JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER最新文献_第4页

POTENSI EKSTRAK KENCUR (Kaemferia galanga L.) SEBAGAI IMUNOMODULATOR PADA TIKUS MODEL YANG TERINFEKSI Mycobacterium tuberculosis

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2022-12-20 DOI: 10.53864/jifakfar.v3i1.155

Rosida Hari, Kukuh Judy Handojo

{"title":"POTENSI EKSTRAK KENCUR (Kaemferia galanga L.) SEBAGAI IMUNOMODULATOR PADA TIKUS MODEL YANG TERINFEKSI Mycobacterium tuberculosis","authors":"Rosida Hari, Kukuh Judy Handojo","doi":"10.53864/jifakfar.v3i1.155","DOIUrl":"https://doi.org/10.53864/jifakfar.v3i1.155","url":null,"abstract":"Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Tuberculosis can infect anyone in the patient's environment. Someone with good body immunity conditions will avoid tuberculosis. Increased immunity for tuberculosis sufferers is very important. The active substances contained in plants such as flavonoids and essential oils are important components in supporting the body's immunity. One plant that contains flavonoids and essential oils is kencur (Kaemferia galanga L.). This study aims to prove the potential of kencur extract as an immunomodulator in model rat infected with Mycobacterium tuberculosis. This study was a laboratory experiment using the kencur extract (EK) and samples of rats as a model. The sample used was 30 animals which were divided into 6 groups. Group 1 was a healthy animal (Normal). Groups 2, 3, 4 and 5 were treatment groups consisting of sick animals given placebo treatment (control), rifampicin (R), EK (Kencur Extract) and CRK (Mixture of Rifampicin and Kencur). Group 6 was a normal group given EK then infected with Mycobacterium tuberculosis (NK). Modeling was done by infecting experimental animals using Mycobacterium tuberculosis. The infection was 30 days and the treatment was 21 days. The parameters in this study were leukocytes and Laju Endap Darah (LED). The results of the kencur extract phytochemical screening study showed the presence of flavonoids. The results of the treatment showed that differences in the number of Leukocytes and LEDs between the control group and the treatment (sig <0.05). These results indicate that kencur extract has the potential as an immunomodulator.","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81729841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BIOENKAPSULASI YOGHURT Lactobacillus acidophillus SEBAGAI ANTIHIPERKOLESTROLEMIA

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2022-12-20 DOI: 10.53864/jifakfar.v2i1.146

Y. A. Prasetya, K. Nisyak

{"title":"BIOENKAPSULASI YOGHURT Lactobacillus acidophillus SEBAGAI ANTIHIPERKOLESTROLEMIA","authors":"Y. A. Prasetya, K. Nisyak","doi":"10.53864/jifakfar.v2i1.146","DOIUrl":"https://doi.org/10.53864/jifakfar.v2i1.146","url":null,"abstract":"Lactobacillus acidophillus dalam bentuk yoghurt mempunyai efek penurunan terhadap hiperkolesterolemia namun dapat mengalami stress akibat asam lambung. Teknik bioenkapsulasi mampu meningkatkan viabilitas dan perlindungan terhadap bakteri asam laktat tersebut. Penelitian ini bertujuan untuk mengetahui bahan bioenkapsulasi L. acidophillus dari Whey Protein Isolate (WPI), kasein, gum arab, dan amilum yang terbaik viabilitasnya terhadap asam lambung dan mengetahui dosis bioenkapsulasi yoghurt (single, double atau triple dose) yang efektif sebagai terapi antihiperkolesterolemia. Viabilitas bioenkapsulasi yoghurt terhadap asam lambung dilakukan secara in vitro dengan teknik Total Plate Count (TPC) kemudian diujikan aktivitas antihiperkolesterolemia secara in vivo terhadap tikus putih galur wistar. Hasil menunjukkan bahwa bahan dari amilum menunjukkan hasil yang terbaik dalam peningkatan viabilitas sebelum dan sesudah diberi perlakuan asam lambung yakni dari 3.0 x106 CFU/g menjadi 2.1 x 108 CFU/g. Dosis yang efektif sebagai antihiperkolesterolemia pada tikus putih wistar yakni single dose dengan nilai rataan kadar Low Density Lipoprotein (LDL) sebesar 15mg.dL-1.","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90470611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PENGARUH VARIASI KONSENTRASI GELLING AGENT HPMC (Hidroxypropyl methylcellulose) TERHADAP SIFAT FISIK GEL EKSTRAK ETANOL BIJI EDAMAME (Glycine max)

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2022-12-20 DOI: 10.53864/jifakfar.v3i2.150

Dewi - Rashati, Icha Ayuning Suprayitno

{"title":"PENGARUH VARIASI KONSENTRASI GELLING AGENT HPMC (Hidroxypropyl methylcellulose) TERHADAP SIFAT FISIK GEL EKSTRAK ETANOL BIJI EDAMAME (Glycine max)","authors":"Dewi - Rashati, Icha Ayuning Suprayitno","doi":"10.53864/jifakfar.v3i2.150","DOIUrl":"https://doi.org/10.53864/jifakfar.v3i2.150","url":null,"abstract":"Edamame seeds (glycine max (L) merr) is a soybean variety that is harvested while still young. Isoflavones present in soybeans such as deidzein, glycitein, and genistein have activity in inhibiting the tyrosinase enzyme to achieve skin lightening effects for skin whitening cosmetics. In this study the gel was formulated with HPMC (Hydroxypropyl methylcellulose) 2%, 3%, 5% as a gel forming agent. Evaluation includes organoleptic, homogeneity, pH, viscosity, and spreadability. The results of organoleptic evaluation of gel form in formula 1 fulfill the requirements, in formula 2 and 3 do not meet the requirements. The physical properties of the odor and color organoleptic formulas 1, 2, and 3 are eligible. in the homogeneity test of formulas 1, 2, and 3 are homogen. In the pH test formula 1,2,3 fulfills skin pH susceptibility pH 6. In the viscosity test of formula 1 250 dPa.S, Formula 2 500 dPa.S and formula 3 800 dPa.S.in the spread test of formula 1 it is 4.4cm, formula 2 is 3.8cm, and formula 3 is 3.7cm. From the results test of the Formula 1 (2% HPMC) meets all physical requirements of the gels.","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84523186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UJI AKTIVITAS EKSTRAK LABU AIR (Lagenaria siceria) TERHADAP LUKA BAKAR TIKUS JANTAN GALUR WISTAR 对雄性树懒烧伤进行抽样检测

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2022-12-20 DOI: 10.53864/jifakfar.v2i2.140

Holdin Eka Prilia, Rosida Hari

引用次数: 0

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL BIJI EDAMAME (Glycin max (L) Merril) DENGAN METODE DPPH 用DPPH方法测试EDAMAME种子(max Glycin)的抗氧化活性和提取物

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2022-12-20 DOI: 10.53864/jifakfar.v1i1.128

Hadi Barru Hakam Fajar Siddiq, Rosida Hari, Erika Fauziah Prabawati

引用次数: 2

PENGARUH VARIASI KONSENTRASI AMILUM Zea mays (L) SEBAGAI BAHAN PENGHANCUR SECARA GRANULASI BASAH TERHADAP SIFAT FISIK TABLET PARASETAMOL 正因为如此，淀粉样酶(L)的浓度变化对糖丸的生理特性产生了湿芽孢杆菌(芽孢杆菌)的影响

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2022-12-20 DOI: 10.53864/jifakfar.v2i1.142

Dewi Rashati, Amirul Fauziah

引用次数: 0

TINGKAT KEPUASAN APOTEK DI WILAYAH LUMAJANG TERHADAP DISTRIBUSI OBAT OLEH PEDAGANG BESAR FARMASI LUMAJANG地区的药房满意度是由大型制药商人分销的

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2022-12-20 DOI: 10.53864/jifakfar.v2i1.144

Kukuh Judy Handojo, Pradanu Satria Rakhmanta, Diyan Ajeng R.

{"title":"TINGKAT KEPUASAN APOTEK DI WILAYAH LUMAJANG TERHADAP DISTRIBUSI OBAT OLEH PEDAGANG BESAR FARMASI","authors":"Kukuh Judy Handojo, Pradanu Satria Rakhmanta, Diyan Ajeng R.","doi":"10.53864/jifakfar.v2i1.144","DOIUrl":"https://doi.org/10.53864/jifakfar.v2i1.144","url":null,"abstract":"PBF services in Lumajang region need to improve the quality of service, includingdelivery time often exceeds the time that had been promised, complaints regarding medication errors and difficulty getting accountability, the price has changed in a short time, and the service was not constant. The purpose of this study was to determine the level of drug store Lumajang region against drug distribution by PBF in tangible dimension (direct evidence), reliablity (reliability), responsivines (responsiveness),assurance (assurance), empathy (caring). Samples were selected in this research is all drug store in Lumajang totaling 30 pharmacies. The research design in this study is descriptive by using survey method.Based on the data collection process,there were only 30 drug store that are willing to be respondenden has qualified for data processing and it can be concluded that the level of satisfaction Pharmacy Lumajang region on tangible dimension (direct evidence) of 86.24%, expressed satisfaction,reliability dimension (reliability) by 80%, otherwise satisfactory, dimensions responsiviness (responsiveness) of 75.84%, expressed quite satisfactory, dimensions assurance (guarantee) amounting to 86.11%, declared satisfactory, the dimensions of empathy (caring) amounted to 86.94%, otherwise satisfactory. Based on the above data,it needs to be evaluated in five dimensions, from the evaluation it would appear that satisfaction level of drug store in Lumajang to PBF service (drug distribution)reach 83,02% and including the satisfactory category .","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81660852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UJI FISIK FORMULASI TABLET FLOATING TEOFILIN DENGAN MATRIK HPMC 用HPMC MATRIK板材配方的物理试验

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2022-12-20 DOI: 10.53864/jifakfar.v1i1.130

Dewi Rashati, Siti Mursidatur Rohmah

引用次数: 1

OPTIMASI HIDROLISIS MEDIA PRODUKSI CANGKANG UDANG MENGGUNAKAN KITINASE SERRATIA MARCESCENS KAHN.15.12 TERHADAP KADAR N-ASETIL GLUKOSAMIN SEBAGAI BAHAN SEDIAAN 虾壳制造中水力学优化利用KITINASE SERRATIA MARCESCENS MARCESCENS KAHN.15.12对葡萄糖乙炔溶液的n -乙酰素水平进行鉴别

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2022-12-20 DOI: 10.53864/jifakfar.v2i2.139

S. Azizah

{"title":"OPTIMASI HIDROLISIS MEDIA PRODUKSI CANGKANG UDANG MENGGUNAKAN KITINASE SERRATIA MARCESCENS KAHN.15.12 TERHADAP KADAR N-ASETIL GLUKOSAMIN SEBAGAI BAHAN SEDIAAN","authors":"S. Azizah","doi":"10.53864/jifakfar.v2i2.139","DOIUrl":"https://doi.org/10.53864/jifakfar.v2i2.139","url":null,"abstract":"Limbah cangkang udang mengandung kitin yang tinggi yaitu sekitar 17-40%. Kitin tersebut dapat digunakan sebagai substat pertumbuhan bakteri kitinolitik yaitu S.marcescens KAHN 15.12. Bakteri tersebut akan mensekresikan enzim kitinase untuk mendegradasi kitin sebagai media pertumbuhannya hingga menghasilkan monomer N-asetil glukosamin (GlcNac). N-asetil glukosamin dapat dimanfaatkan sebagai bahan sediaan suplemen osteoartritis. Penelitian ini bertujuan untuk memproduksi GlcNac hasil hidrolisis kitin cangkang udang menggunakan kitinase Serratia marcescens KAHN.15.12. Hasil konfirmasi aktivitas kitinolitik menggunakan media selektif yaitu agar koloidal kitin 0,3% menunjukkan bahwa Serratia marcescens KAHN 15.12 memiliki index kitinolitik sebesar 2,3 yang ditunjukkan dengan adanya zona bening disekitar koloni. Hasil optimasi perbedaan konsentrasi media produksi menunjukkan bahwa tepung cangkang udang 2% menghasilkan kadar GlcNac tertinggi yaitu sebesar 376,35 μg/ml setelah diuji dengan metode kolorimetri menggunakan reagen shcales pada panjang gelombang 420nm. Berdasarkan hasil tersebut menunjukkan bahwa setiap hidrolisis 1 gram tepung cangkang udang yang mengandung 18,7% kitin akan menghasilkan sebesar 70,54 mg GlcNAc.","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81118595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PERBANDINGAN SIFAT FISIK TABLET SALUT CIPROFLOXACIN 500 MG MEREK GENERIK DAN MEREK DAGANG CIPROFLOXACIN的生理性质比较超过500毫克的通用品牌和商标

JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Pub Date : 2022-12-20 DOI: 10.53864/jifakfar.v1i1.131

Mikhania C.E., Dewi Rashati, Dadang Putra Mardigantara

引用次数: 0