Jurnal Farmasi Udayana最新文献

{"title":"Efek Antineuroinflamasi Ekstrak Etanol 96% Daun Marsilea crenata Presl. Budidaya Papda Sel Mikroglia HMC3","authors":"Burhan Maarif","doi":"10.24843/jfu.2020.v09.i02.p04","DOIUrl":"https://doi.org/10.24843/jfu.2020.v09.i02.p04","url":null,"abstract":"ABSTRACT \u0000Neuroinflamation is a neurodegenerative disease caused by estrogen deficiency. Marsilea crenata Presl. is a plant that contains phytoestrogens, which are compounds that can replace the function of estrogen in maintaining cell homeostasis in the brain. The purpose of this study was to predict the antineuroinflammatory effect of 96% ethanol extract of cultivated Marsilea crenata Presl. leaves in HMC3 microglia cells through activated ER measurements, and observed using the immunocytochemistry method. IFN? is induced into cells 24 hours before treatment to cause an inflammatory condition. 96% ethanol extract of cultivated Marsilea crenata Presl. leaves is given at a dose of 62.5; 125; and 250 ?g/ml. Genistein 50 ?m was used as a positive control. The results showed that 96% ethanol extract of cultivated Marsilea crenata Presl. leaves at doses of 125 and 250 ?g/ml can decrease free ER? expression with values ??of 814,216 and 573,190 AU at p <0.05, and shows an increase in the amount of activated ER?. From these results it can be concluded that the 96% ethanol extract of cultivated Marsilea crenata Presl. leaves provides a potential antineuroinflammatory effect shown by the decreasing of free ER? expression on HMC3 microglia cells with 250 ?g/ml as the best dose. \u0000Keywords: antineuroinflammation; ER?; phytoestrogens; Marsilea crenata Presl.; HMC3 microglia cells \u0000ABSTRAK \u0000Neuroinflamasi merupakan penyakit neurodegeneratif yang disebabkan defisiensi estrogen. Marsilea crenata Presl. merupakan tumbuhan yang mengandung fitoestrogen, yaitu senyawa yang dapat menggantikan fungsi estrogen dalam menjaga homeostasis sel di dalam otak. Tujuan penelitian ini adalah untuk memprediksi efek antineuroinflamasi dari ekstrak etanol 96% daun Marsilea crenata Presl. budidaya pada sel mikroglia HMC3 melalui pengukuran ER teraktivasi, dan diamati menggunakan metode immunocytochemistry. IFN? diinduksikan ke dalam sel 24 jam sebelum perlakuan untuk menimbulkan kondisi inflamasi. Ekstrak etanol 96% daun Marsilea crenata Presl. budidaya diberikan dengan dosis 62.5; 125; dan 250 ?g/ml. Genistein 50 ?m digunakan sebagai kontrol positif. Hasil menunjukkan bahwa ekstrak etanol 96% daun Marsilea crenata Presl. budidaya dengan dosis 125 dan 250 ?g/ml dapat menurunkan ekspresi ER? bebas dengan nilai 814.216 dan 573.190 AU pada p<0.05, serta menunjukkan peningkatan jumlah ER? teraktivasi. Dari hasil ini dapat disimpulkan bahwa ekstrak etanol 96% daun Marsilea crenata Presl. budidaya memberikan efek antineuroinflamasi yang potensial ditunjukkan dengan penurunan ekspresi ER? bebas pada sel mikroglia HMC3 dengan 250 ?g/ml sebagai dosis terbaik. \u0000Kata kunci: antineuroinflamasi, ER?, fitoestrogen, Marsilea crenata Presl., sel mikroglia HMC3","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85753627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifikasi Komponen Volatile Kulit Ari Biji Kopi (Coffea robusta) Guna Optimalisasi Kebermanfaatan","authors":"Arie Dharma Putra Nugraha","doi":"10.24843/jfu.2020.v09.i02.p05","DOIUrl":"https://doi.org/10.24843/jfu.2020.v09.i02.p05","url":null,"abstract":"Bau dapat dibedakan menjadi dua yaitu bau enak dan tidak sedap, bau yang tidak diharapkan tentunya bau tidak sedap, yang dapat memberikan dampak buruk yaitu terganggunya penciuman dan bersifat menyesakkan. Bau yang tidak sedap dapat berasal dari tempat lembab.Tingginya kekayaan hayati di Indonesia, memiliki peluang besar untuk memanfaatkannya sebagai produk pewangi alami. Salah satu produk pewangi dan penyerap bau tidak sedap (absorbent) yaitu memanfaatkan biji kopi robusta (Coffea robusta). Salah satu komponen biji kopi robusta yang jarang dimanfaatkan yaitu kulit ari kopi yang didapatkan saat proses sangrai. Seluruh komponen biji kopi terbukti memiliki kandungan volatile yang tinggi dan beragam, melihat kulit ari kopi yang jarang dimanfaatkan, maka dilakukan ekstraksi minyak atsiri dari kulit ari kopi robusta dengan pelarut metanol. Analisis minyak atsiri yang digunakan yaitu dengan metode GC-MS, menyatakan bahwa dalam ekstrak kulit ari biji kopi robusta komponen volatile yang terdapat dalam ekstrak kulit ari biji kopi robusta yaitu trans-Caryophyllene (1,4.56%), Germacrene D (2, 3.59%), alpha-Farnesene (3, 4.35%) dan Pentan-1,3-dioldiisobutyrate (4, 10.22%). Banyaknya komponen volatile, menunjukan bahwa kulit ari kopi robusta dapat potensial dimanfaatkan massal di masyarakat.","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77820924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kebijakan Industri Farmasi pada Masa Pandemi COVID-19","authors":"Rini Meliawati","doi":"10.24843/jfu.2020.v09.i02.p02","DOIUrl":"https://doi.org/10.24843/jfu.2020.v09.i02.p02","url":null,"abstract":"Drug shortages has been global problem since 2000s until now, and it become in serious condition by the presence of the pandemic COVID-19. The main causes of drug shortages were economic and regulation, business problem, manufacture and supply chain. During this pandemic, the main causes of drug shortages are many pharmaceutical industries closures due to quarantine, logistical problems caused by border closure, export bans, quarantine of exporting active subtances and drugs’countries, increased demand and pilling up. However, this problem has been overcome by making policies and good cooperation between governments, regulatory institution and the pharmaceutical industry throughout the world. Several policies like increasing production capacity, restrict quantity of drugs purchased by the public, facilitate the process of industrial license and making a systems such as i-SPOC (Industry Single Point of Contact).  It is expected to reduce drugs shortages problem during this pandemic.","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80038827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uji Aktivitas Ekstrak Etanol Kulit Durian (Durio zibethinus Murr.) Terhadap Bakteri Propionibacterium acnes dan Staphylococcus aureus","authors":"Andi Tendriani Safitri","doi":"10.24843/jfu.2020.v09.i02.p01","DOIUrl":"https://doi.org/10.24843/jfu.2020.v09.i02.p01","url":null,"abstract":"Kulit durian (Durio zibethinus Murr) merupakan tanaman yang dapat digunakan sebagai pengobatan. Kulit durian memiliki kandungan metabolit sekunder yaitu flavonoid yang memiliki aktivitas sebagai antibakteri. Bakteri yang menjadi penyebab terjadinya jerawat adalah Propionibacterium acnes dan Staphylococcus aureus. Ekstrak diperoleh dengan cara maserasi menggunakan pelarut etanol 70%. Ekstrak etanol kulit durian  yang diperoleh dibuat dalam 3 seri konsentrasi 10%, 15% dan 25% kemudian diujikan pada bakteri propionibacterium acnes dan staphylococcus aureus. Nilai KHM pada bakteri Propionibacterium acnes  yang diperoleh adalah 10% dengan luas zona hambat yang terbentuk sebesar 7,5 mm ± 0,4 mm. 15% dengan luas zona hambat yang terbentuk sebesar 7,7 mm ± 0,3 mm. 25% dengan luas zona hambat yang terbentuk sebesar 8,4 mm ± 0,2 mm sedangkan Nilai KHM pada bakteri Staphylococcus aureus  yang diperoleh adalah 10% dengan luas zona hambat yang terbentuk sebesar  8,11 mm ± 0,4 mm. 15% dengan luas zona hambat yang terbentuk sebesar 8,11 mm ± 0,3 mm. 25% dengan luas zona hambat yang terbentuk sebesar 8,8 mm ± 0,5 mm. berdasarkan hasil penelitian ekstrak etanol kulit durian memiliki aktivitas terhadap Propionibacterium acnes dan Staphylococcus aureus. \u0000Kata kunci: Durio zibethinus Murr , Acne, Propionibacterium acnes,Staphylococcus aureus","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84259322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perbandingan Stabilitas Obat Racikan Yang Dipreparasi Menggunakan Mortir Dan Tablet Crusher Di Apotek Sarana Pelayanan Kesehatan Primer","authors":"M. Jaya","doi":"10.24843/jfu.2020.v09.i02.p06","DOIUrl":"https://doi.org/10.24843/jfu.2020.v09.i02.p06","url":null,"abstract":"Background: Drugs crushed using mortar is indeed already assessed according the procedure and maintained stability of the cure. But this process requires a relatively long that made some pharmacies preparing medications using a tablet crusher machine. There is a possibility of crushed using a tablet crusher will reduce the stability of certain types of drugs if direct contact with the metal blender machine. Purpose: the variable examined was the stability of the region, namely drug comparison of levels of a drug that dipreparasi uses a tablet crusher and mortar in the primary health care facility pharmacies. Methods: UV-VIS spectrophotometry. Results: the maximum wavelength of klorfeniramine maleate acquired was 261.5 nm and paracetamol is 247.7 nm. % recovery of klorfeniramine maleate raw is ± 2.8% whereas 99.82 on paracetamol is 2.09% ± 100.17. The result of the calculation precision value was obtained by tests at on klorfeniramine maleate is 0.76% whereas on paracetamol is 1.13%. LOD and LOQ of klorfeniramine maleate is 3.20 ± 0.05 and 0.15 ± 9.7 while the LOD and LOQ of paracetamol is 0.38 ± 0.22 and 1.16 ± 0.56. Preparation of comparative test results time crushed with a levels has been made aware that the value of significance test of the Mann Whitney absence of difference levels of drugs that are dipreparasi using mortars and tablet crusher. Conclusion: Drug Crushed with tablet crusher and with mortar does not have the difference statistically. \u0000Keyword: blender, crusher, mortars, stability","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91549935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aktivitas Antibakteri Ekstrak Etanol Daun Kapas (Gossypium barbadense L.) terhadap Staphylococcus epidermidis dan Propionibacterium acnes","authors":"Akhmad Khumaidi, Arsa Wahyu Nugrahani, Febriani Gunawan","doi":"10.24843/jfu.2020.v09.i01.p08","DOIUrl":"https://doi.org/10.24843/jfu.2020.v09.i01.p08","url":null,"abstract":"Kapas (Gossypium barbadense L.) merupakan salah satu tanaman yang berpotensi dapat dikembangkan menjadi agen antibakteri. Penelitian ini bertujuan untuk mengetahui kemampuan antibakteri senyawa kimia di dalam ekstrak etanol daun kapas terhadap bakteri Staphylococcus epidermidis dan Propionibacterium acnes yang ditandai dengan terbentuknya zona hambat. Ekstraksi daun kapas dilakukan secara maserasi menggunakan etanol 96%. Pengujian aktivitas antibakteri dilakukan dengan metode difusi agar dengan teknik sumuran dan ekstrak uji dibuat seri konsentrasi. Kromatografi lapis tipis (KLT) bioautografi dan pereaksi kromogenik digunakan dalam identifikasi golongan senyawa yang mempunyai aktivitas antibakteri. Hasil penelitian menunjukkan bahwa ekstrak etanol daun kapas dengan konsentrasi 50% memberikan daya hambat terbesar terhadap Staphylococcus epidermidis dengan diameter 12,28±0,63 mm sedangkan ekstrak etanol 70% memberikan aktivitas terbesar terhadap Propionibacterium acnes dengan diameter 11,40±0,32 mm. Golongan senyawa yang diduga bertanggung jawab terhadap aktivitas antibakteri yaitu golongan flavonoid. \u0000Kata kunci: Antibakteri, Daun Kapas (Gossypium barbadense L.), Propionibacterium acnes, Staphylococcus epidermidis ","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73743820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluasi Penggunaan Antibiotik pada Pasien Tifoid Rawat Inap di Salah Satu Rumah Sakit Pemerintah Provinsi Bali dengan Metode Gyssens dan ATC/DDD","authors":"I. Sukmawati, Made Krisna Adi Jaya, D. A. Swastini","doi":"10.24843/jfu.2020.v09.i01.p06","DOIUrl":"https://doi.org/10.24843/jfu.2020.v09.i01.p06","url":null,"abstract":"Typhoid is a global health problem especially in developing countries, one of which is in Indonesia. The incidence of antibiotic resistance in typhoid therapy can occur due to inappropriate use of antibiotics. This study aims to determine patterns of antibiotic use as well as the quality and quantity of antibiotic use in typhoid therapy in one of the provincial government hospitals in Bali. This study was an observational study conducted retrospectively which was analyzed using the Gyssens and ATC/DDD methods. The research data were taken from the medical records of patients in the January-December 2019 period that met the inclusion criteria. The results showed that of the 40 total antibiotics prescribing, ceftriaxone was the most widely used antibiotic for typhoid therapy. The quality of antibiotic use as much as 40% is stated rational (category 0), while the other 60% is irrational (categories I-VI) which includes the use of antibiotics with incorrect interval of administration (IIB; 5%), the use of antibiotics that is too long (IIIA; 40%), the use of antibiotics that are too short (IIIB; 5%), there are other antibiotics that are more effective (IVA; 5%), and there are other antibiotics that are less toxic/safer (IVB; 5%). The quantity of antibiotic use was stated more than WHO standards which includes the use of ceftriaxone at 83.80 DDD/100 patient days; levofloxacin at 27.47 DDD/100 patient days; and azithromycin at 3.52 DDD/100 patient days. The results of this study are expected to be a consideration for the hospital as a material for evaluation and improvement in order to improve the rationality of antibiotic use.","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78573040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimasi Konsentrasi Pulvis Gummi Arabicum (PGA) sebagai Emulgator Formulasi Emulsi Ekstrak Rimpang Kunyit (Curcuma longa)","authors":"I. Subagia","doi":"10.24843/jfu.2019.v08.i01.p04","DOIUrl":"https://doi.org/10.24843/jfu.2019.v08.i01.p04","url":null,"abstract":"Penyakit maag atau gastritis merupakan suatu keadaan pendarahan atau peradangan mukosa lambung yang bersifat akut maupun kronis. Pengembangan sediaan emulsi ekstrak kunyit sebagai obat maag karena kandungan kurkumin pada ekstrak kunyit bersifat tidak larut dalam air dan kunyit memiliki rasa yang agak pahit. Penggunaan Pulvis Gummi Arabicum (PGA) sebagai emulgator karena dapat menghasilkan emulsi yang sangat stabil. Variasi konsentrasi PGA yaitu 25% dan 30%. Kedua formula yang dibuat memiliki warna coklat, berbau khas aroma mint, dan bertekstur kental. Nilai rheologi dan viskositas mengikuti Pseudoplastis. Pengujian redispersi pada formula 1 dan formula 2 menunjukkan 3 kali pengocokan pada formula 1 dan 2 kali pengocokan pada formula 2 untuk sediaan dapat terdispersi kembali secara homogen. Pada pengukuran pH Formula F1 memiliki pH 4,7, sedangkan formula F2 memiliki pH 4,79. Pengujian tipe emulsi dilakukan dengan metode pengenceran pada kedua formula menunjukkan tipe minyak dalam air. Pada penelitian ini konsentrasi 30% menghasilkan emulsi yang baik dengan waktu terdispersi kembali lebih cepat dibandingkan konsentrasi 25%. Berdasarkan hasil penelitian, bertambahnya konsentrasi emulgator PGA menghasilkan emulsi yang lebih baik.","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76638903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penggunaan Polivinill Pirolidon (PVP) Sebagai Bahan Pengikat Pada Formulasi Tablet Ekstrak Daun Sirih (Piper betle L.)","authors":"Dede Jerry Sartika Putra","doi":"10.24843/jfu.2019.v08.i01.p03","DOIUrl":"https://doi.org/10.24843/jfu.2019.v08.i01.p03","url":null,"abstract":"\u0000 \u0000 \u0000Tablet adalah sediaan padat mengandung bahan obat dengan atau tanpa bahan pengisi. Granul dengan bahan pengikat PVP memiliki sifat alir yang baik, sudut diam yang minimum, menghasilkan fines lebih sedikit dan daya kompaktibilitasnya lebih baik. Variasi konsentrasi polivinil pirolidon (PVP) yang digunakan yaitu 1%, 3%, 5%. Pembuatan tablet menggunakan metode granulasi basah. Uji kelembapan menujukkan bahwa ketiga formula memenuhi persyaratan dengan rentang 2- 5%. Distribusi ukuran partikel ketiga formula baik karena keseragaman ukuran granul telah seragam. Uji laju alir menunjukkan bahwa ketiga formula memenuhi persyaratan yaitu >10 gram/detik. Uji sudut diam hanya dipenuhi oleh formula 1 yaitu kurang dari ?30o. Uji kompresibilitas granul memenuhi persyaratan yakni kurang dari 20%. Tablet yang dihasilkan berbentuk bundar cembung, bau aromatik, dan warna coklat kehitaman. Uji kerapuhan ketiga formula sudah memenuhi syarat yaitu dibawah 1%. Uji keseragaman bobot dalam sediaan tablet ketiga formula yang dibuat telah memenuhi syarat. Waktu hancur yang diperoleh tidak memenuhi persyaratan yaitu kurang dari 15 menit. Penggunaan bahan pengikat polivinil pirolidon (PVP) konsentrasi 1% menghasilkan granul pada konsentrasi tersebut telah menghasilkan granul yang terstandar dan memiliki waktu hancur paling kecil. \u0000 \u0000 \u0000","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78922761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Docking Terpinen-4-ol pada Protein IKK sebagai Antiinflamasi pada Aterosklerosis secara In Silico","authors":"P. P. P. Dewi","doi":"10.24843/jfu.2019.v08.i01.p07","DOIUrl":"https://doi.org/10.24843/jfu.2019.v08.i01.p07","url":null,"abstract":"ABSTRACT \u0000  \u0000Atherosclerosis is a chronic inflammatory disease that begins with endothelial dysfunction, it caused fat accumulation and plaque growth in the inner arteries walls. Endothelial dysfunction will activate the Nuclear Factor Kappa B (NF-kB) pathway involving IKK proteins. Terpinen4-ol is constituent found in the bangle (Zingiber cassumunar) rhizome. The purpose of this study were to determine the affinity and mechanisms of terpinen-4-ol against IKK protein as anti-inflammatory in atherosclerosis performed using molecular docking method. The docking result are assessed from the binding energy and hydrogen bonds formed between terpinen-4-ol and protein. The result showed that terpinen-4-ol has activity in inhibiting the inflammatory process because it is able to disturb IKK protein with bond energy values -4.89 kcal/mol. The molecular mechanism in inhibiting the activity of IKK protein through the formation of hydrogen bonds in these proteins. These result show that terpinen-4-ol has the potential to inhibiting inflammatory process and it caused the formation of atherosclerotic plaque can be obstructed. \u0000  \u0000Keywords: Atherosclerosis, Terpinen-4-ol, Molecular Docking, In Silico","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84045136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}