Journal of Virus Eradication最新文献

{"title":"Existing knowledge, myths, and perceptions about hepatitis B and liver cancer within highly impacted immigrant communities","authors":"Thomas Chen ,&nbsp;Fiona Borondy-Jenkins ,&nbsp;Beatrice Zovich ,&nbsp;Suzanne J. Block ,&nbsp;Kate Moraras ,&nbsp;Alice Chan ,&nbsp;Chari Cohen","doi":"10.1016/j.jve.2024.100379","DOIUrl":"10.1016/j.jve.2024.100379","url":null,"abstract":"<div><h3>Background</h3><p>Immigrant groups from Southeast Asia, the Pacific Islands, sub-Saharan Africa, and the Caribbean bear the heaviest burden of chronic hepatitis B and primary liver cancer in the United States. Educational campaigns to increase knowledge about these diseases and their connection are necessary to promote protective health behaviors within these communities, to ultimately reduce the burden of disease, lessen stigma, and eliminate health disparities.</p></div><div><h3>Objectives</h3><p>This project sought to engage groups within highly impacted communities to identify existing gaps in hepatitis B- and liver cancer-related knowledge, in order to inform future health education programming that will aim to reduce stigma and promote liver cancer prevention and early detection behaviors within and across groups.</p></div><div><h3>Methods</h3><p>Fifteen focus groups and two key informant interviews were conducted virtually with participants from Micronesian, Chinese, Hmong, Nigerian, Ghanaian, Vietnamese, Korean, Somali, Ethiopian, Filipino, Haitian, and Francophone West African communities. Qualitative data were analyzed using thematic coding.</p></div><div><h3>Results</h3><p>There are large gaps in knowledge and awareness of hepatitis B and liver cancer, and the link between these two diseases among Asian, Pacific Islander, African and Haitian immigrant communities. This limited knowledge and misinformation, exacerbated by stigma, hinder these groups’ utilization of hepatitis B and liver cancer diagnostic and preventative healthcare services.</p></div><div><h3>Conclusion</h3><p>To reduce hepatitis B and liver cancer health disparities within heavily burdened groups, health education needs to be community-informed, culturally sensitive, and actionable. Study results can guide the development of culturally and linguistically appropriate education programs that focus on the link between hepatitis B and liver cancer and the need for vaccination and routine screening, and that are responsive to the knowledge gaps and misperceptions of diverse communities. The results also provide valuable insights for healthcare providers to improve the knowledge gaps of the diverse patient populations that they serve.</p></div>","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 2","pages":"Article 100379"},"PeriodicalIF":5.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2055664024000165/pdfft?md5=525262a5fb77f8b09d53ccb5a056abc2&pid=1-s2.0-S2055664024000165-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141396340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conference Report – Recommendations from the Forum for Collaborative Research Symposium on hepatitis B elimination and universal hepatitis B adult vaccination in the United States","authors":"Mitchell Leus ,&nbsp;Mayland Treat ,&nbsp;Veronica Miller ,&nbsp;Arthur Reingold","doi":"10.1016/j.jve.2024.100376","DOIUrl":"10.1016/j.jve.2024.100376","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 2","pages":"Article 100376"},"PeriodicalIF":5.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S205566402400013X/pdfft?md5=f9440ca44e18454f8ab1ff2dfb787814&pid=1-s2.0-S205566402400013X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141130262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial JVE 10.2","authors":"","doi":"10.1016/j.jve.2024.100383","DOIUrl":"https://doi.org/10.1016/j.jve.2024.100383","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 2","pages":"Article 100383"},"PeriodicalIF":3.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2055664024000207/pdfft?md5=abd6da2ebeb48b8c133f224acdabe6f4&pid=1-s2.0-S2055664024000207-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141481380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccination against COVID-19 among healthcare workers as a cocoon strategy for people living with HIV","authors":"Agata Skrzat-Klapaczyńska ,&nbsp;Justyna Kowalska ,&nbsp;Filip Fijołek ,&nbsp;Marcin Paciorek ,&nbsp;Carlo Bieńkowski ,&nbsp;Dominika Krogulec ,&nbsp;Andrzej Horban","doi":"10.1016/j.jve.2024.100377","DOIUrl":"10.1016/j.jve.2024.100377","url":null,"abstract":"<div><h3>Introduction</h3><p>Healthcare professionals working in infectious disease units are often engaged in the care of patients with HIV infection. A cocoon vaccination strategy may protect those who are immunocompromised from a severe course of COVID-19.</p></div><div><h3>Methods</h3><p>The research was conducted between January 2021 and June 2022. The study participants were 450 healthcare workers (HCWs) from the Hospital for Infectious Diseases in Warsaw who were vaccinated against COVID-19 with the BNT162b2 mRNA vaccine (Pfizer-BioNTech) –, thefirst available type of vaccine in Poland. Sera were collected according to the schedule of the study. Statistical analyses were performed with non-parametric tests: Wilcoxon's test was used to compare dependent numerical variables, and Fisher's exact test and the Chi-squared test to compare categorical variables. A <em>p</em> value of &lt;0.05 was considered statistically significant.</p></div><div><h3>Results</h3><p>Among the 450 HCWs working in the Hospital for Infectious Diseases in Warsaw 412 (91,5 %) were vaccinated against COVID-19. In total 170 (41,3 %) vaccinated HCWs were included in the final analysis. Their median age was 51 years [interquartile range (IQR): 41–60 years] and median body mass index (BMI) was 25.10 [IQR: 22.68–29.03]. Most of the cohort consisted of women (n = 137, 80.59 %), with the majority working directly with patients (n = 137, 73.21 %). It was found that as early as 14 days after the second dose of the vaccine, 100 % of the study participants achieved a positive result for SARS CoV-2 S-RBD antibodies. There were 168 subjects who had had a COVID-19 diagnosis before entering study and after vaccination 65 HCWs was diagnosed with COVID-19.</p></div><div><h3>Conclusions</h3><p>Due to the fact that people living with HIV with severe immunodeficiency may have an incomplete immune response to COVID vaccination and be at risk of a severe course of the disease, the cocoon strategy of vaccinating medical personnel may be beneficial for these patients.</p></div>","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 2","pages":"Article 100377"},"PeriodicalIF":5.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2055664024000141/pdfft?md5=8d5f3d22dd455405e92483c07be9374d&pid=1-s2.0-S2055664024000141-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141414827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From awareness to action: Unveiling knowledge, attitudes and testing strategies to enhance human papillomavirus vaccination uptake in Jordan","authors":"Ahmad Al-leimon ,&nbsp;Obada Al-leimon ,&nbsp;Bayan Abdulhaq ,&nbsp;Fadi Al-salieby ,&nbsp;Abdul-Raheem Jaber ,&nbsp;Mohammed Saadeh ,&nbsp;Abdel Rahman Jaber ,&nbsp;Omer Aziziye ,&nbsp;Latefa Ali Dardas","doi":"10.1016/j.jve.2024.100380","DOIUrl":"10.1016/j.jve.2024.100380","url":null,"abstract":"<div><h3>Purpose</h3><p>Vaccination against HPV plays a crucial role in preventing cervical cancer and related health issues. This study aimed to (1) assess knowledge, awareness, intentions, and attitudes regarding HPV and vaccination among Jordanian parents, and (2) evaluate the efficacy of two intervention strategies in promoting knowledge, awareness, and attitudes towards HPV vaccinations.</p></div><div><h3>Methods</h3><p>In study one, a web-based survey was used to collect data from Jordanian parents. In study two, participants were allocated into three groups: video-based intervention, lecture-based intervention, and a control group. Pre-post tests were conducted to evaluate the efficacy of the intervention strategies in promoting knowledge, awareness, and attitudes toward HPV vaccination among Jordanian parents.</p></div><div><h3>Results</h3><p>A total of 572 participants took part in the survey. Knowledge levels about HPV and its vaccine were generally low. Intentions regarding HPV vaccination were uncertain for the majority of participants, with 92 % reported as not receiving any guidance from medical professionals about administering the HPV vaccine to themselves or their children. Only 22 % agreed that their children might get infected with HPV at any time in their lives. The pilot randomized clinical trial revealed an improvement in knowledge, awareness, and attitudes towards HPV vaccination in both intervention groups compared to the control group with large effect sizes (eta squared between 0.29 and 0.68).</p></div><div><h3>Conclusions</h3><p>Findings highlight the need for increased knowledge and awareness regarding HPV and vaccination. It also supported the potential effectiveness of basic educational efforts in significantly improving knowledge, awareness, and attitudes towards the HPV vaccine.</p></div>","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 2","pages":"Article 100380"},"PeriodicalIF":3.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2055664024000177/pdfft?md5=48f64338fb12913cad940d60abea6e51&pid=1-s2.0-S2055664024000177-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141397091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of interrupting antiretroviral therapy started during primary HIV-1 infection on plasma neurofilament light chain protein, a marker of neuronal injury: The SPARTAC trial","authors":"Jasmini Alagaratnam ,&nbsp;Wolfgang Stöhr ,&nbsp;Elizabeth Hamlyn ,&nbsp;Kholoud Porter ,&nbsp;Jamie Toombs ,&nbsp;Amanda Heslegrave ,&nbsp;Henrik Zetterberg ,&nbsp;Magnus Gisslén ,&nbsp;Jonathan Underwood ,&nbsp;Mauro Schechter ,&nbsp;Pontiano Kaleebu ,&nbsp;Giuseppe Tambussi ,&nbsp;Sabine Kinloch ,&nbsp;Jose M. Miro ,&nbsp;Anthony D. Kelleher ,&nbsp;Abdel Babiker ,&nbsp;John Frater ,&nbsp;Alan Winston ,&nbsp;Sarah Fidler ,&nbsp;The SPARTAC Trial Investigators","doi":"10.1016/j.jve.2024.100381","DOIUrl":"https://doi.org/10.1016/j.jve.2024.100381","url":null,"abstract":"<div><h3>Objective</h3><p>Antiretroviral therapy (ART)-conferred suppression of HIV replication limits neuronal injury and inflammation. ART interruption tests efficacy in HIV cure trials and viral rebound after ART interruption may induce neuronal injury. We investigated the impact of protocol-defined ART interruption, commenced during primary HIV-1 infection (PHI) on a biomarker of neuro-axonal injury (neurofilament light protein (NfL)), and its associations with inflammation (D-dimer and interleukin-6 (IL-6)) and HIV-1 reservoir size (total HIV-1 DNA).</p></div><div><h3>Design</h3><p>Retrospective study measuring plasma NfL in 83 participants enrolled in SPARTAC randomised to receive 48-weeks ART initiated during PHI, followed by ART interruption.</p></div><div><h3>Methods</h3><p>NfL (Simoa immunoassay, Quanterix™) was measured before ART, after 48 weeks on ART, and 12 weeks after stopping ART. Plasma D-dimer and IL-6, and total HIV-1 DNA in peripheral CD4⁺ T-cells results were available in a subset of participants. Longitudinal NfL changes were assessed using mixed models, and associations with clinical and laboratory parameters using linear regression.</p></div><div><h3>Results</h3><p>NfL decreased following 48-weeks ART (geometric mean 6.9 to 5.8 pg/mL, p = 0.006) with no further significant change up to 12-weeks post-stopping ART despite viral rebound in the majority of participants (median 1.7 to 3.9 plasma HIV-1 RNA log₁₀ copies/mL). Higher baseline NfL was independently associated with higher plasma HIV-1 RNA (p = 0.020) and older age (p = 0.002). While NfL was positively associated with D-dimer (n = 48; p = 0.002), there was no significant association with IL-6 (n = 48) or total HIV-1 DNA (n = 51).</p></div><div><h3>Conclusions</h3><p>Using plasma NfL as a surrogate marker, a decrease in neuro-axonal injury was observed in a cohort of participants following ART initiation during PHI, with no evidence of neuro-axonal injury rebound following ART interruption for up to 12 weeks, despite viral rebound in the majority of participants.</p></div>","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 2","pages":"Article 100381"},"PeriodicalIF":5.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2055664024000189/pdfft?md5=e27b2f871c80de05181d324e7dfff871&pid=1-s2.0-S2055664024000189-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141322408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community dialogue to enhance understanding of beliefs, behaviours and barriers to care for people living with liver disease and HBV infection in KwaZulu Natal, South Africa","authors":"Busangani Ngwenya ,&nbsp;Motswedi Anderson ,&nbsp;Nondumiso Mpanza ,&nbsp;Welcome Mbokazi ,&nbsp;Luthando Zuma ,&nbsp;Thandeka Khoza ,&nbsp;Gloria Sukali ,&nbsp;Elizabeth Waddilove ,&nbsp;Marion Delphin ,&nbsp;Collins Iwuji ,&nbsp;Ngcebo Mhlongo ,&nbsp;Nomathamsanqa Majozi ,&nbsp;Janet Seeley ,&nbsp;Janine Upton ,&nbsp;Guy Harling ,&nbsp;Philippa C. Matthews ,&nbsp;Anita Edwards","doi":"10.1016/j.jve.2024.100378","DOIUrl":"10.1016/j.jve.2024.100378","url":null,"abstract":"<div><h3>Introduction</h3><p>The World Health Organisation (WHO) has set targets for the elimination of Hepatitis B virus (HBV), which include preventing new infections and reducing deaths. We explored beliefs, behaviours and barriers to diagnosis, prevention and treatment for people living with HBV infection (PLWHB) and those with liver disease in a rural South African population in KwaZulu-Natal, to gather information to inform research and support the development of improved clinical and public health services.</p></div><div><h3>Methods</h3><p>Using an interdisciplinary approach (combining public engagement, social science, clinical and laboratory team members) we conducted a community dialogue with members of the Africa Health Research Institute (AHRI) Community Advisory Board (CAB). Notes from the discussions were used to write up an account from which themes were identified during a team debrief session for data analysis.</p></div><div><h3>Results</h3><p>There was a lack of knowledge and awareness of HBV infection and transmission and prevention amongst CAB members, also reported among community members and healthcare workers. The participants recognised liver disease symptoms. Perceived causes of liver disease reported by the CAB were alcohol and non-adherence to HIV treatment. Barriers to care included stigma, poverty, and delays in referrals for HBV diagnosis and management.</p></div><div><h3>Conclusion</h3><p>Understanding barriers to care is important to shape future services for diagnosis, treatment and prevention of HBV and liver disease which are accessible, affordable and acceptable to the local population. Education, awareness and advocacy for improved liver health care pathways are required to make them effective for local communities.</p></div>","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 2","pages":"Article 100378"},"PeriodicalIF":5.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2055664024000153/pdfft?md5=753eb610beaf8a98f2cb558a403c7fcf&pid=1-s2.0-S2055664024000153-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141394954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying patterns of sexual behaviors and PrEP uptake characteristics among MSM who were eligible for PrEP: A national cross-section study","authors":"Yuanyuan Liu ,&nbsp;Xuan Liu ,&nbsp;Siyue Wei ,&nbsp;Zhaoyu Cheng ,&nbsp;Yidan Xian ,&nbsp;Yicheng Zhao ,&nbsp;Jun Ma ,&nbsp;Jiageng Chen ,&nbsp;Zhongdan Chen ,&nbsp;Jie Yang ,&nbsp;Fengli Liu ,&nbsp;Maohe Yu ,&nbsp;Zhuang Cui ,&nbsp;Changping Li","doi":"10.1016/j.jve.2024.100382","DOIUrl":"https://doi.org/10.1016/j.jve.2024.100382","url":null,"abstract":"<div><p>Men who have sex with men (MSM) are at a high risk of HIV infection and should be offered effective preventive measures, such as pre-exposure prophylaxis (PrEP). However, PrEP uptake among eligible MSM was not as high as desired. Diverse research findings on how risky sexual behaviors affect PrEP uptake highlight the necessity for a comprehensive investigation. Understanding the interconnectedness of different sexual behaviors is crucial for evaluating their impact on PrEP uptake among eligible MSM.</p><p>Using a proportional sampling method, we recruited 5877 MSM aged 16 years and above in mainland China according to PrEP eligibility criteria. Through latent class analysis (LCA), three distinct sexual behavior patterns were identified among eligible MSM. Demographic variances and PrEP uptake among the three distinct sexual behavior patterns were examined using chi-squared tests and multinomial logistic regression.</p><p>LCA revealed three patterns: low-risk (4,815 MSM), medium-risk (516 MSM), and high-risk (546 MSM). MSM aged 25 years or older with a monthly income of ≥¥8,000 were more likely to be in the medium-risk group. Those from areas with high HIV prevalence and engaging as \"top\" in anal sex were more likely to be in the medium- and high-risk groups. The medium- and high-risk groups had a higher willingness, uptake, and adherence rates for PrEP than the low-risk group.</p><p>LCA is effective in identifying diverse sexual behavior patterns among MSM, aiding targeted interventions to enhance PrEP uptake. Addressing demographic variations and tailoring interventions for specific risk groups are crucial for promoting PrEP dissemination and reducing HIV infection risk in eligible MSM.</p></div>","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 2","pages":"Article 100382"},"PeriodicalIF":3.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2055664024000190/pdfft?md5=1a60e545a08bd146cb85b0179964d886&pid=1-s2.0-S2055664024000190-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141444349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with unquantifiable total HIV-1 DNA in peripheral blood in persons living with HIV: An observational study","authors":"Aurélie Ram ,&nbsp;Vanessa Rascon Velasco ,&nbsp;Gilbert Mchantaf ,&nbsp;Véronique Avettand-Fénoël ,&nbsp;Jean-Paul Viard","doi":"10.1016/j.jve.2024.100370","DOIUrl":"https://doi.org/10.1016/j.jve.2024.100370","url":null,"abstract":"<div><h3>Background</h3><p>The human immunodeficiency virus type 1 (HIV-1) cannot be eradicated even with suppressive antiretroviral therapy because its retrotranscribed genome integrates into the DNA of host cells, creating a long-term reservoir. Quantification of total HIV-1 DNA in peripheral blood is a biomarker of this reservoir that can predict progression of the infection, treatment response, and HIV-1-related complications. A deeper understanding of the reservoir may help develop a cures.</p></div><div><h3>Objective</h3><p>This study aimed to characterize persons living with HIV-1 (PLWH) with unquantifiable total HIV-1 DNA in blood (below the quantification threshold) and identify associated factors.</p></div><div><h3>Methods</h3><p>We have conducted a retrospective observational study. During the study period, all PLWH who had total leukocyte-associated HIV-1 DNA measured by quantitative PCR were included. We have isolated a population of participants with HIV-1 DNA levels below the quantification threshold (40 copies/10⁶ leukocytes).</p></div><div><h3>Results</h3><p>Out of 1094 patients analysed, 62 had unquantifiable and 1032 quantifiable HIV-1 DNA levels in blood. We have found that those with unquantifiable HIV-1 DNA had a higher CD4 T cell nadir (p = 0.006) and a lower viral load zenith (p &lt; 0.001). Multivariate analyses showed that initiation of treatment in primary infection was the only protective factor against HIV-1 DNA quantifiability, the odds of HIV-1 DNA quantifiability decreased by 82% in those treated within 30 days of infection, after controlling for other factors.</p></div><div><h3>Conclusion</h3><p>Our research highlights the importance of an early start of anti-retroviral therapy to limit the size of the HIV-1 reservoir, as receiving treatment during primary infection was found as the only protective factor against quantifiability of HIV-1 DNA in blood.</p></div>","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 1","pages":"Article 100370"},"PeriodicalIF":5.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2055664024000074/pdfft?md5=85475b20495f9a09b83dced3f41b8dd3&pid=1-s2.0-S2055664024000074-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140351333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial JVE 10.1","authors":"","doi":"10.1016/j.jve.2024.100373","DOIUrl":"https://doi.org/10.1016/j.jve.2024.100373","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 1","pages":"Article 100373"},"PeriodicalIF":5.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2055664024000104/pdfft?md5=58e0f6fb7f27b3cd7e09be833d758335&pid=1-s2.0-S2055664024000104-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140605835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}