Kidney International Reports最新文献

{"title":"A Cautionary Note on the Generalizability of Urine Protein-To-Creatinine Ratio Findings in Acute Kidney Injury","authors":"Mohamed E. Elrggal","doi":"10.1016/j.ekir.2025.01.048","DOIUrl":"10.1016/j.ekir.2025.01.048","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Page 1602"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of IgG4-Related Renal Disease in Kidney Biopsy","authors":"Malathi CV , Jansi Prema KS , Anila Abraham Kurien","doi":"10.1016/j.ekir.2025.02.026","DOIUrl":"10.1016/j.ekir.2025.02.026","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1598-1599"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Stratification for CKD Progression in Primary Care","authors":"Clyson Mutatiri , Angela Ratsch , Matthew McGrail , Sree Krishna Venuthurupalli , Srinivas Kondalsamy-Chennakesavan","doi":"10.1016/j.ekir.2025.02.037","DOIUrl":"10.1016/j.ekir.2025.02.037","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1559-1561"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Myeloperoxidase Immunostaining in Diagnosing Antineutrophil Cytoplasmic Autoantibody–Associated Crescentic Glomerulonephritis With Immune Complex Deposits","authors":"Jonathan E. Zuckerman","doi":"10.1016/j.ekir.2025.03.014","DOIUrl":"10.1016/j.ekir.2025.03.014","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1321-1323"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering the Link Between Kynurenic Acid Pathway and Kidney Failure","authors":"Carolla El Chamieh ,&nbsp;Sophie Liabeuf ,&nbsp;Islam Amine Larabi ,&nbsp;Natalia Alencar De Pinho ,&nbsp;Margaux Costes-Albrespic ,&nbsp;Luc Frimat ,&nbsp;Céline Lange ,&nbsp;Yves-Édouard Herpe ,&nbsp;Jean-Charles Martin ,&nbsp;Pierre Letourneau ,&nbsp;Benoit Bérengère ,&nbsp;Christophe Soulage ,&nbsp;Stéphane Burtey ,&nbsp;Jean-Claude Alvarez ,&nbsp;Laetitia Koppe ,&nbsp;Ziad A. Massy","doi":"10.1016/j.ekir.2025.02.024","DOIUrl":"10.1016/j.ekir.2025.02.024","url":null,"abstract":"<div><h3>Introduction</h3><div>Recent studies have focused on some uremic toxins, particularly those derived from tryptophan, as potential modifiable risk factors of chronic kidney disease (CKD) progression. The kynurenine pathway is the major enzymatic pathway for sequentially catabolizing tryptophan, resulting in key metabolites including kynurenine and kynurenic acid (KA) by the aminoadipate aminotransferase. We aimed at evaluating the association of serum KA levels and KA-to-kynurenine ratio (as indicators of aminoadipate aminotransferase activity) with kidney failure.</div></div><div><h3>Methods</h3><div>The Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) study is a prospective cohort of patients with CKD having an estimated glomerular filtration rate (eGFR) &lt; 60 ml/min per 1.73 m². Baseline samples of uremic toxins were measured using a validated liquid chromatography tandem mass spectrometry technique. Cause-specific Cox models were used to estimate hazard ratios (HRs) for our outcome. The kidney gene expression of the kynurenine pathway was evaluated in 5 or 6 nephrectomy CKD mice and adenine-diet CKD mice under nephroprotective low protein diet (5% w/w).</div></div><div><h3>Results</h3><div>Over a median follow-up period of 5 years, 608 out of the 2406 patients progressed to kidney failure. A 2-fold increase in serum KA levels and KA-to-kynurenine ratio were respectively associated with a 22% and 20%-increase in the hazard of kidney failure after multiple adjustments. In the mouse model, positive correlation was found between aminoadipate aminotransferase expression and fibrosis-related genes and kidney fibrosis. A low-protein diet was associated with a decrease in aminoadipate aminotransferase expression in the kidney as well as in inflammatory and fibrosis markers.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that the kynurenine pathway is associated with kidney failure, and that the inhibition of aminoadipate aminotransferase and the subsequent reduction of KA accumulation is a promising target to mitigate kidney disease progression.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1404-1414"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differing Sensitivity of Antibodies Against IgG1 Explains the Discrepancy in the Detection of IgG1: A Validation Study","authors":"Satoru Kudose ,&nbsp;Nicholas J. Steers ,&nbsp;Pouneh Dokouhaki ,&nbsp;Pingchuan Zhang ,&nbsp;Mary E. Fidler ,&nbsp;Nicole Andeen ,&nbsp;Vanderlene Kung ,&nbsp;Becky M. Ma ,&nbsp;Sharvari S. Pathak ,&nbsp;Yuancheng Wang ,&nbsp;Alyssa B. Beatty ,&nbsp;Vighnesh Walavalkar ,&nbsp;Miroslav Sekulic ,&nbsp;Ibrahim Batal ,&nbsp;M. Barry Stokes ,&nbsp;Glen S. Markowitz ,&nbsp;Vivette D. D’Agati ,&nbsp;Samih Nasr ,&nbsp;Dominick Santoriello","doi":"10.1016/j.ekir.2025.02.005","DOIUrl":"10.1016/j.ekir.2025.02.005","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1571-1574"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction Between Apolipoprotein L1 Genetic Risk and Neighborhood Socioeconomic Status for Kidney Outcomes in a United States Cohort","authors":"Kullaya Takkavatakarn ,&nbsp;Dinushika Mohottige ,&nbsp;Alexander W. Charney ,&nbsp;Carol Horowitz ,&nbsp;Andrew G. Rundle ,&nbsp;Lili Chan ,&nbsp;Girish N. Nadkarni","doi":"10.1016/j.ekir.2025.02.015","DOIUrl":"10.1016/j.ekir.2025.02.015","url":null,"abstract":"<div><h3>Introduction</h3><div>Apolipoprotein L1 (<em>APOL1</em>) risk alleles G1 and G2, confer a higher risk of kidney outcomes but are influenced by other genetic and environmental factors. The interaction between neighborhood socioeconomic status (SES) and <em>APOL1</em> associated risk of kidney outcomes is unknown.</div></div><div><h3>Methods</h3><div>This retrospective study included self-reported Black individuals with genetic, clinical, and residential data. We defined the neighborhood as a 1 km² radius circle around their primary residence and used a negative binomial regression model to analyze the interaction between <em>APOL1</em> variants and neighborhood SES, specifically poverty rate and median household income, for a composite kidney outcome of a sustained 30% estimated glomerular filtration rate (eGFR) decline or end-stage kidney disease (ESKD) over 8 years.</div></div><div><h3>Results</h3><div>Of 4296 participants, 829 (19%) had the composite kidney outcome; 20% with and 9% without the composite outcome had <em>APOL1</em> high-risk genotypes. Higher poverty was associated with increased kidney risk (adjusted relative risk [aRR]: 1.08; 95% confidence interval [CI]: 1.01–1.17), whereas higher income was protective (aRR: 0.94; 95% CI: 0.89–0.98). Significant interactions were observed between <em>APOL1</em> and SES (<em>P</em> &lt; 0.05). Among high-risk <em>APOL1</em> individuals, higher poverty was linked to lower risk (aRR: 0.86; 95% CI: 0.43–2.75), whereas higher income increased the risk (aRR: 1.07; 95% CI: 0.51–2.13).</div></div><div><h3>Conclusion</h3><div>Significant interactions between <em>APOL1</em> genotypes and neighborhood SES on kidney outcomes suggest that <em>APOL1</em> genetic risk may influence the impact of neighborhood SES on kidney health. Among individuals with <em>APOL1</em> high-risk variants, a higher neighborhood poverty rate was unexpectedly linked to lower risk, whereas higher neighborhood household income was associated with increased risk.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1476-1485"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “A Targeted Release Capsule of Lanthanum Carbonate: A New Efficient Cheap Treatment for Primary Hyperoxalurias” [Volume 10, Issue 2, February 2025, Pages 503-515]","authors":"Marc E. De Broe ,&nbsp;Marc P. Uytterhoeven ,&nbsp;Jan De Causmaecker ,&nbsp;Yannick De Brucker ,&nbsp;Erik D. Snelders ,&nbsp;Johan Van De Walle ,&nbsp;Koen Van Hoeck ,&nbsp;Dominique Trouet ,&nbsp;Monique Elseviers","doi":"10.1016/j.ekir.2025.02.034","DOIUrl":"10.1016/j.ekir.2025.02.034","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Page 1604"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter to the Editor Entitled “A Cautionary Note on the Generalizability of Urine Protein-to-Creatinine Ratio Findings in Acute Kidney Injury”","authors":"Ian E. McCoy ,&nbsp;Aris Oates ,&nbsp;Chi-yuan Hsu","doi":"10.1016/j.ekir.2025.02.022","DOIUrl":"10.1016/j.ekir.2025.02.022","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1602-1603"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Metabolic Signatures of FAM47E–SHROOM3 Haplotypes in a General Population Sample","authors":"Dariush Ghasemi-Semeskandeh ,&nbsp;Eva König ,&nbsp;Luisa Foco ,&nbsp;Nikola Dordevic ,&nbsp;Martin Gögele ,&nbsp;Johannes Rainer ,&nbsp;Markus Ralser ,&nbsp;Dianne Acoba ,&nbsp;Francisco S. Domingues ,&nbsp;Dorien J.M. Peters ,&nbsp;Peter P. Pramstaller ,&nbsp;Cristian Pattaro","doi":"10.1016/j.ekir.2025.02.018","DOIUrl":"10.1016/j.ekir.2025.02.018","url":null,"abstract":"<div><h3>Introduction</h3><div>Genome-wide association studies (GWAS) identified a locus on chromosome 4q21.1, spanning the Family With Sequence Similarity 47 Member E <em>(FAM47E)</em>, Starch Binding Domain 1 (<em>STBD1)</em>, Coiled-Coil Domain Containing 158 (<em>CCDC158)</em>, and Shroom Family Member 3 (<em>SHROOM3)</em> genes, to be associated with kidney function markers. Functional studies implicated <em>SHROOM3</em> as the effector gene, demonstrating its developmental role to guarantee podocyte barrier integrity. However, the locus has also been associated with other clinical traits, including electrolytes, hematological, cardiovascular, and neurological traits, not all of which can be easily traced to the regulation of kidney function. We therefore conducted a systematic analysis of the whole locus’ genetic profiles (haplotypes) to assess which phenotypic profiles they were associated with.</div></div><div><h3>Methods</h3><div>For the 4 genes, we reconstructed haplotypes spanning 71 exonic and intronic variants for 12,834 participants in the Cooperative Health Research in South Tyrol (CHRIS) study based on genotypes imputed on a local whole-exome sequencing (WES) reference panel. Haplotypes were tested for associations with 72 clinical traits, 170 serum metabolites, and 148 plasma protein concentrations, using linear regression models.</div></div><div><h3>Results</h3><div>We identified 11 haplotypes with a population frequency between 2% and 24%. Compared with the most common haplotype, most haplotypes were associated with higher creatinine-based estimated glomerular filtration rate (eGFR) and lower serum magnesium levels. In addition, specific haplotypes were also associated with biologically diverse groups of traits, including albuminuria, blood pressure, red blood cell traits, carnitines, and amino acids. Cluster analysis highlighted the existence of distinct genetic profiles in which individuals with specific haplotypes presented with specific phenotypic and metabolic signatures.</div></div><div><h3>Conclusion</h3><div>The genetic variability of the <em>FAM47E</em>–<em>SHROOM3</em> locus indicates the existence of population subgroups with distinct biomarker profiles.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1495-1508"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}