Annals of the Russian academy of medical sciences最新文献

{"title":"Significance of Tissue Inhibitors of Matrix Metalloproteinases Expression in Pathogenesis and Differential Diagnosis of Periodontal Pathology","authors":"Ludmila A. Kazeko, V. Zakharava, Julia D. Benesh, Eugeny D. Cherstvoy","doi":"10.15690/vramn2041","DOIUrl":"https://doi.org/10.15690/vramn2041","url":null,"abstract":"Background. The balance of metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) is crucial for the manifestation and progression of periodontal diseases and is one of the promising areas of scientific research in terms of developing methods for selective inhibition of MMPs. Aims to determine the significance of TIMP1 and TIMP2 expression parameters in gingival biopsies to identify the type of periodontitis at the stage of disease manifestation. Methods. A prospective study with parallel inclusion of patients with different forms of periodontitis in the compared groups was performed. The object of this study were patients with various forms of periodontitis. Pathological examination with morphometric analysis of TIMPs expression and subsequent statistical data analysis was performed using AperioImageScope v12.4.0.5043, Statistica 10.0, MedCalc19.6. Results. The study included 67 patients with aggressive (AgP, Grade C, n = 19), chronic simplex (CSP, Grade В, n = 10) and chronic complex (CCP, in the presence of occlusal trauma, Grade В, n = 38) periodontitis and 15 conditionally healthy patients (control group). The expression of TIMP1 and TIMP2 was detected with variable intensity both in the epithelium and in the stroma of the gingiva, and was significantly higher in periodontitis groups compared with the control group (MeTIMP1/2 = 32%/70%). Parameters of TIMP1 and TIMP2 expression had no significant differences in the groups with AgP (MeTIMP1/2 = 84%/98%) and CCP (MeTIMP1/2 = 83%/94%), except for higher parameters of the positivity of epithelial expression of TIMP2 (U = 61 372; p 0.05) and lower levels of intensity of its expression in AgP (MeAgP/CCP=180/171; U = 56 491; p 0.001). Correlation analysis revealed an inverse relationship of TIMPs expression parameters with those MMPs, including those most significant for the development of AgP MMP1 ( = 0.40), MMP8 ( = 0.34), and MMP14 ( = 0.24). ROC analysis established acceptable informativeness of all studied parameters of total expression and positivity of epithelial expression of TIMP1, as well as positivity of total expression and intensity of epithelial expression of TIMP2 to distinguish between aggressive and chronic forms of periodontitis at the stage of disease manifestation. Conclusion. Our results show an increase in the expression of TIMP1 and TIMP2 in various forms of periodontitis and an inverse relationship with the MMPs inhibited by them. This complements both the fundamental knowledge of the development and progression of periodontal pathology and may have applied significance in terms of using the studied TIMP1 and TIMP2 expression criteria to establish the aggressive course of periodontitis already at the stage of disease manifestation, which will allow to individualize treatment, prevent or slow down tooth loss in order to preserve and/or improve the quality of life of this patient group.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122503798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of the One-Factor Questionnaire “Patient Satisfaction with Medical Care”","authors":"Lasha D. Сhargaziya, Daria A. Shelegova, V. Vyskochkov, D. S. Tyufilin, I. Shibalkov, I. Deev, O. Kobyakova","doi":"10.15690/vramn2254","DOIUrl":"https://doi.org/10.15690/vramn2254","url":null,"abstract":"Background. One of the most viral principles in the development of modern healthcare is patient-oriented approach providing a medical care considering citizens expectations; ensuring individual approach in solving their personal problems. One of the most important markers for assessing patient-oriented health care provision is patient satisfaction with medical care. Aims the aim of our study was to develop and validate a tool to assess this indicator in the Russian Federation. Methods. A total of 3012 people between the ages of 18 and 83 took part in the study. The ratio of males to females in the sample was approximately 1:1 (1501 females to 1511 males). Quantitative methods were used to conduct the analysis. Construct validity was assessed using exploratory and confirmatory factor analyses (EFA and CFA, respectively) with appropriate assessment of goodness-of-fit. Reliability and internal consistency of the instrument measuring patient satisfaction with medical care was assessed using Cronbachs alpha. Results. The study involved 3012 people aged 18 to 83 years. The ratio of men to women in the sample was approximately 1:1 (1501 women and 1511 men). The proportion of urban residents who took part in the study was 67.2%, rural 32.8%. Less than a month ago, 22.0% of respondents received medical care for the last time; from one to three months 22.7%; four to six 29.1%; from seven to twelve 16.7%; more than a year ago 9.5%. The services of private medical organizations were used by 12.3% of the study participants, state 87.7%. The use of confirmatory factor analysis demonstrated the acceptability of a one-factor solution and confirmed the structural validity of the developed tool. The reliability and internal consistency of the patient satisfaction measurement tool was assessed using Cronbachs alpha. Cronbachs alpha showed excellent internal domain consistency ( 0.9). Bartletts sphericity criterion was met (p-value 0.001). Conclusion. The conducted statistical analysis allows us to assert the acceptability of the one-factor model and the construct validity of the proposed tool.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122903450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary Interpretations of Ophthalmological Manifestations of Chronic Myeloproliferative Neoplasms","authors":"L. Moshetova, L. Egoryan, O. Vinogradova, Ksenia I. Turkina, Dgariat I. Shikhbabaeva","doi":"10.15690/vramn2277","DOIUrl":"https://doi.org/10.15690/vramn2277","url":null,"abstract":"The course of chronic myeloproliferative neoplasms (CMPN), a group of systemic hematological diseases, can be accompanied by various complications and changes in tissues and organs of the whole organism. The eye is the only organ where damage of nerve fibers and blood vessels can be directly observed and examined, and ocular symptoms can be the initial, manifest of systemic pathology, the toxic effects of modern targeted therapy, or the first manifestation of a relapse of the disease after treatment. The most frequently described manifestations are caused by hematological anomalies that cause microvascular disorders. Such changes today remain insufficiently studied in terms of the using new research methods and contemporary targeted therapy. In addition, ocular symptoms may precede more serious extraocular complications. Combined ophthalmological and hematological examination of patients with CMPN can become a preventive approach for early diagnosis and timely treatment.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130922136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical and Signaling Functions of Plasmalogens in the Norm and in Various Diseases","authors":"O. Kytikova, Tatyana P. Novgorodceva, Y. Denisenko","doi":"10.15690/vramn4917","DOIUrl":"https://doi.org/10.15690/vramn4917","url":null,"abstract":"Plasmalogens (PL) are alkenyl ether glycerophospholipids that perform many physiologically important functions in the body and have a variety of properties. The role of PLs as endogenous antioxidants is well studied, as well as PLs that determine the physicochemical properties of biomembranes, deposit polyunsaturated fatty acids, participate in cholesterol biosynthesis, the process of ferroptosis and adaptation of cells to hypoxia, are sources for the synthesis of platelet activating factor and act as its antagonists. At the same time, LPs are involved in the pathogenesis of neurodegenerative, inflammatory, oncological diseases and a number of other pathologies. These conditions are united by the development of chronic inflammation and oxidative stress, accompanied by a change in the activity of synthesis and the content of PL in cells. Despite the fact that PL replacement therapy inhibits inflammation, the molecular mechanisms of the association of PL with inflammation have not been fully elucidated. The purpose of this review is to summarize the latest literature data on the structure, biosynthesis, and functions of PL, their relationship with signaling cascades involved in the pathogenesis of chronic inflammatory and neuroinflammatory diseases, as well as to show current achievements and future prospects for the use of PL in the treatment of certain diseases.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114808418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To the 80th Anniversary of Academician of the Russian Academy of Sciences Alexey Mikhailovich Egorov","authors":"A. Dygai","doi":"10.15690/vramn8386","DOIUrl":"https://doi.org/10.15690/vramn8386","url":null,"abstract":"February 19, 2023 marked the 80th anniversary of the birth of Doctor of Biological Sciences, Professor, Academician of the Russian Academy of Sciences Alexey Mikhailovich Egorov, a leading Russian specialist in the field of medical biotechnology.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123861772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis of Early Outcomes after Isolated Coronary Bypass Surgery: Results of a Single-Center Cohort Study","authors":"E. Golukhova, M. A. Keren, T. V. Zavalikhina, N. Bulaeva, D. Marapov, I. Sigaev, V. Merzlyakov, Mikhail D. Alsibaya, I. V. Volkovskaya, Kumushdzhan B. Yakhiaeva, Nina A. Sheikina","doi":"10.15690/vramn8086","DOIUrl":"https://doi.org/10.15690/vramn8086","url":null,"abstract":"Background. The importance of predictors of adverse outcomes after coronary bypass surgery needs to be regularly review in view of changing standards of practice. Predicting complications will help reduce current mortality and morbidity among patients who have undergone coronary bypass surgery (CABG). Aims prediction and determination of independent predictors of in-hospital mortality after CABG based on the results of preoperative examination. Methods. In a retrospective cohort single-center study, we analyzed the results of 2239 patients who underwent isolated CABG for the period from September 2018 to August 2021. The primary endpoint of the study was hospital death after CABG. Also, the frequency of: non-fatal myocardial infarction, non-fatal stroke, acute heart failure, postoperative rhythm and conduction disorders, acute renal failure, multiple organ failure, infectious complications was analyzed. Next, we searched for independent predictors and built a prognostic model for assessing the risk of death after CABG. Results. Results. Hospital mortality among patients was 1.34% (n = 30). Independent predictors of death after CABG were: ejection fraction (OR 0.91; 95% CI: 0.880.93; p 0.001), body mass index (OR 0.90; 95% CI: 0.820.99; p = 0.035), glomerular filtration rate (OR 0.97; 95% CI: 0.960.99; p = 0.005), repeated CABG (OR 9.3; 95% CI: 2.7431.24; p 0.001), critical atherosclerotic lesion of the arteries of the lower extremities (OR 4.5; 95% CI: 1.93310.268; p 0.001). The model for predicting the probability of death after CABG had high quality metrics: ROC-AUC 0.838 (95% CI: 0.7470.929; p 0.001), sensitivity 72.4%, specificity 84%. The threshold value of the logistic function P at the cut-off point, which corresponded to the highest value of the Yuden index, was 0.015. The outcome was predicted when the value of the logistic function P was higher than or equal to this value. Conclusion. We have developed a model for predicting in-hospital mortality after CABG based on independent linear predictors: left ventricular ejection fraction, body mass index, glomerular filtration rate, repeated CABG, critical atherosclerotic lesion of the main arteries of the lower extremities.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127032071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To the 95th Anniversary of Academician of the Russian Academy of Sciences Leonid Andreevich Ilyin","authors":"","doi":"10.15690/vramn8340","DOIUrl":"https://doi.org/10.15690/vramn8340","url":null,"abstract":"March 15, 2023 marks the 95th anniversary of Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Sciences Ilyin Leonid Andreevich, Hero of Socialist Labor, laureate of the State Prizes of the USSR and the Russian Federation, twice laureate of the Prize of the Government of the Russian Federation, honorary president of the Federal State Budgetary Institution State Research Center of the Federal Medical and Biological Center named after A.I. Burnazyan FMBA of Russia.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126198850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience in a Standardized Algorithm for Surgical Treatment of Patients with Mandibular Fractures","authors":"A. Pankratov, Z. P. Gotsiridze, Svetlana I. Kurshina, A. Karalkin, Vasily M. Grinin, L. Valieva","doi":"10.15690/vramn2128","DOIUrl":"https://doi.org/10.15690/vramn2128","url":null,"abstract":"Background. In recent decades, new surgical technologies for the treatment of patients with mandibular fractures have been introduced into clinical practice. However, the incidence of complications still remains high, practically not differing from the values 30 years ago. According to the Russian Dental Association, the incidence of complications is 1519%. Probably, the introduction of rules governing the use of new methods of treatment can change the current situation for general clinical practice. Aims to evaluate the effectiveness of the algorithm for the surgical treatment of patients with mandibular fractures, developed on the basis of clinical observations and biomechanical studies, based on significant clinical material. Methods. A retrospective study over a 3-year period of medical records of inpatients with mandibular fractures and their complications was carried out, in the surgical treatment of which, in the conditions of the basic clinic, the surgical algorithm developed by the authors was used. Results. Case histories of 442 patients who met the search criteria were examined. In terms of the composition of the patients included in the study group, it reflects a typical picture for this type of injury, which is typical for domestic clinical practice. The incidence of postoperative complications was 4.1% (of which accompanied by a prolongation of treatment 2% of cases). Conclusion. The results of this work showed that the real percentage of complications in patients with injuries of the lower jaw can be significantly reduced due to strict compliance with the requirements of the algorithm, which was shown by a retrospective analysis of medical records of inpatients over a three-year period, reflecting the results of treatment of a significant number of patients. The data obtained can serve as the basis for appropriate multicenter clinical trials.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127248176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally Invasive Surgery for Septal Defects Inchild: Literature Review","authors":"K. Shatalov, I. V. Arnautova, M. A. Abdurazakov","doi":"10.15690/vramn8355","DOIUrl":"https://doi.org/10.15690/vramn8355","url":null,"abstract":"Nowadays a minimally invasive approach is a rapidly evolving strategy in particular in the field of congenital heart surgery. The main advantage of minimally invasive approaches is less trauma to a patient which positively effects early postoperative period and recovery after surgery. Own to continuous technological progress and growing experience minimally invasive approaches become widely used in cardiac surgery as well as in treatments of congenital heart defects. This review highlights the main problems and their potential solutions in using minimally invasive approaches in surgical treatment of atrial septal defect, ventricular septal defect, partial atrioventricular canal, partial anomalous pulmonary venous drainage. We describe specific considerations of cardiopulmonary bypass, operative techniques and results of minimally invasive approanes.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129753251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalization of Anticoagulant Therapy with Direct Oral Anticoagulants in Patients with Atrial Fibrillation and Chronic Kidney Disease Based on Pharmacogenetic Testing","authors":"D. Sychev, S. V. Batyukina, O. D. Ostroumova, K. Mirzaev, A. I. Kochetkov, Sherzod P. Abdullayev, Z. Sozaeva, P. Bochkov, Anastasiia V. Asoskova, N. Denisenko, E. Ebzeeva, M. S. Chernyaeva","doi":"10.15690/vramn7807","DOIUrl":"https://doi.org/10.15690/vramn7807","url":null,"abstract":"Background. Polymorphic variants of the genes encoding these isoenzymes and carrier proteins involved in the pharmacokinetics of direct oral anticoagulants (DOAC) may alter their function and, therefore, hypothetically may increase the risk of bleeding associated with the use of DOAC. Aims to study the possible relationship between the presence of polymorphic variants of ABCB1 (rs2032582, rs1045642, rs1128503), CYP3A5 (rs776746) and CYP3A4 (rs35599367) genes on the residual equilibrium concentration (Cmin,ss /D) of apixaban, CYP3A isoenzyme activity and bleeding development in patients with AF and CKD C3C4 stages. Methods. The study included 142 patients with AF combined with chronic CKD stages C3 and C4, receiving apixaban therapy, aged 58 to 99 years (median age 84 years). Pharmacogenetic, pharmacokinetic testing and assessment of CYP3A isoenzyme group activity were performed. Results. Plasma concentration of apixaban depended on the stage of CKD: a higher level of Cmin,ss /D was observed in patients with CKD stage C4 compared to patients with CKD stage C3a and with CKD stage C3b. When studying the effect of rs1045642 (C3435T) polymorphism of ABCB1 gene on apixaban pharmacokinetics, it was found that carriers of homozygous TT genotype had lower median apixaban concentration in blood compared to carriers of CC and TC genotypes (p = 0.027 and 0.034 respectively). For rs2032582 polymorphism of ABCB1 gene, we recorded that patients with GG genotype had higher Cmin,ss /D level of apixaban compared to GT genotype carriers (p = 0.037). CYP3A metabolic activity was statistically significantly lower (p = 0.036) in the group with a history of bleeding compared with that in patients in the group without a history of bleeding (0.8 (0.5; 1.3) and 1.2 (0.7; 2.1); p = 0.036). CYP3A metabolic activity did not differ between patients with different CYP3A5 (rs776746) and CYP3A4 (rs35599367) polymorphism genotypes. For the rs1045642 polymorphic variant, there were fewer carriers of the heterozygous TC genotype (16 (45.7%) patients) among patients with bleeding during the follow-up period compared to patients with no bleeding (43 (53.1%) patients; p = 0.024). Conclusions. The results of the study indicate the presence of an association between genome-wide changes (polymorphic variants of the ABCB1 (rs1045642) and CYP3A5 (rs776746) gene and the presence of apixaban-associated bleeding in patients with AF and CKD stages 34. Mechanisms of such an association require further study.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"131 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116265287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}