{"title":"Evaluation of secure multi-party computation for reuse of distributed electronic health data","authors":"K. Y. Yigzaw, J. G. Bellika","doi":"10.1109/BHI.2014.6864343","DOIUrl":"https://doi.org/10.1109/BHI.2014.6864343","url":null,"abstract":"There has been an increasing need for reuse of health data (i.e. research, quality assurance, public health, and commercial applications). However, privacy and legal issues have limited the reuse. Several privacy-preserving techniques (both centralized and distributed) have been developed to allow reuse of health data while preserving privacy. The distributed techniques enable institutions to jointly compute on their private data while preserving the privacy of their data. However, the centralize approach applies perturbation or anonymization technique on the private data before giving out the data for computation. This paper presents criteria, such as privacy level, linkability support, efficiency and scalability, to evaluate distributed privacy preserving techniques.","PeriodicalId":177948,"journal":{"name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121125605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis and visualization of metabolic pathways and networks: A hypegraph approach","authors":"Evaggelia Maniadi, I. Tollis","doi":"10.1109/BHI.2014.6864316","DOIUrl":"https://doi.org/10.1109/BHI.2014.6864316","url":null,"abstract":"Metabolic pathways are series of chemical reactions occurring in a cell. Various graph-based models are used to represent metabolic data. However, diverse problems may arise from adopting these models. A more accurate modeling framework can be offered by hypergraphs. In this paper, a new technique for visualizing hypergraphs using common graph drawing techniques is proposed. This method is implemented in VisBolic, a case tool for the analysis and visualization of metabolic pathways; several examples are presented.","PeriodicalId":177948,"journal":{"name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114139582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Parameter estimation of complex mathematical models of human physiology using remote simulation distributed in scientific cloud","authors":"T. Kulhánek, M. Matejak, J. Šilar, J. Kofránek","doi":"10.1109/BHI.2014.6864463","DOIUrl":"https://doi.org/10.1109/BHI.2014.6864463","url":null,"abstract":"A generic system for estimation of model parameters - calibrate models - is introduced. The proposed system architecture is built of several loosely coupled modules behaving as RESTful web services and allowing to integrate other parts of the system via HTTP protocol and data exchanged in JSON format. The system was designed in such a way that the most demanding computational part is computed in parallel and computation may be distributed to remote computational resources. A test deployment was done in scientific cloud provided by czech NGI CESNET. Parameter identification of complex models got significant speedup on cloud computing resources.","PeriodicalId":177948,"journal":{"name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114488977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Automated nuclei clump splitting by combining local concavity orientation and graph partitioning","authors":"Siddharth Samsi, C. Trefois, P. Antony, A. Skupin","doi":"10.1109/BHI.2014.6864390","DOIUrl":"https://doi.org/10.1109/BHI.2014.6864390","url":null,"abstract":"Automated clump decomposition is essential for single cell based analysis of fluorescent microscopy images. This paper presents a new method for automatically splitting clumps of cell nuclei in fluorescence microscopy images. Nuclei are first segmented using histogram concavity analysis. Clumps of nuclei are detected by fitting an ellipse to the segmented objects and examining objects where the fitted ellipse does not overlap accurately with the segmented object. These clumps are then further processed to find concave points on the object boundaries. The orientation of the detected concavities is subsequently calculated based on the local shape of the object border. Finally, a graph segmentation based approach is used to pair concavities that represent best candidates for splitting touching nuclei based on properties derived from the local concavity properties. This approach was validated by manual inspection and has shown promising results in the high throughput analysis of HeLa cell images.","PeriodicalId":177948,"journal":{"name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122036067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mass detection based on pooled mass probability map of 3D reconstructed slices in digital breast tomosynthesis","authors":"Seong-Tae Kim, Dae Hoe Kim, E. Cha, Yong Man Ro","doi":"10.1109/BHI.2014.6864303","DOIUrl":"https://doi.org/10.1109/BHI.2014.6864303","url":null,"abstract":"In this paper, we propose a novel approach for automated detection of breast masses in three-dimensional (3D) reconstructed slices on digital breast tomosynthesis (DBT). The 3D reconstructed slices provide quasi-3D information with limited resolution along the depth direction due to insufficient sampling in depth direction. This problem could cause an error of general 3D segmentation approaches which have to process information with different resolution at the same time. In order to resolve the problem, this paper proposes an effective mass detection method based on pooled mass probability map. The proposed pooled mass probability map contains slice plane information by fusing mass probabilities of initially detected regions along slices. Extensive and comparative experiments have been conducted using clinical data set to validate the effectiveness of proposed mass detection approach. Experimental results demonstrate the feasibility of proposed pooled mass probability map based approach for detecting masses on 3D reconstructed slices.","PeriodicalId":177948,"journal":{"name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129053655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Veronica Peiteado-Brea, D. Álvarez-Estévez, V. Moret-Bonillo
{"title":"A study of heart rate variability as sleep apnoea predictor over two different databases","authors":"Veronica Peiteado-Brea, D. Álvarez-Estévez, V. Moret-Bonillo","doi":"10.1109/BHI.2014.6864377","DOIUrl":"https://doi.org/10.1109/BHI.2014.6864377","url":null,"abstract":"The main aim of this work is to study the consistency of ECG-based approaches for the screening of apnoeic patients, which are based on estimation of the Heart Rate Variability (HRV) by computing the so called High Frequency to Low Frequency (HF/LF) ratio. Different intervals and thresholds proposed in the literature for the previous ratio are compared with those found by the authors, and tested on two different databases. While more studies need to be launched on this area, our results suggest that patient classification according to this approach suffers from high variability and is widely dependent of the set of patients used for the tests.","PeriodicalId":177948,"journal":{"name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123495809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alejandro Mañas Garcia, R. Sanz-Requena, Á. Alberich-Bayarri, G. García-Martí, M. Egea, C. Martinez
{"title":"Coco-Cloud project: Confidential and compliant clouds","authors":"Alejandro Mañas Garcia, R. Sanz-Requena, Á. Alberich-Bayarri, G. García-Martí, M. Egea, C. Martinez","doi":"10.1109/BHI.2014.6864345","DOIUrl":"https://doi.org/10.1109/BHI.2014.6864345","url":null,"abstract":"The Coco-Cloud (Confidential and Compliant Cloud) project is under the scope of the 7th Framework Programme of the European Commission and its main objective is to allow users to share data in the Cloud, guaranteeing its privacy and security in the case of sensitive information, ensuring that the current legislation in the involved countries is enforced. In this context, information regarding patients' health is one of the most important examples of sensitive data. During the diagnostic imaging routine and the subsequent processing, several documents with sensitive information related to the patient are generated. These data are only available either within our healthcare centers' intranet or in some storage device that the patient keeps. The Coco Cloud e-health pilot is driven by our private hospital network in which a Cloud-based radiological patient portal will be developed. Its aim is to allow patient access to their radiological information in a delocalized manner, providing medical images and personalized reports. This system will eliminate patient's need to return to his reference hospital to physically collect the results of imaging acquisitions and/or post-processing, facilitating access to relevant content for any medical specialist authorized by the patient, as well as share images and reports with other users and physicians of different specialties involved in the patient's healthcare. This goal is achieved through a cloud-based system which introduces important advantages such as the flexibility to allocate or remove resources, the data security and the document control mechanism, or the capability to work from anywhere, are just a few reasons which allow cloud-based systems increase the efficiency and decrease the costs of the daily work.","PeriodicalId":177948,"journal":{"name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121665097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quality assessment model of software for managing family medicine practice — Methodology and basic results","authors":"D. Kralj, M. Koncar, S. Tonkovic","doi":"10.1109/BHI.2014.6864371","DOIUrl":"https://doi.org/10.1109/BHI.2014.6864371","url":null,"abstract":"Family medicine practices form the basis of the Croatian health system. They solve the largest number of health problems and collect the most health data with the lowest operational cost. However, the software support required for the running of these offices at the time being is still certified only based on the principal communication criteria, while all other essential functionalities are generally uneven and left to the will of the producers. It is necessary to assess the quality of this type of software. Based on previous theoretical and experimental research in this area, the initial quality assessment model consisting of six basic categories and the questionnaire by which the Croatian family physicians evaluated the quality of the functionalities applied in their software support were made. The resulting novel model is multiple validated, comprehensive and universal. The intense ergonomic orientation of the novel measurement model was particularly emphasized.","PeriodicalId":177948,"journal":{"name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124126926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Karri, Hrushikesh Garud, D. Sheet, J. Chatterjee, Debjani Chakraborty, A. Ray, M. Mahadevappa
{"title":"Learning scale-space representation of nucleus for accurate localization and segmentation of epithelial squamous nuclei in cervical smears","authors":"S. Karri, Hrushikesh Garud, D. Sheet, J. Chatterjee, Debjani Chakraborty, A. Ray, M. Mahadevappa","doi":"10.1109/BHI.2014.6864478","DOIUrl":"https://doi.org/10.1109/BHI.2014.6864478","url":null,"abstract":"Computer vision systems are being introduced in pre-screening of cervical cytopathology slides to identify samples that require study by cytopathologists. These systems work on the principle of imaging and analysis of cytology features in general and nuclear features in particular. Thus accurate localization and segmentation of the nuclei is crucial for the systems. Though several methods have been conceptualized, developed and employed to achieve the tasks of localization and segmentation of nuclei in cytology images, most fail to localize nuclei with opened up chromatin. This paper presents a machine learning approach based framework for accurate localization and segmentation of nuclei. The approach uses the random forest model to learn complete scale-space representation of the nuclear chromatin distribution in green and color saturation channels. Based on the multi scale features of an unknown image this model can predict an image such that gray level value of a pixel is proportionate to the probability that the pixel belongs to nuclear region. This predicted image then can be used for accurate localization and segmentation of the nuclei by random walks approach. Accuracy of the system has been tested on a publicly available dataset images and was found to be approximately 97%.","PeriodicalId":177948,"journal":{"name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130011264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Zarkogianni, K. Mitsis, M. Arredondo, G. Fico, A. Fioravanti, K. Nikita
{"title":"Neuro-fuzzy based glucose prediction model for patients with Type 1 diabetes mellitus","authors":"K. Zarkogianni, K. Mitsis, M. Arredondo, G. Fico, A. Fioravanti, K. Nikita","doi":"10.1109/BHI.2014.6864351","DOIUrl":"https://doi.org/10.1109/BHI.2014.6864351","url":null,"abstract":"This paper presents the design, the development and the evaluation of a personalized glucose prediction model for patients with Type 1 Diabetes Mellitus (T1DM). The personalized model is based on neuro-fuzzy techniques in order to capture the metabolic behavior of a patient with T1DM. Moreover, wavelets are applied as activation functions in order to enhance the prediction performance and avoid local minimum during training stage. The model receives as input, data from sensors which record in real time glucose levels and physical activity, and provides with future glucose levels. The proposed model is evaluated using data from the medical records of 6 patients with T1DM for the time being on CGMSs and physical activity sensors. The obtained results demonstrate the ability of the proposed model to capture the metabolic behavior of a patient with T1DM and to handle intra- and inter-patient variability.","PeriodicalId":177948,"journal":{"name":"IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130265087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}