Kidney International Reports最新文献

{"title":"The Role of Peritoneal Interleukin-6 in Predicting Patient Survival on Peritoneal Dialysis","authors":"Emma H. Elphick ,&nbsp;Vasileios Zavvos ,&nbsp;John Belcher ,&nbsp;Nicholas Topley ,&nbsp;James A. Chess ,&nbsp;Clifford J. Holmes ,&nbsp;Simon J. Davies ,&nbsp;Donald Fraser ,&nbsp;Mark Lambie","doi":"10.1016/j.ekir.2025.06.049","DOIUrl":"10.1016/j.ekir.2025.06.049","url":null,"abstract":"<div><h3>Introduction</h3><div>Systemic inflammation predicts cardiovascular events and mortality in patients on peritoneal dialysis (PD). Peritoneal inflammation potentially causes adverse outcomes by increasing peritoneal solute transfer rates (PSTRs); however, the extent to which it contributes to systemic inflammation is uncertain. We sought to quantify the longitudinal interrelationship between peritoneal and systemic inflammation, to understand whether peritoneal or systemic inflammation should be targeted to reduce mortality.</div></div><div><h3>Methods</h3><div>We used patients recruited to the GLOBAL Fluid Study (GFS) within 90 days of starting PD, with ≥ 3 longitudinal paired dialysate and plasma samples. These were assayed for dialysate and plasma interleukin (IL)-6 levels by electrochemiluminescence (Meso-Scale Discovery, Gaithersburg, MD). Linear mixed models and univariate or bivariate joint longitudinal survival modelling were used.</div></div><div><h3>Results</h3><div>Two hundred seventeen patients with 1273 measurements were included. Dialysate IL-6 levels increased with time (1.14 pg/ml/yr on PD, 95% confidence interval [CI]: 1.10–1.19), with an associated increase in PSTR (<em>P</em> = 0.001). Plasma IL-6 levels increased over time (1.07 pg/ml/yr on PD, 95% CI: 1.04–1.10), with an associated increase in dialysate IL-6 (<em>P</em> &lt; 0.001) and reduction in residual kidney function (<em>P</em> = 0.01). Dialysate IL-6 levels estimated at any given time point weakly predicted mortality area under the curve (AUC: 0.57) and did not improve the prediction of mortality by plasma IL-6 (combined dialysate/plasma IL-6 AUC: 0.79, plasma IL-6 only AUC 0.81).</div></div><div><h3>Conclusion</h3><div>Although rising dialysate IL-6 levels may contribute to rising PSTR and increasing systemic inflammation independently of declining kidney function over time, it is plasma IL-6 that confers mortality risk. This suggests future antiinflammatory interventions to improve patient survival should target systemic rather than peritoneal inflammation.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 9","pages":"Pages 3164-3173"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Laparoscopic Donor Nephrectomy Like Riding a Bike?","authors":"Soo Youn Yi ,&nbsp;Lloyd E. Ratner","doi":"10.1016/j.ekir.2025.07.040","DOIUrl":"10.1016/j.ekir.2025.07.040","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 9","pages":"Pages 2917-2918"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Point-of-Care Testing and Integrated Digital Health Technology for CKD Screening in High-Risk Populations of India” [Kidney International Reports Volume 10, Issue 7, July 2025, Pages 2128-2139]","authors":"Rama Krishna Chinta ,&nbsp;Venkateswar Shri ,&nbsp;Bogdan Milojkovic ,&nbsp;Dennis Begos ,&nbsp;Shyamala Kemisetti ,&nbsp;Naresh Kumar Chintagunti ,&nbsp;Boris Bikbov ,&nbsp;FOCUS-CKD (Frontline Optimization and Comprehensive Upgradation of Services in Chronic Kidney Disease) Project","doi":"10.1016/j.ekir.2025.07.001","DOIUrl":"10.1016/j.ekir.2025.07.001","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 9","pages":"Page 3296"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptance of High Kidney Donor Profile Index Kidneys Among Consented Candidates","authors":"Miko Yu ,&nbsp;Lindsey M. Maclay ,&nbsp;Riya Lahiri ,&nbsp;Syed Ali Husain ,&nbsp;Jesse D. Schold ,&nbsp;Sumit Mohan","doi":"10.1016/j.ekir.2025.06.025","DOIUrl":"10.1016/j.ekir.2025.06.025","url":null,"abstract":"<div><h3>Introduction</h3><div>The Kidney Donor Profile Index (KDPI) is a percentile score based on the relative risk of allograft failure for deceased donor kidneys, where higher scores indicate shorter estimated allograft longevity. The Organ Procurement and Transplantation Network policy requires patients to proactively opt-in via written consent to receive offers for “high-KDPI” (&gt; 85%) kidneys before being considered for organs in this category.</div></div><div><h3>Methods</h3><div>This retrospective cohort study examined United States (US) candidates and recipients from 2012 to 2022 to determine if consent for less-than-ideal organs impacted organ allocation, efficiency, and utilization.</div></div><div><h3>Results</h3><div>Among 138,242 deceased donor transplants, 7031 (5%) were from KDPI of 80% to 85% kidneys, 4847 (4%) from KDPI of 86% to 90% kidneys, and 6089 (4%) from KDPI &gt; 90%. Among transplants with KDPI of 86% to 90% kidneys, representing the best quality among high-KDPI organs, 10% of recipients in 2014 were top-ranked candidates compared with 5% in 2015 and 4% in 2022. The number of declined offers for KDPI of 86% to 90% kidneys increased following implementation of the Kidney Allocation System (11 [interquartile range, IQR: 2–52] in 2014 versus 21.5 [IQR: 6–109] in 2015 vs. 52 [IQR: 12–323] in 2022).</div></div><div><h3>Conclusion</h3><div>These findings demonstrate changes in the centers’ willingness to accept high KDPI kidneys on behalf of their patients after the introduction of the KDPI label and other changes in allocation policy and regulatory oversight in the system.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 9","pages":"Pages 3094-3101"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser Microdissection and Mass Spectrometry Reveals Diverse Membranous Nephropathy Antigens","authors":"António Inácio ,&nbsp;Patrícia Domingues ,&nbsp;Ana Piedade ,&nbsp;Beatriz Mendes ,&nbsp;Francisca Fonseca ,&nbsp;Julie Vrana ,&nbsp;Jason Theis ,&nbsp;Samih Nasr ,&nbsp;Benjamin Madden ,&nbsp;Karina Soto ,&nbsp;Fernando C. Fervenza ,&nbsp;Sanjeev Sethi","doi":"10.1016/j.ekir.2025.06.035","DOIUrl":"10.1016/j.ekir.2025.06.035","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 9","pages":"Pages 3276-3279"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Immune Microenvironment of Transplant Glomerulitis","authors":"Nathan A. Bracey ,&nbsp;Jonathan S. Maltzman ,&nbsp;Adrienne H. Long ,&nbsp;Renu Dhanasekaran ,&nbsp;Vishnu Shankar ,&nbsp;Azam Mohsin ,&nbsp;Neeraja Kambham ,&nbsp;Gerlinde Wernig ,&nbsp;Andrew J. Gentles ,&nbsp;Mark M. Davis ,&nbsp;Vivek Charu","doi":"10.1016/j.ekir.2025.06.015","DOIUrl":"10.1016/j.ekir.2025.06.015","url":null,"abstract":"<div><h3>Introduction</h3><div>Transplant glomerulitis is a morphological lesion seen in kidney allograft rejection that is associated with poor outcomes; however, little is known about how immune cells infiltrate and organize specifically within glomeruli.</div></div><div><h3>Methods</h3><div>We used Co-Detection by Indexing (CODEX) multifluorescent imaging to measure 52 protein markers in a retrospective cohort of 41 human allograft nephrectomies (ANs) and evaluated the immunological landscape of transplant glomerulitis.</div></div><div><h3>Results</h3><div>Characterization of 18 cell types identified diverse immune cells within inflamed glomeruli, with unique phenotypes and compositions compared with the extraglomerular microenvironment. Immunological phenotypes were conserved across glomeruli within individuals and associated with the general state of injury, with M1 macrophages and effector CD8 T cells associated with mild inflammation. Distance-based spatial analysis further revealed a profibrotic community composed of M2 macrophages, memory CD8 T cells and exhausted CD8 T cells surrounding endothelial cell hubs. These interaction networks were associated with regions of adverse glomerular remodeling, expression of profibrotic proteins, and were more prevalent in individuals with C4d-positive rejection.</div></div><div><h3>Conclusion</h3><div>These results implicate distinct cell-cell interactions as hallmarks of alloimmune injury and chronic remodeling during transplant glomerulitis and may give rise to new tools for histological risk assessment of clinical rejection syndromes.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 9","pages":"Pages 3113-3127"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Prognostic Score Based on Cell-Mediated Immunity for Cytomegalovirus Infection After Transplantation","authors":"Delphine Kervella ,&nbsp;Franc Casanova-Ferrer ,&nbsp;Camille N. Kotton ,&nbsp;Laura Donadeu ,&nbsp;Deepali Kumar ,&nbsp;Silvia Pineda ,&nbsp;Elena Crespo ,&nbsp;Maria Meneghini ,&nbsp;José González-Costelo ,&nbsp;Elena García-Romero ,&nbsp;Laura Lladó ,&nbsp;Alba Cachero ,&nbsp;Edoardo Melilli ,&nbsp;Irina B. Torres ,&nbsp;Anna Martínez-Lacalle ,&nbsp;Zaira Castañeda ,&nbsp;Mónica Martinez-Gallo ,&nbsp;Oscar Len ,&nbsp;Ibai Los-Arcos ,&nbsp;Enric Trilla-Herrera ,&nbsp;Oriol Bestard","doi":"10.1016/j.ekir.2025.06.056","DOIUrl":"10.1016/j.ekir.2025.06.056","url":null,"abstract":"<div><h3>Introduction</h3><div>The interferon gamma (IFN-γ) enzyme-linked immunosorbent spot is a highly sensitive immune assay that enables the assessment of cytomegalovirus (CMV)-specific cell-mediated immunity (CMI) and can identify at-risk transplant patients of CMV infection; however, its clinical implementation remains elusive.</div></div><div><h3>Methods</h3><div>We developed a novel CMV-CMI risk-score based on the standardized T-SPOT.CMV assay against 2 CMV antigens (immediate-early protein 1 [IE-1] and 65 kDa phosphoprotein [pp65]), a biomarker predicting CMV infection, both high viral replication, and disease by performing a pooled analysis of 570 kidney transplants participating in different clinical trials and subsequently validating it in 146 consecutives solid organ transplants (SOT) in an interventional trial. By incorporating clinical variables into the CMV-CMI risk-score, we built an integrative prognostic system quantifying the risk of CMV infection (CMV-PrognosTIC score) using elastic net penalized regression analysis.</div></div><div><h3>Results</h3><div>In the pooled derivation cohort, whereas specific IE-1/pp65-specific CMV-CMI frequencies independently correlated with high risk of CMV infection (areas under the curve [AUCs]: 0.694, <em>P</em> &lt; 0.0001; 0.719, <em>P</em> &lt; 0.0001, respectively), by combining both responses, 3 CMV-CMI risk-scores appeared, accurately discriminating low-risk (LR) from intermediate-risk (IR) and high-risk (HR) patients (98.7% negative predictive value [NPV], 97.2% sensitivity). Its prospective implementation guiding decision-making in an independent SOT cohort confirmed the very high NPV and sensitivity identifying LR patients. By integrating type of preventive therapy, patient age, and donor (D) and recipient (R) CMV-serostatus to the CMV-CMI risk-score, we generated a global risk-prognostic model showing accurate discrimination and calibration in both derivation (AUC: 0.807) and validation cohorts (AUC: 0.719).</div></div><div><h3>Conclusion</h3><div>We developed a robust CMV-PrognosTIC score to quantify the risk of CMV infection in SOT, which may be readily implemented in clinical transplantation to personalize CMV preventive therapies.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 9","pages":"Pages 3044-3057"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes After Kidney Transplantation in Antiglomerular Basement Membrane Disease","authors":"Priscille Traversat ,&nbsp;Marine Dekervel ,&nbsp;Christophe Masset ,&nbsp;Dominique Bertrand ,&nbsp;Léonard Golbin ,&nbsp;Philippe Gatault ,&nbsp;Antoine Thierry ,&nbsp;Emilie Cornec-Le Gall ,&nbsp;Maïté Jaureguy ,&nbsp;Cyrille Garrouste ,&nbsp;Dany Anglicheau ,&nbsp;Valérie Chatelet ,&nbsp;Sophie Caillard ,&nbsp;Anna Duval ,&nbsp;Jean-Philippe Rerolle ,&nbsp;Martin Planchais ,&nbsp;Agnès Duveau ,&nbsp;Fabien Duthe ,&nbsp;Jean-François Augusto ,&nbsp;Benoît Brilland","doi":"10.1016/j.ekir.2025.06.021","DOIUrl":"10.1016/j.ekir.2025.06.021","url":null,"abstract":"<div><h3>Introduction</h3><div>Goodpasture disease, or antiglomerular basement membrane (anti-GBM) disease, is a rare autoimmune disorder that often leads to end-stage kidney disease (ESKD). Although kidney transplantation (KT) is the preferred treatment, concerns exist about disease recurrence and graft outcomes in patients with GBM-associated glomerulonephritis (GBM-GN). This study aimed to evaluate posttransplant outcomes in patients with GBM-GN compared with matched controls.</div></div><div><h3>Methods</h3><div>This retrospective, multicenter study included 100 patients with anti-GBM who received KT between 2005 and 2023 in 13 French transplant centers, matched with 200 control recipients. We compared the incidence of delayed graft function (DGF), graft failure, relapse, acute rejection, and death between groups and analyzed risk factors using multivariable models.</div></div><div><h3>Results</h3><div>No significant differences in DGF incidence (22% vs. 19%, <em>P</em> = 0.5), graft survival (87% vs. 88% at 5 years, <em>P</em> = 0.4), or patient survival (93% vs. 89% at 5 years, <em>P</em> = 0.4) were found between patients with GBM-GN and controls. Patients with GBM-GN tended to have lower risk of acute rejection (hazard ratio [HR] = 0.51, 95% confidence interval: 0.25–1.02, <em>P</em> = 0.055). Only 1 patient with GBM-GN (1%) experienced disease relapse. Although patients with GBM-GN were waitlisted and transplanted later than controls, specific transplant timing was not associated with improved outcomes.</div></div><div><h3>Conclusion</h3><div>KT in patients with GBM-GN offers comparable outcomes to other nephropathies in the current era. Disease relapse is rare, even in the few patients with detectable antibodies pretransplantation. The lower incidence of acute rejection in the GBM-GN group warrants further investigation. These findings support KT as a viable option in patients with GBM-GN, though specific pre- and posttransplant monitoring is advised.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 9","pages":"Pages 3150-3163"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Reported Outcome of Living Kidney Donation Correlates With Perioperative Complications not With Surgical Techniques","authors":"Martina Koch ,&nbsp;Jeannine Wegner ,&nbsp;Eike Bormann ,&nbsp;Sylvia Kröncke ,&nbsp;Sarah Riepenhausen ,&nbsp;Philipp Neuhaus ,&nbsp;Julian Varghese ,&nbsp;Joachim Gerß ,&nbsp;Claudia Sommerer ,&nbsp;Barbara Suwelack","doi":"10.1016/j.ekir.2025.06.052","DOIUrl":"10.1016/j.ekir.2025.06.052","url":null,"abstract":"<div><h3>Introduction</h3><div>The German health care system lacks data on surgical complications and self-reported outcomes (SROs) of living donors. The prospective German Living Kidney Donor Registry, SOLKID-GNR aims to improve the assessment of donors’ medical and psychosocial risks.</div></div><div><h3>Methods</h3><div>Data were collected before (PRE) and 3 months after (POST) living kidney donation from transplantation centers (TCs) and donors via SROs. We reported perioperative complication rates for different surgical techniques and correlated them with donors’ SROs. Datasets of 1020 donors from 30 German TCs were analyzed.</div></div><div><h3>Results</h3><div>Donor nephrectomy procedures included laparoscopic (57.9%), retroperitoneoscopic (21.4%), open retroperitoneal (16.0%), or open abdominal nephrectomy (4.7%). Perioperative complications reported by TCs ranged from 9.8% (retroperitoneoscopic) to 17.1% (open abdominal), whereas those reported by donors ranged from 12.2% (open retroperitoneal) to 15.0% (open abdominal). Donors were discharged sooner and returned to work earlier after minimally invasive surgery; however, had comparable quality-of-life (QoL) after donation. The physical component summary (PCS) scores of the Short Form–12 (SF-12) were similar between the 4 surgical methods postdonation; however, they were lower in donors with TC- or self-reported complications than in those without. The mental component summary (MCS) scores of the SF-12 were lower in case of self-reported complications only. Despite 12.5% of self-reported complications, 96.4% expressed a willingness to donate again, and 94.1% felt well-informed.</div></div><div><h3>Conclusion</h3><div>Although the surgical technique does not directly affect donors' QoL shortly after donation, minimally invasive procedures result in shorter hospital stays and a quicker return to work. Self-reported complications have a greater impact on mental QoL than those documented by transplant centers, highlighting the importance of subjective experiences during recovery.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 9","pages":"Pages 3058-3069"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normothermic Kidney Perfusion: Current Status and Future Perspectives","authors":"Barbara Franchin ,&nbsp;Leonie van Leeuwen ,&nbsp;Matthew L. Holzner ,&nbsp;Nicholas Chun ,&nbsp;Lucrezia Furian ,&nbsp;Paolo Cravedi","doi":"10.1016/j.ekir.2025.06.041","DOIUrl":"10.1016/j.ekir.2025.06.041","url":null,"abstract":"<div><div>Normothermic machine perfusion (NMP), the most recent advancement in solid organ preservation, enables <em>ex situ</em> maintenance of grafts in a physiologically active state, offering a significant advantage over traditional cold storage methods. Whereas NMP is now widely adopted for clinical preservation of livers, hearts, and lungs, its application in kidney transplantation remains relatively limited. In this context, NMP holds promise for expanding the use of marginal donor kidneys by enhancing viability assessment and potentially restoring function in grafts that might otherwise be discarded. In addition, NMP provides a valuable platform for studying molecular markers of injury and recovery in human organs, as well as for delivering targeted therapies aimed at modulating immunologic or transcriptomic profiles. Despite its potential, broader clinical implementation is hindered by variability in perfusion devices, protocols, and perfusate compositions across centers, making cross-study comparisons challenging. This review examines the current landscape of kidney NMP and its emerging role in graft reconditioning.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 9","pages":"Pages 2943-2952"},"PeriodicalIF":5.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}