Kidney International Reports最新文献

{"title":"WCN25-628 RISK FACTORS FOR ACUTE KIDNEY INJURY AND THE PROGRESSION INTO ACUTE KIDNEY DISEASE IN HOSPITALISED HEART FAILURE PATIENTS: A SINGLE-CENTRE, RETROSPECTIVE STUDY","authors":"Jia Qi Low ∗ , Soo Ying Yew , Loch Alexander , Ruhana Che Yusof , Soo Kun Lim","doi":"10.1016/j.ekir.2024.11.109","DOIUrl":"10.1016/j.ekir.2024.11.109","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 2","pages":"Pages S21-S22"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WCN25-625 ASSESSING RENAL FUNCTION IN PATIENTS UNDERGOING TARGETED CANCER THERAPIES: THE ROLE OF CYSTATIN C IN PALBOCICLIB-INDUCED SERUM CREATININE ELEVATION","authors":"Kais Harzallah ∗","doi":"10.1016/j.ekir.2024.11.108","DOIUrl":"10.1016/j.ekir.2024.11.108","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 2","pages":"Page S21"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WCN25-4034 ANCA mediated glomerular lesion on top of diabetic nephropathy, a case report","authors":"Sk Md Jaynul Islam ∗ , Meheruba Alam Anannya","doi":"10.1016/j.ekir.2024.11.163","DOIUrl":"10.1016/j.ekir.2024.11.163","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 2","pages":"Pages S57-S58"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WCN25-3657 TACROLIMUS INDUCED HYPONATREMIA TREATED WITH FLUDROCORTISONE","authors":"Shrikant Deshmukh ∗ , Vajed Mogal","doi":"10.1016/j.ekir.2024.11.083","DOIUrl":"10.1016/j.ekir.2024.11.083","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 2","pages":"Page S7"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IFT140-related ADPKD","authors":"Martina Catania , Giulia Mancassola , Liliana Italia De Rosa , Kristiana Kola , Gino Pepe , Paolo Manunta , Giuseppe Vezzoli , Paola Carrera , Maria Teresa Sciarrone Alibrandi","doi":"10.1016/j.ekir.2024.12.008","DOIUrl":"10.1016/j.ekir.2024.12.008","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 2","pages":"Pages 618-619"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reintegration Into the Workforce After Kidney Transplantation Based on Urbanization Status in Switzerland","authors":"Federica Bocchi ,&nbsp;Selina Müller ,&nbsp;Isabelle Binet ,&nbsp;Dela Golshayan ,&nbsp;Fadi Haidar ,&nbsp;Thomas Müller ,&nbsp;Stefan Schaub ,&nbsp;Aurelia Schnyder ,&nbsp;Daniel Sidler ,&nbsp;Federico Storni","doi":"10.1016/j.ekir.2024.10.029","DOIUrl":"10.1016/j.ekir.2024.10.029","url":null,"abstract":"<div><h3>Introduction</h3><div>Most of Switzerland’s population and employment opportunities are concentrated in urban areas. Although kidney transplantation (KT) is the preferred therapy for eligible candidates, individuals in rural areas face challenges accessing specialized medical services due to longer travel distances. Limited understanding exists regarding patients' perspectives on returning to work after KT and whether this correlates with their urbanization status, potentially influencing outcomes.</div></div><div><h3>Methods</h3><div>Retrospective, nationwide (Swiss Transplant Cohort Study [STCS]) study, from May 2008 to 2020, including 1926 patients aged 18 to 60 years who underwent KT. We investigated the self-reported work reintegration at 1, 3, and 5 years after the KT, the recipient and allograft survival, and the allograft function at 12 months, contingent on urbanization status (urban, suburban, rural).</div></div><div><h3>Results</h3><div>The return rate of sufficiently filled-in questionnaires was 81% (1053 participants). Urban recipients were younger, had longer dialysis time before KT, and had less living donor KT. At baseline, the level of education, as well as the workforce defined as work capacity &gt; 50%, were lower in urban areas (37% urban, 39% suburban, and 47% rural). Regression analysis revealed significantly higher odds ratio for employment 1 year post-KT among patients residing in rural and suburban areas (odds ratio: 1.31 [confidence interval: 1.04–1.65] and 1.52 [confidence interval: 1.16–1.98], respectively) compared to patients from urban regions. Stratified according to urbanization environment, recipient and allograft survival were comparable across groups.</div></div><div><h3>Conclusion</h3><div>Patient and graft outcomes were favorable, with improved work reintegration observed at the 1-year mark post-KT for recipients from rural backgrounds compared to those from suburban and urban areas.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 2","pages":"Pages 565-573"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Hepatitis B Virus Reactivation Monitoring Strategies for Kidney Transplant Patients","authors":"Hsien-Chung Yu ,&nbsp;Chien-Liang Chen ,&nbsp;Kung-Hung Lin ,&nbsp;Chih-Yang Hsu ,&nbsp;Po-Tsang Lee","doi":"10.1016/j.ekir.2024.10.031","DOIUrl":"10.1016/j.ekir.2024.10.031","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 2","pages":"Pages 601-604"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Normal” Glomerular Score Correlates With Outcomes in Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis With Glomerulonephritis","authors":"Marta Casal Moura ,&nbsp;Fernando C. Fervenza ,&nbsp;Ulrich Specks ,&nbsp;Sanjeev Sethi","doi":"10.1016/j.ekir.2024.11.019","DOIUrl":"10.1016/j.ekir.2024.11.019","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 2","pages":"Pages 596-600"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and Prioritization of Canadian Society of Nephrology Clinical Practice Guideline Topics","authors":"Tyrone G. Harrison ,&nbsp;Melissa Schorr ,&nbsp;Brigitte H. Baragar ,&nbsp;Gregory L. Hundemer ,&nbsp;Krista S. Ryz ,&nbsp;Nancy Verdin ,&nbsp;Tania Woodlock ,&nbsp;David A. Clark ,&nbsp;Reem A. Mustafa ,&nbsp;Anna Mathew ,&nbsp;Canadian Society of Nephrology Clinical Practice Guidelines Committee","doi":"10.1016/j.ekir.2024.11.006","DOIUrl":"10.1016/j.ekir.2024.11.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Nephrology clinical practice guideline topics are routinely determined by clinicians and researchers, without extensive engagement of people with lived experience (PWLE) of kidney disease and their caregivers. The Canadian Society of Nephrology (CSN) Clinical Practice Guidelines Committee (CPGC) completed this modified Delphi study to incorporate diverse stakeholder perspectives in identifying and prioritizing future guideline topics.</div></div><div><h3>Methods</h3><div>We recruited nephrology clinicians, researchers, PWLE of kidney disease or their caregivers for this study. We collated literature-derived guideline topics from international and national guideline organizations that had relevance to nephrology, in addition to suggestions from participants. Consenting participants were taken through a 3 round Delphi survey process, where items were ranked on a 9-point Likert scale in terms of their importance. Based on predetermined consensus criteria, items were accepted as a priority or excluded from further consideration. We ranked the prioritized topics and compared the median ranking between clinicians or researchers and PWLE in the round where consensus was reached.</div></div><div><h3>Results</h3><div>Of the 85 consenting participants, 76 to 78 completed each Delphi round. From the initial list of 100 topics for consideration, 12 were priorities. All stakeholder groups felt it was important for PWLE to be included in topic prioritization and guideline development. The 3 most highly prioritized topics were <em>de novo</em> guidelines on novel therapeutics to prevent or slow progression of chronic kidney disease (CKD), recommendations for primary care, and patient-oriented guidelines on diet and exercise in kidney disease. There were no statistical differences in the median ranking between stakeholder groups (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>This study will inform the future nephrology guidelines and commentaries developed by the CSN.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 2","pages":"Pages 396-405"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143161291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addition of a Loop Diuretic to Norepinephrine During Treatment of Hepatorenal Syndrome Type 1","authors":"Juan Carlos Q. Velez ,&nbsp;Terrance J. Wickman ,&nbsp;Kasra Tayebi ,&nbsp;Muner M.B. Mohamed ,&nbsp;Adil Yousuf ,&nbsp;Swetha R. Kanduri ,&nbsp;Ivo Lukitsch ,&nbsp;Derek Vonderhaar ,&nbsp;Karthik Kovvuru ,&nbsp;Cathy Wentowski","doi":"10.1016/j.ekir.2024.11.013","DOIUrl":"10.1016/j.ekir.2024.11.013","url":null,"abstract":"<div><h3>Introduction</h3><div>Diuretics are commonly discontinued in patients with cirrhosis with acute kidney injury (AKI) because they are presumed to trigger hepatorenal syndrome type 1 (HRS-1). We hypothesized that if HRS-1 is adequately treated with a vasoconstrictor (mean arterial pressure [MAP] effectively increased), diuretics are safe and effective.</div></div><div><h3>Methods</h3><div>Records of hospitalized patients with cirrhosis who received i.v. furosemide while receiving i.v. norepinephrine as a vasoconstrictor to treat HRS-1 were examined. We assessed change in urine output (UOP), trajectory of serum creatinine (sCr), and impact of portopulmonary hypertension (PoPHTN) on the therapeutic response.</div></div><div><h3>Results</h3><div>Twenty-six patients with HRS-1 received i.v. furosemide (median: 2 days, 160 mg boluses every 6–24 hours) added to i.v. norepinephrine. Median age was 51 years; 91% were of White race, 36% were women, and median model for end-stage liver disease score was 32. The median initial sCr was 4.0 mg/dl. Before treatment, median UOP was 358 ml/d. Norepinephrine alone led to a median increase in UOP to 850 ml/d. Addition of furosemide to norepinephrine induced a subsequent increase in median UOP to 2072 ml/d (<em>P</em> &lt; 0.0001), which was not observed in a control group (<em>n</em> = 22) who did not receive furosemide. Nineteen patients (73%) treated with norepinephrine plus furosemide (median MAP increase, 16 mm Hg) either maintained or improved their sCr trajectory. The magnitude of norepinephrine-induced increase in MAP correlated with the norepinephrine plus furosemide-induced UOP (<em>r</em> = 0.67, <em>P</em> = 0.0002), and the correlation coefficient was numerically stronger among those with PoPHTN.</div></div><div><h3>Conclusion</h3><div>In patients with HRS-1 who are adequately treated with norepinephrine and achieved an optimal MAP increment, addition of i.v. furosemide enhances diuresis without negatively affecting renal recovery.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 2","pages":"Pages 466-474"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143161354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}