Batel Blechter, Chao Agnes Hsiung, Xiaoyu Wang, Haoyu Zhang, Wei Jie Seow, Jianxin Shi, Nilanjan Chatterjee, Hee Nam Kim, Maria Pik Wong, Yun-Chul Hong, Jason Y Y Wong, Juncheng Dai, H Dean Hosgood, Zhaoming Wang, I-Shou Chang, Jiyeon Choi, Jiucun Wang, Minsun Song, Wei Hu, Wei Zheng, Jin Hee Kim, Baosen Zhou, Demetrius Albanes, Min-Ho Shin, Lap Ping Chung, She-Juan An, Hong Zheng, Yasushi Yatabe, Xu-Chao Zhang, Young Tae Kim, Xiao-Ou Shu, Young-Chul Kim, Roel C H Vermeulen, Bryan A Bassig, Jiang Chang, James Chung Man Ho, Bu-Tian Ji, Michiaki Kubo, Yataro Daigo, Yukihide Momozawa, Yoichiro Kamatani, Takayuki Honda, Hideo Kunitoh, Shun-Ichi Watanabe, Yohei Miyagi, Haruhiko Nakayama, Shingo Matsumoto, Masahiro Tsuboi, Koichi Goto, Zhihua Yin, Atsushi Takahashi, Akiteru Goto, Yoshihiro Minamiya, Kimihiro Shimizu, Kazumi Tanaka, Tangchun Wu, Fusheng Wei, Jian Su, Yeul Hong Kim, In-Jae Oh, Victor Ho Fun Lee, Wu-Chou Su, Yuh-Min Chen, Gee-Chen Chang, Kuan-Yu Chen, Ming-Shyan Huang, Hsien-Chih Lin, Adeline Seow, Jae Yong Park, Sun-Seog Kweon, Chien-Jen Chen, Yu-Tang Gao, Chen Wu, Biyun Qian, Daru Lu, Jianjun Liu, Hyo-Sung Jeon, Chin-Fu Hsiao, Jae Sook Sung, Ying-Huang Tsai, Yoo Jin Jung, Huan Guo, Zhibin Hu, Tzu-Yu Chen, Laurie Burdett, Meredith Yeager, Amy Hutchinson, Sonja I Berndt, Wei Wu, Junwen Wang, Jin Eun Choi, Kyong Hwa Park, Sook Whan Sung, Li Liu, Chang Hyun Kang, Chung-Hsing Chen, Jun Xu, Peng Guan, Wen Tan, Chih-Liang Wang, Alan Dart Loon Sihoe, Ying Chen, Yi Young Choi, Jun Suk Kim, Ho-Il Yoon, Qiuyin Cai, In Kyu Park, Ping Xu, Qincheng He, Chih-Yi Chen, Junjie Wu, Wei-Yen Lim, Kun-Chieh Chen, John K C Chan, Jihua Li, Hongyan Chen, Chong-Jen Yu, Li Jin, Joseph F Fraumeni, Jie Liu, Maria Teresa Landi, Taiki Yamaji, Yang Yang, Belynda Hicks, Kathleen Wyatt, Shengchao A Li, Hongxia Ma, Bao Song, Zhehai Wang, Sensen Cheng, Xuelian Li, Yangwu Ren, Motoki Iwasaki, Junjie Zhu, Gening Jiang, Ke Fei, Guoping Wu, Li-Hsin Chien, Fang-Yu Tsai, Jinming Yu, Victoria L Stevens, Pan-Chyr Yang, Dongxin Lin, Kexin Chen, Yi-Long Wu, Keitaro Matsuo, Nathaniel Rothman, Kouya Shiraishi, Hongbing Shen, Stephen J Chanock, Takashi Kohno, Qing Lan
{"title":"Polygenic Risk Score and Lung Adenocarcinoma Risk Among Never-Smokers by EGFR Mutation Status: A Brief Report.","authors":"Batel Blechter, Chao Agnes Hsiung, Xiaoyu Wang, Haoyu Zhang, Wei Jie Seow, Jianxin Shi, Nilanjan Chatterjee, Hee Nam Kim, Maria Pik Wong, Yun-Chul Hong, Jason Y Y Wong, Juncheng Dai, H Dean Hosgood, Zhaoming Wang, I-Shou Chang, Jiyeon Choi, Jiucun Wang, Minsun Song, Wei Hu, Wei Zheng, Jin Hee Kim, Baosen Zhou, Demetrius Albanes, Min-Ho Shin, Lap Ping Chung, She-Juan An, Hong Zheng, Yasushi Yatabe, Xu-Chao Zhang, Young Tae Kim, Xiao-Ou Shu, Young-Chul Kim, Roel C H Vermeulen, Bryan A Bassig, Jiang Chang, James Chung Man Ho, Bu-Tian Ji, Michiaki Kubo, Yataro Daigo, Yukihide Momozawa, Yoichiro Kamatani, Takayuki Honda, Hideo Kunitoh, Shun-Ichi Watanabe, Yohei Miyagi, Haruhiko Nakayama, Shingo Matsumoto, Masahiro Tsuboi, Koichi Goto, Zhihua Yin, Atsushi Takahashi, Akiteru Goto, Yoshihiro Minamiya, Kimihiro Shimizu, Kazumi Tanaka, Tangchun Wu, Fusheng Wei, Jian Su, Yeul Hong Kim, In-Jae Oh, Victor Ho Fun Lee, Wu-Chou Su, Yuh-Min Chen, Gee-Chen Chang, Kuan-Yu Chen, Ming-Shyan Huang, Hsien-Chih Lin, Adeline Seow, Jae Yong Park, Sun-Seog Kweon, Chien-Jen Chen, Yu-Tang Gao, Chen Wu, Biyun Qian, Daru Lu, Jianjun Liu, Hyo-Sung Jeon, Chin-Fu Hsiao, Jae Sook Sung, Ying-Huang Tsai, Yoo Jin Jung, Huan Guo, Zhibin Hu, Tzu-Yu Chen, Laurie Burdett, Meredith Yeager, Amy Hutchinson, Sonja I Berndt, Wei Wu, Junwen Wang, Jin Eun Choi, Kyong Hwa Park, Sook Whan Sung, Li Liu, Chang Hyun Kang, Chung-Hsing Chen, Jun Xu, Peng Guan, Wen Tan, Chih-Liang Wang, Alan Dart Loon Sihoe, Ying Chen, Yi Young Choi, Jun Suk Kim, Ho-Il Yoon, Qiuyin Cai, In Kyu Park, Ping Xu, Qincheng He, Chih-Yi Chen, Junjie Wu, Wei-Yen Lim, Kun-Chieh Chen, John K C Chan, Jihua Li, Hongyan Chen, Chong-Jen Yu, Li Jin, Joseph F Fraumeni, Jie Liu, Maria Teresa Landi, Taiki Yamaji, Yang Yang, Belynda Hicks, Kathleen Wyatt, Shengchao A Li, Hongxia Ma, Bao Song, Zhehai Wang, Sensen Cheng, Xuelian Li, Yangwu Ren, Motoki Iwasaki, Junjie Zhu, Gening Jiang, Ke Fei, Guoping Wu, Li-Hsin Chien, Fang-Yu Tsai, Jinming Yu, Victoria L Stevens, Pan-Chyr Yang, Dongxin Lin, Kexin Chen, Yi-Long Wu, Keitaro Matsuo, Nathaniel Rothman, Kouya Shiraishi, Hongbing Shen, Stephen J Chanock, Takashi Kohno, Qing Lan","doi":"10.1016/j.jtho.2024.11.019","DOIUrl":null,"url":null,"abstract":"<p><p>We assessed the association between a genome-wide polygenic risk score (PRS) developed for lung adenocarcinoma (LUAD) risk and mutation on the EGFR gene in 998 East Asian never-smoking female LUAD cases (518 EGFR-positive; 480 EGFR-negative) and 4544 never-smoking controls using case-case and multinomial regression analyses. We found that the PRS was more strongly associated with EGFR-positive LUAD compared with EGFR-negative LUAD, where the association between the fourth quartile of the PRS and EGFR-positive LUAD (odds ratio = 8.63, 95% confidence interval: 5.67-13.14) was significantly higher than the association between the fourth quartile of the PRS with EGFR-negative LUAD (odds ratio = 3.50, 95% confidence interval: 2.44-5.00) (p-heterogeneity = 3.66 × 10<sup>-3</sup>). Our findings suggest that germline genetic susceptibility may be differentially associated with LUAD in never-smoking female East Asian patients depending on the cancer's mutation status, which may have important public health and clinical implications.</p>","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":" ","pages":""},"PeriodicalIF":21.0000,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Thoracic Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jtho.2024.11.019","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
We assessed the association between a genome-wide polygenic risk score (PRS) developed for lung adenocarcinoma (LUAD) risk and mutation on the EGFR gene in 998 East Asian never-smoking female LUAD cases (518 EGFR-positive; 480 EGFR-negative) and 4544 never-smoking controls using case-case and multinomial regression analyses. We found that the PRS was more strongly associated with EGFR-positive LUAD compared with EGFR-negative LUAD, where the association between the fourth quartile of the PRS and EGFR-positive LUAD (odds ratio = 8.63, 95% confidence interval: 5.67-13.14) was significantly higher than the association between the fourth quartile of the PRS with EGFR-negative LUAD (odds ratio = 3.50, 95% confidence interval: 2.44-5.00) (p-heterogeneity = 3.66 × 10-3). Our findings suggest that germline genetic susceptibility may be differentially associated with LUAD in never-smoking female East Asian patients depending on the cancer's mutation status, which may have important public health and clinical implications.
期刊介绍：
Journal of Thoracic Oncology (JTO), the official journal of the International Association for the Study of Lung Cancer,is the primary educational and informational publication for topics relevant to the prevention, detection, diagnosis, and treatment of all thoracic malignancies.The readship includes epidemiologists, medical oncologists, radiation oncologists, thoracic surgeons, pulmonologists, radiologists, pathologists, nuclear medicine physicians, and research scientists with a special interest in thoracic oncology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
