Association of 5-HT1A and 5-HT1B Gene Polymorphisms with Obsessive-Compulsive Disorder in a Turkish Population

Q Medicine

Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology Pub Date : 2016-11-08 DOI:10.5455/BCP.20151003063454

S. Aldemir, M. Acar, Z. Ocak, E. Dalbudak, M. R. Yiğitoğlu, E. Gunduz

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引用次数: 1

Abstract

ABSTRACTObjective: Obsessive-compulsive disorder (OCD) is a frequent neuropsychiatric disorder, in which genetic factors play important causative roles. We investigated the roles of the (-1019 C/G) promoter region polymorphism of 5-HTR1A and the G861C coding region polymorphism of 5-HTR1B genes in susceptibility to OCD in a Turkish population.Methods: Two single nucleotide polymorphisms, 5-HTR1A (rs6296) and 5-HTR1B (rs6295) genes were genotyped in 76 OCD patients and 57 healthy controls that were unrelated, using PCR-RFLP method.Results: We did not observe any difference in the genotype distributions of rs6296 and rs6295 between the OCD patient and control groups.Conclusions: As far as we know, our study is the first to establish the association of genetic variants 5-HTR1A (rs6296) and 5-HTR1B (rs6295) with OCD in a Turkish population. Based on our results, the relationship between polymorphisms of 5-HTR1A (rs6296) and 5-HTR1B (rs6295) with OCD do not seem.

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5-HT1A和5-HT1B基因多态性与土耳其人群强迫症的关联

摘要目的:强迫症(Obsessive-compulsive disorder, OCD)是一种常见的神经精神障碍，遗传因素在其中起着重要的致病作用。我们研究了5-HTR1A (-1019 C/G)启动子区多态性和5-HTR1B基因G861C编码区多态性在土耳其人群中对强迫症易感性的作用。方法:采用PCR-RFLP方法，对76例强迫症患者和57例健康对照进行5-HTR1A (rs6296)和5-HTR1B (rs6295)两个单核苷酸多态性基因分型。结果:强迫症患者与对照组rs6296和rs6295基因型分布无明显差异。结论:据我们所知，我们的研究是第一个在土耳其人群中建立遗传变异5-HTR1A (rs6296)和5-HTR1B (rs6295)与强迫症的关联。根据我们的研究结果，5-HTR1A (rs6296)和5-HTR1B (rs6295)的多态性与强迫症之间的关系似乎并不明显。

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