Klinicheskaia meditsina最新文献

Modern possibilities of prevention of gastrointestinal bleeding in patients with gastric and duodenal stress ulcers 现代预防胃和十二指肠应激性溃疡患者消化道出血的可能性

Klinicheskaia meditsina Pub Date : 2023-11-14 DOI: 10.30629/0023-2149-2023-101-9-10-505-508

A. A. Sheptulin, S. S. Kardasheva, A. A. Kurbatova

引用次数: 0

Comparative characteristics of the clinical course of a new coronavirus infection depending on the vaccination status 新型冠状病毒感染临床病程与疫苗接种状况的比较

Klinicheskaia meditsina Pub Date : 2023-11-14 DOI: 10.30629/0023-2149-2023-101-9-10-483-488

S. A. Sokotun, A. I. Simakova, N. G. Plekhova, A. O. Mikhailov, M. D. Barbashev, D. Yu. Barbasheva, A. V. Alexandrova, L. Ya. Hafizova

{"title":"Comparative characteristics of the clinical course of a new coronavirus infection depending on the vaccination status","authors":"S. A. Sokotun, A. I. Simakova, N. G. Plekhova, A. O. Mikhailov, M. D. Barbashev, D. Yu. Barbasheva, A. V. Alexandrova, L. Ya. Hafizova","doi":"10.30629/0023-2149-2023-101-9-10-483-488","DOIUrl":"https://doi.org/10.30629/0023-2149-2023-101-9-10-483-488","url":null,"abstract":"Objective: to provide a comparative analysis of clinical manifestations of the new coronavirus infection in vaccinated and unvaccinated patients. Materials and methods. А retrospective analysis of 160 medical histories of patients with laboratoryconfi rmed diagnosis of coronavirus infection (COVID-19) was presented, including 80 unvaccinated individuals and 80 vaccinated with “EpiVacCorona”, “CoviVac”, and “Gam-COVID-Vac” vaccines. Results. Vaccination against COVID-19 does not completely eliminate the possibility of infection with the virus, but there are a number of significant advantages and diff erences in the course of coronavirus infection among vaccinated patients. The duration of the disease on average was about 2 weeks, and for unvaccinated individuals — 18.1 ± 0.4 days. Vaccinated patients, regardless of the vaccine used, recovered significantly earlier. Signs of polysegmental pneumonia were not observed in 21.3% of vaccinated patients. Respiratory support lasted for 6.0 ± 0.3 days in unvaccinated patients, and for vaccinated individuals with “EpiVacCorona” — 4.4 ± 0.7 days, “CoviVac” — 3.5 ± 0.6 days, “Gam-COVID-Vac” — 3.2 ± 0.4 days, which was signifi cantly lower than the indicators for the control group (p <0.05). Conclusion. Сlinically, COVID-19 in vaccinated patients was milder compared to unvaccinated individuals, who most commonly experienced weakness, coughing, and extensive lung damage.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"77 18","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134900600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rehabilitation of patients who underwent surgery for transverse flatfoot using exercise therapy 运动疗法治疗横向扁平足术后患者的康复

Klinicheskaia meditsina Pub Date : 2023-11-14 DOI: 10.30629/0023-2149-2023-101-9-10-502-504

N. A. Zadorozhnaya, A. A. Domozhilova, N. V. Dubkova

引用次数: 0

Selection of drain diameter in initial drainage of patients with acute necrotizing pancreatitis 急性坏死性胰腺炎初始引流管直径的选择

Klinicheskaia meditsina Pub Date : 2023-11-14 DOI: 10.30629/0023-2149-2023-101-9-10-496-501

S. I. Remizov, A. V. Andreev, V. M. Durleshter, S. A. Gabriel, O. V. Zasyadko

{"title":"Selection of drain diameter in initial drainage of patients with acute necrotizing pancreatitis","authors":"S. I. Remizov, A. V. Andreev, V. M. Durleshter, S. A. Gabriel, O. V. Zasyadko","doi":"10.30629/0023-2149-2023-101-9-10-496-501","DOIUrl":"https://doi.org/10.30629/0023-2149-2023-101-9-10-496-501","url":null,"abstract":"Objective. To evaluate the treatment outcomes of acute necrotizing pancreatitis using drains of different diameters in patients with acute necrotic accumulations. Materials and methods. From 2013 to 2018, 124 patients with acute necrotizing pancreatitis were treated using minimally invasive surgical techniques. Group 1 consisted of 56 patients who were initially given drains with a diameter of 8–16 Fr, while Group 2 consisted of 68 patients who were given drains with a diameter of 28–32 Fr. The patient groups were comparable in terms of main indicators (p > 0.05). Results. In Group 1, replacement with larger diameter drains was needed in 100% of cases, while in Group 2 it was needed in 18.7% of patients (p < 0.05). As a final treatment method, puncture-drainage technology was used in Group 1 for 31 (55.4%) patients, and in Group 2 for 57 (83.8%) (p < 0.05). The incidence of perioperative complications was 51.7% in Group 1 and 16.1% in Group 2 (p < 0.05). The duration of hospitalization in Group 1 was on average 16 ± 7.3 days longer. Mortality rate was 30.4% in Group 1 and 11.8% in Group 2 (p < 0.05). Conclusion. The use of wide-bore drains at the initial stage increases the effectiveness of puncture-drainage treatment of acute necrotizing pancreatitis and allows for a reduction in mortality rate.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"30 16","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134992091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Academician A.N. Kryukov is one of the founders of Russian hematology (on the 145th anniversary of his birth) A.N.克留科夫院士是俄罗斯血液学的创始人之一(纪念他诞辰145周年)

Klinicheskaia meditsina Pub Date : 2023-11-14 DOI: 10.30629/0023-2149-2023-101-9-10-513-516

M. Sh. Knopov

引用次数: 0

Hybrid approach in the surgical treatment of multiple cerebral aneurysm in the acute period of rupture 复合入路在多发性脑动脉瘤急性破裂期手术治疗中的应用

Klinicheskaia meditsina Pub Date : 2023-11-14 DOI: 10.30629/0023-2149-2023-101-9-10-509-512

V. V. Krivetsky, A. A. Zavyalov, M. V. Strutsenko, V. A. Antipov, V. S. Fomin

引用次数: 0

Dynamics and variability of regional mortality rates from liver and biliary tract diseases in the period from 2019 to 2021 2019 - 2021年区域肝脏和胆道疾病死亡率的动态和变异性

Klinicheskaia meditsina Pub Date : 2023-11-14 DOI: 10.30629/0023-2149-2023-101-9-10-489-495

I. V. Samorodskaya, T. E. Afanasenkova

{"title":"Dynamics and variability of regional mortality rates from liver and biliary tract diseases in the period from 2019 to 2021","authors":"I. V. Samorodskaya, T. E. Afanasenkova","doi":"10.30629/0023-2149-2023-101-9-10-489-495","DOIUrl":"https://doi.org/10.30629/0023-2149-2023-101-9-10-489-495","url":null,"abstract":"Objective: to assess the variability and dynamics of mortality from liver and bile duct diseases in the regions of Russia for the period of 2019–2021. Materials and methods. Rosstat data on the number of deaths according to form C51 and on the average annual population by one-year age groups by gender and age were used. Standardized mortality rates (SMRs) were calculated for 12 causes of death related to liver and bile duct diseases and included in the Brief Nomenclature of Causes of Death of Rosstat (BNCD) for 82 regions of the Russian Federation. Results. The mean SMRs from all liver and bile duct diseases in 2020 (42.4 ± 11.9 per 100,000 population) and 2021 (42.8 ± 13.2) were higher than in 2019 (39.4 ± 11.4), with annual increases observed in 38 regions, decreases in 7, and mixed trends in 37. The contribution of liver diseases to all-cause mortality was 3.95 ± 0.91% in 2019, 3.65 ± 0.85% in 2020, and 3.26 ± 0.92% in 2021. The highest SMRs were registered for liver fibrosis and cirrhosis, while the lowest SMRs were for acute hepatitis. Considerable variability in SMRs was observed between regions in 2021: the maximum SMR for liver cancer was more than 14 times higher than the minimum, while for liver fibrosis and cirrhosis it was 25 times higher. Hypotheses explaining the reasons for these differences are discussed. Conclusions. Significant regional variability in SMRs does not allow for a stable trend towards reducing mortality from these causes to be identified.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"77 17","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134900601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of DNA damage and repair in chronic eye diseases DNA损伤和修复在慢性眼病中的作用

Klinicheskaia meditsina Pub Date : 2023-11-13 DOI: 10.30629/0023-2149-2023-101-9-10-474-482

G. O. Gaisina, Yu. A. Luchnikova, A. V. Khrushcheva, L. H. Rufullayeva, R. R. Tagirova, S. E. Mamedli, M. Yu. Lyashok, S. Yu. Smorodova, P. A. Boriskina, D. A. Vatulin, A. S. Lazarenko, V. A. Magafurova, N. E. Kosinskaya

引用次数: 0

Cardiovascular eff ects of psychotropic drugs 精神药物对心血管的影响

Klinicheskaia meditsina Pub Date : 2023-11-13 DOI: 10.30629/0023-2149-2023-101-9-10-467-473

Ya. Т. Vardanyan

引用次数: 0

Nanoparticles for targeted drug delivery in modern cardiology 纳米颗粒靶向药物递送在现代心脏病学

Klinicheskaia meditsina Pub Date : 2023-11-12 DOI: 10.30629/0023-2149-2023-101-9-10-454-466

V. A. Kidenko, M. M. Metova, E. Yu. Gabrielyan, Yu. A. Trusov, A. D. Melikhova, E. P. Muslimova, Ya. V. Sedmova, K. R. Khabibullina, E. V. Malikova, L. A. Valiullina, D. D. Bagautdinova, A. V. Petrakova, K. S. Terekhina

{"title":"Nanoparticles for targeted drug delivery in modern cardiology","authors":"V. A. Kidenko, M. M. Metova, E. Yu. Gabrielyan, Yu. A. Trusov, A. D. Melikhova, E. P. Muslimova, Ya. V. Sedmova, K. R. Khabibullina, E. V. Malikova, L. A. Valiullina, D. D. Bagautdinova, A. V. Petrakova, K. S. Terekhina","doi":"10.30629/0023-2149-2023-101-9-10-454-466","DOIUrl":"https://doi.org/10.30629/0023-2149-2023-101-9-10-454-466","url":null,"abstract":"Myocardial infarction (MI) is the leading cause of death worldwide. The loss of cardiomyocytes resulting from injuries such as acute MI often leads to fibrotic scarring and depressed cardiac function. The use of targeted drug delivery systems is always necessary as they provide unique advantages for increasing efficacy and reducing undesirable effects. Nanoparticles (NPs) are the most common means of delivering therapeutic agents to target tissues. NPs for drug delivery can be composed of various nanomaterials and structures, including lipids, polymers, dendrimers, carbon nanotubes, and metal nanoparticles. We have reviewed approaches to cardio-specific drug delivery based on NPs for the treatment of ischemic heart disease in preclinical and clinical studies. Drug delivery based on NPs has the potential for specific targeting of tissues and cells, as well as for prolonged release of multiple therapeutic agents. However, the use of NPs in the therapy of cardiovascular diseases is relatively limited compared to other areas such as oncology and neurology. One of the main obstacles is the lack of specificity in current targeting systems for the heart. Future research is needed to identify specific ligands/receptors in cardiomyocytes and develop new NPs with high affinity and specificity.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"35 36","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135037999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0