Annals of the Russian academy of medical sciences最新文献

{"title":"Efficacy of Propafenone for Treating Idiopathic Premature Ventricular Contractions in Children","authors":"K. Alekseeva, T. Kruchina, Mohiniso Sh. Maljarova, G. A. Novik","doi":"10.15690/vramn13677","DOIUrl":"https://doi.org/10.15690/vramn13677","url":null,"abstract":"Background. Premature ventricular contractions (PVCs) are a common heart rhythm disorder in children, often following a benign course. However, in rare cases, antiarrhythmic therapy is required for managing this arrhythmia. Limited data is available regarding the effectiveness of such therapy specifically in children. Objective. To evaluate the efficacy and safety of propafenone administration in children with idiopathic PVCs. Methods. The study enrolled 33 children aged 11.1 ± 4.8 years (29 days — 17 years) with idiopathic PVCs. Propafenone dose was titrated from initial (5–7 mg/kg/day) to effective (no more than 15 mg/kg/day) dose under clinical and electrocardiographic control to monitor for proarrhythmias and other side effects. An increase in PQ interval duration and a widening of the QRS complex no more than 25% compared to baseline was considered acceptable. Results. The incidence of PVCs before propafenone administration was 36.3 ± 10.1 (22.0–60.6) thousands/day or 33.2 ± 8.4% (20.5–50.0). Complex forms of PVCs were observed in 25 (75.8%) children: 25 (75.8%) had frequent paired PVCs, 6 (18.2%) had polymorphic PVCs, 20 (60.6%) had short runs of ventricular tachycardia (VT), and 19 (27.6%) had a combination of various forms of PVCs. The starting dose of propafenone was 5.6 ± 2.2 mg/kg/day with subsequent increases to 10 ± 0.8 mg/kg/day. Propafenone was employed as the initial therapy in 23 (69.7%) children and as a second line therapy in 10 (30.3%) children, following the ineffectiveness or adverse effects of beta-adrenoblockers. The duration of propafenone therapy was 95.8 ± 62.8 days. Propafenone was effective in 25 (75.8%) children. The average reduction in the number of PVCs during therapy was 71.7 ± 32.6% (13.0–100.0) during therapy. One (3%) child developed proarrhythmia — sustained VT and 1 (3%) child had gastrointestinal side effects. Conclusion. Propafenone is an effective antiarrhythmic drug in children with idiopathic PVCs, including patients with poor response to beta-adrenoblockers. Arrhythmogenic and extracardiac side effects are possible during propafenone therapy, which require clinical and electrocardiographic observation in the process of selecting an effective dose of the drug.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"48 11-12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140499355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Technologies in Pediatric Neuro-Oncology","authors":"G. Novichkova, L. Papusha, A. Druy","doi":"10.15690/vramn15999","DOIUrl":"https://doi.org/10.15690/vramn15999","url":null,"abstract":"At the present time pediatric neuro-oncology develops rapidly mostly due to the deep understanding of etiology and pathogenesis of the brain tumors in children, widespread introduction of molecular genetic technologies into diagnostic workflow and emergence of targeted therapeutic agents directing to the neoplastic cells. Many tumor entities undistinguishable at the level of histopathology were classified by the molecular techniques and now present as unique disorders. Clinical heterogeneity unraveled by molecular classification is a basis for modern risk stratification approaches. Variety of new tumor entities were discovered only because of implementation of advanced molecular diagnostics, which led to identification of the recurrent genetic aberration in neuroepithelial tumors with BCOR and PATZ1 genes alteration, intracranial mesenchymal tumors with FET-CREB rearrangements. The discovery of the targetable molecular drivers in gliomas allows the introduction of targeted therapies to the pediatric neuro-oncology with high results unreachable by other methods. In the current article we describe the experience of D. Rogachev National Medical Research Center in molecular diagnostics of pediatric brain tumors and targeted therapy in patients with different types of gliomas.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"7 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140499584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence of Sensitization Profiles to Various Allergens in Children in the Moscow Metropolitan Area","authors":"Juliya G. Levina, V. Kalugina, K. Efendieva, A. Alekseeva, K. Volkov, Elena V. Vishneva, E. T. Ambarchian, V. V. Ivanchikov, V. A. Bulgakova","doi":"10.15690/vramn10923","DOIUrl":"https://doi.org/10.15690/vramn10923","url":null,"abstract":"Background. In Russian scientific literature there is a limited amount of data on the prevalence of sensitization to various types of allergens in children. The determination of sensitization profiles is important for the formation of personalized measures for patients. Aim — to reveal the prevalence of sensitization profiles to allergen extracts and components in children with different variants of the atopic phenotype, taking into account regional characteristics. Methods. A cross-sectional study was conducted in 160 children from 0 months to 17 years 11 months with symptoms of allergic rhinitis, food allergy, atopic dermatitis, living in the Moscow metropolitan area. The sensitization to 9 extracts of allergens was analyzed in all children using the ImmunoCAP method, component resolved diagnostics was held with “Allergochip ISAC ImmunoCAP” in 143 patients. Results. sensitization to birch pollen was detected most often (68%), less often (52%) — to timothy grass, (48.1%) — to mugwort. Among food allergens, most often (55% each) children were sensitized to extracts of egg white, wheat flour, less often — cow’s milk (48%), Atlantic cod (15.6%). Analysis of molecular sensitization showed that most often patients were sensitized to Bet v 1 (64%), Aln g 1 (50.3%), Сor 1.0101 (48.3%), Fel d 1 (42.7%) cases. Sensitization to cat/dog allergen components was detected in 79.7% patients. Asymptomatic sensitization to cat allergens was observed in 35.8%, to dog — in 40% patients. More than half of the patients had sensitization to the PR-10 components. From 2 to 10% of patients had sensitization to LTP, most often to the Jug r 3 walnut component in 10.5% patients. Conclusion. The profiles of molecular sensitization in children with various variants of the atopic phenotype were clarified, the prevalence of sensitization to extracts and components of pollen, household, food and animal allergens, the incidence of true and asymptomatic sensitization were determined.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"22 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140500551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Single-Stage Population-Based Study of the Relationship between Cognitive and Somatic Health Parameters in Children of Secondary School Age","authors":"Georgiy A. Karkashadze, Elena V. Kaitukova, T. Gogberashvili, T. Konstantinidi, O. Gordeeva, Aishat M. Gazalieva, M. Soloshenko, S. E. Kondratova, E. Abashidze, Grigorii V. Revunenkov, Elena V. Komarova, M.I. Ivardava, O. Drapkina, R. Shepel, K. Mezhidov, L. S. Namazova-Baranova","doi":"10.15690/vramn14392","DOIUrl":"https://doi.org/10.15690/vramn14392","url":null,"abstract":"Background. One of the four important components of the formation of cognitive functions is somatic health. But to date, there are no population studies that consider the relationship with cognitive functions and school performance of a large range of somatic factors, which allows us to compare the strength of their hypothetical contribution to cognitive functioning with each other. This study is the second part of a population-based study, the first part of which is presented in the previous publication \"A Single-Stage Population-Based Study of the Prevalence of Mild Cognitive Impairment in Children of Secondary School Age\". Aims — to determine the main patterns in the relationship between cognitive-academic and somatic factors in a cohort of Russian children, 5th grade students at school. Methods. In Russian schoolchildren of the 5th grades of municipalities representing cities of all federal districts of the Russian Federation, the links with integrative cognitive success, the number of subtests performed at the level of mild cognitive impairment, the results of individual cognitive subtests, academic performance and the leading hand factor were analyzed — the following somatic factors: the presence of skin pathology, bronchial asthma, orthopedic, ophthalmological disorders, visual acuity, body mass index, parameters of the study of the function of external respiration, electrocardiography, ultrasound examination of the thyroid gland, laboratory blood tests. Results. The results of the survey of 1036 participants, 51% of them girls, were admitted to the analysis. It has been established that iron content is directly related to integrative cognitive success and school performance, the relationship is especially strong between subgroups of iron content above and below 26.4 mmol/l. Clinical levels of erythrocytes are more strongly associated with integrative cognitive success and individual cognitive functions than other factors: in erythropenia cognitive parameters are worse. The presence of thyroid cysts directly correlates with some of the worst parameters of cognitive activity. High body mass index and low hemoglobin are associated with poorer academic performance. Conclusions. The results of the study for the first time on a cohort of Russian schoolchildren showed a connection with cognitive activity and school performance of a number of somatic factors, including iron content, which requires further in-depth study.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"278 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140499771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific Research in the Field of Children’s Health and Development","authors":"V. Starodubov, L. S. Namazova-Baranova, A. A. Baranov","doi":"10.15690/vramn16007","DOIUrl":"https://doi.org/10.15690/vramn16007","url":null,"abstract":"The focus on the interests of children has always been inherent in the Russian State, but the most effective measures have been implemented already in this century: 4 years before WHO announced the Global Strategy for Mothers and Children in 2016, Russian President Vladimir Putin signed the Decree on the National Strategy for Children for 2012–2017, in 2017. The President announced the “Decade of Childhood”, and in 2020 The priority of childhood was enshrined in the Constitution of the Russian Federation. In the Russian Federation, the most child-oriented system of children’s healthcare has been built, in medical and scientific organizations of the pediatric profile of the Russian Federation, specialists with medical, biomedical, psychological, pedagogical, and social education are specially trained to work with children of different ages, and scientific research in the field of pediatrics is carried out by specialized researchers within the framework of special programs focused on the needs of children’s healthcare. A detailed analysis of the structure and content of the projects implemented in 2022 has been carried out. Scientific projects involving children compared to 2018, when the implementation of the “Decade of Childhood” program began, which indicates that scientific research in the field of children’s health and development is voluminous, but uncoordinated. Many topics are carried out simultaneously by several scientific and medical or educational organizations, but they are not coordinated in unified scientific and methodological approaches. At the same time, there are systemic problems, to solve which it is necessary to switch to network scientific research of population health; to strengthen the integration of research teams both in the context of interdepartmental cooperation (the Ministry of Education and Science of the Russian Federation and the Ministry of Health of the Russian Federation — Rospotrebnadzor — Federal Medical and Biological Agency), and joint scientific work with other ministries (the Ministry of Education of the Russian Federation, the Ministry of Sports of the Russian Federation, the Ministry of Culture of the Russian Federation, etc.); as well as to improve financial mechanisms for managing scientific activities.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"51 5-6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140499476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychophysical and Electrophysiological Parameters of the Auditory Analyzer as Indicators of the Effectiveness of Cochlear Implantation in Children with Bilateral Deafness","authors":"A. Pashkov, I. V. Naumova, K. I. Voevodina, A. Pashkova, V. Popadyuk, N. Ustinova, Ayaz M. Mamedyarov","doi":"10.15690/vramn10922","DOIUrl":"https://doi.org/10.15690/vramn10922","url":null,"abstract":"Background. The results of rehabilitation of patients with deafness after cochlear implantation (CI) depends on many factors related on both the individual characteristics of the patient and the technical parameters of auditory nerve stimulation — fitting of the CI system processor. Article presents the results of a study of the relationship between psychophysical (subjective) auditory sensations and electrophysiological (objective) responses of the structures of the auditory analyzer to electrical stimulation. Aims — to evaluate the relationship between the electrophysiological responses of the auditory analyzer and the psychophysical parameters of the thresholds of sound perception and speech intelligibility in patients with deafness after CI. Methods. The study involved 88 patients with IV bilateral sensorineural hearing loss, borderline with deafness, aged 6 to 17 years 11 months, among whom 54.5% (n = 48) of girls and 45.5% (n = 40) of boys. Of the patients included in the follow-up, 40% (n = 35) underwent unilateral CI; 60% (n = 53) of children underwent bilateral sequential CI. In our study, slightly more than half of the patients (51.1%) had experience using the CI system for more than 5 years. At the first stage of the study, we studied the relationship between sound perception thresholds (tonal audiometry in a free field) and registered ASSR (auditory steady state response) thresholds in patients with deafness receiving rehabilitation after CI surgery. The relationship between behavioral and electrophysiological (objective) thresholds was assessed by comparing the results of tonal threshold audiometry and the responses received during ASSR registration to acoustic stimulation in a free field. At the second stage, patients with indications for processor fitting (decreased speech intelligibility, uncomfortable sensations) underwent speech audiometry, evoked compound action potentials (ECAP) registration, according to the results of which the parameters of the CI processor were changed. Results. Research data showed the effectiveness of the approach of including the ECAP registration test, followed by the creation of a fitting card and correction of the level of auditory nerve stimulation under the control of speech audiometry in the protocol of fitting the CI processor. Conclusions. The results of the conducted studies allow us to recommend the use of the developed method of objective recording of sound perception thresholds in patients with CI as one of the indicators of the effectiveness of CI in the early period of auditory-speech rehabilitation in patients with undeveloped speech skills and when it is impossible to conduct objective tests accompanied by supra-threshold stimulation of the auditory nerve.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"33 11-12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140499570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Treatment of Congenital Heart Diseases Associated with Pulmonary Hypertension in Adults","authors":"S. Gorbachevsky, I. Chazova, T. Martynyuk, A. A. Shmalts","doi":"10.15690/vramn8360","DOIUrl":"https://doi.org/10.15690/vramn8360","url":null,"abstract":"The outcome of treatment of adult patients with congenital heart disease (CHD) and pulmonary hypertension (PH) depends on the adequacy of diagnosis with a thorough assessment of hemodynamics and the correctness of the chosen tactics. Enormous success has been achieved, various classifications and algorithms for managing children and adults with this nosology have been created and are widely used. Thanks to the creation and widespread introduction into clinical practice of various types of drugs, the results of surgical treatment of CHD with PH have improved significantly. A new cluster of patients has emerged who can undergo palliative surgery against the background of irreversible pulmonary hypertension, leading to a significant improvement in the quality and life expectancy. At the same time, to this day, it is far from always possible to evaluate each specific case with full confidence in the possibility of performing surgical treatment. Modern advances in CHD cardiac surgery have significantly expanded the indications for the correction of defects with high PH in adults. Operability (implying normalization of pulmonary artery pressure) and indications for palliative surgery (without regression of PH, but with an improvement in the quality and life expectancy of patients) are still the main debatable issues.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117315222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To the 75th anniversary Academician of the Russian Academy of Sciences of Yuri Konstantinovich Yanov","authors":"I. Reshetov, N. Sergeeva, Alexei A. Serikov","doi":"10.15690/vramn8410","DOIUrl":"https://doi.org/10.15690/vramn8410","url":null,"abstract":"On December 18, Lieutenant General of the medical service Yuri Konstantinovich Yanov turned 75 years old.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130012931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socio-Psychological Aspects of Introducing Mobile Technologies into Clinical Trials","authors":"A. Khokhlov, A. Andreenkova, E. Dmitrieva, M. Ilyin, E. G. Lileeva, P. Chizhov, A. E. Miroshnikov, N. O. Pozdnyakov","doi":"10.15690/vramn2265","DOIUrl":"https://doi.org/10.15690/vramn2265","url":null,"abstract":"Background: High political and economic turbulence, changes in the international relations and cross-national economic ties enhance the demand for developing and launching new pharmacological treatments as a part of nationally independent health care program and import substitution policy. The number of clinical trials is growing rapidly, increasing the need for more effective solutions in organizing these trials optimizing the time, financial resources and efforts of medical personnel. The global trend of creating a new digital ecosystem in health care also raises the issues of higher patient involvement, taking into account the patient's psychological and physical barriers including the issues of personal data security. Aims: Evaluating the motivation and readiness of current clinical trials participants to switch to mobile technologies and identifying the barriers for these shifts. Method: The survey among 75 participants of clinical trials using offline self-completed questionnaire, data processing using statistical tools for data analysis. \u0000Results: Currently, 56% of respondents who are current participants of traditional medical trials would definitely agree to participate in mobile clinical trials. Compared to the consistency rate between traditional clinical trials estimated as 73%, the shift to a new format will result in 17% additional losses. The serious barrier for participation is the concerns about the security of personal information it is highly relevant for 37% of respondents and moderately relevant for 44%. The important motivating factor for the participation is the open access to personal medical data - 44% of respondents were highly interested in obtaining this data and 31% are somewhat interested. Conclusion. The results of the pilot study confirmed relatively high readiness of current participants to join mobile clinical trials and use mobile devices and solutions in future trials. However the level of readiness is unequal between different socio-demographic groups. Differentiating parameters are age, former experience of clinical trials and the skills in using digital technologies. Training programs for managers and researchers of clinical trials, provision of devices for non-users, timely technical support during the data collection and transparency in data usages can help to address key issues which slow down the peoples participation in mobile trials.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114226334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Assessment of Technological Readiness of an Innovative Project during the Development of a Pharmaceutical Product","authors":"A. M. Pyatigorsky, G. Brkich, V. Beregovykh, N. Pyatigorskaya","doi":"10.15690/vramn8349","DOIUrl":"https://doi.org/10.15690/vramn8349","url":null,"abstract":"Most of RD, technological and experimental works carried out in Russia result in the development of technologies with low-level readiness for possible integration into the production cycles of industrial enterprises, which, on the one hand, demonstrates a lack of understanding by developers of the requirements for the product life cycle, and on the other hand, it is the possible reason for the low share of Russia in the total world exports of high-technology goods. In order to create a scientific and technical reserve in a target time, the world practice uses the Technology Readiness Levels (TRL) scale. This approach is used in various industries and has shown the possibility to develop technologies and launch production of innovative product by a target time. However, the Ministry of Education and Science notes that this approach has not yet been used to determine the readiness levels of chemical-technological processes and pharmaceutical technologies. The article discusses main scientific problems associated with conducting a comprehensive assessment of technological readiness levels of an innovative project during the development of a pharmaceutical product, using the TRL scale and the QbD concept for a systematic and early approach to development, based on a scientific understanding of the drug life cycle processes.","PeriodicalId":178392,"journal":{"name":"Annals of the Russian academy of medical sciences","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114799340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}