Jurnal Kimia最新文献_第10页

FORMULASI SEDIAAN SIRUP PENINGKAT IMUNITAS DARI HERBA MENIRAN (Phyllanthus niruri L.) 苯海拉草本植物的一种免疫力增强糖浆制剂。

Jurnal Kimia Pub Date : 2019-07-31 DOI: 10.24843/jchem.2019.v13.i02.p03

W. O. Sugarda, K. Dewi, K. Putra, M. B. Yogiswara, C. Sukawati, P.A.R. Sutresna, N. Dewi, C. Arisanti, P. S. Yustiantara

引用次数: 1

KADAR Fe DAN Zn DALAM KRIM KENTAL MANIS KEMASAN KALENG EXPIRE DAN NON EXPIRE MENGGUNAKAN HIDROGEN PEROKSIDA (H2O2) UNTUK DESTRUKSI BASAH SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA)

Jurnal Kimia Pub Date : 2019-07-31 DOI: 10.24843/jchem.2019.v13.i02.p08

Putri Go, I. Sudiarta, P. Suarya

{"title":"KADAR Fe DAN Zn DALAM KRIM KENTAL MANIS KEMASAN KALENG EXPIRE DAN NON EXPIRE MENGGUNAKAN HIDROGEN PEROKSIDA (H2O2) UNTUK DESTRUKSI BASAH SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA)","authors":"Putri Go, I. Sudiarta, P. Suarya","doi":"10.24843/jchem.2019.v13.i02.p08","DOIUrl":"https://doi.org/10.24843/jchem.2019.v13.i02.p08","url":null,"abstract":"Sweetened condensed milk is generally packaged in a can which is made from iron and zinc. Iron and zinc can have corrosion with the increasing of contact time and changing condition so that they will contaminate the milk. The purpose of this research are to determine the best wet destruction method, find out the effect of adding 30% H2O2 at varied volume in the process of wet destruction, to find out Fe and Zn content in expire and non-expired sweetened condensed milk and to compare the results with the national quality standard. Sample was wet destructed by using variation of 70% HNO3: 30% H2O2 which is 3:0 (method A); 3:0.5 (method B) 3:1 (method C); 3:2 (method D) then the results were measured by using Atomic Absorption Spectrophotometer. Analysis of Fe used standard addition curve method whereas the analysis of Zn used calibration curve method. The results of the analysis showed that the best variation of HNO3:H2O2 in wet destruction method was 3:0.5 for Fe analysis and 3:2 for Zn analysis. The addition of 30% H2O2 at varied volume in wet destruction for Fe analysis gave significantly different results for non-expired sweetened condensed milk but were not significantly different for expired sweetened condensed milk. Whereas, the analysis of Zn gave significantly different results for both non-expired and expired sweetened condensed milk. The metal content in the expired and non-expired sweetened condensed milk which were wet destructed by using the best solvent compotition obtained 0,2759 and 0,7126 mg/kg for Fe and 4,1645 and 2,4367 mg/kg for Zn metal. The Fe and Zn content in the sweetened condensed milk are still below the maximum limit that set by SNI. \u0000Keywords: Fe, H2O2, Atomic Absorption Spectrophotometer, sweetened condensed milk, Zn","PeriodicalId":17780,"journal":{"name":"Jurnal Kimia","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90391366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AKTIVITAS AGEN PENCERAH KULIT DARI KATEKIN SECARA IN SILICO 硅胶中的皮肤荧光剂

Jurnal Kimia Pub Date : 2019-07-31 DOI: 10.24843/jchem.2019.v13.i02.p12

N. K. M. Giantari, I. W. I. Prayoga, N. Laksmiani

{"title":"AKTIVITAS AGEN PENCERAH KULIT DARI KATEKIN SECARA IN SILICO","authors":"N. K. M. Giantari, I. W. I. Prayoga, N. Laksmiani","doi":"10.24843/jchem.2019.v13.i02.p12","DOIUrl":"https://doi.org/10.24843/jchem.2019.v13.i02.p12","url":null,"abstract":"Darkening of the skin results from excessive production of melanin in the skin caused by an increase in tyrosinase related protein 1 enzyme activity. Catechins are flavonoid compounds which contain antioxidants. This study aims to determine the affinity and mechanism of catechins as skin lightening agents by inhibiting tyrosinase related protein 1 target proteins in silico using molecular docking methods. The study was carried out exploratively with the stages of preparing a database of 3D structures of catechins and tyrosinase related protein 1, optimization of 3D structure of catechins, protein preparation, validation of molecular docking methods, and docking of catechins in tyrosinase related protein 1. Docking results are assessed from the bonding energy and hydrogen bonds formed between catechins and proteins. The smaller the bond energy value, the stronger the bond between the catechins and proteins. The results showed that catechins had activity as skin lightening agents because they were able to inhibit the tyrosinase related protein 1 with a bond energy value of -6,35 Kcal/mol. The energy value of the catechin bond with the tyrosinase related protein 1 is smaller than the tyrosinase related protein 1 with its native ligand. This shows that catechins have greater potential and affinity in inhibiting the tyrosinase related protein 1 enzyme with hydrogen bonds on amino acid residues, namely ARG374. Based on the results obtained, catechins have activity as skin lightening agents with the mechanism of inhibiting the tyrosinase related protein 1 enzyme so that the amount of eumelanin formed is less and the skin becomes brighter. \u0000Key words: catechins, skin lightening, tyrosinase related protein 1, in silico, molecular docking","PeriodicalId":17780,"journal":{"name":"Jurnal Kimia","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76383097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SENYAWA KUERSETIN SEBAGAI AGEN ANTIKANKER KOLOREKTAL SECARA IN SILICO

Jurnal Kimia Pub Date : 2019-07-31 DOI: 10.24843/jchem.2019.v13.i02.p07

P. P. Putri, N. Susanti, N. Laksmiani

{"title":"SENYAWA KUERSETIN SEBAGAI AGEN ANTIKANKER KOLOREKTAL SECARA IN SILICO","authors":"P. P. Putri, N. Susanti, N. Laksmiani","doi":"10.24843/jchem.2019.v13.i02.p07","DOIUrl":"https://doi.org/10.24843/jchem.2019.v13.i02.p07","url":null,"abstract":"Colorectal cancer is a third rank malignant cancer in Indonesia, generally caused by the diet of the Indonesian people who have change with the consumption of food with high fat and low in fiber, also due to the production of carcinogenic substances from the breakdown of fat. In the condition of colorectal cancer there is overexpression of COX-2 and inhibition of Caspase-3 which causes the increase of cancer cells survival and causes inhibition of apoptosis mechanism. Quercetin is one of flavonoid which known have activity as an antitumor and tested in vitro can induce apoptosis on WiDr colorectal cancer cells . The purpose of this study was to determine the affinity and mechanism of quercetin compounds on COX-2 and Caspase-3 target proteins as colorectal anticancer by in silico with molecular docking. The study was conducted exploratively with the stages of preparing a database of 3D quercetin structures, as well as COX-2 and Caspase-3 proteins, optimization of 3D quercetin structure, protein preparation, molecular docking method validation, and quercetin docking on these proteins. Docking results were assessed from the binding energy and hydrogen bonds that formed between quercetin with proteins. The smaller binding energy value, the stronger the bond between quercetin and proteins is. The results showed that quercetin had an activity as a colorectal anticancer because it was able to inhibit COX-2 and induce Caspase-3 with binding energy values of -9.54 and -4.59. These results showed that quercetin has the potential to induce apoptosis in colorectal cancer. \u0000Keywords: colorectal cancer, quercetin, caspase-3, in silico","PeriodicalId":17780,"journal":{"name":"Jurnal Kimia","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89956595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

AKTIVITAS DARI KUERSETIN SEBAGAI AGEN PENCERAH KULIT SECARA IN SILICO KUERSETIN的活动是硅co的去角质剂

Jurnal Kimia Pub Date : 2019-07-31 DOI: 10.24843/jchem.2019.v13.i02.p14

K. D. Adnyani, L. E. Lestari, H. Prabowo, P. A. I. A. Siaka, N. Laksmiani

{"title":"AKTIVITAS DARI KUERSETIN SEBAGAI AGEN PENCERAH KULIT SECARA IN SILICO","authors":"K. D. Adnyani, L. E. Lestari, H. Prabowo, P. A. I. A. Siaka, N. Laksmiani","doi":"10.24843/jchem.2019.v13.i02.p14","DOIUrl":"https://doi.org/10.24843/jchem.2019.v13.i02.p14","url":null,"abstract":"Increasing melanogenesis process causes excessive melanin synthesis resulting in darkening of the skin color. The melanogenesis process requires mealnogenesis enzymes, one of which is tyrosinase-related protein 1. One of the flavonoid compounds that has the potential as a skin lightening agent is quercetin. The antioxidant activity of quercetin plays a very important role in antimelanogenesis. This study aims to determine the affinity and molecular mechanism of quercetin on the target protein tyrosinase-related protein 1 using in silico molecular docking method. Molecular docking is carried out through stages including optimization of the structure of quercetin compounds, preparation of the target protein tyrosinase-related protein 1, validation of the molecular docking method, and docking of quercetin on the tyrosinase-related protein 1. Docking of quercetin with tyrosinase-related protein 1 produces binding energy values of -7.81 kcal/mol, while docking of native ligand with tyrosinase-related protein 1 produces binding energy values of -5.39 kcal/mol. Quercetin has a strong affinity for tyrosinase-related protein 1 which is indicated by the binding energy from the docking results. Quercetin has activity as a skin whitening agent with in silico test with molecular mechanisms through inhibition of the activity of tyrosinase-related protein 1 enzyme. \u0000Keywords: skin whitening agent, in silico, quercetin, tyrosinase-related protein 1","PeriodicalId":17780,"journal":{"name":"Jurnal Kimia","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76059608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

PEMBUATAN DAN KARAKTERISASI ARANG AKTIF DARI BATANG LIMBAH TANAMAN GUMITIR DENGAN AKTIVATOR ZnCl2 GUMITIR工厂废物棒的活性炭制造和描述与ZnCl2挖掘机

Jurnal Kimia Pub Date : 2019-01-16 DOI: 10.24843/JCHEM.2019.V13.I01.P15

E. Sahara, D. E. Permatasaari, I. W. Suarsa

{"title":"PEMBUATAN DAN KARAKTERISASI ARANG AKTIF DARI BATANG LIMBAH TANAMAN GUMITIR DENGAN AKTIVATOR ZnCl2","authors":"E. Sahara, D. E. Permatasaari, I. W. Suarsa","doi":"10.24843/JCHEM.2019.V13.I01.P15","DOIUrl":"https://doi.org/10.24843/JCHEM.2019.V13.I01.P15","url":null,"abstract":"The agricultural waste of gumitir plants stem can be used as an ingredient in producing an activated carbon. Some researchers have reported that the additions of phosphoric acid and NaOH as chemical activators have resulted in an activated carbon that met the SNI (Indonesian National Standard) 06-3730-1995 about technical activated carbon. The purpose of this study was to produce and characterize the activated carbon from the stem of gumitir plants carbonized at 300oC for 90 minutes with the use of ZnCl2 as the activator. The activation was carried out by adding ZnCl2 to an amount of carbon in various mole ratios. The characteristics of the activated carbon obtained were compared to the SNI. It was evident that the addition of 0.1 mole of ZnCl2 to 1 gram of the carbon produced an activated carbon that met the SNI standard, namely, water content of 5.00%, as content of 8.33%, volatile content of 950oC of heating of 7.36%, carbon content of 79,30%, iodine absorption capacity of 788.1271 mg/g, and methylene blue absorption capacity of 260.7917 mg/g. The surface area and surfae acidity of this carbon was of 677,6270 mg2/g and 0.3396 mmol/g, respectively. The functional group analysis of this activated carbon showed the presence of O-H, COOH, C-O aldehyde, alkaline C-C and C-H groups.","PeriodicalId":17780,"journal":{"name":"Jurnal Kimia","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81493946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

AKTIVITAS ANTIBAKTERI EKSTRAK KULIT PISANG KEPOK KUNING (Musa paradisiaca L.) TERHADAP BAKTERI Staphylococcus aureus DAN Escherichia coli SERTA PENENTUAN TOTAL FLAVONOID DAN FENOL DALAM FRAKSI AKTIF 香蕉皮提取物的抗菌活性(摩西的例子)针对菌根葡萄球菌和大肠杆菌以及总测定类黄酮和苯酚的活性成分

Jurnal Kimia Pub Date : 2019-01-16 DOI: 10.24843/JCHEM.2019.V13.I01.P02

N. D. Wahyuni, W. S. Rita, I. Asih

{"title":"AKTIVITAS ANTIBAKTERI EKSTRAK KULIT PISANG KEPOK KUNING (Musa paradisiaca L.) TERHADAP BAKTERI Staphylococcus aureus DAN Escherichia coli SERTA PENENTUAN TOTAL FLAVONOID DAN FENOL DALAM FRAKSI AKTIF","authors":"N. D. Wahyuni, W. S. Rita, I. Asih","doi":"10.24843/JCHEM.2019.V13.I01.P02","DOIUrl":"https://doi.org/10.24843/JCHEM.2019.V13.I01.P02","url":null,"abstract":"Peel of yellow kepok banana (Musa paradisiaca L). has not been used optimally, while the peel can be used as an infection medicine The aim of this study was to reveal the activity of kepok yellow banana peel extract against Staphylococcus aureus and Escherichia coli and to determine the total content of flavonoids and phenols in active extract.. Extraction peel of yellow kepok banana was done by maceration and partition method, anti bacterial activity was assayed by wells diffusion method, determination total flavonoid and phenolic contents was done by UV-Vis Spectrophotometer. Maceration of 1 kg peel of yellow banana produced 80.9173 g of crude ethanol extract. The partition of 20 g crude ethanol extract produced 1,3758 g of n-hexane extract, 3,5818 g of ethyl acetate extract, and 1,0762 g of n-butanol extract. Anti bacterial test result showed that the 10% n-butanol extract was active towards S.aureus and E.coli with strong activity compared with ethanol, ethyl acetate, and n-hexane extract. MIC value was 0.5% for S.aureus and 0,2% for E.coli bacteria. The contain total flavonoid and phenol in n-butanol extract respectively were 0.06% and 0.15%.","PeriodicalId":17780,"journal":{"name":"Jurnal Kimia","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90359572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

SINTESIS DAN KARAKTERISASI ZEOLIT-TiO2 SERTA PEMANFAATANNYA SEBAGAI FOTOKATALIS UNTUK DEGRADASI RHODAMIN B 它的合成和对二氧的特性特性以及利用其作为罗达敏B退化的催化剂

Jurnal Kimia Pub Date : 2019-01-16 DOI: 10.24843/jchem.2019.v13.i01.p12

W. A. Fauzi, I. Simpen, I. Sudiarta

引用次数: 2

KARAKTERISASI BATU KAPUR ALAM BUKIT JIMBARAN BALI 巴厘岛山天然石灰岩的特性

Jurnal Kimia Pub Date : 2019-01-16 DOI: 10.24843/JCHEM.2019.V13.I01.P11

Y. Ulfa, A. A. B. Putra, I. Simpen

引用次数: 0

KARAKTERISTIK DAN SKRINING FITOKIMIA EKSTRAK ETANOL 70% BATANG KEPUH (Sterculia foetida L.)

Jurnal Kimia Pub Date : 2019-01-16 DOI: 10.24843/JCHEM.2019.V13.I01.P04

N. Cahyani, J. Susiarni, K. Dewi, N. L. Melyandari, K. W. Putra, D. A. Swastini

引用次数: 3