JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER最新文献_第7页

LEVEL OF PATIENT SATISFACTION TOWARDS PHARMACY SERVICES IN KIMIA FARMA TALANGSARI PHARMACY kimia farma talangsari药房患者对药学服务的满意度

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2021-08-12 DOI: 10.53864/jifakfar.v4i1.47

R. Agustina, Amaliyah Nurul Hidayah

{"title":"LEVEL OF PATIENT SATISFACTION TOWARDS PHARMACY SERVICES IN KIMIA FARMA TALANGSARI PHARMACY","authors":"R. Agustina, Amaliyah Nurul Hidayah","doi":"10.53864/jifakfar.v4i1.47","DOIUrl":"https://doi.org/10.53864/jifakfar.v4i1.47","url":null,"abstract":"Pharmacy is one of the health service place that has product and service activities that are highly dependent on patient satisfaction. Patient satisfaction can be used as a benchmark for companies to develop their business in the future. The purpose of this study was to determine the level of patient satisfaction with pharmaceutical services at Kimia Farma Pharmacy Talangsari Jember. The type of this research was qualitative descriptive using cross sectional study. The population were patients who came to buy prescription or non-prescription drugs at the Kimia Farma Pharmacy Talangsari Jember in June 2020 with a total samples of 100 patients. The result showed that patient satisfaction to the services at Kimia Farma Pharmacy Talangsari Jember were quiet satisfied in reliability dimensions (60%) and tangible dimensions (55%) also in responsiveness dimensions (48%) and less satisfied in empathy dimensions (54%) and assurance dimensions (41%). It can be concluded that the level of patient satisfaction with pharmaceutical services at Kimia Farma Pharmacy Talangsari Jember were Keywords: level of satisfaction, quality of service","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75802381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AKTIVITAS ANTIINFLAMASI FRAKSI ETANOL DAUN GEDI (Abelmoschus manihot L. Medik) PADA TIKUS PUTIH GALUR WISTAR 白老鼠的茎

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2021-01-28 DOI: 10.53864/jifakfar.v2i2.141

Agnis Pondinekaria Aditama

{"title":"AKTIVITAS ANTIINFLAMASI FRAKSI ETANOL DAUN GEDI (Abelmoschus manihot L. Medik) PADA TIKUS PUTIH GALUR WISTAR","authors":"Agnis Pondinekaria Aditama","doi":"10.53864/jifakfar.v2i2.141","DOIUrl":"https://doi.org/10.53864/jifakfar.v2i2.141","url":null,"abstract":"Gedi leaves (Abelmoschus manihot L. Medik) has been used empirically by the people of North Sulawesi to cure the disease. Flavonoids and steroids in Gedi leaves suspected to have anti-inflammatory effects. This Study aims to examine the anti-inflammatory effects of ethanol fraction from Gedi leaves (Abelmoschus manihot L. Medik) on edema of white males wistar foot induced with 1 % caragen, and to determine an effective dose of fraction to decrease the edema volume of Rat foot. The test was done using Rat Hind Paw Edeme or esthablished an artificial inflammation in left foot of white male rats. The treatments were carried out on five groups, the positive control group was administered with diclofenac sodium, the negative control group was administered with CMC Na 0,5 % solution, and the fraction groups were administered with 12 mg/Kg BB, 27 mg/Kg BB, 54 mg/Kg BB. Edema volume were measured every hour for 5 hours using a pletismometer. The average of edema volume (mL) and time (hour) were used to calculate the percentage of anti-inflammatory on each group compared to the negative control group. Obtained data were analyzed by one-way ANOVA followed by LSD test with confident level was 0,05. The result of this study indicate that gedi leaves can reduce edema volume of rat foot that induced with 1 % caragen and anti-inflammatory activity showed in ethanol fraction from Gedi leaves 12 mg/Kg BB by 55,2 %, 27 mg/Kg BB by 64,4% and 54 mg/Kg BB by 62,2%.","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"212 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76211492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PENGARUH VARIASI KONSENTRASI AMILUM Zea mays (L) SEBAGAI BAHAN PENGHANCUR SECARA GRANULASI BASAH TERHADAP SIFAT FISIK TABLET PARASETAMOL 正因为如此，淀粉样酶(L)的浓度变化对糖丸的生理特性产生了湿芽孢杆菌(芽孢杆菌)的影响

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2021-01-28 DOI: 10.53864/jifakfar.v2i1.15

Dewi rashati, Amirul Fauziah

{"title":"PENGARUH VARIASI KONSENTRASI AMILUM Zea mays (L) SEBAGAI BAHAN PENGHANCUR SECARA GRANULASI BASAH TERHADAP SIFAT FISIK TABLET PARASETAMOL","authors":"Dewi rashati, Amirul Fauziah","doi":"10.53864/jifakfar.v2i1.15","DOIUrl":"https://doi.org/10.53864/jifakfar.v2i1.15","url":null,"abstract":"This research is aims to determine the effect of variation concentration starch Zea mays (L) as disintegration agent in wet granulation to physical characteristics paracetamo. This research used eperimental method by one shot case study. Paracetamol as active ingredient, starch zea mays (L)as desintegrant agent, PVPK30 as binding agent, avicel as filler and Mg stearat as lubricants. The result of SPSS showed significant (p0,05), that means no difference in the three formulation. The first test is weight uniformity show that from column A and B qualify weight requirement range, hardness test. Showed significant (p0,05) that means nodifference in the three formulation. Friability test showed significant (p 0,05) the last is disintegration time test showed that significant (P0,05) no difference in the three formulation. The research of physic characteristic of the tablet showed that hardness test and time test not qualif. Analysis SPSS showed (p0,05) no difference in the three formulation and amilum had no effect on physical test of paracetamol tablet.Keywords: zea mays (L),paracetamol,physicial characteristic","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82717702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TINGKAT KEPUASAN APOTEK DI WILAYAH LUMAJANG TERHADAP DISTRIBUSI OBAT OLEH PEDAGANG BESAR FARMASI LUMAJANG地区的药房满意度是由大型制药商人分销的

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2021-01-28 DOI: 10.53864/jifakfar.v2i1.17

Kukuh Judy Handojo,Pradanu Satria Rakhmanta,Diyan Ajeng R

{"title":"TINGKAT KEPUASAN APOTEK DI WILAYAH LUMAJANG TERHADAP DISTRIBUSI OBAT OLEH PEDAGANG BESAR FARMASI","authors":"Kukuh Judy Handojo,Pradanu Satria Rakhmanta,Diyan Ajeng R","doi":"10.53864/jifakfar.v2i1.17","DOIUrl":"https://doi.org/10.53864/jifakfar.v2i1.17","url":null,"abstract":"PBF services in Lumajang region need to improve the quality of service, includingdelivery time often exceeds the time that had been promised, complaints regarding medication errors and difficulty getting accountability, the price has changed in a short time, and the service was not constant. The purpose of this study was to determine the level of drug store Lumajang region against drug distribution by PBF in tangible dimension (direct evidence), reliablity (reliability), responsivines (responsiveness),assurance (assurance), empathy (caring). Samples were selected in this research is all drug store in Lumajang totaling 30 pharmacies. The research design in this study is descriptive by using survey method.Based on the data collection process,there were only 30 drug store that are willing to be respondenden has qualified for data processing and it can be concluded that the level of satisfaction Pharmacy Lumajang region on tangible dimension (direct evidence) of 86.24%, expressed satisfaction,reliability dimension (reliability) by 80%, otherwise satisfactory, dimensions responsiviness (responsiveness) of 75.84%, expressed quite satisfactory, dimensions assurance (guarantee) amounting to 86.11%, declared satisfactory, the dimensions of empathy (caring) amounted to 86.94%, otherwise satisfactory. Based on the above data,it needs to be evaluated in five dimensions, from the evaluation it would appear that satisfaction level of drug store in Lumajang to PBF service (drug distribution)reach 83,02% and including the satisfactory category .Keywords: Level of satisfaction - Drugs distribution – PBF","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74009265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

POTENSI STREPTOMYCES ENDOFIT RIMPANG KENCUR DAN DAUN SIRIH MERAH SEBAGAI ANTITUBERKULOSIS PADA MYCOBACTERIUM TUBERCULOSIS GALUR SENSITIF

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2021-01-28 DOI: 10.53864/jifakfar.v3i1.38

Siti Nur Azizah, Mikhania Cristiningtyas Eryani

{"title":"POTENSI STREPTOMYCES ENDOFIT RIMPANG KENCUR DAN DAUN SIRIH MERAH SEBAGAI ANTITUBERKULOSIS PADA MYCOBACTERIUM TUBERCULOSIS GALUR SENSITIF","authors":"Siti Nur Azizah, Mikhania Cristiningtyas Eryani","doi":"10.53864/jifakfar.v3i1.38","DOIUrl":"https://doi.org/10.53864/jifakfar.v3i1.38","url":null,"abstract":"The objective of this research was to obtain Endophitic Streptomyces from some medical plants which have antituberculosis effect and also to test its antitubercullosis activity againts sensitive stain of Mycobacterium tuberculosis. Medicinal plants used in this study were Kaemferia galanga, Hibiscus sabdariffa and Piper cronatum. Streptomyces was isolated using two different media namely Humic Acid Vitamin (HV) agar and HV with plant extract, and purified on Yeast Malt Agar (YMA) medium. Morphological characterization of Streptomyces obtained was observed including aerial mycelium and substrate mycelium, pigmentation, and colony surface. A total of 5 endophitic Streptomyces genus were obtained from medicinal plant. Isolates K.J3A, K.J3B, K.J4 and K.J11 from Kaemferia galanga radix, S.MJ1 from Piper cronatum folium. Streptomyces was not found from Hibiscus sabdariffa calyx. Each isolate had variety of characteristics which could be seen in aerial mass color, substrate mass color, and pigmentation. Antitubercullosis activity showed that total of 5 endophitic Streptomyces were not capable to inhibit the growth sensitive stain of M. tubercullosis.Keywods: Antituberculosis, endophitic actinomycetes, Kaemferia galanga, Hibiscus sabdariffa","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84308666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

PENENTUAN AKTIVITAS ANTIOKSIDAN DAN KADAR FENOL TOTAL PADA EKSTRAK KULIT BUAH PISANG (Musa acuminata Colla) 确定香蕉果实提取物的抗氧化剂活性和苯酚总浓度(摩西acuminata Colla)

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2021-01-28 DOI: 10.53864/jifakfar.v2i1.20

Rosida, Diyan Ajeng RA

{"title":"PENENTUAN AKTIVITAS ANTIOKSIDAN DAN KADAR FENOL TOTAL PADA EKSTRAK KULIT BUAH PISANG (Musa acuminata Colla)","authors":"Rosida, Diyan Ajeng RA","doi":"10.53864/jifakfar.v2i1.20","DOIUrl":"https://doi.org/10.53864/jifakfar.v2i1.20","url":null,"abstract":"Antioksidan merupakan senyawa yang mampu menghambat oksidasi molekul lain. Tubuh tidak mempunyai sistem pertahanan antioksidatif yang berlebihan, sehingga tubuh membutuhkan antioksidan eksogen. Kekhawatiran terhadap efek samping antioksidan sintetik menjadikan antioksidan alami menjadi alternatif yang dipilih. Flavonoid merupakan senyawa fenolat (hidroksil fenolik) yang mampu bertindak sebagai antioksidan dan umumnya terdapat pada tanaman. Salah satu limbah tanaman yang mempunyai kandungan flavonoid adalah kulit buah pisang (Musa acuminata). Tujuan dari penelitian ini adalah untuk menetapkan kadar flavonoid total dan melakukan pengujian aktivitas antioksidan kulit buah pisang menggunakan diphenyl picryl hydrazil hydrate (DPPH) sebagai radikal bebas. Metode ekstraksi yang digunakan adalah remaserasi dengan pelarut etanol 96%. Penetapan kadar flavonoid total menggunakan katekin sebagai standar dan pengujian DPPH menggunakan metode spetrofotometri. Hasil penelitian menunjukkan kandungan flavonoid total ekstrak etanol kulit buah pisang sebesar 0,79 ± 0,03 %b/b, aktivitas antioksidan tertinggi dalam IC50 terhadap DPPH sebesar 70,41 mg/L.Kata Kunci : kulit buah pisang, flavonoid total, aktivitas antioksidan, IC50","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91536614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

PENGARUH VARIASI KONSENTRASI MINYAK ZAITUN (OLIVE OIL) TERHADAP KELEMBUTAN SABUN CAIR 橄榄油油浓度的变化对液体肥皂的温和影响

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2021-01-28 DOI: 10.53864/jifakfar.v1i2.12

Mikhania Christiningtyas Eryani, Dewi Rashati

{"title":"PENGARUH VARIASI KONSENTRASI MINYAK ZAITUN (OLIVE OIL) TERHADAP KELEMBUTAN SABUN CAIR","authors":"Mikhania Christiningtyas Eryani, Dewi Rashati","doi":"10.53864/jifakfar.v1i2.12","DOIUrl":"https://doi.org/10.53864/jifakfar.v1i2.12","url":null,"abstract":"Zaitun tree (Olea europaea) comes from the Middle East and widely grown in Asia. The fruit and oil extraction widely used as food and medicine. The oil derived from olives is known as olive oil. Olive oil can be used for skin emolient. The aims of this study was to determine olive oil variation concentration to liquid soap softness. The soap was made with varying olive oil concentration (20% known as F1, 30% known as F2 and 40% known as F3). True experimental design with The Posttest Only Experiment was used as the study design. Evaluation of the soap including organoleptic test, pH, spesific gravity, free alkali assay, and responden emolient test. Responden emolient test was taken from 20 responden who has given questioner. The data from emolient test study was calculate by Kruskal Wallis test. The organoleptic test result showed that all formula showed liquid green, homogen, and jasmine odor. pH from F1, F2 and F3 were 10,39; 9,75 dan 9,34 respectively. The spesicic gravity from F1, F2 and F3 were 1,648%; 1,441% dan 0,863 % respectively. The free alkali from F1, F2 and F3 were 0,032%; 0,08% dan 0,064% respectively. The responden emolient test showed that F1 was soft, F2 was midle soft and F3 was very soft.Keywords: oilive oil, soap, softness","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84759086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KARAKTERISASI SENYAWA ANALGETIKA-ANTIINFLAMASI N-(4t-BUTILBENZOIL)-p-AMINOFENOL YANG DISINTISES DENGAN KATALIS ASAM 镇痛剂的特性

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2021-01-28 DOI: 10.53864/jifakfar.v2i2.27

Hadi Barru Hakam Fajar Siddiq, Dewi Rashati, Farida Suryaningsih

{"title":"KARAKTERISASI SENYAWA ANALGETIKA-ANTIINFLAMASI N-(4t-BUTILBENZOIL)-p-AMINOFENOL YANG DISINTISES DENGAN KATALIS ASAM","authors":"Hadi Barru Hakam Fajar Siddiq, Dewi Rashati, Farida Suryaningsih","doi":"10.53864/jifakfar.v2i2.27","DOIUrl":"https://doi.org/10.53864/jifakfar.v2i2.27","url":null,"abstract":"The N-(4t-Butylbenzoyl)-p-Aminophenol compound was a synthesis compound between p-aminophenol and 4t-Butylbenzoyl chloride by using H2SO4 catalyst. The addition of H2SO4 catalyst purposed to accelerate the rate of rection in the synthesis of the compound and increased yield of product. The N-(4t-Butylbenzoil)-p-Aminophenol compound is beneficial as an antiinflammatory analgesic. This research were proposed to determine characteristics of the anti-inflammatory analgesic synthesis of N-(4t-Butylbenzoyl)-p-Aminophenol compound by using H2SO4 catalyst. Characterization conducted in this research were physical and chemical characterization. The physical characterization were organoleptic test, crystal form test and melting point test. While chemical characterization were UV-Vis spectrophotometry and FTIR. Result of organoleptic test showed sample had powder form, white-gray colour and not taste. Melting point of N-(4t-Butylbenzoyl)-p-Aminophenol compound was 193.33 °C. The optimum wavelength of UV-Vis spectrophotometry got 2 peaks at the wavelengths 290 and 295 nm. The result of FTIR showed that N-(4t-Butylbenzoyl)-p-Aminophenol compound had peaks.Keywords: N-(4t-butyl benzoil)-p-aminophenol, catalyst","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89642168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PENGARUH VARIASI KONSENTRASI HPMC TERHADAP MUTU FISIK DAN STABILITAS SEDIAAN SHAMPO EKSTRAK ETANOL DAUN KATUK (Sauropus androgynus (L) Merr) HPMC浓度变化对乙醇提取物(Sauropus androgynus提取物(L) Merr)的物理质量和稳定性的影响

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2021-01-28 DOI: 10.53864/jifakfar.v1i2.9

Dewi Rashati, Mikhania Christiningtyas Eryani

引用次数: 0

OPTIMASI HIDROLISIS MEDIA PRODUKSI CANGKANG UDANG MENGGUNAKAN KITINASE SERRATIA MARCESCENS KAHN.15.12 TERHADAP KADAR N-ASETIL GLUKOSAMIN SEBAGAI BAHAN SEDIAAN 虾壳制造中水力学优化利用KITINASE SERRATIA MARCESCENS MARCESCENS KAHN.15.12对葡萄糖乙炔溶液的n -乙酰素水平进行鉴别

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2021-01-28 DOI: 10.53864/jifakfar.v2i2.28

Siti Nur Azizah, Rosida

{"title":"OPTIMASI HIDROLISIS MEDIA PRODUKSI CANGKANG UDANG MENGGUNAKAN KITINASE SERRATIA MARCESCENS KAHN.15.12 TERHADAP KADAR N-ASETIL GLUKOSAMIN SEBAGAI BAHAN SEDIAAN","authors":"Siti Nur Azizah, Rosida","doi":"10.53864/jifakfar.v2i2.28","DOIUrl":"https://doi.org/10.53864/jifakfar.v2i2.28","url":null,"abstract":"Limbah cangkang udang mengandung kitin yang tinggi yaitu sekitar 17-40%. Kitin tersebut dapat digunakan sebagai substat pertumbuhan bakteri kitinolitik yaitu S.marcescens KAHN 15.12. Bakteri tersebut akan mensekresikan enzim kitinase untuk mendegradasi kitin sebagai media pertumbuhannya hingga menghasilkan monomer N-asetil glukosamin (GlcNac). N-asetil glukosamin dapat dimanfaatkan sebagai bahan sediaan suplemen osteoartritis. Penelitian ini bertujuan untuk memproduksi GlcNac hasil hidrolisis kitin cangkang udang menggunakan kitinase Serratia marcescens KAHN.15.12. Hasil konfirmasi aktivitas kitinolitik menggunakan media selektif yaitu agar koloidal kitin 0,3% menunjukkan bahwa Serratia marcescens KAHN 15.12 memiliki index kitinolitik sebesar 2,3 yang ditunjukkan dengan adanya zona bening disekitar koloni. Hasil optimasi perbedaan konsentrasi media produksi menunjukkan bahwa tepung cangkang udang 2% menghasilkan kadar GlcNac tertinggi yaitu sebesar 376,35 μg/ml setelah diuji dengan metode kolorimetri menggunakan reagen shcales pada panjang gelombang 420nm. Berdasarkan hasil tersebut menunjukkan bahwa setiap hidrolisis 1 gram tepung cangkang udang yang mengandung 18,7% kitin akan menghasilkan sebesar 70,54 mg GlcNAc.Kata Kunci: N-asetil glukosamin, kitinase, Serratia marcescens","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75794618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0