Kidney International Reports最新文献

{"title":"Digital Lifestyle Interventions in CKD: No Better Time Than Now.","authors":"Chien-Yao Sun, Jessica Elia, Aric A Prather, Anoop Sheshadri","doi":"10.1016/j.ekir.2024.10.017","DOIUrl":"10.1016/j.ekir.2024.10.017","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 12","pages":"3358-3361"},"PeriodicalIF":5.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Limits of Generalizability: Pitfalls of Applying Western GFR Estimation Models to Global Populations.","authors":"Maria Clarissa Tio, Tariq Shafi","doi":"10.1016/j.ekir.2024.10.018","DOIUrl":"10.1016/j.ekir.2024.10.018","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 12","pages":"3355-3357"},"PeriodicalIF":5.7,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the Persistent Burden of Diabetic Kidney Disease in Type 1 Diabetes: A Call for Adjunctive Therapies.","authors":"Phoom Narongkiatikhun, Petter Bjornstad","doi":"10.1016/j.ekir.2024.10.010","DOIUrl":"10.1016/j.ekir.2024.10.010","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 12","pages":"3351-3354"},"PeriodicalIF":5.7,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Genetic Variants of <i>APOL1</i> Are Major Determinants of Kidney Failure in People of African Ancestry With HIV\" [<i>Kidney International Reports</i> Volume 7, Issue 4, April 2022, Pages 786-796].","authors":"Rachel K Y Hung, Elizabeth Binns-Roemer, John W Booth, Rachel Hilton, Mark Harber, Beatriz Santana-Suarez, Lucy Campbell, Julie Fox, Andrew Ustianowski, Catherine Cosgrove, James E Burns, Amanda Clarke, David A Price, David Chadwick, Denis Onyango, Lisa Hamzah, Kate Bramham, Caroline A Sabin, Cheryl A Winkler, Frank A Post","doi":"10.1016/j.ekir.2024.10.011","DOIUrl":"https://doi.org/10.1016/j.ekir.2024.10.011","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.ekir.2022.01.1054.].</p>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 12","pages":"3604"},"PeriodicalIF":5.7,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological Characteristics and Kidney Outcomes in Biopsy-Confirmed Acute Interstitial Nephritis.","authors":"Jing Miao, Charat Thongprayoon, Pajaree Krisanapan, Alessia Buglioni, Iasmina M Craici, Wisit Cheungpasitporn","doi":"10.1016/j.ekir.2024.09.026","DOIUrl":"10.1016/j.ekir.2024.09.026","url":null,"abstract":"<p><strong>Introduction: </strong>Acute interstitial nephritis (AIN) is a significant cause of acute kidney injury, with varying etiologies and outcomes. This study aimed to examine the causes, clinical characteristics, management, and kidney outcomes in patients with biopsy-confirmed AIN.</p><p><strong>Methods: </strong>A retrospective review was conducted on 166 patients diagnosed with AIN through kidney biopsy at Mayo Clinic between 2012 and 2023. Demographic, clinical, laboratory, and pathological data were collected. The primary outcome was kidney function recovery within the first 6 months. Statistical analyses included univariable and multivariable logistic regression, Kaplan-Meier survival analysis, and Cox proportional hazards modeling.</p><p><strong>Results: </strong>Medications were the primary cause of AIN (67%), followed by autoimmune diseases (20%) and infections (6%). Within 6 months, 76% of patients achieved kidney recovery. Multivariable analysis indicated that moderate to severe interstitial fibrosis and tubular atrophy (IFTA) and dialysis requirement were associated with nonrecovery, whereas a prebiopsy diagnosis of AIN was positively associated with kidney recovery. Drug-related AIN had higher recovery rates compared to all other causes (81% vs. 66%, <i>P</i> = 0.04), and moderate to severe IFTA and dialysis need remained significant predictors of decreased recovery. Steroid therapy, used in 81% of patients, did not significantly influence kidney recovery in the overall cohort or in drug-induced AIN.</p><p><strong>Conclusion: </strong>This study provides insights into the characteristics and outcomes of biopsy-confirmed AIN. IFTA and dialysis requirement were significant factors associated with worse kidney outcomes. These findings may help inform clinical management and prognostication in patients with AIN.</p>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 12","pages":"3542-3552"},"PeriodicalIF":5.7,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Kidney Outcome of Lupus Nephritis by Renal Response Status.","authors":"Desmond Yat Hin Yap, Xiaomeng Xu, Patricia C Juliao, Colin S O Tang, Laura Ng, Dominique Milea, Tak Mao Chan","doi":"10.1016/j.ekir.2024.09.028","DOIUrl":"10.1016/j.ekir.2024.09.028","url":null,"abstract":"<p><strong>Introduction: </strong>Limited evidence exists that clinical trial treatment response criteria predict long-term outcomes in Asian patients with lupus nephritis (LN).</p><p><strong>Methods: </strong>This retrospective analysis of prospectively collected data from the Hong Kong Queen Mary Hospital Cohort categorized adults with biopsy-proven LN (Class III, IV, V, or mixed [III ± V, IV ± V]) after standard treatment for 2 years postbiopsy and immunosuppression induction according to modified primary efficacy renal response (mPERR: estimated glomerular filtration rate [eGFR] ≥ 60 ml/min per 1.73 m² or ≤ 20% below biopsy value AND urine protein-to-creatinine ratio [uPCR] ≤ 0.7) and modified complete renal response (mCRR; eGFR ≥ 90 ml/min per 1.73 m² or ≤ 10% below biopsy value AND uPCR ≤ 0.5). Associations between 2-year mPERR/mCRR status and long-term kidney survival and mild chronic kidney disease (CKD) or worse (stage ≥ 3) were assessed.</p><p><strong>Results: </strong>Of the 176 Chinese patients, 64.2% achieved mPERR and 43.8% achieved mCRR at 2 years postbiopsy. After mean follow-up of 15.3 years, significantly higher proportions of mPERR and mCRR responders versus nonresponders achieved long-term kidney survival (mPERR: 85.8% vs. 71.4%; <i>P</i> = 0.029; mCRR: 92.2% vs. 71.7%; <i>P</i> < 0.001). mPERR and mCRR achievement was associated with adjusted risk reductions for kidney nonsurvival of 60% (<i>P</i> = 0.034) and 86% (<i>P</i> < 0.001), respectively. Adjusted risk for mild CKD or worse (stage ≥ 3) was 82% (<i>P</i> = 0.013) and 87% (<i>P</i> = 0.012) lower for mPERR and mCRR responders, respectively, versus nonresponders.</p><p><strong>Conclusion: </strong>In Chinese patients with LN, mPERR and mCRR at 2 years postbiopsy predict superior long-term kidney outcomes and lower CKD progression risk.</p>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 12","pages":"3532-3541"},"PeriodicalIF":5.7,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Studies of Sustained Remission of Membranous Glomerulonephritis With Dupilumab Treatment.","authors":"Mark H Kaplan, Jessica M Greco, Brad H Rovin, Anthony M Cannon, Abigail Pajulas, Jeffrey B Travers, Ayman Hallab, Matthew J Turner","doi":"10.1016/j.ekir.2024.09.024","DOIUrl":"10.1016/j.ekir.2024.09.024","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 12","pages":"3600-3603"},"PeriodicalIF":5.7,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Race-Neutral Glomerular Filtration Rate Estimating Equations in an Indian Population.","authors":"Ashok Kumar Yadav, Jaskiran Kaur, Prabhjot Kaur, Kajal Kamboj, Yoshinari Yasuda, Masaru Horio, Arnab Pal, Nusrat Shafiq, Nancy Sahni, Harbir Singh Kohli, Seiichi Matsuo, Vivek Kumar, Vivekanand Jha","doi":"10.1016/j.ekir.2024.09.020","DOIUrl":"10.1016/j.ekir.2024.09.020","url":null,"abstract":"<p><strong>Introduction: </strong>Glomerular filtration rate (GFR) estimation equations have not been extensively validated in the Indian population. Preliminary data showed that the widely used creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI_Cr) 2009 significantly overestimated GFR in Indians. Newer estimated GFR (eGFR) equations based on creatinine and cystatin C, omitting the race, have been recently proposed. We investigated the performance of race-free eGFR equations in the Indian population.</p><p><strong>Methods: </strong>Patients with chronic kidney disease (CKD) and potential kidney donors attending the outpatient clinic at the Postgraduate Institute of Medical Education and Research Chandigarh, India, were screened for enrolment. GFR was measured by urinary clearance of inulin and plasma clearance of iohexol. Performance of eGFR equations (CKD-EPI_Cr(2021), CKD-EPI_{Cr-Cys(2021),} CKD-EPI_Cr(2009), CKD-EPI_Cr-Cys(2012), CKD-EPI_Cys, 2020_Csy-B2M-BTP and 2020_{Cr-Csy-B2M-BTP}, EKFC_cr, EKFC_cys, and EKFC_cr-cys) were assessed against measured GFR (mGFR) using bias, precision, and accuracy (root mean square error [RMSE], mean absolute error [MAE] and P₃₀ [% with eGFR within 30% of mGFR]).</p><p><strong>Results: </strong>A total of 412 subjects (55% with CKD), average age 47 ± 11 years with an equal distribution of males and females were enrolled. The mean mGFR in the study population was 54.2 ± 30.2 ml/min per 1.73 m². The average mGFR in the potential kidney donor's subgroup was 79.5 ± 23.2 ml/min per 1.73 m². Bias was highest for creatinine-based eGFR equations (CKD-EPI_cr(2021): -19.2 [-21.3 to -17.0] ml/min per 1.73 m²and CKD-EPI_cr(2009): -17.0 [-19.1 to -15.0] ml/min per 1.73 m²). Cystatin C- (either alone or with other markers) based equations were slightly better but still did not reach P₃₀ ≥ 80%.</p><p><strong>Conclusions: </strong>Race-neutral CKD-EPI_Cr(2021) equation did not significantly improve performance as compared to CKD-EPI_Cr(2009) equation. These observations emphasize the need for developing new eGFR equations for Indians and to standardize the mGFR for easy access to care providers for individualized patient care.</p>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 12","pages":"3414-3426"},"PeriodicalIF":5.7,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring How the Kidney BEAM Physical Activity Digital Health Intervention Improved Mental Health-Related Quality of Life for People Living With Kidney Disease.","authors":"Ellen M Castle, Roseanne E Billany, Hannah M L Young, Christy Walklin, Juliet Briggs, Elham Asgari, Sunil Bhandari, James O Burton, Kate Bramham, Vashist Deelchand, Alexander Hamilton, Mark Jesky, Philip A Kalra, Kieran McCafferty, Andrew C Nixon, Maarten W Taal, James Tollit, David C Wheeler, Jamie Macdonald, Sharlene A Greenwood","doi":"10.1016/j.ekir.2024.09.029","DOIUrl":"10.1016/j.ekir.2024.09.029","url":null,"abstract":"<p><strong>Introduction: </strong>The Kidney BEAM randomized controlled trial reported clinically meaningful and statistically significant improvements in mental health-related quality of life (HRQoL), physical function (sit-to-stand-60, but not the physical component of HRQoL) and patient activation after a 12-week physical activity digital health intervention (DHI). This study explores factors that contributed to the effectiveness of Kidney BEAM through mixed methods analyses.</p><p><strong>Methods: </strong>Quantitative data analysis was obtained from the recently published primary manuscript. Participants from the Kidney BEAM trial intervention group (<i>n</i> = 30) completed individualized semistructured interviews after the 12-week DHI. Interviews were analyzed using the framework method with inductive and deductive coding. Quantitative and qualitative data collection and analyses occurred concurrently, and independently, before combining using a mixed methods analysis with joint displays to triangulate datasets and further explore the primary findings.</p><p><strong>Results: </strong>The integrated mixed methods analyses facilitated explanation of the primary findings. The Kidney BEAM intervention was shown to have mental and physical wellbeing benefits and enhanced self-management in this cohort of people living with chronic kidney disease (CKD). Elements that contributed to the effectiveness of the intervention were reported, including the different functional levels and gradual progression of the program, shared lived experiences with other participants, self-monitoring, the sense of achievement, taking back control of their health, moving beyond medications, and feeling safe and confident to exercise.</p><p><strong>Conclusion: </strong>Elements of the Kidney BEAM intervention that contributed to the main quantitative trial findings were identified. This will allow researchers and practitioners to maximize the effectiveness of DHIs to enhance healthy behaviors in people living with CKD.</p>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 12","pages":"3517-3531"},"PeriodicalIF":5.7,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporation of Cystatin C Testing in Clinical Practice: Real World Experience in Sweden.","authors":"Shoshana H Ballew, Yingying Sang, Josef Coresh, Edouard L Fu, Dorothea Nitsch, Juan Jesus Carrero, Morgan E Grams","doi":"10.1016/j.ekir.2024.10.003","DOIUrl":"10.1016/j.ekir.2024.10.003","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"9 12","pages":"3596-3599"},"PeriodicalIF":5.7,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}