Klinicheskaia meditsina最新文献_第9页

[DENGUE FEVER IN RUSSIA: PROBLEMS OF DIAGNOSTICS]. [俄罗斯的登革热:诊断问题]。

Klinicheskaia meditsina Pub Date : 2017-01-01 DOI: 10.18821/0023-2149-2017-95-2-154-157

A. A. Nafeev, L. Il'mukhina

引用次数: 0

[ACUTE HEPATIC LESION ASSOCIATED WITH MYOCARDIAL INFARCTION: CLINICAL SIGNIFICANCE AND MODERN DIAGNOSTICS]. 【急性肝损害合并心肌梗死:临床意义及现代诊断】。

Klinicheskaia meditsina Pub Date : 2017-01-01

A S Il'ina, N Yu Borovkova, A A Spassky, N N Borovkov

引用次数: 0

[DIFFERENTIAL APPROACH TO THE EVALUATION OF RIGHT VENTRICULAR SYSTOLIC FUNCTION BY PULSED WAVE DOPPLER ULTRASOUND]. [脉冲波多普勒超声评价右心室收缩功能的鉴别方法]。

Klinicheskaia meditsina Pub Date : 2017-01-01

E S Mirzoyan, N Yu Nelasov, M V Babaev, G P Volkov, K A Shumarin

引用次数: 0

[Landmark events in the history of medicine to be commemorated in 2017]. 【2017年医学史上值得纪念的里程碑事件】。

Klinicheskaia meditsina Pub Date : 2017-01-01

引用次数: 0

[PITUITARY ADENOMA APOPLEXY]. [垂体腺瘤中风]。

Klinicheskaia meditsina Pub Date : 2017-01-01 DOI: 10.18821/0023-2149-2017-95-2-177-180

I. V. Tereshchenko

引用次数: 1

[PROINFLAMMATORY CYTOKINES AND SIGNALING PATHWAYS IN PERIPHERAL BLOOD MONONUCLEAR CELLS IN PATIENTS WITH CORONARY ARTERY DISEASE]. [冠心病患者外周血单核细胞的促炎细胞因子和信号通路]。

Klinicheskaia meditsina Pub Date : 2017-01-01 DOI: 10.18821/0023-2149-2017-95-3-238-244

A. V. Logatkina, V. S. Nikiforov, S. Bondar, I. Terekhov

{"title":"[PROINFLAMMATORY CYTOKINES AND SIGNALING PATHWAYS IN PERIPHERAL BLOOD MONONUCLEAR CELLS IN PATIENTS WITH CORONARY ARTERY DISEASE].","authors":"A. V. Logatkina, V. S. Nikiforov, S. Bondar, I. Terekhov","doi":"10.18821/0023-2149-2017-95-3-238-244","DOIUrl":"https://doi.org/10.18821/0023-2149-2017-95-3-238-244","url":null,"abstract":"Aim To determine content of mononuclear ells (MNC) in peripheral blood of patients with coronary heart disease (CHD) and factors responsible for their functional state and cytokine production. Materials and methods Concentration of proteinkinases JNK1/2, ERK1/2, MAPK38, AKT1, JAK2, FAK, AMPK, p70S6K, STAT3, STAT5B and STAT6 was determined in MNC lysate by immune-enzyme assay. Interleukin 1β, 2, 4 and y-interferon levels were measured in blood sera. Results In patients with angina of effort and unstable angina, the JNK level was 59,8% and 53,1% higher than the normal one respectively (р=0,013) and (р=0,012). The level of the nuclear transcription factor was 26,9% (р=0,015) and 27,9% (р=0,017), JAK2 31,5% (р=0,022) and 48,6% (р=0,018), STAT3 49,6% (р=0,025) and 55,3% (р=0,02), STAT5B 21,5% (р=0,018) and 30,2% (р=0,011) lower. These changes were associated with a 13,1% (р=0,047) and 51,4% (р=0,019) rise in the STAT6 level, 30,1% (р=0,025) and 79,4% (р=0,003) FAK level, 7,6% (р=0,09) and 15,2% (р=0,039) АКТ1 level, 65,3 (р=0,02) and 76,2% (р=0,017) p70S6K level. Conclusion Results of the study suggest persistent pro-inflammatory activation of whole blood cells in CHD patients due to enhanced levels of IL-1 and IL-2, components of the MAPK/SAPK signal pathway in MNC and decreased STAT3 level determining cell sensitivity to IL-10. The elevated intracellular level of ERK and JNK us responsible for high responsiveness of MNC to pro-inflammatory cytokines.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"37 1","pages":"238-44"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79794487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

[INTESTINAL MICROBIOTA: ITS ROLE IN PATHOGENESIS OF ARTERIAL HYPERTENSION]. [肠道微生物群:在动脉高血压发病机制中的作用]。

Klinicheskaia meditsina Pub Date : 2017-01-01 DOI: 10.18821/0023-2149-2017-95-2-123-126

K. Aitbaev, I. Murkamilov

引用次数: 2

[RESEARCH ON THE LEVEL, COMPONENTS AND THE TYPE OF COOPERATIVITY IN THE PATIENTS WITH ASTHMA]. [哮喘患者协同性水平、成分及类型的研究]。

Klinicheskaia meditsina Pub Date : 2017-01-01 DOI: 10.18821/0023-2149-2017-95-3-254-259

L. Bogovin

{"title":"[RESEARCH ON THE LEVEL, COMPONENTS AND THE TYPE OF COOPERATIVITY IN THE PATIENTS WITH ASTHMA].","authors":"L. Bogovin","doi":"10.18821/0023-2149-2017-95-3-254-259","DOIUrl":"https://doi.org/10.18821/0023-2149-2017-95-3-254-259","url":null,"abstract":"The patient’s cooperativity is the major factor which determines the patient’s adherence to doctor’s prescriptions and, consequently, the achievement of disease control. We proposed the “Evaluation of the cooperativity in asthma” questionnaire to evaluate the level, components and types of cooperativity in 141 patients with the mixed or atopic form of asthma (94.3 and 5.7%, respectively) at admission to hospital who were aware about their disease. The analysis of investigated parameters depending on the level of patients’ awareness of their condition (according to the “Awareness of patients about asthma” test), severity and duration of the disease, presence of alexithymia and social and economic index was done. It was found out that patients with asthma exaggerate the degree of their compliance. The general indices of cooperativity (GIC=58.1±7.3%) and understanding of danger (35.8±3.3%) in the patients who were aware about their disease were low. Qualitative characteristics of individual cooperativity components in examined patients are presented. Nearly 76% of the patients showed negative cooperativity inversely correlating with the severity of asthma and the duration of the disease. Positive cooperativity appeared to be directly related with the higher educational level, occupation and higher income level of the patients. Generally speaking, low average GIC ratings and low patients’ adherence to asthma treatment suggest their low cooperativity.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"16 1","pages":"254-9"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89540123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Medical scores in clinical practice. Part III. Heart Failure]. 【临床实践中的医学分数】第三部分。心力衰竭)。

Klinicheskaia meditsina Pub Date : 2017-01-01 DOI: 10.18821/0023-2149-2017-95-1-72-77

F. I. Belyalov

引用次数: 2

[MELATONIN: THE POSSIBILITY TO ANALYSE THE MARKER OF AGE-RELATED PATHOLOGY IN THE BUCCAL EPITHELIUM AND URINE]. [褪黑素:分析口腔上皮和尿液中年龄相关病理标志物的可能性]。

Klinicheskaia meditsina Pub Date : 2017-01-01 DOI: 10.18821/0023-2149-2017-95-2-136-139

S. Konovalov, V. Polyakova, A. Drobintseva, I. Kvetnoy, T. Kvetnaia, N. Linkova

引用次数: 1