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Journal of Virus Eradication最新文献

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Development of a novel bivalent vaccine candidate against hepatitis A virus and rotavirus using reverse vaccinology and immunoinformatics
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2025-01-23 DOI: 10.1016/j.jve.2024.100578
Hassan Yarmohammadi , Abbas Akhavan Sepahi , Mojtaba Hamidi-fard , Mohammadreza Aghasadeghi , Golnaz Bahramali
{"title":"Development of a novel bivalent vaccine candidate against hepatitis A virus and rotavirus using reverse vaccinology and immunoinformatics","authors":"Hassan Yarmohammadi ,&nbsp;Abbas Akhavan Sepahi ,&nbsp;Mojtaba Hamidi-fard ,&nbsp;Mohammadreza Aghasadeghi ,&nbsp;Golnaz Bahramali","doi":"10.1016/j.jve.2024.100578","DOIUrl":"10.1016/j.jve.2024.100578","url":null,"abstract":"<div><div>The hepatitis A virus (HAV) and rotavirus are mainly transmitted through fecal-oral and person-to-person contact, and cause severe gastrointestinal complications and liver disease. This work used reverse vaccinology and immunoinformatic methods to create a novel bivalent vaccine against rotavirus and HAV. The amino acid sequences of HAV-rotavirus proteins (VP1 and VP8∗) were retrieved from the GenBank database. Various computational approaches were employed to predict highly conserved regions and the most immunogenic B-cell and T-cell epitopes of VP8 and VP1 of rotavirus and HAV proteins in both humans and BALB/c. Moreover, the predicted fusion protein was analyzed regarding primary and secondary structures and homology validation. In this study, we used two highly conserved peptide sequences of VP8 and VP1 of rotavirus and HAV that induce T and B cell immunogenicity. According to T-cell epitope prediction, this area comprises 2713 antigenic peptides for HLA class II and 30 HLA class I antigenic peptides, both of which are virtually entirely conserved in the Iranian population. In this study, validation as well as analysis of the secondary and three-dimensional structure of the VP8∗-rotavirus + AAY + HAV-VP1 fusion protein, with the aim of designing a multi-epitope vaccine with different receptors. TLR 3, 4 high immunogenic binding ability with immunological properties and interaction between multi-epitope target and TLR were predicted, and it is expected that the target fusion protein has stable antigenic potency and compatible half-life. The above is suggested as a universal vaccination program.</div></div>","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"11 1","pages":"Article 100578"},"PeriodicalIF":3.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2.1 – 00040 Lenacapavir impairs gag proteins expression by HIV-infected cells
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100400
C. Faua, S. Bernacchi, A. Ursenbach, M. Negroni, P. Gantner
{"title":"2.1 – 00040 Lenacapavir impairs gag proteins expression by HIV-infected cells","authors":"C. Faua,&nbsp;S. Bernacchi,&nbsp;A. Ursenbach,&nbsp;M. Negroni,&nbsp;P. Gantner","doi":"10.1016/j.jve.2024.100400","DOIUrl":"10.1016/j.jve.2024.100400","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 4"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PP1.3 – 00155 Robust proviral transcription but complete restriction of HIV virion production in fetal liver macrophages: a new model for viral persistence in tissue-resident macrophages
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100452
D. Gludish, J. Choi
{"title":"PP1.3 – 00155 Robust proviral transcription but complete restriction of HIV virion production in fetal liver macrophages: a new model for viral persistence in tissue-resident macrophages","authors":"D. Gludish,&nbsp;J. Choi","doi":"10.1016/j.jve.2024.100452","DOIUrl":"10.1016/j.jve.2024.100452","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 40-41"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PP4.5 – 00144 Unveiling Cellular Phenotypes and Transcriptional Dynamics in Early Treated Acute HIV Infection
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100492
S. Rutsaert, J. De Clercq, L. Vandekerckhove, S. Gerlo
{"title":"PP4.5 – 00144 Unveiling Cellular Phenotypes and Transcriptional Dynamics in Early Treated Acute HIV Infection","authors":"S. Rutsaert,&nbsp;J. De Clercq,&nbsp;L. Vandekerckhove,&nbsp;S. Gerlo","doi":"10.1016/j.jve.2024.100492","DOIUrl":"10.1016/j.jve.2024.100492","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 66-67"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143180199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
7.5 – 00009 Postmortem analyses of the central nervous system in individuals with HIV demonstrate that infection of microglia contributes to inflammatory pathways despite viral suppression
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100434
M. Nühn, N. Sabet, K. Van Abeelen, P. Schipper, A. Basson, A. Wensing, L. De Witte, M. Papathanasopoulos, M. Nijhuis, J. Symons, Justine T. Blonk, Nanouk Zuidmeer
{"title":"7.5 – 00009 Postmortem analyses of the central nervous system in individuals with HIV demonstrate that infection of microglia contributes to inflammatory pathways despite viral suppression","authors":"M. Nühn,&nbsp;N. Sabet,&nbsp;K. Van Abeelen,&nbsp;P. Schipper,&nbsp;A. Basson,&nbsp;A. Wensing,&nbsp;L. De Witte,&nbsp;M. Papathanasopoulos,&nbsp;M. Nijhuis,&nbsp;J. Symons,&nbsp;Justine T. Blonk,&nbsp;Nanouk Zuidmeer","doi":"10.1016/j.jve.2024.100434","DOIUrl":"10.1016/j.jve.2024.100434","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 27-28"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143181178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ST2.2 – 00065 Models and correlates of intact and defective HIV DNA decay in Kenyan children over 8 years of ART
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100447
D. Reeves, M. Litchford, C. Fish, A. Farrell-Sherman, N. Ahmed, M. Poindexter, N. Cassidy, J. Neary, D. Wamalwa, A. Langat, D. Chebet, H. Moraa, J. Slyker, S. Benki-Nugent, L. Cohn, J. Schiffer, J. Overbaugh, G. John-Stewart, D. Lehman
{"title":"ST2.2 – 00065 Models and correlates of intact and defective HIV DNA decay in Kenyan children over 8 years of ART","authors":"D. Reeves,&nbsp;M. Litchford,&nbsp;C. Fish,&nbsp;A. Farrell-Sherman,&nbsp;N. Ahmed,&nbsp;M. Poindexter,&nbsp;N. Cassidy,&nbsp;J. Neary,&nbsp;D. Wamalwa,&nbsp;A. Langat,&nbsp;D. Chebet,&nbsp;H. Moraa,&nbsp;J. Slyker,&nbsp;S. Benki-Nugent,&nbsp;L. Cohn,&nbsp;J. Schiffer,&nbsp;J. Overbaugh,&nbsp;G. John-Stewart,&nbsp;D. Lehman","doi":"10.1016/j.jve.2024.100447","DOIUrl":"10.1016/j.jve.2024.100447","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 36"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143181215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PP1.4 – 00138 SIV and HIV Infection of Mast Cells
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100453
K.L. Walker, Y. Thomas, S. Arif, S. Samer, C. Rische, R. Krier, J.A. O’Sullivan, R.L. Redondo, A.M. Carias, T. Russo, M. McRaven, E. Allen, C.T. Thuruthiyil, F. Engleman, E. Martinelli, F. Villinger, B. Bochner, T.J. Hope
{"title":"PP1.4 – 00138 SIV and HIV Infection of Mast Cells","authors":"K.L. Walker,&nbsp;Y. Thomas,&nbsp;S. Arif,&nbsp;S. Samer,&nbsp;C. Rische,&nbsp;R. Krier,&nbsp;J.A. O’Sullivan,&nbsp;R.L. Redondo,&nbsp;A.M. Carias,&nbsp;T. Russo,&nbsp;M. McRaven,&nbsp;E. Allen,&nbsp;C.T. Thuruthiyil,&nbsp;F. Engleman,&nbsp;E. Martinelli,&nbsp;F. Villinger,&nbsp;B. Bochner,&nbsp;T.J. Hope","doi":"10.1016/j.jve.2024.100453","DOIUrl":"10.1016/j.jve.2024.100453","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 41-42"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143181386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PP2.6 – 00048 The HIV reservoir can be established in either quiescent or senescent CD4 T cells
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100476
R. Matus Nicodemos, D. Ambrozak, D. Douek, R. Koup
{"title":"PP2.6 – 00048 The HIV reservoir can be established in either quiescent or senescent CD4 T cells","authors":"R. Matus Nicodemos,&nbsp;D. Ambrozak,&nbsp;D. Douek,&nbsp;R. Koup","doi":"10.1016/j.jve.2024.100476","DOIUrl":"10.1016/j.jve.2024.100476","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 56-57"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143181421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3.5 – 00053 Monovalent SMAC mimetics enhance proliferation of HIV-specific CD8 T cells 3.5 - 00053 单价 SMAC 拟态物质能增强艾滋病毒特异性 CD8 T 细胞的增殖能力
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100410
K. Tanaka, Y. Kim, H. King, M. Roche, S.R. Lewin
{"title":"3.5 – 00053 Monovalent SMAC mimetics enhance proliferation of HIV-specific CD8 T cells","authors":"K. Tanaka,&nbsp;Y. Kim,&nbsp;H. King,&nbsp;M. Roche,&nbsp;S.R. Lewin","doi":"10.1016/j.jve.2024.100410","DOIUrl":"10.1016/j.jve.2024.100410","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 11"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143181916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PP2.11 – 00011 The cellular factors BRD4 and HSF1 are critical initiators of P-TEFbdependent HIV-1 latency reversal in primary T cells
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100481
M. Yang, U. Mbonye, S. Wu, C.M. Chang, J. Karn
{"title":"PP2.11 – 00011 The cellular factors BRD4 and HSF1 are critical initiators of P-TEFbdependent HIV-1 latency reversal in primary T cells","authors":"M. Yang,&nbsp;U. Mbonye,&nbsp;S. Wu,&nbsp;C.M. Chang,&nbsp;J. Karn","doi":"10.1016/j.jve.2024.100481","DOIUrl":"10.1016/j.jve.2024.100481","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 59"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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