Klinicheskaia meditsina最新文献_第10页

[EVALUATION OF BODY MASS INDICES AND ARTERIAL PRESSURE AS CARDIOVASCULAR RISK FACTORS IN THE ADULT POPULATION OF THE CITY OF VORONEZH]. [评价沃罗涅日市成人体重指数和动脉压作为心血管危险因素]。

Klinicheskaia meditsina Pub Date : 2017-01-01

A V Kryuchkova, N M Seminina, Yu V Kondusova, I A Poletaeva, A M Knyazeva

{"title":"[EVALUATION OF BODY MASS INDICES AND ARTERIAL PRESSURE AS CARDIOVASCULAR RISK FACTORS IN THE ADULT POPULATION OF THE CITY OF VORONEZH].","authors":"A V Kryuchkova, N M Seminina, Yu V Kondusova, I A Poletaeva, A M Knyazeva","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To determine body mass index (BMI) and blood pressure (BP) of the Voronezh city adult population.Materials and methods: 1108 residents of Voronezh city at the age from 20 to 75 years were examined in 2015 including measurement of their height, body mass, arterial pressure, and BMI calculation. Medical histories were analyzed to reveal arterial hypertension in the preceding period in the following age groups: 20-29, 30-39, 40-49, 50-59, 60-75 yr and the entire study group (20-75 yr).Results: The mean BMI of the residents of Voronezh was 28.5 (23.8; 33.1) kg/m. The highest values were found between 40 and 59 years. BMI in women under 40 was lower than in men of the same age. The education level affected the prevalence of obesity in that people with secondary vocational education were more likely to be obese than those given higher education. At the age of 40, the incidence of hypertension among women was lower than among men of the same age, it more frequently occurred at the age of 60-75 years. Both age and BMI were related to the level of blood pressure: higher BMI and blood pressure were recorded at an older age. The prevalence of hypertension also increased with age.Conclusion: Obesity was detected in 29.7% of the Voronezh population recruited to the study. The prevalence of obesity among young adults (20-29 years) iproved lower than in the middle and old age groups. 30.9% of the residents suffered from AH.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"95 2","pages":"148-53"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36560662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[DIAGNOSTIC SIGNIFICANCE OF PLASMA TROPONIN AND CARDIOMYOCYTE FATTY ACID-BINDING PROTEIN LEVELS IN ACUTE CORONARY SYNDROME]. 血浆肌钙蛋白和心肌细胞脂肪酸结合蛋白水平对急性冠脉综合征的诊断意义。

Klinicheskaia meditsina Pub Date : 2017-01-01 DOI: 10.18821/0023-2149-2017-95-3-207-215

V. Titov

{"title":"[DIAGNOSTIC SIGNIFICANCE OF PLASMA TROPONIN AND CARDIOMYOCYTE FATTY ACID-BINDING PROTEIN LEVELS IN ACUTE CORONARY SYNDROME].","authors":"V. Titov","doi":"10.18821/0023-2149-2017-95-3-207-215","DOIUrl":"https://doi.org/10.18821/0023-2149-2017-95-3-207-215","url":null,"abstract":"Blood serum content of fatty acid-binding (FABP) protein increases within 2-3 h after the onset of acute coronary syndrome and myocardial infarction (MI) and reaches the maximum 8.5 h after the initiation of cardiomyocyte death. FABP content considerably decreases by the end of at 24-h period due to excretion with urine, remaining elevated for subsequent 24 h. High clinical sensitivity and relatively high organ specificity are typical of FABP for 12 h after ACS. Within the early period of MI clinical specificity of FABP prevails over troponin in terms of concentration. Troponins display higher clinical sensitivity and diagnostic specificity during a 12-h period after ACS, prevailing for several days after MI. Simultaneous measuring of FABP and troponins (Tr) within the first 12 h increases the sensitivity of biochemical diagnostics by 30%. At later periods, simultaneous determination of FABP and Tr becomes unnecessary: FABP is excreted with urine and Tr level acquires predominant diagnostic significance. No relationship has been revealed between blood content of FABP and reperfusion according to electrocardiography data, probably due to rare measurements of this highly dynamic parameter. FABP test cannot be used in patients with circulatory disorders since its results are not adequate. The best option for differential diagnostics of ACS within the first 24 h would be a combined express immunochromatographic test which allows to measure blood FABP and Tr levels pending objective evaluation.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"19 1","pages":"207-15"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81651213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[ZIKA FEVER: CLINICAL, EPIDEMIOLOGICAL, LABORATORY, AND DIAGNOSTIC ASPECTS]. [寨卡热:临床、流行病学、实验室和诊断方面]。

Klinicheskaia meditsina Pub Date : 2017-01-01 DOI: 10.18821/0023-2149-2017-95-2-112-117

K. Zhdanov, S. Zakharenko, A. Kovalenko, A. Semenov, S. Kozlov, A. Fisun

引用次数: 1

[TRENDS IN DEVELOPMENT OF GI-SAFE ANTI-INFLAMMATORY DRUGS]. [gi安全抗炎药的发展趋势]。

Klinicheskaia meditsina Pub Date : 2017-01-01 DOI: 10.18821/0023-2149-2017-95-3-222-227

O. Sulaieva, J. Wallace

{"title":"[TRENDS IN DEVELOPMENT OF GI-SAFE ANTI-INFLAMMATORY DRUGS].","authors":"O. Sulaieva, J. Wallace","doi":"10.18821/0023-2149-2017-95-3-222-227","DOIUrl":"https://doi.org/10.18821/0023-2149-2017-95-3-222-227","url":null,"abstract":"Despite the introduction of anti-inflammatory drugs that selectively inhibit cyclo-oxygenase-2 (COX-2), and potent inhibitors of gastric acid secretion, the gastrointestinal adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs) remain a significant clinical problem. Combined use of antisecretory drugs and COX-2 inhibitors is helpful to limit the damage in the proximal gastrointestinal tract (stomach and duodenum), but it increases the risk of injury of small intestine and colon. It was proven that proton pump inhibitors and H2 receptor antagonists significantly worsen NSAID-induced small intestinal damage and microbiota balance. Nowadays, there is no proven effective preventative or curative treatment for NSAID-induced enteropathy. The new strategy of gastrointestinal protection is based on the discovery of endogenous cytoprotective molecules such as hydrogen sulfide (H₂S). H2S is a gaseous mediator that produces strong cytoprotective and antioxidant effect on the gastrointestinal tract. The role of H₂S in promoting mucosal integrity, healing of tissue injury and resolution of inflammation has been well documented. In addition, H₂S stimulates productions of other cytoprotective molecules including prostaglandins, carbon monoxide and nitric oxide. Nowadays, the new generation of H₂S-releasing non-steroidal anti-inflammatory drugs is developed and tested in clinical trials. H₂S-NSAIDs possess enhanced anti-inflammatory activity and high gastrointestinal safety.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"5 5 1","pages":"222-7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83607675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

[TYPICAL ERRORS IN THERAPY OF GASTROESOPHAGEAL REFLUX DISEASE]. [胃食管反流病治疗的典型错误]。

Klinicheskaia meditsina Pub Date : 2017-01-01 DOI: 10.18821/0023-2149-2017-95-2-163-167

M. Chikunova, I. Khlynov, D. V. Khromtsova

{"title":"[TYPICAL ERRORS IN THERAPY OF GASTROESOPHAGEAL REFLUX DISEASE].","authors":"M. Chikunova, I. Khlynov, D. V. Khromtsova","doi":"10.18821/0023-2149-2017-95-2-163-167","DOIUrl":"https://doi.org/10.18821/0023-2149-2017-95-2-163-167","url":null,"abstract":"Aim To analyze compliance of doctors with the clinical guidelines for the management of patients with gastroesophageal reflux disease (GERD) under outpatient clinic conditions. Material and methods An anonymous questionnaire study involving 104 general practitioners was undertaken. The questionnaires included items concerning lifestyle modifications, the use of proton pump inhibitors (PPI), dosage and time of their administration, combined therapy and endoscopic control. Results The analysis of the filled questionnaires demonstrated that 15,6% of the doctors always discuss the necessity changing lifestyle with GERD patients, 75% of the doctors discuss it but occasionally, and 9,4% never hold such discussions. 56,7% of the doctors begin treatment from double doses of proton pump inhibitors regardless of the endoscopic stage of esophagus damage. The mode of PPI administration is at variance with that recommended by the instruction in 61,5% of the cases. The basic course of erosive esophagitis treatment lasts 4, 2, and 8 weeks in 45,2%, 9,6%, and 45,2% of the cases. Treatment of GERD starts from combined therapy in 14,4% of the cases. Monotherapy with PPI is inefficient in 85,6% of the cases. Endoscopic control of erosive esophagitis is practiced by 51,9% of the doctors, 48,1% of the respondents recommend this diagnostic procedure only in the absence of clinical effect. Conclusion Our analysis revealed typical mistakes in the treatment of patients with GERD, demonstrated the importance of expert control and support of training physicians, and introduction of modern quality standards into the practical management of patients with this pathology.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"292 1","pages":"163-7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79513649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A critical incident during marathon competition as a result of metabolic decompensation]. [马拉松比赛中因代谢失代偿引起的严重事件]。

Klinicheskaia meditsina Pub Date : 2017-01-01

Yu P Orlov, N V Govorova, A V Glushchenko, E N Efremov, Yu B Vasilenko

引用次数: 0

[Therapeutic Monitoring Plasma Imatinib to Improve Results of the Treatment of Chronic Myeloleukosis]. [监测血浆伊马替尼改善慢性骨髓白化症的治疗效果]。

Klinicheskaia meditsina Pub Date : 2017-01-01

M I Savelyeva, A V Kryukov

引用次数: 0

[Obesity and cardiovascular system]. 肥胖和心血管系统。

Klinicheskaia meditsina Pub Date : 2017-01-01

A F Verbovoy, A V Pashentseva, L A Sharonova

引用次数: 0

[THE ROLE OF LOW-FREQUENCY PIEZOTHROMBOELASTOGRAPHY IN THE COMPREHENSIVE EVALUATION OF HEMOSTASIS IN CORONARY BYPASS SURGERY WITH CARDIOPULMONARY BYPASS]. [低频压电血栓弹性成像在冠状动脉搭桥术合并体外循环止血的综合评价中的作用]。

Klinicheskaia meditsina Pub Date : 2017-01-01

E V Fanaskova, O V Gruzdeva, O E Akbasheva, I I Tyutrin, T Yu Penskaya, E G Uchasova, G P Plotnikov, K E Krivoshapova, O L Barbarash

{"title":"[THE ROLE OF LOW-FREQUENCY PIEZOTHROMBOELASTOGRAPHY IN THE COMPREHENSIVE EVALUATION OF HEMOSTASIS IN CORONARY BYPASS SURGERY WITH CARDIOPULMONARY BYPASS].","authors":"E V Fanaskova, O V Gruzdeva, O E Akbasheva, I I Tyutrin, T Yu Penskaya, E G Uchasova, G P Plotnikov, K E Krivoshapova, O L Barbarash","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To monitor the hemostatic system during platelet concentrate transfusions using low-frequency piezothromboelastography in patients with coronary bypass surgery given aspirin therapy.Materials and methods: The study involved 148 patients with coronary bypass surgery, with 76 ones undergoing intraoperative transfusion of platelet concentrate and 72 treated without transfusion. The control group consisted of 20 healthy individuals. In the perioperative period indicators of vascular-platelet, coagulation, anticoagulant and fibrinolytic components of hemostasis were evaluated by low-frequency pezotromboelastography using the ARP-01M \"Mednord\" hardware and software system (Russia).Results: It was shown that the antiplatelet effect of aspirin in the preoperative period was manifest as inhibition of the initial stage of blood coagulation accompanied by increased thrombin potential, the total gain of anticoagulant and fibrinolytic activity of the blood. Heart-lung bypass was accompanied by structural and chronometric anticoagulation, reduction of anticoagulation and increase of blood fibrinolytic activity. In the postoperative period, structural and chronometric anticoagulation was more pronounced in patients who did not undergo transfusion of platelet concentrate than in the group of patients with transfusion. Donor platelets further increased the blood hemostatic potential by neutralizing the antiplatelet effect of aspirin. Perioperative thrombohemorrhagic complications were absent in both groups.Conclusion: Low-frequency piezothromboelastography provides a tool for real-time monitoring the functional state of hemostasis system. Transfusion of platelet concentrate is not advisable given that the thrombin potential is preserved as confirmed by the results of low-frequency piezothromboelastography.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"95 3","pages":"245-53"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36570424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[RESEARCH ON THE LEVEL, COMPONENTS AND THE TYPE OF COOPERATIVITY IN THE PATIENTS WITH ASTHMA]. [哮喘患者协同性水平、成分及类型的研究]。

Klinicheskaia meditsina Pub Date : 2017-01-01

L V Bogovin

{"title":"[RESEARCH ON THE LEVEL, COMPONENTS AND THE TYPE OF COOPERATIVITY IN THE PATIENTS WITH ASTHMA].","authors":"L V Bogovin","doi":"","DOIUrl":"","url":null,"abstract":"The patient’s cooperativity is the major factor which determines the patient’s adherence to doctor’s prescriptions and, consequently, the achievement of disease control. We proposed the “Evaluation of the cooperativity in asthma” questionnaire to evaluate the level, components and types of cooperativity in 141 patients with the mixed or atopic form of asthma (94.3 and 5.7%, respectively) at admission to hospital who were aware about their disease. The analysis of investigated parameters depending on the level of patients’ awareness of their condition (according to the “Awareness of patients about asthma” test), severity and duration of the disease, presence of alexithymia and social and economic index was done. It was found out that patients with asthma exaggerate the degree of their compliance. The general indices of cooperativity (GIC=58.1±7.3%) and understanding of danger (35.8±3.3%) in the patients who were aware about their disease were low. Qualitative characteristics of individual cooperativity components in examined patients are presented. Nearly 76% of the patients showed negative cooperativity inversely correlating with the severity of asthma and the duration of the disease. Positive cooperativity appeared to be directly related with the higher educational level, occupation and higher income level of the patients. Generally speaking, low average GIC ratings and low patients’ adherence to asthma treatment suggest their low cooperativity.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"95 3","pages":"254-9"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36570428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0