静脉曲张发展过程中的瘀滞与炎症:从内膜到中膜的白细胞介素介导过程。

IF 1.8 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE
Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2024-07-20 DOI:10.1159/000539861
Min Jung Ku, Young Hee Maeng, Jee Won Chang, Jung-Kook Song, Young Ree Kim
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引用次数: 0

摘要

简介:本研究探讨了静脉淤积和炎症在静脉曲张发展过程中的共同作用:本研究探讨了静脉淤血和炎症在静脉曲张发展过程中的共同作用:研究对象包括使用大隐静脉高位结扎和剥脱术治疗的原发性静脉曲张患者。所有患者在术前多普勒超声检查中均显示隐股交界处有静脉回流。来自早期或晚期胃癌标本的肠系膜静脉作为对照组。通过免疫组化法测定静脉壁表达的炎症介质,并对两组进行比较:根据慢性静脉疾病的临床-病因-解剖-病理生理学(CEAP)分类和报告标准,有水肿或皮肤改变的患者有 29 人(49.2%),其中男性 35 人(59.3%),女性 24 人,平均年龄 52.8 岁(23-77 岁)。白细胞介素 6(IL-6)和转化生长因子 β1(TGF-β1)在大隐静脉内膜中的表达和 IL-6 在中膜中的表达均有所增加,两组间差异有统计学意义(P < 0.001)。静脉内膜介质中的 IL-6 和静脉内膜中的 TGF-β1 水平是静脉曲张的独立预测因子(调整后的几率比分别为 74.62 和 66.69):结论:多普勒超声显示的静脉回流所代表的静脉压力升高以及炎性细胞因子(包括介质中的 IL-6 和内膜中的 TGF-β1)的表达增加与静脉曲张的发生有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Stasis and Inflammation in Varicose Vein Development: An Interleukin-Mediated Process from Intima to Media.

Introduction: This study investigated the combination of venous stasis and inflammation in varicose vein development.

Methods: The study included patients with primary varicose veins operated using high ligation and stripping of greater saphenous vein. All of them showed reflux at sapheno-femoral junction on preoperative Doppler ultrasound. Mesenteric veins from early or advanced gastric cancer specimens were used as control group. Inflammatory mediators expressed in the venous wall were measured via immunohistochemistry and compared between the two groups.

Results: Thirty-five (59.3%) men and 24 women with a mean age of 52.8 years (range, 23-77 years) were included and 29 (49.2%) patients had edema or skin changes according to Clinical-Etiology-Anatomy-Pathophysiology (CEAP) classification and reporting standards for chronic venous disorders. The expression of interleukin 6 (IL-6) and transforming growth factor β1 (TGF-β1) in intima and those of IL-6 in media of greater saphenous veins increased, with statistically significant differences between the two groups (p < 0.001). IL-6 in media and TGF-β1 levels in intima were independent predictors of varicose veins (adjusted odds ratios 74.62 and 66.69, respectively).

Conclusion: Elevated venous pressure represented by reflux on Doppler ultrasound and increased expression of inflammatory cytokines including IL-6 in media and TGF-β1 in intima are associated with the development of varicose veins.

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来源期刊
Journal of Vascular Research
Journal of Vascular Research 医学-生理学
CiteScore
3.40
自引率
0.00%
发文量
25
审稿时长
>12 weeks
期刊介绍: The ''Journal of Vascular Research'' publishes original articles and reviews of scientific excellence in vascular and microvascular biology, physiology and pathophysiology. The scope of the journal covers a broad spectrum of vascular and lymphatic research, including vascular structure, vascular function, haemodynamics, mechanics, cell signalling, intercellular communication, growth and differentiation. JVR''s ''Vascular Update'' series regularly presents state-of-the-art reviews on hot topics in vascular biology. Manuscript processing times are, consistent with stringent review, kept as short as possible due to electronic submission. All articles are published online first, ensuring rapid publication. The ''Journal of Vascular Research'' is the official journal of the European Society for Microcirculation. A biennial prize is awarded to the authors of the best paper published in the journal over the previous two years, thus encouraging young scientists working in the exciting field of vascular biology to publish their findings.
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