Annals of the Russian academy of medical sciences最新文献

{"title":"From Molecule to Drug. Pharmaceutical Logistics Approach","authors":"V. Petrov, I. Tyurenkov, D. Kurkin","doi":"10.15690/vramn2237","DOIUrl":"https://doi.org/10.15690/vramn2237","url":null,"abstract":"The development of original drugs is a complex, time-consuming, labor-intensive, costly, and risky process. The pharmaceutical industry is a critically important area of technological sovereignty of the country. Effective functioning of the drug supply system is impossible without original drug development process, which provide the foundation for progressive evolution of a number of branches of the socio-economic sector of the countrys economy. Domestic pharmacology faces several unresolved problems, many of which must be viewed through the prism of pharmacological disciplines, primarily theoretical and clinical pharmacology, and considering the evolution of approaches used in them. Pharmacology is a system of thought for pharmacologists and experts in drug development, aiming not only to improve the quality and quantity of drugs created, but also to accelerate this process. This article describes the essence of the pharmacological approach, briefly describing the main stages of the development of an original drug from the idea to research conducted, after the widespread introduction of the drug into clinical practice. At the end of the article the authors presented the successful experience of pharmacological approach application by pharmacologists of Volgograd State Medical University on the example of the development of an original drug for the treatment of diabetes mellitus and its complications.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132542396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI for Quantitative Determination of Iron in the Liver and Heart in Patients with Primary and Secondary Hemochromatoses in Association with Serrum Ferritin: Single-Stage Observational Study","authors":"A. M. Titova, V. Fokin, G. Trufanov, K. S. Shalygina, N. Tsvetkova","doi":"10.15690/vramn2328","DOIUrl":"https://doi.org/10.15690/vramn2328","url":null,"abstract":"Background. An extremely small number of studies have been devoted to the study of differences in LIC (liver iron concentration) and MIC (myocardium iron concentration) indicators, as well as their correlation with each other and with ferritin levels in patients with various nosological forms. Aims to study the relationship of ferritin, LIC and MIC levels in patients with various causes of hemochromatosis (hereditary hemochromatosis (HH), aplastic anemia (AA), primary myelofibrosis (PMF), thalassemia (TL), myelodysplastic syndrome (MDS)). Methods. The design of the study is a singlestage observational one. The study included 91 patients with primary hemochromatosis and secondary transfusion-dependent hemochromatosis receiving regular blood transfusion and iron chelate therapy from 2015 to 2018. The studies were carried out on 1.5 T MR-scanner Magnetom Espree (Siemens, Germany), and myocardial iron concentration (MIC) was calculated using the formula MIC = 45 (T2*) 1.22. Liver iron concentration (LIC) was calculated using the formula LIC = 0.03 R2* + 0.74. The ferritin level was determined by enzyme immunoassay. Statistical processing of the results obtained was carried out using the SPSS software package. Results. Connections between LIC and ferritin (r = 0.867; p 0.001), MIC and ferritin (r = 0.759; p = 0.004) and LIC and MIC (r = 0.737; p = 0.006) were found in patients with primary hemochromatosis, while in patients with secondary hemochromatosis significant correlations were found only between LIC and MIC (r = 0.503; p 0.001), while the relationship was average. Links between LIC and ferritin were found in patients with AA (r = 0.656; p = 0.040), an average relationship, in patients with TL (r = 0.714; p = 0.020), an average relationship. The relationship between MIC and ferritin was revealed in patients with AA (r = 0.703; p = 0.050), an average relationship, in patients with TL (r = 0.757; p = 0.018), an average relationship. At the same time, in patients with MDS and PMF in this study, there was no association between ferritin and LIC, ferritin and MIC. Conclusions. In patients with hereditary hemochromatosis, LIC and MIC are associated with ferritin, and MIC is also associated with LIC (medium bond). In patients with iron overload due to thalassemia, an average correlation between LIC and ferritin, MIC and ferritin was revealed. In patients with iron overload due to aplastic anemia, an average correlation between LIC and ferritin, MIC and ferritin was revealed.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"250 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115264091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To the 70th Anniversary of Academician of the Russian Academy of Sciences Evgeny Lhamatsyrenovich Choynzonov","authors":"I. Reshetov, N. Sergeeva, Alexei A. Serikov","doi":"10.15690/vramn7806","DOIUrl":"https://doi.org/10.15690/vramn7806","url":null,"abstract":"On December 14, 2022, Yevgeny Lhamatsyrenovich Choinzonov, Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Sciences, Honored Scientist of the Russian Federation, Director of the Research Institute of Oncology of the Tomsk National Research Medical Center of the Russian Academy of Sciences, Head of the Department of Oncology of the Siberian State Medical University (Tomsk), turned 70 years old.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"151 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114750267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Infections in Human Pathology","authors":"V. Maleev, V. Akimkin, A. Ploskireva, S. Ugleva","doi":"10.15690/vramn2184","DOIUrl":"https://doi.org/10.15690/vramn2184","url":null,"abstract":"Infectious diseases, due to their epidemic potential, are capable of global spread, they are unpredictable, and their effective control is possible only on a planetary scale. In no other field of medicine, such radical and often unpredictable changes occur in a short time in the form of the elimination of individual diseases, the identification of a large number of previously unknown and the return of already forgotten diseases, a significant change in the pathogenesis and clinical symptoms of a significant number of them. Under these conditions, these changes often create problems for the health authorities and the public, ahead of their ability to recognize and respond in a timely manner to the emergence of epidemics and the transformation of pathological manifestations. Significant recent scientific progress has only slightly clarified our knowledge of the biological and genetic diversity of pathogens. Until now, the entire spectrum of infectious pathology remains unclear, and its numerous manifestations often take even experienced specialists by surprise. Evidence of our limited knowledge and ability to control the situation is the ongoing COVID-19 pandemic for three years now, the increasingly frequent detection of new infections, the return of infections declared defeated, evidence of the role of infectious factors in the etiology of many other human diseases.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127718241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arctic Stress: Mechanisms and Experimental Models","authors":"I. Gmoshinski, D. B. Nikityuk","doi":"10.15690/vramn2209","DOIUrl":"https://doi.org/10.15690/vramn2209","url":null,"abstract":"Humans stay in the Polar regions results in the development of stress caused by a combination of factors such as low air temperature, hypodynamia, hypoxia, and disruption of the daylight cycle. All this strongly indicates the increased requirements for health protection and prevention of morbidity in the population of the Arctic. The problem is topical of search for optimal biological models of Arctic stress intended for preclinical testing of pharmacological and dietary correction of its consequences. Aim analysis of literature data on the pathophysiological mechanisms of polar stress, existing methods for its modeling in the experiment, informative biomarkers and prospects for dietary correction. Selection by keywords and analysis of literary sources using PubMed, Web of Science and Scopus online resources for the period, mainly, 20102022. The reaction to adverse environmental conditions in the Arctic is based on universal mechanisms associated with the excitation of midbrain centers (primarily the hypothalamus) with the development of a subsequent hormonal response from peptide hormones, corticosteroids, catecholamines, and thyroid hormones. The secondary targets of these effects are muscle tissue, endothelium, white and brown adipose tissue, cells of the immune system, in which changes occur aimed at neutralizing external adverse effects. A number of laboratory animal models have been developed to reproduce conditions associated with polar stress, including various types of acute, subacute and chronic cold exposure, as well as its combination with forced physical activity and additional stress factors. Sensitive biomarkers that allow monitoring the severity of polar stress are, firstly, the content of corticosteroids, catecholamines, neuropeptides, micro-RNA (miR-210) in blood plasma, organs and compartments of the brain, expression levels of uncoupling proteins (UCP) in brown adipose tissue, indicators of oxidative stress (lipoperoxide and malondialdehyde content, activity of antioxidant defense enzymes GPX, GR, SOD, catalase and others), levels of bioantioxidants (vitamin E, ascorbic acid, carotenoids, GSH), cytokines and chemokines, including IL-1, IL-6, IL-10, IL-17, IL-33, RANTES, FGF21 and various forms of their receptors, gene expression of signaling molecules (proteinkinases). In the issue of dietary correction of disorders caused by polar stress, the main place is given to the use of dietary antioxidant factors (vitamins E and C, selenium, zinc, coenzyme Q10, cinnamic acids and bioflavonoids). The data available in the world literature form the basis for further study of the molecular mechanisms of polar stress and pathogenetically substantiated methods of its dietary correction.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115033044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The First Domestic Experience of Detecting the Association of Anaerobic Bacteria Filifactor Alocis and Porphyromonas Gingivalis by Molecular Biological Methods in Periodontal Diseases and Comorbid Pathology (Comparative Research)","authors":"O. Yanushevich, V. Tsarev, E. N. Nikolaeva, I. Balmasova, E. V. Ippolitov, Tatiana V. Tsareva, M. Podporin, Anna Ponomareva","doi":"10.15690/vramn2262","DOIUrl":"https://doi.org/10.15690/vramn2262","url":null,"abstract":"Background. The widespread global increase in the incidence of periodontitis and the role of its pathogens in comorbid pathology and systemic complications determines the need to create new molecular genetic systems for diagnosis and the use of metagenomic and bioinformatic analysis methods. \u0000Aims to use methods of microbiological genodiagnostics and bioinformatic analysis to prove the etiological role of the key periodontal pathogens Filifactor alocis and Porphyromonas gingivalis, characterizing the degree of progression of chronic periodontitis, and its association with a systemic pathological process (type 2 diabetes mellitus). \u0000Methods. A comparative assessment of the identification of key periodontopathogenic species P. gingivalis and F. alocis in different forms of periodontitis according to the degree of progression (84 people) using a previously patented system of primers in patients in 4 comparison groups, differing in the degree of progression. 16S sequencing and bioinformatic analysis were performed in 69 patients (including 38 with type 2 diabetes mellitus). All nondiabetic patients were required to have HbA1c level 6.0%. \u0000Results. A higher frequency of detection of periodontal pathogens was established in patients of group C with a pronounced tendency to progression (93 and 100% respectively). The simultaneous presence of P. gingivalis and F. alocis in chronic periodontitis of grade B was noted in 20% of cases, and in grade C in 93% of cases. \u0000Conclusions. The proposed method can be used to effectively determine the degree of periodontitis progression based on the determination of oligonucleotide primers of P. gingivalis and F. alocis, including comorbid pathology periodontitis and type 2 diabetes mellitus.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131157410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Significance of the Characteristics of Microembolic Signals Recorded in the Recovery Period of Ischemic Stroke, a Cross-Sectional Observational Study","authors":"E. Orlova, A. Berdalin, V. Lelyuk","doi":"10.15690/vramn2136","DOIUrl":"https://doi.org/10.15690/vramn2136","url":null,"abstract":"Background. Microembols detected during transcranial Doppler monitoring with microembolodetection (TCDM with MED) are different in nature and, accordingly, in structure, as well as in size and consequences of their impact on the cerebral vessels. The following biophysical characteristics of microembolic signals (MES) can be assessed during TCDM with MED: frequency, which indirectly reflects the structure of the microembolus, duration, which indirectly reflects the size of the microembolus, and power, which is an integral characteristic. The issues of the relationship between characteristics of MES and clinical indicators have been little studied according to literature. \u0000Aims study of the biophysical characteristics of microembolic signals recorded in patients with ischemic stroke, as well as the factors affecting these characteristics, the clinical and prognostic significance of microembolism. \u0000Methods. This is a cross-sectional observational study that is part of a prospective cohort study. Data on 28 patients in the recovery period of ischemic stroke are included, in whom the biophysical characteristics of MES were analyzed (the total number of cases in the cohort study was 1600), and who underwent: duplex scanning of the brachiocephalic arteries, transcranial duplex scanning, TCDM with MED, transthoracic echocardiography, magnetic-resonance tomography of the brain, electrocardiography. Study enrollment was carried out in the period from 2019 to 2021. The MES characteristics included frequency, duration, power, energy index (the product of power and duration), of which the MES power was the main one. \u0000Results. MES characteristics correlated with anthropometric parameters: average duration - with the patients age (r = 0.421; p = 0.029); average frequency with body surface area (r = 0.624; p = 0.010). The average power, duration and energy index of MES were significantly higher in persons with intraluminal masses in the carotid arteries (p 0.05). Correlations of biophysical characteristics of MES with blood flow velocities in brain vessels (inverse correlation between the duration of the MES and the value of the peak systolic velocity in the M2 segment of the right MCA r = 0.529, p = 0.02; correlations between the power of MES, as well as the duration of MES with peak systolic and end-diastolic velocities in the V4 segment of the right VA r = 0.4810.572, p = 0.0270.007), as well as with signs of atrophy of the temporal and occipital lobes of the brain were identified (inverse correlation between MES frequency and regional atrophy in the right temporal lobe r = 0.434, p = 0.038; inverse correlation between MES frequency and regional atrophy in the left temporal lobe r = 0.422, p = 0.045; inverse correlation between MES frequency and regional atrophy in the left occipital lobe r = 0.465, p = 0.025). Significant differences were found in the number of MES and their average power, duration, energy index in the presence and absence of atrial fibrilla","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121344251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"99mTc-Labelled Low Molecular Weight Inhibitors of Prostate-Specific Membrane Antigen","authors":"Viktoriia K. Tishchenko, V. Petriev, O. Vlasova, A. Pankratov, N. Morozova, P. Shegai, Sergei A. Ivanov, A. Kaprin","doi":"10.15690/vramn2207","DOIUrl":"https://doi.org/10.15690/vramn2207","url":null,"abstract":"High morbidity and mortality rates of prostate cancer (PCa) determine the requirement of looking for new methods of its early diagnosis. Methods of nuclear medicine have a special place in addressing this problem as they allow functional, metabolic and other processes imaging in body, which occur during the cancer development. This approach supposes the use of radiopharmaceuticals (RP), which are capable of selective binding to a specific biological target, for example, prostate-specific membrane antigen (PSMA), which is known to be overexpressed in PCa. Current development of new radiotracers for PCa imaging is focused on low molecular weight PSMA inhibitors due to their high specific binding to PSMA and rapid urinary excretion. Technetium-99m remains the appropriate radionuclide for diagnostic studies due to its optimal nuclear properties, ease of production and versatile coordination chemistry. Therefore, single-photon emission computed tomography (SPECT) imaging with 99mTc-PSMA radioligands can be a cost effective alternative to PET with 68Ga- or 18F-labeled RP. The aim of this review is to summarize and analyze currently available data on 99mTc-labeled low molecular weight PSMA inhibitors for metastatic PCa imaging.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116360045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Inflammatory Response as a Prognostic Factor in Breast Cancer. Part II. Hematological Markers of Inflammation","authors":"N. Sergeeva, T. Karmakova, M. A. Polyak, I. Alentov","doi":"10.15690/vramn2235","DOIUrl":"https://doi.org/10.15690/vramn2235","url":null,"abstract":"Chronic inflammation is one of the recognized factors contributing to the onset and progression of malignant neoplasms. At the systemic level, a chronic inflammatory process is accompanied by an increased levels of inflammatory mediators and a change in hematological parameters of peripheral blood. According to numerous clinical studies, the change in the ratio of blood cell populations in cancer patients is an independent prognostic factor in malignant tumors of various localizations. This review is devoted to hematological parameters of the systemic inflammatory response (SIR) in breast cancer (BC). The review presents the characteristics of blood cells used for calculations of hematological indices (neutrophils, lymphocytes, monocytes, platelets); approaches for assessing SIR using these indices (NLR, PLR, LMR, etc.); comparative analysis of data on the association of the hematological indices with the clinical and morphological features of BC, patient survival and tumor response to chemotherapy. The data indicating the benefit of SIR hematological markers investigation during monitoring after treatment are summarized. Complex algorithms, including clinical, morphological and hematological factors, which are proposed to improve the quality of prognosis assessment, are considered. The information accumulated to date suggests that hematological indices reflecting SIR activity in BC patients can serve as additional independent prognostic factors. The development of the prognostic algorithms that are informative for certain clinical groups of BC patients is a promising area of research.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"2015 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114604428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Obesity and Sedentary Lifestyle on Testosterone Level and the Main Indicators of the Metabolic Status in Young Men","authors":"L. Osadchuk, A. Osadchuk","doi":"10.15690/vramn2114","DOIUrl":"https://doi.org/10.15690/vramn2114","url":null,"abstract":"Background. It is considered an established fact that there is an adverse trend in the male reproductive potential, which has been observed in various countries over the past decades. It is assumed that it can be formed due to the influence of individual lifestyle factors, in particular, a decrease in the level of physical activity and excessive nutrition, leading to obesity. However, the effect of obesity combined with sedentary or physically active lifestyle on the reproductive hormone level and metabolic homeostasis has not been studied well. \u0000Aims the aim of the work was to study the effects of obesity combined with sedentary or active physical lifestyle on the level of reproductive hormones and the main indicators of metabolic status of young men. \u0000Methods. In young male volunteers (median age 23 years, n = 295) from the general population, anthropometry was performed, which included body height and weight, waist and hip circumference, and body mass index (BMI); and they were also asked to fill out a questionnaire containing questions about individual lifestyle. In addition, serum concentrations of follicle stimulating and luteinizing hormones, testosterone, estradiol, inhibin B and triglycerides, total cholesterol, high and low density lipoprotein cholesterol, glucose, uric acid were evaluated. \u0000Results. The most important lipid metabolism disorders observed in overweight and obesity included an increase in triglycerides, total cholesterol, low-density lipoprotein cholesterol and a decrease in high-density lipoprotein cholesterol. Overweight and obesity in men was accompanied by an increase in waist and hip circumference, a decrease in the serum level of testosterone and inhibin B reaching in obese men the testosterone values characteristic for hypogonadism. Sedentary obese men had the increased waist circumference, lower testosterone level (median 13.6 vs. 18.0 nmol/L), elevated glucose level (median 5.8 vs. 4.9 mmol/L) compared to physically active obese men or those who prefer sports or physical recreation. \u0000Conclusions. In men, obesity negatively affects the serum level of testosterone and glucose, increases the accumulation of visceral fat, but a physically active lifestyle and sports give significant advantages to obese men, as it contributes to an increase in testosterone levels and normalization of metabolic parameters.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116282560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}