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Journal of Thrombosis and Thrombolysis最新文献

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Impact of an Anticoagulation Management Service-Led Annual Review on Antiplatelet Use and Gastrointestinal Bleeding Prophylaxis in Ambulatory Patients on Background Direct Oral Anticoagulants. 以抗凝管理服务为主导的年度回顾对直接口服抗凝药物的门诊患者抗血小板使用和胃肠道出血预防的影响。
IF 2.2 3区 医学
Journal of Thrombosis and Thrombolysis Pub Date : 2026-04-29 DOI: 10.1007/s11239-026-03283-7
Chau Hoang, Peter Collins, David DeiCicchi, Ewan McNicol, Devan Hawkins, Kathy Zaiken
{"title":"Impact of an Anticoagulation Management Service-Led Annual Review on Antiplatelet Use and Gastrointestinal Bleeding Prophylaxis in Ambulatory Patients on Background Direct Oral Anticoagulants.","authors":"Chau Hoang, Peter Collins, David DeiCicchi, Ewan McNicol, Devan Hawkins, Kathy Zaiken","doi":"10.1007/s11239-026-03283-7","DOIUrl":"https://doi.org/10.1007/s11239-026-03283-7","url":null,"abstract":"<p><p>Patients on long-term anticoagulation face increased bleeding risk when antiplatelets are co-prescribed, especially upper gastrointestinal (GI) bleeding. Guidelines recommend limiting antiplatelet use to highly select patients on background anticoagulants and promoting GI prophylaxis with proton pump inhibitors (PPIs) for those requiring dual antithrombotic therapy. To assess the impact of an anticoagulation management service (AMS)-led intervention on reducing excess antiplatelet use and increasing PPI prescribing in patients who require continued antiplatelet therapy. This study of retrospective chart review included adults (≥ 18 years) on long-term direct oral anticoagulant (DOAC) therapy from October 2023 to September 2024. The intervention group included AMS-enrolled patients who received structured annual anticoagulation review. The control group consisted of DOAC patients receiving usual care outside AMS. The AMS annual review aims to optimize antithrombotic therapy by deprescribing unnecessary antiplatelets and initiating PPIs when clinically indicated. Of 8,462 eligible patients, 3,125 were in the AMS group and 5,337 in the non-AMS group. Antiplatelet use was significantly lower in AMS patients at baseline (9% vs. 15%) and study end (7% vs. 16%) (p < 0.0001). PPI use was significantly higher in AMS patients at both time points (50% vs. 30% for baseline, 67% vs. 38% at the end of study) (p < 0.0001). Acceptance rates for AMS recommendations were 18.8% for antiplatelet discontinuation and 33% for PPI initiation. AMS-led interventions effectively reduced concurrent antiplatelet use in patients on background DOAC and increased PPI prescribing in those on dual therapy, demonstrating the value of centralized anticoagulation services in primary care.</p>","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Four-factor prothrombin complex concentrate for the reversal of apixaban prior to deceased donor kidney transplant: A case series. 四因子凝血酶原复合物浓缩物在死亡供者肾移植前逆转阿哌沙班：一个病例系列。
IF 2.2 3区 医学
Journal of Thrombosis and Thrombolysis Pub Date : 2026-04-29 DOI: 10.1007/s11239-026-03296-2
Michelle S Dierker, Anne Przybylski, Laura Cotiguala, Reynold Lopez-Soler, Kaitlin Ferguson
{"title":"Four-factor prothrombin complex concentrate for the reversal of apixaban prior to deceased donor kidney transplant: A case series.","authors":"Michelle S Dierker, Anne Przybylski, Laura Cotiguala, Reynold Lopez-Soler, Kaitlin Ferguson","doi":"10.1007/s11239-026-03296-2","DOIUrl":"https://doi.org/10.1007/s11239-026-03296-2","url":null,"abstract":"","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mutant neutrophils and NETosis in clonal hematopoiesis: an emerging contributor of thromboinflammation and organ dysfunction. 突变中性粒细胞和NETosis在克隆造血：血栓炎症和器官功能障碍的新贡献者。
IF 2.2 3区 医学
Journal of Thrombosis and Thrombolysis Pub Date : 2026-04-29 DOI: 10.1007/s11239-026-03290-8
Muhammad Shaheer Mannan, Muhammad Waqas Khan, Muhammad Abdul Haseeb Khan, Ahmed Javed, Syed Mujtaba Hussain, Waleed Ahmad
{"title":"Mutant neutrophils and NETosis in clonal hematopoiesis: an emerging contributor of thromboinflammation and organ dysfunction.","authors":"Muhammad Shaheer Mannan, Muhammad Waqas Khan, Muhammad Abdul Haseeb Khan, Ahmed Javed, Syed Mujtaba Hussain, Waleed Ahmad","doi":"10.1007/s11239-026-03290-8","DOIUrl":"https://doi.org/10.1007/s11239-026-03290-8","url":null,"abstract":"","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Number of thrombosed venous segments and clinical outcomes in cancer-associated isolated distal deep vein thrombosis: insights from the ONCO DVT Study. 癌症相关孤立远端深静脉血栓形成的静脉段数量和临床结果：来自ONCO DVT研究的见解
IF 2.2 3区 医学
Journal of Thrombosis and Thrombolysis Pub Date : 2026-04-29 DOI: 10.1007/s11239-026-03287-3
Kanna Nakamura, Yugo Yamashita, Takeshi Morimoto, Nao Muraoka, Michihisa Umetsu, Yuji Nishimoto, Takuma Takada, Yoshito Ogihara, Tatsuya Nishikawa, Nobutaka Ikeda, Kazunori Otsui, Daisuke Sueta, Yukari Tsubata, Masaaki Shoji, Ayumi Shikama, Yutaka Hosoi, Yasuhiro Tanabe, Ryuki Chatani, Kengo Tsukahara, Naohiko Nakanishi, Kitae Kim, Satoshi Ikeda, Koh Ono, Takeshi Kimura
{"title":"Number of thrombosed venous segments and clinical outcomes in cancer-associated isolated distal deep vein thrombosis: insights from the ONCO DVT Study.","authors":"Kanna Nakamura, Yugo Yamashita, Takeshi Morimoto, Nao Muraoka, Michihisa Umetsu, Yuji Nishimoto, Takuma Takada, Yoshito Ogihara, Tatsuya Nishikawa, Nobutaka Ikeda, Kazunori Otsui, Daisuke Sueta, Yukari Tsubata, Masaaki Shoji, Ayumi Shikama, Yutaka Hosoi, Yasuhiro Tanabe, Ryuki Chatani, Kengo Tsukahara, Naohiko Nakanishi, Kitae Kim, Satoshi Ikeda, Koh Ono, Takeshi Kimura","doi":"10.1007/s11239-026-03287-3","DOIUrl":"https://doi.org/10.1007/s11239-026-03287-3","url":null,"abstract":"","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive value of thromboelastography with platelet mapping on hematoma expansion in spontaneous intracerebral hemorrhage. 血小板定位血小板弹性成像对自发性脑出血血肿扩张的预测价值。
IF 2.2 3区 医学
Journal of Thrombosis and Thrombolysis Pub Date : 2026-04-29 DOI: 10.1007/s11239-026-03292-6
Nora Sammani, John J Radosevich, Sydni Martinez, Travis Lam, Daniel Gonzalez, Tracie Schroeder, Sai Alekha Challa, John Tyler Haller
{"title":"Predictive value of thromboelastography with platelet mapping on hematoma expansion in spontaneous intracerebral hemorrhage.","authors":"Nora Sammani, John J Radosevich, Sydni Martinez, Travis Lam, Daniel Gonzalez, Tracie Schroeder, Sai Alekha Challa, John Tyler Haller","doi":"10.1007/s11239-026-03292-6","DOIUrl":"https://doi.org/10.1007/s11239-026-03292-6","url":null,"abstract":"","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined circuit-directed (pre-oxygenator) nafamostat and low-dose systemic unfractionated heparin anticoagulation in ecmo patients with high bleeding risk: A case series and safety evaluation. 电路导向（预充氧器）纳莫他与低剂量全身无分级肝素联合抗凝治疗ecmo高危出血患者：病例系列和安全性评价
IF 2.2 3区 医学
Journal of Thrombosis and Thrombolysis Pub Date : 2026-04-29 DOI: 10.1007/s11239-026-03293-5
Yunjiu Hu, Shihui Lin, Mu Zhang, Lin Ye, Zhijiao Zhang, Jing Fan, Fang Xu
{"title":"Combined circuit-directed (pre-oxygenator) nafamostat and low-dose systemic unfractionated heparin anticoagulation in ecmo patients with high bleeding risk: A case series and safety evaluation.","authors":"Yunjiu Hu, Shihui Lin, Mu Zhang, Lin Ye, Zhijiao Zhang, Jing Fan, Fang Xu","doi":"10.1007/s11239-026-03293-5","DOIUrl":"https://doi.org/10.1007/s11239-026-03293-5","url":null,"abstract":"","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personalised Antithrombotic Strategies in Diverse Clinical Populations. 不同临床人群的个体化抗血栓策略。
IF 2.2 3区 医学
Journal of Thrombosis and Thrombolysis Pub Date : 2026-04-23 DOI: 10.1007/s11239-026-03291-7
Diana A Gorog
{"title":"Personalised Antithrombotic Strategies in Diverse Clinical Populations.","authors":"Diana A Gorog","doi":"10.1007/s11239-026-03291-7","DOIUrl":"https://doi.org/10.1007/s11239-026-03291-7","url":null,"abstract":"","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clopidogrel vs. aspirin in addition to oral anticoagulation as part of double antithrombotic therapy following PCI: a post-hoc analysis of the PERSEO registry. 氯吡格雷与阿司匹林联合口服抗凝作为PCI术后双重抗血栓治疗的一部分：PERSEO注册的事后分析
IF 2.2 3区 医学
Journal of Thrombosis and Thrombolysis Pub Date : 2026-04-20 DOI: 10.1007/s11239-026-03286-4
Andrea Rubboli, Graziella Pompei, Salvatore De Rosa, Paolo Calabrò, Carolina Moretti, Bernardo Cortese, Mauro Colletta, Vanessa Porretta, Giuseppe Andò, Alessandro Sciahbasi
{"title":"Clopidogrel vs. aspirin in addition to oral anticoagulation as part of double antithrombotic therapy following PCI: a post-hoc analysis of the PERSEO registry.","authors":"Andrea Rubboli, Graziella Pompei, Salvatore De Rosa, Paolo Calabrò, Carolina Moretti, Bernardo Cortese, Mauro Colletta, Vanessa Porretta, Giuseppe Andò, Alessandro Sciahbasi","doi":"10.1007/s11239-026-03286-4","DOIUrl":"https://doi.org/10.1007/s11239-026-03286-4","url":null,"abstract":"","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From body size to body composition: mechanisms linking obesity to venous thromboembolism. 从体型到身体组成：肥胖与静脉血栓栓塞的联系机制。
IF 2.2 3区 医学
Journal of Thrombosis and Thrombolysis Pub Date : 2026-04-20 DOI: 10.1007/s11239-026-03285-5
Judith P L Verlaan, Astrid van Hylckama Vlieg, Luuk J J Scheres
{"title":"From body size to body composition: mechanisms linking obesity to venous thromboembolism.","authors":"Judith P L Verlaan, Astrid van Hylckama Vlieg, Luuk J J Scheres","doi":"10.1007/s11239-026-03285-5","DOIUrl":"https://doi.org/10.1007/s11239-026-03285-5","url":null,"abstract":"","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
miR-221-3p mediates endothelial injury and predicts cerebral ischemic in carotid artery stenosis. miR-221-3p介导颈动脉狭窄的内皮损伤并预测脑缺血。
IF 2.2 3区 医学
Journal of Thrombosis and Thrombolysis Pub Date : 2026-04-17 DOI: 10.1007/s11239-026-03265-9
Yanbin Huang, Lifen Wang, Lihong Ren, Danian Liu, Xiaolin Wu
{"title":"miR-221-3p mediates endothelial injury and predicts cerebral ischemic in carotid artery stenosis.","authors":"Yanbin Huang, Lifen Wang, Lihong Ren, Danian Liu, Xiaolin Wu","doi":"10.1007/s11239-026-03265-9","DOIUrl":"https://doi.org/10.1007/s11239-026-03265-9","url":null,"abstract":"","PeriodicalId":17546,"journal":{"name":"Journal of Thrombosis and Thrombolysis","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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