Klinicheskaia meditsina最新文献_第4页

[DIAGNOSTIC SIGNIFICANCE OF PLASMA TROPONIN AND CARDIOMYOCYTE FATTY ACID-BINDING PROTEIN LEVELS IN ACUTE CORONARY SYNDROME]. 血浆肌钙蛋白和心肌细胞脂肪酸结合蛋白水平对急性冠脉综合征的诊断意义。

Klinicheskaia meditsina Pub Date : 2017-01-01

V N Titov

{"title":"[DIAGNOSTIC SIGNIFICANCE OF PLASMA TROPONIN AND CARDIOMYOCYTE FATTY ACID-BINDING PROTEIN LEVELS IN ACUTE CORONARY SYNDROME].","authors":"V N Titov","doi":"","DOIUrl":"","url":null,"abstract":"Blood serum content of fatty acid-binding (FABP) protein increases within 2-3 h after the onset of acute coronary syndrome and myocardial infarction (MI) and reaches the maximum 8.5 h after the initiation of cardiomyocyte death. FABP content considerably decreases by the end of at 24-h period due to excretion with urine, remaining elevated for subsequent 24 h. High clinical sensitivity and relatively high organ specificity are typical of FABP for 12 h after ACS. Within the early period of MI clinical specificity of FABP prevails over troponin in terms of concentration. Troponins display higher clinical sensitivity and diagnostic specificity during a 12-h period after ACS, prevailing for several days after MI. Simultaneous measuring of FABP and troponins (Tr) within the first 12 h increases the sensitivity of biochemical diagnostics by 30%. At later periods, simultaneous determination of FABP and Tr becomes unnecessary: FABP is excreted with urine and Tr level acquires predominant diagnostic significance. No relationship has been revealed between blood content of FABP and reperfusion according to electrocardiography data, probably due to rare measurements of this highly dynamic parameter. FABP test cannot be used in patients with circulatory disorders since its results are not adequate. The best option for differential diagnostics of ACS within the first 24 h would be a combined express immunochromatographic test which allows to measure blood FABP and Tr levels pending objective evaluation.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"95 3","pages":"207-15"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36613712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The risk of cardiovascular death in type 2 diabetes]. [2型糖尿病的心血管死亡风险]。

Klinicheskaia meditsina Pub Date : 2017-01-01 DOI: 10.18821/0023-2149-2016-95-1-57-59

N. V. Zeinalova, Yagub Ziyaddin Kurbanov, V. A. Mirzazade, R. A. Rzayeva, M. S. Novruzova

引用次数: 2

[The risk of cardiovascular death in type 2 diabetes]. [2型糖尿病的心血管死亡风险]。

Klinicheskaia meditsina Pub Date : 2017-01-01

N V Zeinalova, Y Z Kurbanov, V A Mirzazade, R A Rzayeva, M S Novruzova

引用次数: 0

[Pathogenesis of myocarditis in patients with bronchial asthma and pecilomycosis]. 【支气管哮喘和纤毛菌病合并心肌炎的发病机制】。

Klinicheskaia meditsina Pub Date : 2017-01-01

V M Akhunov, Zh M Sizova, A M Akhunova, T P Lavrent'eva

{"title":"[Pathogenesis of myocarditis in patients with bronchial asthma and pecilomycosis].","authors":"V M Akhunov, Zh M Sizova, A M Akhunova, T P Lavrent'eva","doi":"","DOIUrl":"","url":null,"abstract":"We studied the influence of activation ofpecilomycotic infection in blood on the morphofunctional state of myocardium based on the clinical and pathomorphological data. The study included 23 patients with bronchial asthma (BA) concomitant with pecilomycosis after acute viral respiratory infection; protocols of autopsies and pathological sections of the heart muscle of the patients who died from asphixy and acute cardiac insufficiency were analyzed. Histological sections showed up vascular dystonia of the microcirculation bed, arteriole spasms, wall destruction in small and medium-size vessels and the adjacent muscular tissue, stromal oedema, valvular swelling, andperiwall endocarditis. Cardiac cavities and coronary vessels contained erythrocyte-rich thrombi with ferulas of Paecilomyces at different stages of development. Clinical manifestations of destructive changes in the heart muscle developing under effect of Paecilomyces infection had the form of rhythm and conductivity disorders. The local protective inflammatory reaction of productive type had the form of intermediate and vascular-type myocarditis passing to postmyocarditic cardiosclerosis. Periodic bursts of activation ofpecilomycotic infection in blood with the accumulation of fungal phospholipase A2 and lipid metabolites produced membranotoxic effect and can play the key role in the development of atherosclerosis and hypertensive disease in patients with BA and pecilomycosis.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"95 1","pages":"66-71"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36569073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[DENGUE FEVER IN RUSSIA: PROBLEMS OF DIAGNOSTICS]. [俄罗斯的登革热:诊断问题]。

Klinicheskaia meditsina Pub Date : 2017-01-01

A A Nafeev, L V Il'mukhina

引用次数: 0

[A CASE OF FAMILIAL PULMONARY AND HEPATIC ECHINOCOCCOSIS)]. [家族性肺肝包虫病1例]。

Klinicheskaia meditsina Pub Date : 2017-01-01

O A Tsvetkova, O O Voronkova, D V Ovchinnikova

引用次数: 0

[Criteria for granting permission for disabled persons to participate in the Ready for Labor and Defense training program]. [残疾人参加劳动防卫预备训练的准予标准]。

Klinicheskaia meditsina Pub Date : 2017-01-01 DOI: 10.18821/0023-2149-2017-95-1-23-30

E. V. Mashkovsky, K. Predatko, A. Magomedova, S. V. Shteĭnerdt, K. Volodina

{"title":"[Criteria for granting permission for disabled persons to participate in the Ready for Labor and Defense training program].","authors":"E. V. Mashkovsky, K. Predatko, A. Magomedova, S. V. Shteĭnerdt, K. Volodina","doi":"10.18821/0023-2149-2017-95-1-23-30","DOIUrl":"https://doi.org/10.18821/0023-2149-2017-95-1-23-30","url":null,"abstract":"Rehabilitation, adaptation, and social integration of the disabled are the priority issues of social welfare policy in the Russian Federation. This includes the enhancement of availability ofphysical education and adapted sports programs. One of the best practices for the improvement ofphysical activity among the population is the \"Ready for labour and defense\" training system (GTO). However, it is not adapted for those with physical challenges and disabilities. To involve this special fraction of the population in physical activity and participation in the GTO system, disability groups eligible for this activity need to be identified. They can include individuals with visual (VI), intellectual (II), hearing (HI), and locomotor problems as well as those with transplanted organs (TO). Also, minimum disability criteria (MDC) for the participants from each group which would make them eligible to practice an adapted GTO system should be defined. The development of MDC for individuals with VI, II, HI, and TO is relatively easy as they are common for most adapted sports. However, it remains a challenge for persons with locomotor problems since they make up a very diverse group bearing in mind that the rules of the International Paralympic Committee envisage different MDC for different adapted sports. There are two possible solutions: (1) to develop specialized MDC for each sport discipline included in the GTO system, (2) to develop universal MDC for all disciplines. The next step in promoting the GTO system among individuals with physical challenges and disabilities will be the development of the para- GTO program that would be unique and adapted for all categories of the disabled individuals.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"9 1","pages":"23-30"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82493125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[EVALUATION OF CARDIOVASCULAR RISKS WITH THE USE OF MORPHOGENETIC KLOTHO PROTEIN IN PATIENTS WITH CHRONIC RENAL DISEASE]. [在慢性肾病患者中使用形态发生klotho蛋白评估心血管风险]。

Klinicheskaia meditsina Pub Date : 2017-01-01 DOI: 10.18821/0023-2149-2017-95-3-272-277

N. Mukhin, L. Milovanova, V. Fomin, L. Kozlovskaya, M. Taranova, T. Androsova, A. Borisov

{"title":"[EVALUATION OF CARDIOVASCULAR RISKS WITH THE USE OF MORPHOGENETIC KLOTHO PROTEIN IN PATIENTS WITH CHRONIC RENAL DISEASE].","authors":"N. Mukhin, L. Milovanova, V. Fomin, L. Kozlovskaya, M. Taranova, T. Androsova, A. Borisov","doi":"10.18821/0023-2149-2017-95-3-272-277","DOIUrl":"https://doi.org/10.18821/0023-2149-2017-95-3-272-277","url":null,"abstract":"The aim of the study was to explore the Klotho protein significance in patients with different stages of chronic kidney disease (CKD) and to assess the influence of antihypertensive therapy on Klotho protein serum levels. Materials and methods 130 patients with stage 5 CKD1 were included in the study. Serum PTH, calcium and phosphorus were measured. ELISA was used to determine serum soluble alpha Klotho. Blood pressure including brachial and central (aortic) pressure was measured in all patients together with pulse wave velocity (using a «Sfigmokor» device); in addition, echocardiography (EchoCG), and X-ray examination of the abdominal aorta by Kauppila method were performed. Results The dynamic study of serum Klotho level showed that it changes with decreasing glomerular filtration rate faster than a rise in phosphate and PTH levels starting from stage 3A of CKD. The two later variables increased at stages 4-5.According to the ROC analysis, the values of serum Klotho below 387 pg /ml suggested enhanced risk of myocardial calcification with 80% sensitivity and 76% specificity. In addition, the highest Klotho serum levels were observed in patients whose target BP values were achieved with angiotensin receptor blockers (ARB) compared to those who used other drugs [р<0,01] or failed to reached target BP levels [p=0,008]. Conclusion The study showed the possibility of practical use of Klotho protein as an early diagnostic marker of cardiovascular risk. Reduced serum Klotho was less pronounced in patients who used ARB for correction of high blood pressure. Normal Klotho protein levels in serum have been associated with a lower frequency of heart and vessels calcification in CKD patients.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"11 1","pages":"272-7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81885938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[CYTOKINE PROFILE IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION WITH AND WITHOUT COMPLICATIONS]. [有或无并发症的急性心肌梗死患者的细胞因子谱]。

Klinicheskaia meditsina Pub Date : 2017-01-01 DOI: 10.18821/0023-2149-2017-95-3-233-237

A. O. Aimagambetova, L. Karazhanova, A. Kotlyar

{"title":"[CYTOKINE PROFILE IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION WITH AND WITHOUT COMPLICATIONS].","authors":"A. O. Aimagambetova, L. Karazhanova, A. Kotlyar","doi":"10.18821/0023-2149-2017-95-3-233-237","DOIUrl":"https://doi.org/10.18821/0023-2149-2017-95-3-233-237","url":null,"abstract":"The aim of this study was to evaluate the prognostic role of the cytokine profile in patients with ST segment elevation myocardial infarction (STEMI). Materials and methods In the present paper we studied cytokines IL-6, IL-1β, IL-10, TNFα and CRP in 81 patients with different course of STEMI. Results In patients with complicated course of STEMI a significant increase in the concentration of IL-6, IL-10, FNOα, CRP was recorded on the 1st, 7th and 14th days compared with control group of healthy subjects and a group of patients with uncomplicated STEMI. Concentrations of TNFα>35.49 pg/ml, IL-6>33.37 pg/ml, IL-10>34 pg/ml, CRP>10.84 mg/l on day 1 may suggest cardiovascular complications in STEMI patients within 1 year after the onset of the disease. We have not found reliable prognostic levels of IL-1β, as the concentration of this cytokine remained within the accepted normal range.. Discussion It is concluded that initially elevated levels of CRP l, TNFα, IL-6, IL-10 in the blood make it possible to identify groups of patients with myocardial infarction with ST-segment elevation at high risk of cardiovascular events throughout the year.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"39 1","pages":"233-7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76641953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Dynamics of clinical, X-ray and functional data during treatment of patients with sarcoidosis]. [结节病患者治疗过程中临床、x线和功能资料的动态变化]。

Klinicheskaia meditsina Pub Date : 2017-01-01 DOI: 10.18821/0023-2149-2017-95-1-60-65

I. Vizel’, A. Vizel’

{"title":"[Dynamics of clinical, X-ray and functional data during treatment of patients with sarcoidosis].","authors":"I. Vizel’, A. Vizel’","doi":"10.18821/0023-2149-2017-95-1-60-65","DOIUrl":"https://doi.org/10.18821/0023-2149-2017-95-1-60-65","url":null,"abstract":"Aim To analyze the literature data and the results of original studies on the respiratory function in patients with sarcoidosis. Material and methods The study included 1199 patients with sarcoidosis (67.8% women and 32.2% of males, median age 43 years). The first X-ray stage was documented in 34.8% of patients , stage II in 57.0%, stage III in 6.1%, stage IV in 1.3%, stage 0 in 0.7%. One patient (0.1%) had pleural sarcoidosis. Loefgren syndrome was diagnosed in 20% of the patients. In 658 patients (54.9%) the diagnosis was confirmed by biopsy studies. Results The patients with sarcoidosis exhibited significant correlation between radiographic and spirometric characteristics. In those with Loefgren syndrome, all breathing parameters were much better than in the remaining ones. Changes of spirometry parameters were more pronounced in smokers and in patients with concomitant lung diseases. However, the lung function remained impaired after adjustment for these factors, and 9,7% of the cases positively responded to the administration of a short-acting bronchodilator. Х-ray examination and spirometry are independent methods for the evaluation of the health status of patients with sarcoidosis and their results do not always correlate with each other after different treatment regimens. Changes in Х-ray image and lung vital capacity were consistent in patients treated with prednisone, methotrexate and pentoxifylline, but not in the cases treated with vitamin E and in the absence of treatment. Spirometry with simultaneous X-ray examination is recommended for all patients with intrathoracic sarcoidosis. Conclusion Forced vital capacity of lungs (FVC) is an independent criterion for evaluating the condition of patients with sarcoidosis and the effectiveness of the treatment.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"20 1","pages":"60-5"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75807680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1