PENGARUH VARIASI KONSENTRASI AMILUM Zea mays (L) SEBAGAI BAHAN PENGHANCUR SECARA GRANULASI BASAH TERHADAP SIFAT FISIK TABLET PARASETAMOL

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2021-01-28 DOI:10.53864/jifakfar.v2i1.15

Dewi rashati, Amirul Fauziah

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Abstract

This research is aims to determine the effect of variation concentration starch Zea mays (L) as disintegration agent in wet granulation to physical characteristics paracetamo. This research used eperimental method by one shot case study. Paracetamol as active ingredient, starch zea mays (L)as desintegrant agent, PVPK30 as binding agent, avicel as filler and Mg stearat as lubricants. The result of SPSS showed significant (p0,05), that means no difference in the three formulation. The first test is weight uniformity show that from column A and B qualify weight requirement range, hardness test. Showed significant (p0,05) that means nodifference in the three formulation. Friability test showed significant (p 0,05) the last is disintegration time test showed that significant (P0,05) no difference in the three formulation. The research of physic characteristic of the tablet showed that hardness test and time test not qualif. Analysis SPSS showed (p0,05) no difference in the three formulation and amilum had no effect on physical test of paracetamol tablet.Keywords: zea mays (L),paracetamol,physicial characteristic

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正因为如此，淀粉样酶(L)的浓度变化对糖丸的生理特性产生了湿芽孢杆菌(芽孢杆菌)的影响

本研究旨在确定湿造粒中不同浓度玉米淀粉(L)作为崩解剂对扑热息痛物理特性的影响。本研究采用单次个案研究的实验方法。对乙酰氨基酚为活性成分，玉米淀粉(L)为崩解剂，PVPK30为结合剂，avicel为填充剂，硬脂酸Mg为润滑剂。SPSS统计分析结果显示显著性(p0,05)，即三种配方无差异。首先测试重量均匀性，表明从A列和B列均符合重量要求范围，进行硬度测试。三种剂型差异无统计学意义(p0,05)。最后是崩解时间试验，三种配方间差异无统计学意义(p < 0.05)。对其物理特性的研究表明，硬度试验和时间试验均不合格。SPSS分析结果显示，三种剂型间差异无统计学意义(p0,05)，对扑热息痛片理化指标无影响。关键词:玉米多糖;扑热息痛;物理特性

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JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER

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