I. W. Suirta, I. Asih
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摘要

用96%乙醇浸渍槟榔叶,制备槟榔叶提取物。植物化学筛选得到的次生代谢产物如:萜类、类固醇、酚类和皂苷。结果表明,正己烷部分(IC50为26、73 mg/L)的抗氧化活性高于乙醚部分(IC50为114、54 mg/L)。MDA分析表明,槟榔叶具有很好的降低MDA水平的能力。添加别嘌呤醇(阳性对照)后MDA浓度为0,41±0,0021?槟榔叶的含量为0.44±0.0021 L/mL。结构鉴定得到了活性抗氧化化合物,如:丁香酚、丁香酚、香石竹酚和异丁香酚。关键词:槟榔叶;丙二醛;槟榔
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SUPLEMEN EKSTRAK DAUN SIRIH, Piper betle, Lin DALAM MENURUNKAN KADAR MALONDIALDEHID PADA TIKUS WISTAR
Betel leaf extract supplements, Piper betle Lin , was made by extracting maceration of betel leaves with ethanol 96%. Phytochemical screening of betle leaf extract obtained secondary metabolites such as : terpenoids, steroids, phenolics, and saponins . The results of the antioxidant activity test test showed that n-hexane fraction was more reactive as an antioxidant (IC50 26,73 mg/L)  than the diethyl ether fraction (IC50 114,54 mg/L). The MDA analysis showed that the betel leaves have a very good ability to reduce MDA levels. The concentration of MDA with addition of allopurinol (as positive control) was 0,41±0,0021?L/mL, while with addition of betel leaves the level was 0,44±0,0021?L/mL. The structure identification obtained active antioxidant compounds such as: cavicol, eugenol, caryophilene and isoeugenol. Keywords : betel leaf, malondialdehyde, Piper betle, wistar rat
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