Journal of Thrombosis and Thrombolysis最新文献

{"title":"Optical coherence tomography versus angiography guided percutaneous coronary intervention: a systematic review and meta-analysis.","authors":"Zeeshan Sattar, Mohammad Hamza, Junaid Mir, Asad Ur Rab, Safia Shaikh, Syed Murtaza Ishaq, Prakash Upreti, Astha Upadhyaya, Ali Awad, Muhammad Burhan, Farhan Sattar, Karthik Gonuguntla, Ramesh Daggubati, Yasar Sattar, M Chadi Alraies, M Akram Kawsara","doi":"10.1007/s11239-026-03263-x","DOIUrl":"https://doi.org/10.1007/s11239-026-03263-x","url":null,"abstract":"","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging technology to improve care: a real-time electronic dashboard within an anticoagulation stewardship service to optimise anticoagulant safety.","authors":"Emma Jane Leitinger, Nadishani Ratnayake, Simone Taylor, Hiu Lam Agnes Yuen, Jasmine Singh, Charithani Keragala, Kay Htun, Nicholas Ling, Katherine Wilson, Tania Duncan, Zane Kaplan, Mark Sheppard, Susan Brown, Sanjeev Chunilal, Anastasios Nalpantidis","doi":"10.1007/s11239-026-03277-5","DOIUrl":"https://doi.org/10.1007/s11239-026-03277-5","url":null,"abstract":"","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of early intravenous administration of tirofiban after thrombolysis in acute ischemic stroke: a systematic review and meta-analysis of randomized controlled trials.","authors":"Emanuele Spina, Antonio Luca Spiezia, Flavo Della Pia, Antonio de Mase, Carlo Maurea, Giovanna Servillo, Simone Aramini, Angelo Ranieri, Stefano Barbato, Claudia Cuccurullo, Stefano Tozza, Antonio Esposito, Vincenzo Andreone, Fiore Manganelli, Paolo Candelaresi","doi":"10.1007/s11239-026-03273-9","DOIUrl":"https://doi.org/10.1007/s11239-026-03273-9","url":null,"abstract":"<p><p>Intravenous thrombolysis (IVT) is the cornerstone of reperfusion therapy for acute ischemic stroke (AIS), yet only a minority of patients achieve functional independence with vessel re-occlusion in up to one-third of cases. IVT targets fibrin but does not inhibit platelet aggregation, providing a rationale for adjunctive early platelet inhibition; so in this context tirofiban, a short-acting glycoprotein IIb/IIIa antagonist, may synergize with thrombolysis, favoring better outcome for AIS patients. We conducted a systematic review and meta-analysis up to August 2025 on MEDLINE (via PubMed), EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL) of RCTs assessing efficacy and safety of early intravenous infusion of tirofiban after thrombolysis in AIS. Outcomes presented as forest plot included functional independence (mRS 0-2), excellent outcome (mRS 0-1), mortality, symptomatic intracranial hemorrhage (sICH), any ICH and early neurological deterioration (END). Risk of Bias was evaluated through Cochrane RoB 2.0 tool. Five RCTs (1,428 patients) were included. At 90 days, functional independence occurred in 78.7% tirofiban-treated versus in 67.8% control patients (RR 1.22, 95% CI 1.05-1.40), with a lower number of END in tirofiban group (RR 0.35, 95% CI 0.15-0.82). Excellent outcome did not significantly differ (RR 2.72, 95% CI 0.26-27.97), as well as mortality (RR 1.07, 95% CI 0.55-2.09), overall ICH rate (RR 1.14, 95% CI 0.75-1.72) and sICH (RR 1.74, 95% CI 0.41-7.42), although an increased number of sICH was observed in tirofiban group. Tirofiban after thrombolysis may be associated with higher rates of functional independence and reduced END. However, given the very low certainty of evidence due to substantial heterogeneity, and imprecision, this meta-analysis should be interpreted as hypothesis-generating, and larger RCTs are required to confirm these findings. PROSPERO: number 1230163.</p>","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ticagrelor-based DAPT after CABG: in whom and for how long?","authors":"Mattia Galli, Mattia Vinciguerra, Ernesto Greco","doi":"10.1007/s11239-026-03284-6","DOIUrl":"https://doi.org/10.1007/s11239-026-03284-6","url":null,"abstract":"","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complement Factor H as a Novel Predictive Biomarker for Deep Vein Thrombosis Recurrence: A Prospective Cohort Study.","authors":"Qian Yi, Fei Wang, Mingyi Zhang, Xue Chen, Yueqin Liu, Mingdong Wu, Wu Yu, Yikuan Chen, Xiaoqing Bu","doi":"10.1007/s11239-026-03279-3","DOIUrl":"https://doi.org/10.1007/s11239-026-03279-3","url":null,"abstract":"","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tenecteplase vs. alteplase for ischemic stroke beyond 4.5 hours: a network meta-analysis of randomized controlled trials.","authors":"Davi Chaves Rocha de Souza, Marcos Paulo Rodrigues de Oliveira, Pedro Henrique Ferreira Sandes, Gabriel Teles de Oliveira Piñeiro, Geane Vasconcellos de Vasconcelos, Gabriel Souza Medrado-Nunes, Felipe Asaf Borges Millard, Caio Fontes do Nascimento, Victor Ogando-Santana, Pedro Antonio Pereira de Jesus","doi":"10.1007/s11239-026-03276-6","DOIUrl":"https://doi.org/10.1007/s11239-026-03276-6","url":null,"abstract":"","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-4443 alleviates myocardial injury in acute myocardial infarction by targeting and regulating TIMP2.","authors":"Huihui Zhu, Danmin Wang","doi":"10.1007/s11239-026-03264-w","DOIUrl":"https://doi.org/10.1007/s11239-026-03264-w","url":null,"abstract":"<p><p>Acute myocardial infarction (AMI) continues to be a leading cause of global morbidity and mortality, where adverse left ventricular remodeling and subsequent heart failure serve as primary determinants of long-term prognosis. This study aimed to delineate the expression pattern, clinical significance, and molecular mechanisms of miR-4443 in AMI. The study included 100 patients diagnosed with AMI and 100 normal healthy controls. Serum miR-4443 levels were measured by qRT-PCR, and their correlations with patient prognosis were analyzed by Kaplan-Meier curve and Cox regression analysis. To mimic ischemia-reperfusion injury in vitro, human AC16 cardiomyocytes underwent hypoxia/reoxygenation (H/R) treatment. MTT for cell viability, flow cytometry for apoptosis, and ELISA for TNF-α, IL-1β, and IL-6 levels were performed to determine the regulatory role of miR-4443. A bioinformatics analysis predicted the targeting relationship between miR-4443 and TIMP2, and this was validated by the dual-luciferase reporter assay. For matrix remodeling evaluation, MMP2 and MMP9 mRNA expressions were detected by qRT-PCR. The expression of miR-4443 in serum samples from AMI patients was significantly downregulated. The low levels of miR-4443 indicate a poor prognosis for AMI. During H/R injury, miR-4443 expression was downregulated in AC16 cells, its overexpression significantly rescued H/R-induced cell viability decline, increased apoptosis, inflammatory factor release, and upregulation of MMP2/MMP9 expression. TIMP2 was a direct target gene for miR-4443. Functional rescue experiments showed that overexpression of TIMP2 could reverse the protective effect of miR-4443 mimics on H/R injury in cells. Our findings demonstrate that miR-4443 is downregulated in AMI and exerts protective effects against H/R injury in cardiomyocytes, at least in part, through targeting TIMP2, suggesting that the miR-4443/TIMP2 axis may be a potential critical regulatory target in AMI. Further in vivo validation is warranted to substantiate its therapeutic potential.</p>","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-grade endotoxemia as an additional prothrombotic mechanism in adults with Fontan circulation.","authors":"Paweł Skorek, Lidia Tomkiewicz-Pająk, Agnieszka Bartczak-Rutkowska, Mirosław Kowalski, Anetta Undas","doi":"10.1007/s11239-026-03278-4","DOIUrl":"https://doi.org/10.1007/s11239-026-03278-4","url":null,"abstract":"<p><p>The Fontan procedure, the standard palliation for single-ventricle congenital heart disease, is associated with a high burden of thromboembolic complications of unclear etiology. We investigated whether increased circulating lipopolysaccharide (LPS) related to a compromised intestinal barrier is involved in thromboembolic manifestations and markers in the Fontan population. We examined 48 stable adults with Fontan circulation (median age 23 years; range 18-40) and 31 age-matched controls. We assessed serum LPS, and zonulin (marker of increased gut permeability), along with coagulation factors (F; prothrombin, FV, FVII-FX), thrombin generation (prothrombin fragment 1 + 2, thrombin-antithrombin complexes), endogenous anticoagulants (antithrombin, free protein S, tissue factor pathway inhibitor), markers of fibrinolysis (α2-antiplasmin, clot lysis time, plasminogen activator inhibitor-1, thrombin-activatable fibrinolysis inhibitor), platelet activation (P-selectin, sCD40L), and endothelial injury (von Willebrand factor (vWF), thrombomodulin). Compared with controls, patients with Fontan circulation exhibited higher LPS (+ 207%) and zonulin (+ 125%), which were strongly correlated (r = 0.63; P < 0.001). In the Fontan group, LPS was positively associated with vWF (r = 0.76; P < 0.001), and inversely with free protein S (r = - 0.30; P = 0.04), but not with any other markers. Ten patients (21%) with prior thromboembolic events had higher adjusted (age, sex, BMI) LPS (+ 198%; P < 0.001) and zonulin (+ 147%; P < 0.001) compared with remainder, accompanied by higher vWF (+ 119%), P-selectin (+ 137%), sCD40L (+ 139%), as well as lower FVIII (- 20%) and protein S (- 22%). We are the first to report that patients with Fontan circulation exhibit higher LPS levels related to increased intestinal permeability, which may predispose to thromboembolism and have practical implications.</p>","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of ticagrelor plus aspirin vs. aspirin monotherapy in patients undergoing coronary artery bypass grafting: A meta-analysis with trial sequential analysis.","authors":"Bara M Hammadeh, Ayham Mohammad Hussein, Nesreen Alhamwi, Ramez M Odat, Masooma Naseem, Majid Asawaeer","doi":"10.1007/s11239-026-03275-7","DOIUrl":"https://doi.org/10.1007/s11239-026-03275-7","url":null,"abstract":"","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indobufen versus aspirin for platelet inhibition: efficacy and safety insights from the INSURE and OPTION trials.","authors":"Chunxing Li, Zhao Ren, Hui Zhu","doi":"10.1007/s11239-026-03274-8","DOIUrl":"https://doi.org/10.1007/s11239-026-03274-8","url":null,"abstract":"","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}