[基于区域登记资料的红斑狼疮现代临床流行病学特征]。

Klinicheskaia meditsina Pub Date : 2017-01-01
D V Shaduro, V A Beloglazov, A V Petrov, K A Aliev
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引用次数: 0

摘要

系统性红斑狼疮(SLE)是一种以多症状临床表现为特征的严重风湿病。在目前阶段,由于该病的流行率较低,没有最新的流行病学数据。该研究的目的是根据地区登记册所载的信息、对疾病早期发生和症状的分析,检查系统性红斑狼疮患者目前的临床和流行病学特征。本研究通过对2011 -2013年107例SLE病例的分析,以及对1980-2013年病例的回顾性分析,揭示SLE的流行病学和临床特征。采用统计软件许可,基于广泛和密集的指标对流行病学情况进行评估。目前的SLE患病率估计在2013年为5.59 / 10万人口,1994年至2003年为0.29 / 10万人口,2004年至2013年为0.49 / 10万人口,2010年达到峰值,达到1.35 / 10万人口。SLE前10年的平均绝对增长率和增长率分别为0.05%和0.24%,后10年的平均绝对增长率和增长率分别为0.001%和0.006%,男女比例为9:1,患者平均年龄(37,62±11,65岁),民族组成为斯拉夫人87人,克里米亚鞑靼人15人。早期(多发性关节炎、发热、皮炎)和晚期(多发性关节炎、雷诺综合征、心炎、肌痛)最常见的症状与美国风湿病学会(1997)所规定的不同。SLE早期和晚期症状的差异被记录下来。根据所获得的数据,提出将疾病划分为临床亚型(表型)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[MODERN CLINICAL EPIDEMIOLOGICAL CHARACTERISTIC OF LUPUS ERYTHEMATOSUS BASED ON THE DATA OF REGIONAL REGISTRY].

Systemic lupus erythematosus (SLE) is a severe rheumatic disease characterized by polysymptomatic clinical picture. At the present stage, there are no updated epidemiological data due to the low prevalence of the disease. The aim of the study was to examine the current clinical and epidemiological characteristics of patients with systemic lupus erythematosus based on the information contained in the territorial register, analysis of occurrence and symptoms at the early stage of the disease. This study demonstrated the epidemiological and clinical characteristics of SLE from the analysis of 107 cases during the period from 2011 to 2013 and retrospective analysis of the cases for 1980-2013. The epidemiological situation was evaluated based on extensive and intensive indicators using statistical software license. The current SLE prevalence was estimated at 5,59 per 100 000 population in 2013, the incidence between 1994 and 2003 at 0,29 per 100 000 population and between 2004 and 2013 at 0,49, with the peak in 2010 up to 1,35 per 100 000 population. The average absolute growth and growth rate of SLE in the first decade was 0,05% and 0,24%, in the second decade 0,001% and 0,006% respectively, with the female to male ratio being 9:1, mean age of the patients 37,62±11,65 years), and ethnic composition of 87 Slavs and 15 Crimean Tatars. The most common symptoms at the early (polyarthritis, fever, dermatitis) and advanced (polyarthritis, Raynaud's syndrome, carditis, myalgia) stages differed from those specified by American College of Rheumatology (1997). The difference between early and late symptoms of SLE was documented . Based on the data obtained, the division of the disease into clinical subtypes (phenotypes) is proposed.

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