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A Case of Chronic Schizophrenia Who were Switched from Combined Treatment to Monotherapy and Achieved a Decrease in Positive Symptoms after Lowering the Clozapine Dose 慢性精神分裂症患者由联合治疗转为单药治疗，降低氯氮平剂量后阳性症状减轻1例
Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology Pub Date : 2016-11-08 DOI: 10.5455/BCP.20130127023102
H. Hamurcu, A. Çayköylü, Eda Peksen, M. Ozturk, Neslihan Sevil
{"title":"A Case of Chronic Schizophrenia Who were Switched from Combined Treatment to Monotherapy and Achieved a Decrease in Positive Symptoms after Lowering the Clozapine Dose","authors":"H. Hamurcu, A. Çayköylü, Eda Peksen, M. Ozturk, Neslihan Sevil","doi":"10.5455/BCP.20130127023102","DOIUrl":"https://doi.org/10.5455/BCP.20130127023102","url":null,"abstract":"ABSTRACTDespite the limited evidence to support the combination of antipsychotics in treatment resistant schizophrenia in the literature, this situation is common in clinical practice. Treatment guidelines recommend monotherapy for schizophrenia primarily. In this article, a chronic schizophrenic case whose treatment is changed from combination of clozapine with aripiprazole to clozapine monotherapy and whose positive symptoms decreased with the decrease of clozapine doses 900 mg/day to 625 mg/day is reported.","PeriodicalId":17852,"journal":{"name":"Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77344969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Suicide Attempt with High Dose Long Acting Methylphenidate Ingestion: A Case Presentation 高剂量长效哌甲酯摄入自杀企图:一例报告
Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology Pub Date : 2016-11-08 DOI: 10.5455/BCP.20151223093022
Handan Özek Erkuran, B. Çakaloz, Özlem Önen, A. Kutlu
{"title":"Suicide Attempt with High Dose Long Acting Methylphenidate Ingestion: A Case Presentation","authors":"Handan Özek Erkuran, B. Çakaloz, Özlem Önen, A. Kutlu","doi":"10.5455/BCP.20151223093022","DOIUrl":"https://doi.org/10.5455/BCP.20151223093022","url":null,"abstract":"ABSTRACTAttention Deficit and Hyperactivity Disorder (ADHD) is among the most commonly encountered neurodevelopmental disorders in childhood with its reported worldwide prevalance as 5%. Among the recommended treatment regimens as stimulants, the most frequently advised ones are methylphenidate (MPH) preparates. Among long acting MPH preparates, the form that contains an osmotic release oral system (MPH-OROS) is frequently used in clinical practice. Studies about risks, causes and outcomes regarding high dose MPH intake and effects of high dose MPH preparates in humans are limited. This article presents the clinical picture of a 12 year old boy who attempted suicide by ingesting 15 tablets of 36- mg MPH OROS. Exposure to an overdose of MPH-OROS exhibited acute sympathomimetic toxicity but no life-threatening symptoms in this patient. This case report might suggest that higher doses of MPH-OROS could be tolerated well under fine clinical observation and management; although more larger scale studies in thi...","PeriodicalId":17852,"journal":{"name":"Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84079228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Association of 5-HT1A and 5-HT1B Gene Polymorphisms with Obsessive-Compulsive Disorder in a Turkish Population 5-HT1A和5-HT1B基因多态性与土耳其人群强迫症的关联
Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology Pub Date : 2016-11-08 DOI: 10.5455/BCP.20151003063454
S. Aldemir, M. Acar, Z. Ocak, E. Dalbudak, M. R. Yiğitoğlu, E. Gunduz
{"title":"Association of 5-HT1A and 5-HT1B Gene Polymorphisms with Obsessive-Compulsive Disorder in a Turkish Population","authors":"S. Aldemir, M. Acar, Z. Ocak, E. Dalbudak, M. R. Yiğitoğlu, E. Gunduz","doi":"10.5455/BCP.20151003063454","DOIUrl":"https://doi.org/10.5455/BCP.20151003063454","url":null,"abstract":"ABSTRACTObjective: Obsessive-compulsive disorder (OCD) is a frequent neuropsychiatric disorder, in which genetic factors play important causative roles. We investigated the roles of the (-1019 C/G) promoter region polymorphism of 5-HTR1A and the G861C coding region polymorphism of 5-HTR1B genes in susceptibility to OCD in a Turkish population.Methods: Two single nucleotide polymorphisms, 5-HTR1A (rs6296) and 5-HTR1B (rs6295) genes were genotyped in 76 OCD patients and 57 healthy controls that were unrelated, using PCR-RFLP method.Results: We did not observe any difference in the genotype distributions of rs6296 and rs6295 between the OCD patient and control groups.Conclusions: As far as we know, our study is the first to establish the association of genetic variants 5-HTR1A (rs6296) and 5-HTR1B (rs6295) with OCD in a Turkish population. Based on our results, the relationship between polymorphisms of 5-HTR1A (rs6296) and 5-HTR1B (rs6295) with OCD do not seem.","PeriodicalId":17852,"journal":{"name":"Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89653881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Night Eating Syndrome Frequency in University Students: Association with Impulsivity, Depression, and Anxiety 大学生夜食综合症频率:与冲动、抑郁和焦虑的关系
Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology Pub Date : 2016-11-08 DOI: 10.5455/BCP.20160322093750
G. Sevinçer, E. Ince, Ibrahim Taymur, N. Konuk
{"title":"Night Eating Syndrome Frequency in University Students: Association with Impulsivity, Depression, and Anxiety","authors":"G. Sevinçer, E. Ince, Ibrahim Taymur, N. Konuk","doi":"10.5455/BCP.20160322093750","DOIUrl":"https://doi.org/10.5455/BCP.20160322093750","url":null,"abstract":"Objective: The aim of this study was to examine frequency of night eating syndrome and its correlates with depression, anxiety, impulsivity and problematic eating behaviors in a university sample f...","PeriodicalId":17852,"journal":{"name":"Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87138280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
Sertraline-Induced Diplopia Sertraline-Induced复视
Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology Pub Date : 2016-11-08 DOI: 10.5455/BCP.20160109124021
Ş. Eray, H. Uçar, Assoc. Prof. Ayse Pinar Vural
{"title":"Sertraline-Induced Diplopia","authors":"Ş. Eray, H. Uçar, Assoc. Prof. Ayse Pinar Vural","doi":"10.5455/BCP.20160109124021","DOIUrl":"https://doi.org/10.5455/BCP.20160109124021","url":null,"abstract":"Diplopia is a condition that involves seeing double and impairs quality of life. Acute diplopia can be seen with some general medical drugs and psychotropic drugs. Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed to treat a variety of psychiatric disorders. Sertraline is a relatively selective serotonin reuptake \u0000inhibitor with some dopamine reuptake inhibitor activity. This paper reports development of diplopia, a rare adverse effect of SSRI, in a 14 years old patient with major depressive disorder following use of sertraline. Clinicians should keep in mind that diplopia may occur with sertraline treatment.","PeriodicalId":17852,"journal":{"name":"Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82750680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Psychometric Properties of the Turkish PTSD-Short Scale in a Sample of Undergraduate Students 土耳其ptsd短量表在大学生样本中的心理测量特征
Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology Pub Date : 2016-11-08 DOI: 10.5455/BCP.20151205113132
C. Evren, E. Dalbudak, Ö. Aydemir, Ertuğrul Köroğlu, B. Evren, S. Ozen, K. Coskun
{"title":"Psychometric Properties of the Turkish PTSD-Short Scale in a Sample of Undergraduate Students","authors":"C. Evren, E. Dalbudak, Ö. Aydemir, Ertuğrul Köroğlu, B. Evren, S. Ozen, K. Coskun","doi":"10.5455/BCP.20151205113132","DOIUrl":"https://doi.org/10.5455/BCP.20151205113132","url":null,"abstract":"Objective: The National Stressful Events Survey for Posttraumatic Stress Disorder (PTSD)-Short Scale (NSESSS-PTSD) allows dimensional self-rating assessment of PTSD according to the DSM-5. The aim of the present study was to evaluate psychometric properties of this scale as Turkish PTSD-Short Scale (PTSD-SS) in a sample of undergraduate students in Turkey. \u0000Method: Participants included 415 university students, among which 351 (84.8%) reported trauma and thus were included in the analysis. Participants were evaluated with the PTSD-SS and the PTSD Checklist Civilian (PCL-C) version. \u0000Results: Turkish version of the PTSD-SS was found to be psychometrically sound PTSD screening measure with high convergent validity when compared with PCL-C (r=0.79) and having a Cronbach’s ? of 0.87. In addition, a single component accounted for 49.94% of total variance for PTSD-SS. The PTSD-SS had sensitivity and specificity scores of 0.91 and 0.77, respectively, when using the optimal cut-off score of 24. Additionally, the PTSD-SS showed good discriminant validity as it significantly differentiated students with high risk of PTSD from those with low risk of PTSD. \u0000Conclusion: These findings supported the Turkish PTSD-SS as reliable and valid PTSD screening instrument with a unidimensional scale construct.","PeriodicalId":17852,"journal":{"name":"Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78235740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Association of the Neuropeptide Y LEU7PRO rs16139 and NEUREXIN 3 rs760288 Polymorphisms with Alcohol Dependence 神经肽Y LEU7PRO rs16139和NEUREXIN 3 rs760288多态性与酒精依赖的关系
Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology Pub Date : 2016-11-08 DOI: 10.5455/BCP.20151016123639
C. Sengul, M. Erdal, C. Sengul, Özlem İzci Ay, Ahmet Buber, H. Alacam, M. Ay, H. Herken
{"title":"Association of the Neuropeptide Y LEU7PRO rs16139 and NEUREXIN 3 rs760288 Polymorphisms with Alcohol Dependence","authors":"C. Sengul, M. Erdal, C. Sengul, Özlem İzci Ay, Ahmet Buber, H. Alacam, M. Ay, H. Herken","doi":"10.5455/BCP.20151016123639","DOIUrl":"https://doi.org/10.5455/BCP.20151016123639","url":null,"abstract":"Association of the Neuropeptide Y LEU7PRO rs16139 and NEUREXIN 3 rs760288 polymorphisms with alcohol dependence Objective: Alcoholism is associated with genetic variants of genes related to alcohol metabolizing enzymes, dopaminergic, gamma-aminobutyric acidergic, glutamatergic, opioid, cholinergic, and serotonergic systems. Neurpeptide Y system and Neurexins were shown to be associated with alcohol dependence. Recent studies identified new genetic polymorphisms related to endogenous cannabinoid system, neuropetide Y and neurexin. In the present study, we aimed to investigate the association of Neurpeptide Y LEU7PRO rs16139 and neurexin 3 gene rs760288 polymorphisms with alcohol dependence in patients with alcohol dependence and healthy control subjects. Methods: 123 patients who were diagnosed with alcohol dependence according to the DSM-IV criteria and 159 healthy volunteers were included in the study. Blood samples were used to investigate polymorphisms. The genotyping of the neurexin 3 gene rs760288 and the neuropetide Y gene Leu7Pro rs16139 polymorphisms was performed using TaqMan SNP Genotyping Assays Real-Time PCR System. Results: Of the 2 genetic polymorphisms investigated in the present study, we detected association between and neurexin 3 gene rs760288 polymorphisms with alcohol dependence. Conclusions: Neurexin gene polymorphisms might be an important factor in development of alcohol addiction.","PeriodicalId":17852,"journal":{"name":"Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87713752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Acute Unilateral Myopia Induced by Add-On Aripiprazole: A Case Report 加用阿立哌唑致急性单侧近视1例
Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology Pub Date : 2016-11-08 DOI: 10.5455/BCP.20150813023217
M. Güneş, S. Demir, M. Bulut, M. Kaya, A. Atlı, A. Ibiloğlu, H. Yüksel
{"title":"Acute Unilateral Myopia Induced by Add-On Aripiprazole: A Case Report","authors":"M. Güneş, S. Demir, M. Bulut, M. Kaya, A. Atlı, A. Ibiloğlu, H. Yüksel","doi":"10.5455/BCP.20150813023217","DOIUrl":"https://doi.org/10.5455/BCP.20150813023217","url":null,"abstract":"ABSTRACTThe partial agonist aripiprazole is a novel atypical antipsychotic with a relatively safer side effect profile. Acute unilateral myopia is a very rare condition that is commonly associated with drug use. Here, we present a woman diagnosed with obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) who have been treated for two years in our clinic. She was on fluoxetine (Prozac) 80 mg/day when adding aripiprazole (Abilify) 10 mg/day as an augmentation agent has triggered unilateral myopia. After cessation of aripirazole her myopia has disappeared. Psychiatrists should keep in mind that unilateral myopia as a side effect may develop after combining aripiprazole with fluoxetine in patients with OCD and MDD.","PeriodicalId":17852,"journal":{"name":"Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5455/BCP.20150813023217","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72450530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Turkish validity & reliability of the quick inventory of depressive symptomatology adolescent version (QIDS-A17-SR) in comparison with the beck depression inventory-II among late adolescents - 青少年抑郁症状快速量表(QIDS-A17-SR)与贝克抑郁量表ii在晚期青少年中的有效性和信度比较
Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology Pub Date : 2016-11-08 DOI: 10.5455/BCP.20151221100426
B. E. Mergen, H. Arslan, Ebru Arslan, H. Mergen, Sibel Turgut, I. Bernstein
{"title":"Turkish validity & reliability of the quick inventory of depressive symptomatology adolescent version (QIDS-A17-SR) in comparison with the beck depression inventory-II among late adolescents -","authors":"B. E. Mergen, H. Arslan, Ebru Arslan, H. Mergen, Sibel Turgut, I. Bernstein","doi":"10.5455/BCP.20151221100426","DOIUrl":"https://doi.org/10.5455/BCP.20151221100426","url":null,"abstract":"ABSTRACTIntroduction: The Quick Inventory of Depressive Symptomatology Adolescent Version QIDS-A17-SR has never been used before as an instrument measuring major depressive disorder symptomatology ...","PeriodicalId":17852,"journal":{"name":"Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77948770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Determination of CYP2C19 polymorphism, side effects, and medication adherence in patients who have utilized selective serotonin reuptake inhibitors - 使用选择性血清素再摄取抑制剂的患者CYP2C19多态性、副作用和药物依从性的测定
Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology Pub Date : 2016-11-08 DOI: 10.5455/BCP.20151003060610
Semanur Deniz, M. Sancar, B. Okuyan, P. Ata, O. Ozakpinar, A. Talas, T. Gunes, M. Çalışkan, F. Izzettin
{"title":"Determination of CYP2C19 polymorphism, side effects, and medication adherence in patients who have utilized selective serotonin reuptake inhibitors -","authors":"Semanur Deniz, M. Sancar, B. Okuyan, P. Ata, O. Ozakpinar, A. Talas, T. Gunes, M. Çalışkan, F. Izzettin","doi":"10.5455/BCP.20151003060610","DOIUrl":"https://doi.org/10.5455/BCP.20151003060610","url":null,"abstract":"Objective: The aim of this study is to determine relationship of cytochrome P-450 2C19 (CYP2C19) enzymes polymorphism, side effects, and medication adherence in patients who have been diagnosed wit...","PeriodicalId":17852,"journal":{"name":"Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90548409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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