Journal of Thoracic Oncology最新文献

{"title":"Prospective Evaluation of Lung Cancer Screening Eligibility Criteria and Lung Cancer Detection in the Yorkshire Lung Screening Trial","authors":"Rhian Gabe PhD ,&nbsp;Philip A.J. Crosbie PhD ,&nbsp;Daniel Vulkan MSc ,&nbsp;Hannah Bailey M.B.B.S. ,&nbsp;David R. Baldwin MD ,&nbsp;Claire Bradley MBBCh ,&nbsp;Richard Booton PhD ,&nbsp;Michael J. Darby FRCR ,&nbsp;Claire Eckert PhD ,&nbsp;Neil Hancock BEng ,&nbsp;Sebastian Hinde PhD ,&nbsp;Sam M. Janes PhD ,&nbsp;Martyn P.T. Kennedy MBChB ,&nbsp;Catriona Marshall PhD ,&nbsp;Henrik Moller Dr.Med. ,&nbsp;Rachael L. Murray PhD ,&nbsp;Richard D. Neal PhD ,&nbsp;Samantha L. Quaife PhD ,&nbsp;Suzanne Rogerson RN ,&nbsp;Bethany Shinkins DPhil ,&nbsp;Matthew E.J. Callister PhD","doi":"10.1016/j.jtho.2024.12.016","DOIUrl":"10.1016/j.jtho.2024.12.016","url":null,"abstract":"<div><h3>Introduction</h3><div>Low-dose computed tomography screening for lung cancer reduces lung cancer mortality, but there is a lack of international consensus regarding the optimal eligibility criteria for screening. The Yorkshire Lung Screening Trial was designed to evaluate lung cancer screening (LCS) implementation, and a primary objective was prospective evaluation of three predefined eligibility criteria.</div></div><div><h3>Methods</h3><div>Individuals who had ever smoked, aged 55 to 80 years, who responded to written invitation, underwent telephone risk assessment and if eligible by at least one criterion (PLCO_M2012 ≥ 1.51%, LLP_v2 ≥ 5%, USPSTF₂₀₁₃) were offered biennial low-dose computed tomography screening.</div></div><div><h3>Results</h3><div>Of 44,957 individuals invited, 22,814 responded and underwent eligibility assessment, of whom a total of 7826 were eligible according to any of the three LCS criteria. Comparing PLCO_M2012 ≥ 1.51%, LLP_v2 ≥ 5%, and USPSTF₂₀₁₃, the proportions of responders eligible for screening were 28.0%, 20.5%, and 18.9%, respectively (<em>p</em> &lt; 0.0001 for each comparison), and the proportion of all cancers detected 91.1%, 77.0%, and 62.8%, respectively (<em>p</em> ≤ 0.0002 for each comparison). When risk thresholds were selected to result in equivalent numbers of people eligible for screening, cancer detection proportions were higher for PLCO_M2012 (74.5%) and LLP_v2 (71.3%) than USPSTF₂₀₁₃ (62.8%) (<em>p</em> = 0.0002 and <em>p</em> = 0.032, respectively), but there was no significant difference between the two risk models. Reducing the LLPv2 risk threshold from 5% to 2.5% (as currently used in the English LCS program) and reducing the pack-year requirement for the USPSTF₂₀₂₁ versus the USPSTF₂₀₁₃ criteria increased the numbers eligible for screening, but subsequent cancer yield was not measured in this study.</div></div><div><h3>Conclusion</h3><div>The PLCO_M2012 ≥ 1.51% criteria identified more people eligible for screening in Yorkshire Lung Screening Trial and resulted in more screen-detected lung cancers than LLP_v2 ≥ 5% or USPSTF₂₀₁₃. When compared in equivalent populations, there was no significant difference between risk models in terms of lung cancer detection and each appeared more efficient at screening population selection than USPSTF₂₀₁₃.</div></div>","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Pages 425-436"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concerns Regarding Linear Assumptions in Principal Component Analysis: Advocating for Nonlinear and Nonparametric Approaches in Pulmonary Carcinoid Research","authors":"Yoshiyasu Takefuji PhD","doi":"10.1016/j.jtho.2024.12.024","DOIUrl":"10.1016/j.jtho.2024.12.024","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Pages e54-e55"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Response to the Letter to the Editor: “Clinical Value of Incidental Lung Nodule Detection”","authors":"Stephanie Tuminello PhD,&nbsp;Matthew Untalan MS,&nbsp;Raja Flores MD,&nbsp;Emanuela Taioli MD, PhD","doi":"10.1016/j.jtho.2025.01.005","DOIUrl":"10.1016/j.jtho.2025.01.005","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Page e58"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP01.15 Transcriptional Changes Associated with Tolerance to EGFR Tyrosine Kinase Inhibitors in Mutant EGFR Lung Cancer PDX Models","authors":"Nhu-An Pham ,&nbsp;Quan Li ,&nbsp;Arundhathi Arivajiagane ,&nbsp;Katrina Hueniken ,&nbsp;Yoshiaki Inoue ,&nbsp;Masashi Mikubo ,&nbsp;Ming Li ,&nbsp;Ming-Sound Tsao","doi":"10.1016/j.jtho.2025.03.022","DOIUrl":"10.1016/j.jtho.2025.03.022","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Pages S8-S9"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP01.09 Integrin-Linked Kinase Drives Drug-Tolerant Persister Cell Survival and EMT in Response to EGFR Inhibition in Lung Adenocarcinoma","authors":"Rocky Shi ,&nbsp;Dylan A. Farnsworth ,&nbsp;Christopher A. Febres-Aldana ,&nbsp;Justine LM. Chow ,&nbsp;Ravinder Sheena ,&nbsp;Tejveer Atwal ,&nbsp;Juan Luis Gomez Marti ,&nbsp;Kiersten N. Thomas ,&nbsp;Che-Min Lee ,&nbsp;Shannon J. Awrey ,&nbsp;Paul C. McDonald ,&nbsp;Romel Somwar ,&nbsp;Shoukat Dedhar ,&nbsp;Marc Ladanyi ,&nbsp;Kevin L. Bennewith ,&nbsp;William W. Lockwood","doi":"10.1016/j.jtho.2025.03.017","DOIUrl":"10.1016/j.jtho.2025.03.017","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Page S6"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP01.25 Exploring the Impact of Socioeconomic and Geographic Factors on Immunotherapy Discontinuation and Success in Northern Ontario: A Retrospective, Single-Center Cohort Study","authors":"Alesha Bishop ,&nbsp;Olexiy Aseyev","doi":"10.1016/j.jtho.2025.03.028","DOIUrl":"10.1016/j.jtho.2025.03.028","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Pages S10-S11"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP01.22 Targeting GTP-Bound KRAS and mTOR in Lung Adenocarcinoma and Squamous Cell Carcinoma Harboring KRAS G12C","authors":"Masaoki Ito ,&nbsp;Yoshihiro Miyata ,&nbsp;Kenichi Suda ,&nbsp;Yasuhiro Tsutani ,&nbsp;Morihito Okada","doi":"10.1016/j.jtho.2025.03.026","DOIUrl":"10.1016/j.jtho.2025.03.026","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Page S10"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP01.17 Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR) as Independent Prognostic Markers in EGFR- Tested Advanced Non-small Cell Lung Cancer","authors":"Kijjakom Thanasombunsukh ,&nbsp;Sukrit Treewattanawong","doi":"10.1016/j.jtho.2025.03.024","DOIUrl":"10.1016/j.jtho.2025.03.024","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Page S9"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tobacco News Update–From the IASLC Tobacco Control Committee","authors":"","doi":"10.1016/j.jtho.2025.02.015","DOIUrl":"10.1016/j.jtho.2025.02.015","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Pages 408-410"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Response to “Equipoise Is No Longer a Major Consideration in the Ethical Evaluation of Phase 3 Randomized Controlled Trials Involving Precision Oncology Approaches in NSCLC”","authors":"Sarah Heynemann M.B.B.S., BMedSci, FRACP, MBioeth,&nbsp;Wendy Lipworth M.B.B.S., PhD,&nbsp;Sue-Anne McLachlan M.B.B.S., MSc, FRACP,&nbsp;Jennifer Philip M.B.B.S., GDipPallMed, MMed, PhD,&nbsp;Tom John M.B.B.S., PhD, FRACP,&nbsp;Ian Kerridge BA, BMed(Hons), MPhil(Cantab), FRACP, FRCPA","doi":"10.1016/j.jtho.2024.12.017","DOIUrl":"10.1016/j.jtho.2024.12.017","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Pages e51-e52"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}