Luca De Nicola, Ricardo Correa-Rotter, Juan F Navarro-González, Albert Power, Michal Nowicki, Istvan Wittmann, Jean-Michel Halimi, Juan Jose Garcia Sanchez, Claudia Cabrera, Salvatore Barone, Timothy Coker, Lise Retat
{"title":"Projecting the Population Level Burden of CKD Progression According to Urine Albumin-to-Creatinine Ratio Categories.","authors":"Luca De Nicola, Ricardo Correa-Rotter, Juan F Navarro-González, Albert Power, Michal Nowicki, Istvan Wittmann, Jean-Michel Halimi, Juan Jose Garcia Sanchez, Claudia Cabrera, Salvatore Barone, Timothy Coker, Lise Retat","doi":"10.1016/j.ekir.2024.09.021","DOIUrl":"10.1016/j.ekir.2024.09.021","url":null,"abstract":"<p><strong>Introduction: </strong>Urinary albumin-to-creatinine ratio (uACR) is an independent predictor of chronic kidney disease (CKD) progression. However there is limited evidence on the burden of CKD according to uACR categories at the population level. This study estimates future clinical and financial burden of CKD according to uACR categories using the Inside CKD microsimulation.</p><p><strong>Methods: </strong>The Inside CKD model is an individual patient level microsimulation that emulates national populations based on demographic, epidemiological, and economic data. The analysis estimates clinical and economic outcomes over time according to the Kidney Disease: Improving Global Outcomes (KDIGO) uACR categories (A1-A3) at a population level for 31 countries and regions.</p><p><strong>Results: </strong>CKD populations (diagnosed and undiagnosed individuals, stages G3-G5) were projected to be predominantly within uACR categories A1 and A2 in 2022. Projected cumulative incidence of CKD stage transitions (disease progression) and cardio-renal complications (heart failure, myocardial infarction, stroke, and all-cause mortality) occurred mostly in uACR categories A1 and A2 between 2022 and 2027. Patients in uACR categories A1 and A2, who represent the largest proportion of patients with CKD, were projected to incur most of the health care costs associated with CKD management and cardio-renal complications for the diagnosed population (prevalence 2027).</p><p><strong>Conclusion: </strong>This study highlights the disproportionate population-level clinical and economic burden associated with individuals within KDIGO uACR categories A1 and A2, who represent most of the CKD population. This awareness will help health care decision makers to appropriately allocate resources and interventions to the CKD population, including those with mild to moderately increased albuminuria, to reduce clinical and economic burden associated with CKD.</p>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 12","pages":"3464-3476"},"PeriodicalIF":5.7,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Phoom Narongkiatikhun, Ye Ji Choi, Hailey Hampson, Jimmy Gotzamanis, Guanshi Zhang, Daniel H van Raalte, Ian H de Boer, Robert G Nelson, Kalie L Tommerdahl, Phillip J McCown, Jenny Kanter, Kumar Sharma, Petter Bjornstad, Pierre Jean Saulnier
{"title":"Unraveling Diabetic Kidney Disease: The Roles of Mitochondrial Dysfunction and Immunometabolism.","authors":"Phoom Narongkiatikhun, Ye Ji Choi, Hailey Hampson, Jimmy Gotzamanis, Guanshi Zhang, Daniel H van Raalte, Ian H de Boer, Robert G Nelson, Kalie L Tommerdahl, Phillip J McCown, Jenny Kanter, Kumar Sharma, Petter Bjornstad, Pierre Jean Saulnier","doi":"10.1016/j.ekir.2024.09.019","DOIUrl":"10.1016/j.ekir.2024.09.019","url":null,"abstract":"<p><p>Mitochondria are essential for cellular energy production and are implicated in numerous diseases, including diabetic kidney disease (DKD). Current evidence indicates that mitochondrial dysfunction results in alterations in several metabolic pathways within kidney cells, thereby contributing to the progression of DKD. Furthermore, mitochondrial dysfunction can engender an inflammatory milieu, leading to the activation and recruitment of immune cells to the kidney tissue, potentially perturbing intrarenal metabolism. In addition, this inflammatory microenvironment has the potential to modify immune cell metabolism, which may further accentuate the immune-mediated kidney injury. This understanding has led to the emerging field of immunometabolism, which views DKD as not just a metabolic disorder caused by hyperglycemia but also one with significant immune contributions. Targeting mitochondrial function and immunometabolism may offer protective effects for the kidneys, complementing current therapies and potentially mitigating the risk of DKD progression. This comprehensive review examines the impact of mitochondrial dysfunction and the potential role of immunometabolism in DKD. We also discuss tools for investigating these mechanisms and propose avenues for integrating this research with existing therapies. These insights underscore the modulation of mitochondrial function and immunometabolism as a critical strategy for decelerating DKD progression.</p>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 12","pages":"3386-3402"},"PeriodicalIF":5.7,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Massicotte Azarniouch , Daniel J. Crona , Priscilla Karnabi , Bhadran Bose , Patrick H. Nachman , Marc Carrier , Mark Canney , David W. Johnson , Taewoo Lee , Raja Ramachandran , Vivekanand Jha , Nigel S. Key , Vimal K. Derebail
{"title":"Anticoagulation for the Prevention of Thrombotic Events in Nephrotic Syndrome","authors":"David Massicotte Azarniouch , Daniel J. Crona , Priscilla Karnabi , Bhadran Bose , Patrick H. Nachman , Marc Carrier , Mark Canney , David W. Johnson , Taewoo Lee , Raja Ramachandran , Vivekanand Jha , Nigel S. Key , Vimal K. Derebail","doi":"10.1016/j.ekir.2024.07.013","DOIUrl":"10.1016/j.ekir.2024.07.013","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 10","pages":"Pages 3053-3056"},"PeriodicalIF":5.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141851625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Droxidopa for Management of Chronic Hypotension in Hemodialysis","authors":"Anuradha Jayanti , Mohamed Elewa","doi":"10.1016/j.ekir.2024.07.016","DOIUrl":"10.1016/j.ekir.2024.07.016","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 10","pages":"Pages 3074-3076"},"PeriodicalIF":5.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141853073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nassim Kamar , Dominique Bertrand , Sophie Caillard , Danièle Pievani , Marie Joelle Apithy , Nicolas Congy-Jolivet , Bertrand Chauveau , Fabienne Farce , Arnaud François , Audrey Delas , Jérôme Olagne , Cédric Usureau , Jean-Luc Taupin , Gwenda Line Guidicelli , Lionel Couzi
{"title":"Imlifidase in Highly Sensitized Kidney Transplant Recipients With a Positive Crossmatch Against a Deceased Donor","authors":"Nassim Kamar , Dominique Bertrand , Sophie Caillard , Danièle Pievani , Marie Joelle Apithy , Nicolas Congy-Jolivet , Bertrand Chauveau , Fabienne Farce , Arnaud François , Audrey Delas , Jérôme Olagne , Cédric Usureau , Jean-Luc Taupin , Gwenda Line Guidicelli , Lionel Couzi","doi":"10.1016/j.ekir.2024.07.024","DOIUrl":"10.1016/j.ekir.2024.07.024","url":null,"abstract":"<div><h3>Introduction</h3><div>Imlifidase is authorized for desensitization of highly sensitized adult kidney transplant candidates with a positive crossmatch (XM) against a deceased donor. Here, we report on the results for the first 9 patients transplanted in this context who had at least 3 months of follow-up.</div></div><div><h3>Methods</h3><div>The eligibility criteria were as follows: calculated panel reactive antibodies (cPRA) ³ 98%, ³ 3 years on the waiting list, immunodominant donor-specific antibodies (DSAs) with mean fluorescence intensity (MFI) > 6000 (and < 5000 at 1:10 dilution) and a negative post-imlifidase complement-dependent cytotoxic XM (CDCXM).</div></div><div><h3>Results</h3><div>All 9 patients had been on dialysis for an average of 123 ± 41 months, with cPRA at 99% (<em>n</em> = 2) or 100% (<em>n</em> = 7). At transplantation, the mean number of DSAs was 4.3 ± 1.4. The median immunodominant DSA MFI was 9153 (6430–16,980). Flow cytometry XM (FCXM) and CDCXM before imlifidase were positive in 9 and 2 patients, respectively. After 1 injection of imlifidase, all were negative. Patients received polyclonal antibodies, i.v. Igs (IVIg), rituximab, tacrolimus, and mycophenolate. Five patients had a DSA rebound within the first 14 days: 2 had concomitant clinical antibody-mediated rejection (ABMR), 2 had subclinical ABMR, and 1 had isolated positive C4d staining. No ABMR was observed in patients without rebound. Chronic Kidney Disease-Epidemiology Collaboration formula estimated glomerular filtration rate (eGFR) was 56 ± 22 ml/min per 1.73 m<sup>2</sup> at the last follow-up (7 ± 2.8 months). No graft loss or death were observed. Four patients developed at least 1 infection.</div></div><div><h3>Conclusion</h3><div>These real-life data demonstrate that the use of imlifidase to desensitize highly sensitized patients can have an acceptable short-term efficacy and safety profile in selected patients.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 10","pages":"Pages 2927-2936"},"PeriodicalIF":5.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141941312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ioannis Parodis , Alvaro Gomez , Julius Lindblom , Brad H. Rovin
{"title":"Response to Comment on “Effect of Belimumab on Preventing De Novo Renal Lupus Flares”","authors":"Ioannis Parodis , Alvaro Gomez , Julius Lindblom , Brad H. Rovin","doi":"10.1016/j.ekir.2024.07.037","DOIUrl":"10.1016/j.ekir.2024.07.037","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 10","pages":"Pages 3077-3078"},"PeriodicalIF":5.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142181700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yang Li , Yueping Shen , Hongyu Yang , Min Li , Lei Jiang , Wei Ma , Fude Zhou , Tao Su
{"title":"Q Fever-Related Glomerulonephritis Unveiled by Metagenomic Next-Generation Sequencing","authors":"Yang Li , Yueping Shen , Hongyu Yang , Min Li , Lei Jiang , Wei Ma , Fude Zhou , Tao Su","doi":"10.1016/j.ekir.2024.07.036","DOIUrl":"10.1016/j.ekir.2024.07.036","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 10","pages":"Pages 3062-3066"},"PeriodicalIF":5.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142181701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriel Figueroa-Parra , María C. Cuéllar-Gutiérrez , Alí Duarte-García
{"title":"Comment on “Belimumab on Preventing De Novo Renal Flares”","authors":"Gabriel Figueroa-Parra , María C. Cuéllar-Gutiérrez , Alí Duarte-García","doi":"10.1016/j.ekir.2024.04.073","DOIUrl":"10.1016/j.ekir.2024.04.073","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 10","pages":"Page 3077"},"PeriodicalIF":5.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142181703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anita Marie Slominska , Elizabeth Anne Kinsella , Saly El-Wazze , Kathleen Gaudio , M. Khaled Shamseddin , Ann Bugeja , Marie-Chantal Fortin , Mireille Farkouh , Amanda Vinson , Julie Ho , Shaifali Sandal
{"title":"Losing Much More Than a Transplant: A Qualitative Study of Kidney Transplant Recipients’ Experiences of Graft Failure","authors":"Anita Marie Slominska , Elizabeth Anne Kinsella , Saly El-Wazze , Kathleen Gaudio , M. Khaled Shamseddin , Ann Bugeja , Marie-Chantal Fortin , Mireille Farkouh , Amanda Vinson , Julie Ho , Shaifali Sandal","doi":"10.1016/j.ekir.2024.07.011","DOIUrl":"10.1016/j.ekir.2024.07.011","url":null,"abstract":"<div><h3>Introduction</h3><div>Kidney transplant recipients with graft failure are a growing cohort of patients who experience high morbidity and mortality. Limited evidence guides their care delivery and patient perspective to improve care processes is lacking. We conducted an in-depth exploration of how individuals experience graft failure, and the specific research question was: “What impact does the loss of an allograft have on their lives?”</div></div><div><h3>Methods</h3><div>We adopted an interpretive descriptive methodological design. Semistructured in-depth narrative interviews were conducted with adult recipients who had a history of ≥1 graft failure. Data were collected until data saturation was achieved and analyzed using an inductive and thematic approach.</div></div><div><h3>Results</h3><div>Our study included 23 participants from 6 provinces of Canada. The majority were on dialysis and not waitlisted for retransplantation (60.9%). Our thematic analysis identified that the lives of participants were impacted by a range of tangible and experiential losses that go beyond the loss of the transplant itself. The themes identified include loss of control, loss of coherence, loss of certainty, loss of hope, loss of quality of life, and loss of the transplant team. Although many perceived that graft failure was inevitable, the majority were unprepared. The confusion about eligibility for retransplantation appears to contribute to these experiences.</div></div><div><h3>Conclusion</h3><div>Individuals with graft failure experience complex mental and emotional challenges which may contribute to poor outcomes. The number of patients with graft failure globally is increasing and our findings can help guide practices aimed at supporting and guiding them toward self-management and adaptive coping.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 10","pages":"Pages 2937-2945"},"PeriodicalIF":5.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rethinking Living Donor Kidney Transplantation Through a Healthcare System Lens","authors":"Itunu Owoyemi , Emilio D. Poggio , Anne M. Huml","doi":"10.1016/j.ekir.2024.08.024","DOIUrl":"10.1016/j.ekir.2024.08.024","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 10","pages":"Pages 2857-2859"},"PeriodicalIF":5.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142181663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}