Journal of Vascular Research最新文献_第5页

In Memoriam: A Tribute to Eva Aralikatti. 悼念向伊娃-阿拉里卡蒂致敬。

IF 1.8 4区医学

Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2024-08-30 DOI: 10.1159/000540829

Pooneh Bagher

引用次数: 0

Cytoprotection as an Innovative Therapeutic Strategy to Cardiogenic Shock: Exploring the Potential of Cytidine-5-Diphosphocholine to Mitigate Target Organ Damage. 细胞保护作为心源性休克的创新治疗策略：探索胞苷-5-二磷酸胆碱减轻靶器官损伤的潜力。

IF 1.8 4区医学

Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2024-05-22 DOI: 10.1159/000538946

Héctor González-Pacheco, Luis Manuel Amezcua-Guerra, Martha Franco, Alexandra Arias-Mendoza, Jorge A Ortega-Hernández, Felipe Massó

{"title":"Cytoprotection as an Innovative Therapeutic Strategy to Cardiogenic Shock: Exploring the Potential of Cytidine-5-Diphosphocholine to Mitigate Target Organ Damage.","authors":"Héctor González-Pacheco, Luis Manuel Amezcua-Guerra, Martha Franco, Alexandra Arias-Mendoza, Jorge A Ortega-Hernández, Felipe Massó","doi":"10.1159/000538946","DOIUrl":"10.1159/000538946","url":null,"abstract":"Background: Preservation of organ function and viability is a crucial factor for survival in cardiogenic shock (CS) patients. There is not information enough on cytoprotective substances that may delay organs damage in CS. We hypothesize that cytidine-5-diphosphocholine (CDP-choline) can act as a cytoprotective pharmacological measure that diminishes the target organ damage. So, we aimed to perform a review of works carried out in our institution to evaluate the effect of therapeutic cytoprotection of the CDP-choline.Summary: CDP-choline is an intermediate metabolite in the synthesis of phosphatidylcholine. It is also a useful drug for the treatment of acute ischaemic stroke, traumatic brain injury, and neurodegenerative diseases and has shown an excellent pharmacological safety profile as well. We review our institution's work and described the cytoprotective effects of CDP-choline in experimental models of heart, liver, and kidney acute damage, where this compound was shown to diminish reperfusion-induced ventricular arrhythmias, oxidative stress, apoptotic cell death, inflammation, lactic acid levels and to preserve mitochondrial function.Key messages: We propose that additional research is needed to evaluate the impact of cytoprotective therapy adjuvant to mitigate target organ damage in patients with CS.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":" ","pages":"160-165"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endothelial Dysfunction Does Not Occur after Acute, Elevated Homocysteine Exposure of the Lumen of the Iliac Artery of the Anaesthetised Pig. 麻醉猪髂动脉腔内同型半胱氨酸急性升高后不会出现内皮功能障碍

IF 1.8 4区医学

Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2024-10-09 DOI: 10.1159/000541398

Farouk Markos, Andrew J O'Leary, Mark I M Noble, Therese Ruane-O'Hora

{"title":"Endothelial Dysfunction Does Not Occur after Acute, Elevated Homocysteine Exposure of the Lumen of the Iliac Artery of the Anaesthetised Pig.","authors":"Farouk Markos, Andrew J O'Leary, Mark I M Noble, Therese Ruane-O'Hora","doi":"10.1159/000541398","DOIUrl":"10.1159/000541398","url":null,"abstract":"Introduction: Elevated luminal homocysteine has been linked with cardiovascular disease; however, whether there is a direct effect of homocysteine on blood vessel endothelium is not clear. In this study, the acute effect of luminal homocysteine on iliac artery endothelial function was assessed in the anaesthetised pig.Methods: Hyperhomocysteinaemic blood was injected into an occluded segment of the iliac in the anaesthetised pig for 20 min, and the effect on atrial diameter during the occlusion and during the reactive hyperaemia assessed.Results: No significant changes in arterial diameter or pressure were observed during the incubation period at homocysteine concentrations of 10, 20, 40 and 100 µ<sc>M</sc>. There was also no difference in the magnitude of the iliac diameter increase in the response to reactive hyperaemia when the incubation period was completed.Conclusion: There is no evidence of endothelial dysfunction in response to an acute 20-min elevation in homocysteine in an intact conduit artery.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":" ","pages":"298-303"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum. 勘误。

IF 1.8 4区医学

Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2024-07-04 DOI: 10.1159/000539549

引用次数: 0

Blood Urea Nitrogen to Left Ventricular Ejection Ratio as a Predictor of Short-Term Outcome in Acute Myocardial Infarction Complicated by Cardiogenic Shock. 血尿素氮与左心室射血比值可预测急性心肌梗死并发心源性休克的短期预后

IF 1.8 4区医学

Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2024-09-23 DOI: 10.1159/000541021

Linfeng Xie, Yuanzhu Li, Jing Chen, Suxin Luo, Bi Huang

{"title":"Blood Urea Nitrogen to Left Ventricular Ejection Ratio as a Predictor of Short-Term Outcome in Acute Myocardial Infarction Complicated by Cardiogenic Shock.","authors":"Linfeng Xie, Yuanzhu Li, Jing Chen, Suxin Luo, Bi Huang","doi":"10.1159/000541021","DOIUrl":"10.1159/000541021","url":null,"abstract":"Introduction: Cardiogenic shock (CS) is the most critical complication after acute myocardial infarction (AMI) with mortality above 50%. Both blood urea nitrogen and left ventricular ejection fraction were important prognostic indicators. We aimed to evaluate the prognostic value of admission blood urea nitrogen to left ventricular ejection fraction ratio (BUNLVEFr) in patients with AMI complicated by CS (AMI-CS).Methods: 268 consecutive patients with AMI-CS were divided into two groups according to the admission BUNLVEFr cut-off value determined by Youden index. The primary endpoint was 30-day all-cause mortality and the secondary endpoint was the composite events of major adverse cardiovascular events (MACEs). Cox proportional hazard models were performed to analyze the association of BUNLVEFr with the outcome.Results: The optimal cut-off value of BUNLVEFr is 16.63. The 30-day all-cause mortality and MACEs in patients with BUNLVEFr≥16.63 was significantly higher than in patients with BUNLVEFr<16.63 (30-day all-cause mortality: 66.2% vs. 17.1%, p < 0.001; 30-day MACEs: 80.0% vs. 48.0%, p < 0.001). After multivariable adjustment, BUNLVEFr≥16.63 remained an independent predictor for higher risk of 30-day all-cause mortality (HR = 3.553, 95% CI: 2.125-5.941, p < 0.001) and MACEs (HR = 2.026, 95% CI: 1.456-2.820, p < 0.001). Subgroup analyses found that the effect of BUNLVEFr was consistent in different subgroups (all p-interaction>0.05).Conclusion: The admission BUNLVEFr provided important prognostic information for AMI-CS patients.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":" ","pages":"233-243"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laser Doppler Fluximetry in Cutaneous Vasculature: Methods for Data Analyses. 皮肤血管中的激光多普勒通量测量法：数据分析方法。

IF 1.8 4区医学

Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2024-05-15 DOI: 10.1159/000538718

Sophie J Y Huang, Xuan Wang, Brayden D Halvorson, Yuki Bao, Stephanie J Frisbee, Jefferson C Frisbee, Daniel Goldman

{"title":"Laser Doppler Fluximetry in Cutaneous Vasculature: Methods for Data Analyses.","authors":"Sophie J Y Huang, Xuan Wang, Brayden D Halvorson, Yuki Bao, Stephanie J Frisbee, Jefferson C Frisbee, Daniel Goldman","doi":"10.1159/000538718","DOIUrl":"10.1159/000538718","url":null,"abstract":"Introduction: Acquisition of a deeper understanding of microvascular function across physiological and pathological conditions can be complicated by poor accessibility of the vascular networks and the necessary sophistication or intrusiveness of the equipment needed to acquire meaningful data. Laser Doppler fluximetry (LDF) provides a mechanism wherein investigators can readily acquire large amounts of data with minor inconvenience for the subject. However, beyond fairly basic analyses of erythrocyte perfusion (fluximetry) data within the cutaneous microcirculation (i.e., perfusion at rest and following imposed challenges), a deeper understanding of microvascular perfusion requires a more sophisticated approach that can be challenging for many investigators.Methods: This manuscript provides investigators with clear guidance for data acquisition from human subjects for full analysis of fluximetry data, including levels of perfusion, single- and multiscale Lempel-Ziv complexity (LZC) and sample entropy (SampEn), and wavelet-based analyses for the major physiological components of the signal. Representative data and responses are presented from a recruited cohort of healthy volunteers, and computer codes for full data analysis (MATLAB) are provided to facilitate efforts by interested investigators.Conclusion: It is anticipated that these materials can reduce the challenge to investigators integrating these approaches into their research programs and facilitate translational research in cardiovascular science.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":" ","pages":"197-211"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Silver Ion Decreases Foreign Body Reaction and Venous Neointimal Hyperplasia through the Inhibition of Interleukin-33 Expression]. 银离子通过抑制白细胞介素-33的表达减少异物反应和静脉新内膜增生

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2024-02-16 DOI: 10.1159/000536003

Cong Zhang, Shunbo Wei, Liwei Zhang, Chunyang Lou, Jianbang Fang, Yuanfeng Liu, Hao He, Zhuo Li, Jing'an Li, Hualong Bai

{"title":"[Silver Ion Decreases Foreign Body Reaction and Venous Neointimal Hyperplasia through the Inhibition of Interleukin-33 Expression].","authors":"Cong Zhang, Shunbo Wei, Liwei Zhang, Chunyang Lou, Jianbang Fang, Yuanfeng Liu, Hao He, Zhuo Li, Jing'an Li, Hualong Bai","doi":"10.1159/000536003","DOIUrl":"10.1159/000536003","url":null,"abstract":"Introduction: Vascular prosthetic grafts are widely used in vascular surgery; however, graft infection remains a major concern. Silver-coated vascular grafts have demonstrated anti-infection properties in clinical settings; however, whether the silver irons influence foreign body reaction or neointimal hyperplasia remains unclear.Methods: Sodium alginate and hyaluronic acid (SA/HA) hydrogel patches loaded with rhodamine, with or without silver, were fabricated. Patches were implanted in the subcutaneous or abdominal cavity and inferior vena cava of rats. Samples were harvested on day 14 and examined via immunohistochemical and immunofluorescence analyses.Results: Silver hydrogel was found to decrease the foreign body reaction; after subcutaneous and abdominal cavity implantation in rats, the capsule was found to be thinner in the silver hydrogel group than in the control hydrogel group. The silver hydrogel group had fewer CD68-positive cells and proliferating cell nuclear antigen and interleukin-33 (IL-33) dual-positive cells than the control hydrogel group. Additionally, the silver hydrogel patch reduced the neointimal thickness after patch venoplasty in rats, and the number of IL-33- and IL-1β-positive cells was lower than that in the control patch.Conclusion: Silver-loaded SA/HA hydrogel patches decreased the foreign body reaction and venous neointimal hyperplasia in rats by the inhibition of IL-33 expression.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":" ","pages":"89-98"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139900129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stasis and Inflammation in Varicose Vein Development: An Interleukin-Mediated Process from Intima to Media. 静脉曲张发展过程中的瘀滞与炎症：从内膜到中膜的白细胞介素介导过程。

IF 1.8 4区医学

Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2024-07-20 DOI: 10.1159/000539861

Min Jung Ku, Young Hee Maeng, Jee Won Chang, Jung-Kook Song, Young Ree Kim

{"title":"Stasis and Inflammation in Varicose Vein Development: An Interleukin-Mediated Process from Intima to Media.","authors":"Min Jung Ku, Young Hee Maeng, Jee Won Chang, Jung-Kook Song, Young Ree Kim","doi":"10.1159/000539861","DOIUrl":"10.1159/000539861","url":null,"abstract":"Introduction: This study investigated the combination of venous stasis and inflammation in varicose vein development.Methods: The study included patients with primary varicose veins operated using high ligation and stripping of greater saphenous vein. All of them showed reflux at sapheno-femoral junction on preoperative Doppler ultrasound. Mesenteric veins from early or advanced gastric cancer specimens were used as control group. Inflammatory mediators expressed in the venous wall were measured via immunohistochemistry and compared between the two groups.Results: Thirty-five (59.3%) men and 24 women with a mean age of 52.8 years (range, 23-77 years) were included and 29 (49.2%) patients had edema or skin changes according to Clinical-Etiology-Anatomy-Pathophysiology (CEAP) classification and reporting standards for chronic venous disorders. The expression of interleukin 6 (IL-6) and transforming growth factor β1 (TGF-β1) in intima and those of IL-6 in media of greater saphenous veins increased, with statistically significant differences between the two groups (p < 0.001). IL-6 in media and TGF-β1 levels in intima were independent predictors of varicose veins (adjusted odds ratios 74.62 and 66.69, respectively).Conclusion: Elevated venous pressure represented by reflux on Doppler ultrasound and increased expression of inflammatory cytokines including IL-6 in media and TGF-β1 in intima are associated with the development of varicose veins.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":" ","pages":"244-251"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pilot Assessment of Piezoelectric Transducers as a Cost-Effective Alternative to EndoPAT. 压电传感器作为内窥器经济高效替代品的试点评估。

IF 1.8 4区医学

Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2024-07-29 DOI: 10.1159/000540200

Olivia Ramraj, Smriti Badhwar, Tania J Pereira, Heather Edgell

{"title":"Pilot Assessment of Piezoelectric Transducers as a Cost-Effective Alternative to EndoPAT.","authors":"Olivia Ramraj, Smriti Badhwar, Tania J Pereira, Heather Edgell","doi":"10.1159/000540200","DOIUrl":"10.1159/000540200","url":null,"abstract":"Introduction: Current microvascular assessments may not be practical or accessible requiring experienced personnel and/or ongoing equipment costs. Piezoelectric transducers can reliably obtain finger blood pressure waves, similar to peripheral arterial tonometry devices; thus, they could be used to estimate microvascular function. We aimed to validate piezoelectric transducers as an alternative measure of microvascular function compared to EndoPAT.Methods: Twenty-five adults (aged 20-64 years) completed reactive hyperemia (5 min forearm circulatory occlusion and 3 min recovery) with piezoelectric transducers on the middle fingers and EndoPAT probes on the index fingers. Average area under the curve (AUC) of the pulse wave signal for the occluded and control arms was determined at baseline, every 30 s post-occlusion, and 10 s around the peak response. Microvascular function index (MFI) was calculated as the ratio of AUC post-occlusion to AUC baseline in the test arm, then normalized to the same ratio in the control arm. MFI at each time point was correlated with the reactive hyperemia index (RHI) from the EndoPAT.Results: The greatest significance was found between RHI and MFI at 10 s around the peak response (Spearman's r = 0.67, p = 0.0002; Pearson's r = 0.76, p = 0.00001).Conclusion: MFI is a reusable and user-friendly microvascular function assessment that could provide better access to vascular health screening.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":" ","pages":"252-259"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics and Correlations of Wall Shear Stress and Flow Turbulence in the Carotid Bifurcation Evaluated Using an Ultrasound Vector Flow Imaging 利用超声矢量血流成像评估颈动脉分叉处壁剪应力和血流湍流的特征及相关性

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2023-12-07 DOI: 10.1159/000534738

Mengmeng Liu, Di Song, Shaofu Hong, Yinghui Dong, Wenjing Gao, Yigang Du, Lei Zhu, Jinfeng Xu, F. Dong

{"title":"Characteristics and Correlations of Wall Shear Stress and Flow Turbulence in the Carotid Bifurcation Evaluated Using an Ultrasound Vector Flow Imaging","authors":"Mengmeng Liu, Di Song, Shaofu Hong, Yinghui Dong, Wenjing Gao, Yigang Du, Lei Zhu, Jinfeng Xu, F. Dong","doi":"10.1159/000534738","DOIUrl":"https://doi.org/10.1159/000534738","url":null,"abstract":"Introduction: The aim of the study was to evaluate characteristics and provide the normal values of wall shear stress (WSS) and flow turbulence (Tur), and the relationship between them in the carotid bifurcation based on an ultrasound vector flow imaging (V Flow) in healthy adults. Methods: Max and mean WSS and Tur values at three segments (initial segments of internal and external carotid arteries [IICA and IECA]; distal segment of common carotid artery [DCCA]), both in anterior and posterior walls, were successfully obtained in 56 healthy adults, using ultrasound V Flow function. Relationship between mean WSS and Tur was further explored. Results: The mean WSS value was 0.71 Pa, 0.86 Pa, and 0.96 Pa at IICA, IECA, and DCCA, respectively (IICA < IECA < DCCA, p < 0.05). The mean Tur value was 13.85%, 5.46%, and 4.17% at IICA, IECA, and DCCA, respectively (IICA > IECA > DCCA, p < 0.05). A cutoff value (WSS = 0.4 Pa) was selected and Tur values were significantly higher in group with WSS cutoff value <0.4 Pa than group with WSS cutoff value ≥0.4 Pa (p < 0.01). Conclusion: WSS and Tur are moderately negatively correlated, which can be used in the quantitative evaluation of carotid bifurcation and could be a potential dual-parameter tool in the clinical research for early detection of carotid atherosclerosis.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":"33 13","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138594427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0