology clinic at the Seoul National University Hospital between September 2018 and December 2021. Patients with axial length measurements and UWF images taken within 3 months of axial length measurement were included in the study. The dataset was divided into a development set and a test set at an 8:2 ratio while maintaining an equal distribution of axial lengths (stratified splitting with binning). We used transfer learning-based on EfficientNet B3 to develop the model. We evaluated the model's performance using mean absolute error (MAE), R-squared (R2), and 95% confidence intervals (CIs). We used vanilla gradient saliency maps to illustrate the regions predominantly used by convolutional neural network.</p><p><strong>Results: </strong>In total, 8,657 UWF retinal fundus images from 3,829 patients (mean age, 63.98 ±15.25 years) were included in the study. The deep learning model predicted the axial lengths of the test dataset with MAE and R2 values of 0.744 mm (95% CI, 0.709-0.779 mm) and 0.815 (95% CI, 0.785-0.840), respectively. The model's accuracy was 73.7%, 95.9%, and 99.2% in prediction, with error margins of ±1.0, ±2.0, and ±3.0 mm, respectively.</p><p><strong>Conclusions: </strong>We developed a deep learning-based model for predicting the axial length from UWF images with good performance.</p>","PeriodicalId":17883,"journal":{"name":"Korean Journal of Ophthalmology : KJO","volume":"37 2","pages":"95-104"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ec/2d/kjo-2022-0059.PMC10151162.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9402749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Outcomes of Vitrectomy for Primary Treatment of Rhegmatogenous Retinal Detachment in Patients with Atopic Dermatitis.","authors":"Kyung Ho Lee,&nbsp;Yoo-Ri Chung,&nbsp;Ha Ryung Park,&nbsp;Tae Kyoung Woo,&nbsp;Kihwang Lee","doi":"10.3341/kjo.2022.0103","DOIUrl":"https://doi.org/10.3341/kjo.2022.0103","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the clinical results of vitrectomy alone as the primary treatment for rhegmatogenous retinal detachment (RD) in patients with atopic dermatitis (AD).</p><p><strong>Methods: </strong>The medical records of patients with AD treated for rhegmatogenous retinal detachment (RD) were retrospectively reviewed. We investigated the characteristics of retinal breaks and detachments, applied surgical methods, and results.</p><p><strong>Results: </strong>Twenty eyes of 14 patients with AD who presented with rhegmatogenous RD and treated by vitrectomy were included in this analysis. Sixteen eyes (80%) were treated with vitrectomy, either alone or in combination with cataract surgery, and the retina was successfully attached to 94% of the eyes. There were four cases in which vitrectomy was combined with encircling. Reoperation was needed in half of the eyes that received vitrectomy with encircling, which presented nearly total detachment, severe proliferative vitreoretinopathy, and pseudophakia.</p><p><strong>Conclusions: </strong>Vitrectomy alone, in combination with cataract surgery, may be sufficient to treat rhegmatogenous RD in patients with AD. Additional encircling or buckling should still be considered in complicated cases.</p>","PeriodicalId":17883,"journal":{"name":"Korean Journal of Ophthalmology : KJO","volume":"37 2","pages":"105-111"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/b9/kjo-2022-0103.PMC10151170.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9402752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Exacerbation of Conjunctival Papilloma after High-frequency Radio Wave Electrosurgery for Conjunctivochalasis: A Case Report.","authors":"Dae Sung Kim,&nbsp;Yeon Hee Choi,&nbsp;Yoo Jung Kim,&nbsp;Min Ho Kang","doi":"10.3341/kjo.2022.0152","DOIUrl":"https://doi.org/10.3341/kjo.2022.0152","url":null,"abstract":"Dear Editor, Conjunctivochalasis (CCH) is a chronic loosening of the conjunctiva that occurs significantly in the inferior bulbar conjunctiva. High-frequency radio wave electrosurgery is a surgical procedure for the treatment of CCH. There are fewer complications related to postoperative discomfort and suture; only minor complications, such as subconjunctival hemorrhage and chemosis, have been reported [1,2]. To the best of our knowledge, this is the first report of an human papillomavirus (HPV)-positive conjunctival papilloma in a patient who underwent high-frequency radio wave electrosurgery. Written informed consent for publication of the research details and clinical images was obtained from the patient. A 78-year-old Asian woman visited the outpatient with not having shed tears for 3 years and had irritation in both eyes, was treatmented for dry eye at a private hospital, but did not improve, so she visited Hanyang University Guri Hospital. On examination, she exhibited bilateral CCH. Conjunctival hyperemia, conjunctiva and plica semilunaris thickening, papillomatous lesion, and abnormal blood vessels were not visible in the conjunctiva (Fig. 1A, 1B). Even with proper dry eye treatment, the symptoms did not improve even after a month. Therefore, high-frequency radio electric surgery for CCH was planned and performed. Postsurgery, artificial tears, 0.1% f luorometholone, and 0.5% levofloxacin were instilled in both eyes four times a day. Two months after electrosurgery, the patient presented with hyperemia of both eyes and a burning sensation. She had a grayish-red, fleshy, and irregular surfaces on the inferior bulbar conjunctiva in the right eye. The left eye showed several small pedunculated masses in the inferior bulbar conjunctiva (Fig. 1C, 1D). Excisional biopsy was performed, and histological examination showed atypical squamous proliferation, moderate dysplasia, with a positive polymerase chain reaction (PCR) for HPV (low-risk type 11). Immunohistochemistry revealed that the right eye was p16-positive, p53-positive (15%), and Ki-67–positive (20%); the left eye was p16-negative, p53-positive (2%), and Ki-67–positive (10%) (Fig. 1E–1H). Topical mitomycin C 0.02% drops (four times a day for a week) were prescribed for both eyes. The drops were administered for a week, followed by a week of rest. Existing small recurrent lesions were resected during follow-up. As a result of observation after 5 months, no recurrence lesion was observed. Conjunctival papilloma is an acquired benign tumor that occurs in the stratified squamous epithelium of the conjunctiva. Exposure to solar ultraviolet radiation B is an important risk factor, and other risk factors include immunosuppression and the presence of HPV [3]. Patients with conjunctival intraepithelial neoplasia, conjunctival carcinoma in situ, or conjunctival squamous carcinoma showed HPV-positivity by PCR in 21% of primary tumors and 36% cases of recurrence [4]. In order for HPV to infect basal ","PeriodicalId":17883,"journal":{"name":"Korean Journal of Ophthalmology : KJO","volume":"37 2","pages":"187-189"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/62/1b/kjo-2022-0152.PMC10151167.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9401651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}