Kidney International Reports最新文献_第3页

A Pan-Inhibitor of Phosphate Transporters AP306 in Hemodialysis Patients 血液透析患者磷酸转运蛋白AP306泛抑制剂

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-05-01 DOI: 10.1016/j.ekir.2025.03.011

Nicholas S. Kowalczyk , Stuart M. Sprague

引用次数: 0

Prospective Cohort Study in Alport Syndrome Patients Under Standard Therapy 标准治疗下Alport综合征患者的前瞻性队列研究

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-05-01 DOI: 10.1016/j.ekir.2025.02.036

Oliver Gross , Michelle N. Rheault , James Simon , Bertrand Knebelmann , Yuqian Shen , Qi Zhang , Ali Hariri , Julie Lin , Shiguang Liu , Clifford E. Kashtan

{"title":"Prospective Cohort Study in Alport Syndrome Patients Under Standard Therapy","authors":"Oliver Gross , Michelle N. Rheault , James Simon , Bertrand Knebelmann , Yuqian Shen , Qi Zhang , Ali Hariri , Julie Lin , Shiguang Liu , Clifford E. Kashtan","doi":"10.1016/j.ekir.2025.02.036","DOIUrl":"10.1016/j.ekir.2025.02.036","url":null,"abstract":"<div><h3>Introduction</h3><div>Patients with Alport syndrome (AS), a common genetic kidney disease, exhibit variable rates of decline in kidney function. Consequently, this global, multicenter, prospective observational study aimed to generate data useful for designing future interventional trials.</div></div><div><h3>Methods</h3><div>The study included patients aged 12 to 65 years with a confirmed diagnosis of AS and estimated glomerular filtration rate (eGFR) of 45 to 90 ml/min. For up to 120 weeks in 12-weekly intervals, blood and urine samples, patient and family history, genotype, adverse events (AEs), medications, and patient-related outcome data were collected under International Conference on Harmonization-Good Clinical Practice (ICH-GCP) standards.</div></div><div><h3>Results</h3><div>Out of 165 patients enrolled, 101 (61.2%) were classified as X-linked (62.4% females, 37.6% males) and 32 (19.4%) as autosomal (recessive or dominant) inheritance. Baseline mean eGFR was 64 ml/min per 1.73 m<sup>2</sup>, and yearly eGFR slope in ml/min per 1.73 m<sup>2</sup> was −2.94 (−6.7 in X-linked males, 0.6 in X-linked females, −1.66 in heterozygous autosomal patients). Baseline urine albumin-to-creatinine ratio (UACR) was the best predictor for rapid loss of eGFR with a yearly eGFR slope of −10.16 ml/min per 1.73 m<sup>2</sup> in patients with UACR > 1 g/g compared with−0.90 ml/min per 1.73 m<sup>2</sup> if UACR was ≤ 1.0 g/g. Out of 353 AEs, only 26 (7.4%) were related to AS. In addition to UACR, neutrophil gelatinase-associated lipocalin, clusterin, and kidney injury molecule-1 correlated with the eGFR slope.</div></div><div><h3>Conclusion</h3><div>In patients with AS receiving standard of care, rapid decline in kidney function strongly correlates with UACR and AEs related to the underlying medical condition are rare. Both findings enrich the design of future interventional trials.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1360-1371"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Retinal Vasculature and Risk of Age-Related GFR Decline — The Renal Iohexol Clearance Survey 视网膜血管和年龄相关性GFR下降的风险——肾碘己醇清除率调查

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-05-01 DOI: 10.1016/j.ekir.2025.02.006

Silje Småbrekke , Karl Marius Brobakk , Nikoline B. Rinde , Therese Von Hanno , Geir Bertelsen , Bjørn Odvar Eriksen , Toralf Melsom

{"title":"The Retinal Vasculature and Risk of Age-Related GFR Decline — The Renal Iohexol Clearance Survey","authors":"Silje Småbrekke , Karl Marius Brobakk , Nikoline B. Rinde , Therese Von Hanno , Geir Bertelsen , Bjørn Odvar Eriksen , Toralf Melsom","doi":"10.1016/j.ekir.2025.02.006","DOIUrl":"10.1016/j.ekir.2025.02.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Age-related decline in glomerular filtration rate (GFR) significantly contributes to chronic kidney disease (CKD). This longitudinal study in a nondiabetic population investigated whether retinal microvascular changes are associated with GFR decline.</div></div><div><h3>Methods</h3><div>The Renal Iohexol Clearance Survey (RENIS) included 1837 participants aged 50 to 62 years without self-reported diabetes, kidney or cardiovascular disease. Baseline retinal vessel measurements and retinopathy were assessed with a Visucam PRONM retinal camera. Iohexol clearance was measured over 1 to 4 visits across an 11-year median follow-up. Linear mixed models and logistic regression were used to analyze associations between retinal vessel measurements, retinopathy, mean annual GFR decline, and accelerated GFR decline.</div></div><div><h3>Results</h3><div>In multiple adjusted linear mixed models, wider central retinal venular equivalent (CRVE) and wider central retinal arteriolar equivalent (CRAE) were associated with a steeper mean measured GFR (mGFR) decline. For each SD increase, CRVE was associated with an mGFR decline of −0.08 ml/min/yr (95% confidence interval [CI]:−0.15 to −0.02; <em>P</em> = 0.012), and CRAE was associated with a decline of −0.09 ml/min/yr (95% CI:−0.15 to −0.02; <em>P</em> = 0.007). CRVE, but not CRAE, was associated with accelerated mGFR decline in the model adjusted for age, sex, and height [OR 1.31 (95% CI 1.07-1.61, <em>P</em> = 0.008]. No significant associations were observed between retinopathy, microaneurysms, and hemorrhages with annual or accelerated mGFR decline.</div></div><div><h3>Conclusion</h3><div>CRVE and CRAE, but not retinopathy, retinal microaneurysms, or hemorrhages, were associated with steeper mean mGFR, suggesting that microvascular changes may be one of the underlying mechanisms for age-related GFR loss in a general nondiabetic population.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1384-1392"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Urinary Kidney Tubule Biomarkers With Curcumin in CKD 姜黄素对CKD患者尿肾小管生物标志物的评价

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-05-01 DOI: 10.1016/j.ekir.2025.02.016

Colin J. Gimblet , Mingyao Sun , Katharine Geasland , Sadaf Akbari , Patrick Ten Eyck , Joachim H. Ix , Diana I. Jalal

引用次数: 0

Corrigendum to “SAT-040 RENAL SAFETY OF DIRECT ACTING ANTIVIRAL DRUGS IN POST LIVER TRANSPLANT PATIENTS WITH CHRONIC HEPATITIS C VIRUS INFECTION” [Volume 5, Issue 3, Supplement, March 2020, Pages S18-S19] “SAT-040直接作用抗病毒药物对慢性丙型肝炎病毒感染肝移植后患者肾脏安全性的影响”的更正[第5卷，第3期，增刊，2020年3月，页S18-S19]

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-05-01 DOI: 10.1016/j.ekir.2025.03.003

Elzorkany KMA , Zahran A , Kora M , Sabry A , Zaghla H

引用次数: 0

Focus on a CKD-Associated Locus: SHROOM3 and Other Suspects 关注ckd相关位点：SHROOM3和其他可疑基因

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-05-01 DOI: 10.1016/j.ekir.2025.03.037

Long Qian, Anand C. Reghuvaran, Madhav C. Menon

引用次数: 0

Corrigendum to “Outcomes of Living Kidney Donors Following Donor Nephrectomy in Aotearoa New Zealand” [Volume 10, Issue 3, March 2025, Pages 762-771] “活体肾脏捐赠者在新西兰奥特罗阿肾切除术后的结果”的更正[第10卷，第3期，2025年3月，762-771页]

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-05-01 DOI: 10.1016/j.ekir.2025.03.002

Lai Wan Chan , Georgina L. Irish , Tze L. Goh , Basil Alnasrallah , Christopher E. Davies , Matthew P. Sypek , Philip A. Clayton , Michael G. Collins

引用次数: 0

Lymphocyte Transformation Test: A Promising Tool for Identifying the Causative Agent in Drug-Induced Acute Interstitial Nephritis 淋巴细胞转化试验：鉴别药物性急性间质性肾炎病原体的一种有前途的工具

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-05-01 DOI: 10.1016/j.ekir.2025.02.029

Javier Azores Moreno , Rosario Cabañas , Teresa Bellón , Eugenia García Fernández , Irene Vázquez Raso , Sara Aldana , María Maldonado , Lina León-Machado , Amir Shabaka , Begoña Rivas Becerra , Cristina Vega Cabrera , Gema Fernández Juárez

引用次数: 0

Exploring Avacopan Potential in Bartonella Endocarditis Associated Glomerulonephritis 探索Avacopan在巴尔通体心内膜炎相关性肾小球肾炎中的作用

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-05-01 DOI: 10.1016/j.ekir.2025.03.010

Clément Deltombe , Pierre Braud , Charles Ronsin , Simon Ville

引用次数: 0

Corrigendum to “The Bromodomain and Extraterminal Protein Inhibitor Apabetalone Ameliorates Kidney Injury in Diabetes by Regulating Cholesterol Accumulation and Modulating the Gut Microbiota” [Volume 10, Issue 2, February 2025, Pages 522-534] “Bromodomain和外蛋白抑制剂Apabetalone通过调节胆固醇积累和调节肠道微生物群改善糖尿病肾损伤”的勘误表[第10卷，第2期，2025年2月，522-534页]

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-05-01 DOI: 10.1016/j.ekir.2025.02.035

Min Wang , Zhaohui Huang , Yonghong Zhu , Xin Li , He Sun , QiuLing Fan

引用次数: 0