Journal of The Serbian Chemical Society最新文献_第5页

Binuclear azide-bridged hydrazone Cu(II) complex: Synthesis, characterization and evaluation of biological activity 双核叠氮化物桥接腙Cu(II)配合物:合成、表征及生物活性评价

IF 1 4区化学

Journal of The Serbian Chemical Society Pub Date : 2023-01-01 DOI: 10.2298/jsc230623044v

Teodora Vitomirov, Božidar Čobeljić, Andrej Pevec, Dušanka D. Radanović, I. Novaković, M. Savić, K.K. Andjelković, M. Sumar-Ristovic

{"title":"Binuclear azide-bridged hydrazone Cu(II) complex: Synthesis, characterization and evaluation of biological activity","authors":"Teodora Vitomirov, Božidar Čobeljić, Andrej Pevec, Dušanka D. Radanović, I. Novaković, M. Savić, K.K. Andjelković, M. Sumar-Ristovic","doi":"10.2298/jsc230623044v","DOIUrl":"https://doi.org/10.2298/jsc230623044v","url":null,"abstract":"The condensation product of 7-acetyl-6-azaindole and Girard's T reagent ((E)-2-(2-(1-(1H-pyrrolo[2,3-c]pyridin-7-yl)ethylidene)hydrazineyl)- N,N,N-trimethyl-2-oxoethan-1-aminium, HL ligand) was used as a ligand in the reaction with Cu(BF4)2?6H2O and NaN3. The reaction led to the formation of a binuclear Cu(II) complex containing two end-to-end (di-m-1,3-N3) azide bridges, as well as two NNO-donor hydrazone ligands, forming an axially elongated square pyramidal geometry around each Cu(II) center. This end-to-end (di-m-1,3- N3) azide bridge binding mode has not yet occurred in Cu(II) complexes containing the NNO-donor hydrazone ligands, which makes the structure of the complex even more interesting for further studies. The complex was characterized by elemental analysis, IR spectroscopy and X-ray crystallography, and it was found that it crystallizes in the triclinic space group P-1 with the asymmetric unit comprising one Cu(II) centre, zwitterionic ligand L, one azide (N3?) ligand, and BF4? counter anion. Examination of antimicrobial activity of the complex shows higher antifungal and antibacterial activity towards tested Gram-positive bacteria in comparison to the hydrazone ligand, with the antifungal activity of the complex even being comparable to the activity of amphotericin B.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68517828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of the metal ion adsorption capacity of palygorskite by computer simulation 坡缕石对金属离子吸附能力的计算机模拟研究

4区化学

Journal of The Serbian Chemical Society Pub Date : 2023-01-01 DOI: 10.2298/jsc230708082l

Chuan-Wen Liu, Min-Hsien Liu, To-Mai Wang, Cheng-Lung Chen

{"title":"Study of the metal ion adsorption capacity of palygorskite by computer simulation","authors":"Chuan-Wen Liu, Min-Hsien Liu, To-Mai Wang, Cheng-Lung Chen","doi":"10.2298/jsc230708082l","DOIUrl":"https://doi.org/10.2298/jsc230708082l","url":null,"abstract":"Palygorskite is a magnesium-rich aluminosilicate clay mineral with a unique chain-layered structure. This structure gives palygorskite a large specific surface area and interesting physical properties. Many researchers have investigated the applications of palygorskite in various fields, including heavy metal adsorption, petroleum and chemical industries, building materials, medicine, and agriculture. In this study, molecular dynamics simulations were used to explore the heavy metal adsorption ability of palygorskite. The results showed that polyacrylic acid (PAA) had a heavy metal adsorption ability. In terms of the ability of the substrate to adsorb Pb2+, Ni2+, and Cr3+, palygorskite (attapulgite, ATP) was more effective than SiO2 or clay. Based on this study, the same phenomenon reported in the literature was confirmed, and it was demonstrated that molecular dynamics could properly simulate the filtration of heavy metal ions in water using novel materials. Moreover, H+ ions were found to play an essential role in assisting PAA/ATP in capturing heavy metal ions. Using this method, we were able to observe the details of heavy-ion adsorption.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135211083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Admet profiles of selected anabolic steroid derivatives 选定的合成代谢类固醇衍生物的Admet概况

4区化学

Journal of The Serbian Chemical Society Pub Date : 2023-01-01 DOI: 10.2298/jsc230803086b

Andrei Bitang, Viorel Bitang, Vlad Grosu, Alecu Ciorsac, Adriana Isvoran

{"title":"Admet profiles of selected anabolic steroid derivatives","authors":"Andrei Bitang, Viorel Bitang, Vlad Grosu, Alecu Ciorsac, Adriana Isvoran","doi":"10.2298/jsc230803086b","DOIUrl":"https://doi.org/10.2298/jsc230803086b","url":null,"abstract":"There is control over the use and marketing of steroids, and new compounds that mimic their effects, steroid derivatives, are being synthesized. They are frequently produced as dietary supplements intended to improve physical activity, and usually no information is provided regarding their ingredients, dosages, and efficacy or safety. In this study, a computational approach was used to evaluate the absorption, distribution, metabolism, excretion and toxicity (ADMET) profiles of several steroid derivatives: methasterone, methyl-1-testosterone, 4-hydroxytestosterone, methyldienolone, methyltrienolone, 19-nor-5-androstenedione. The following computational prediction tools were applied: admetSAR2.0, ADMETLab2.0, Endocrine Disruptome, PredSkin3.0. All investigated compounds showed good human intestinal absorption, are not able to penetrate the blood-brain barrier and inhibit cytochrome P450 enzymes involved in the metabolism of xenobiotics. These compounds have potential for skin sensitisation, induce reproductive toxicity and endocrine disruption, and have a low potential for hepatotoxicity and respiratory toxicity. The results of the study are important to be known by those who are exposed at workplaces where these compounds are produced and packed and by consumers. These predictions can also guide the experimental evaluation of the possible toxicity of the investigated compounds, the results of which can be further used for purposes of regulating the use of these steroid derivatives.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"148 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135447646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-detection of eugenol and butylated hydroxyltoluene by green and selective hydrodistillation of Heliotropium europaeum L. using ionic liquids as additives 以离子液体为添加剂，绿色选择性加氢蒸馏法检测丁香酚和丁基羟基甲苯

4区化学

Journal of The Serbian Chemical Society Pub Date : 2023-01-01 DOI: 10.2298/jsc230713075b

Sara Bendjelloul, Choukry Bendeddouche, Souhila Bendeddouche, Madani Sarri, Feriha Bensafiddine, Nadia Kambouche, Ludovic Paquin, Mohamed Yousfi, Mohamed Harrat

{"title":"Co-detection of eugenol and butylated hydroxyltoluene by green and selective hydrodistillation of Heliotropium europaeum L. using ionic liquids as additives","authors":"Sara Bendjelloul, Choukry Bendeddouche, Souhila Bendeddouche, Madani Sarri, Feriha Bensafiddine, Nadia Kambouche, Ludovic Paquin, Mohamed Yousfi, Mohamed Harrat","doi":"10.2298/jsc230713075b","DOIUrl":"https://doi.org/10.2298/jsc230713075b","url":null,"abstract":"This study is the first work that focuses on unconventional ionic liquids hydrodistillation (IL-HD) extraction of the essential oil of Heliotropium europaeum L. using ionic liquids (ILs) as additives. Two ILs based on 1-butyl- 3-methylimidazolium were used by switching the anions (Cl- and PF6-). The effect of mass percent adding ILs on its yield and composition was evaluated. Compared to conventional hydrodistillation (HD), ILs-HD gives a higher yield of essential oils (0.10-0.36%). Particularly, with [C4mim] [PF6], observation of morphological changes using scanning electron microscopy (SEM) confirmed the effectiveness of the ionic liquid in this distillation process. The GC-MS analysis of essential oils (EOs) revealed the presence of sixty-six compounds in HD, ILs-HD methods. GC-MS analyze of the EOs revealed predominance of Eugenol (1.70-72.35%), Butylated hydroxytoluene (8.95-65.39%) and Phytol (18.20%). The new distillation methods of H. europaeum with ILs identifies more compounds (50 compounds in ILs-HD [C4mim] [PF6]; 22 compounds in ILs-HD [C4mim] [Cl]) than conventional hydrodistillation (25 compounds in HD). Therefore, the ILs-based hydrodistillation approach is superior in improving the production of EOs. It is important to emphasize that the data presented in this study are not yet available for any of this Algerian Heliotropium species of genus and reveal in literature the great potential of this medicinal plant as a source of novel bioactive extracts with potential therapeutic uses.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136301950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, computational and pharmacological evaluation of novel N-{4-[2-(4-aryl-piperazin-1-yl)ethyl]phenyl}-arylamides 新型N-{4-[2-(4-芳基-哌嗪-1-基)乙基]苯基}芳基酰胺的合成、计算和药理学评价

4区化学

Journal of The Serbian Chemical Society Pub Date : 2023-01-01 DOI: 10.2298/jsc230906076a

Deana Andric, Sladjana Dukic-Stefanovic, Mihajlo Krunic, Ivana Jevtic, Jelena Penjisevic, Vladimir Sukalovic, Sladjana Kostic-Rajacic

{"title":"Synthesis, computational and pharmacological evaluation of novel N-{4-[2-(4-aryl-piperazin-1-yl)ethyl]phenyl}-arylamides","authors":"Deana Andric, Sladjana Dukic-Stefanovic, Mihajlo Krunic, Ivana Jevtic, Jelena Penjisevic, Vladimir Sukalovic, Sladjana Kostic-Rajacic","doi":"10.2298/jsc230906076a","DOIUrl":"https://doi.org/10.2298/jsc230906076a","url":null,"abstract":"Serotonin, or 5-hydroxytryptamine (5-HT), is a biogenic amine most noted as a neurotransmitter, an activator of the utmost subtype family of G-protein-coupled receptors (GPCR). Drugs targeting 5-HT1A and other 5-HT receptors treat central nervous system diseases such as schizophrenia and depression. Recent advances in serotonin receptor structure research gave us several crystal 5-HT1A receptor structures, most notably 5-HT1A bound to the antipsychotic drug aripiprazole (Abilify?). This discovery prompted us to evaluate a series of newly synthesized ligands for serotonergic activity since those arylpiperazine derivatives share minimal general structure with aripiprazole. The results of molecular docking analysis of unsubstituted starting substances encouraged us to propound further modifications of the tail and head parts of the parent molecules to maximize receptor binding affinity. Intrigued by the results of molecular analysis, all foreseen derivatives were synthesized. The pharmacological activity of all nine (5a and 6a are synthesised previously) compounds was assessed by the in vitro tests, and in silico pharmacokinetics predictions for the most promising candidates. All tested ligands have improved affinity compering to parent compounds (10a and 11a), 8b and 9b expressed the best pharmacological profile with an improved binding affinity toward serotonin 5-HT1A receptors (Ki 12.1 and 4.8 nM, respectively.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136302322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diorganotin(IV) complexes with hydroxamic acids derivatives of some histone deacetylases inhibitors 一些组蛋白去乙酰化酶抑制剂的羟肟酸衍生物双有机锡配合物

4区化学

Journal of The Serbian Chemical Society Pub Date : 2023-01-01 DOI: 10.2298/jsc230630064n

Danijela Nikolic, Marija Gencic, Jelena Aksic, Niko Radulovic, Dusan Dimic, Goran Kaludjerovic

{"title":"Diorganotin(IV) complexes with hydroxamic acids derivatives of some histone deacetylases inhibitors","authors":"Danijela Nikolic, Marija Gencic, Jelena Aksic, Niko Radulovic, Dusan Dimic, Goran Kaludjerovic","doi":"10.2298/jsc230630064n","DOIUrl":"https://doi.org/10.2298/jsc230630064n","url":null,"abstract":"Organotin(IV) compounds show great potential as antitumor metallodrugs with lower toxicity and higher antiproliferative activity. Histone deacetylases (HDAC) inhibitors are characterized by high bioavailability and low toxicity. In this contribution, the two novel octahedral organotin(IV) complexes of physiologically active hydroxamate-based ligands, N-hydroxy-4- phenylbutanamide (HL1) and N-hydroxy-2-propylpentanamide (HL2), have been prepared and characterized using FTIR, 1H, 13C, and 119Sn NMR spectroscopy. Particular emphasis was put on the binding characteristics of ligands. The structures were additionally analyzed by the Density functional theory at B3LYP-D3BJ/6-311++G(d,p)(H,C,N,O)/LanL2DZ(Sn) level. The theoretical IR and NMR spectra were compared to the spectroscopic data, and it was concluded that the predicted structures described well the experimental ones. The stability of different isomers of HL1 and HL2 was assessed by the Natural Bond Orbital analysis, and the importance of intramolecular hydrogen bond was outlined. The interactions between donor atoms and Sn were investigated and correlated with changes in chemical shift and wavenumbers of characteristic vibrations.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"58 21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135550598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O Schiff base copper(II) complexes 四齿N,N,O,O希夫碱铜(II)配合物的DNA/BSA相互作用和细胞毒性研究

4区化学

Journal of The Serbian Chemical Society Pub Date : 2023-01-01 DOI: 10.2298/jsc230614063m

Aleksandar Mijatovic, Angelina Cakovic, Aleksandar Lolic, Snezana Sretenovic, Marko Zivanovic, Dragana Seklic, Jovana Bogojeski, Biljana Petrovic

{"title":"DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O Schiff base copper(II) complexes","authors":"Aleksandar Mijatovic, Angelina Cakovic, Aleksandar Lolic, Snezana Sretenovic, Marko Zivanovic, Dragana Seklic, Jovana Bogojeski, Biljana Petrovic","doi":"10.2298/jsc230614063m","DOIUrl":"https://doi.org/10.2298/jsc230614063m","url":null,"abstract":"Three Schiff base Cu(II) complexes, (N,N?-bis(acetylacetone)- propylenediimine)copper(II) complex, [Cu(acac2pn)] (1), (N,N'-bis- (benzoylacetone)propylenediimine)copper(II) complex, [Cu(phacac2pn)] (2) and (N,N?-bis-(trifluoroacetylacetone)propylenediimine)copper(II) complex, [Cu(tfacac2pn)] (3), were used to investigate the interactions with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) using the electronic absorption and spectroscopic fluorescence methods. UV-Vis absorption studies showed that studied complexes interact with DNA molecule and exhibit moderate binding affinity. Fluorescence studies of complexes 1-3 also showed a possibility for DNA intercalation as well as a relatively high binding ability toward BSA. Among the tested complexes, the highest affinity for DNA and BSA molecules was shown by complex 1. Cytotoxic analyses, performed on human colorectal carcinoma HCT-116 and healthy lung fibroblast MRC-5 cell lines, showed that complex 2 exhibited activity on both cell lines, while complexes 1 and 3 did not show any activity.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135557155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ligands containing 7-azaindole functionality for inner-sphere hydrogen bonding: structural and photophysical investigations 含7-氮杂吲哚功能的内球氢键配体:结构和光物理研究

4区化学

Journal of The Serbian Chemical Society Pub Date : 2023-01-01 DOI: 10.2298/jsc230623061c

Alec Coles, Oskar Wood, Chris Hawes

{"title":"Ligands containing 7-azaindole functionality for inner-sphere hydrogen bonding: structural and photophysical investigations","authors":"Alec Coles, Oskar Wood, Chris Hawes","doi":"10.2298/jsc230623061c","DOIUrl":"https://doi.org/10.2298/jsc230623061c","url":null,"abstract":"The synthesis, structural analysis and spectroscopic characterisation of three new 7-azaindole ligands is reported, alongside a novel 7-azaindole derived coordination polymer, with the aim of identifying new bridging ligands containing inner-sphere hydrogen bond donor functionality. Structural characterisation shows that the 7-azaindole hydrogen bond donor ability is significantly stronger in the hydrazone and imine species 1 and 2 compared to the amine 3, with the opposite trend evident in their hydrogen bond acceptor character. These findings are mirrored by the fluorescence spectroscopy results which show bimodal emission, characteristic of multiple emissive species related by proton transfer, is only evident in the amine species and not the more acidic imines. The polymeric copper(II) complex of the hydrazone ligand 1 shows the anticipated inner-sphere hydrogen bonding with a similar donor strength to that observed in the free ligand, which leads to deformation in the remainder of the coordination sphere. These results show the untapped versatility of the 7-azaindole functional group as a building block for ligands in coordination polymers and other multinuclear assemblies, with the potential for both stabilisation through hydrogen bonding and interesting photophysical properties.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135557160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Square-pyramidal mononuclear, dinuclear and polymeric copper(II) complexes with (2-pyridinylmethyl)amino derivatives 与(2-吡啶基甲基)氨基衍生物的方锥体单核、双核和聚合铜(II)配合物

4区化学

Journal of The Serbian Chemical Society Pub Date : 2023-01-01 DOI: 10.2298/jsc230818072r

Stefan Richter, Peter Lönnecke, Dijana Bovan, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Goran Kaludjerovic, Evamarie Hey-Hawkins

{"title":"Square-pyramidal mononuclear, dinuclear and polymeric copper(II) complexes with (2-pyridinylmethyl)amino derivatives","authors":"Stefan Richter, Peter Lönnecke, Dijana Bovan, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Goran Kaludjerovic, Evamarie Hey-Hawkins","doi":"10.2298/jsc230818072r","DOIUrl":"https://doi.org/10.2298/jsc230818072r","url":null,"abstract":"The coordination behavior of three ligand precursors 2-[(2- pyridinylmethyl)amino]acetic acid hydrochloride, 4-[(2- pyridinylmethyl)amino]benzoic acid hydrochloride and 4-{[2-(pyridin-2- ylmethylamino)ethylamino]methyl}benzoic acid hydrochloride, HL1?HCl- HL3?HCl, respectively, in copper(II) complexes is described. The complexes were characterized by elemental analysis, ESI mass spectrometry and IR spectroscopy, as well as X-ray structural analysis. The reaction of copper(II) with HL1?HCl in methanol afforded the polymeric complex [{Cu(?-Cl)2(MeL1- ?2N,N?)}n] (1) featuring the methyl ester of L1 (MeL1). With HL2?HCl or HL3?HCl, the dimeric complex [{CuCl(?-Cl)(HL2-?2N,N?)}2] (2) or the mononuclear complex [CuCl2(HL3-?3N,N?,N??)] (3) were obtained. All complexes exhibited square-pyramidal geometries. In 1, polymeric chains are formed through bridging chlorido ligands without typical hydrogen bonding interaction. Contrarily, the COOH group in 2 is participating in the formation of intermolecular hydrogen bonding forming a supramolecular structure. In 3, intermolecular hydrogen bonding (Cl?O) leads to a 1-D polymeric structure. The copper(II) complex 2 diminished viability of human 8505C, MCF-7, 518A2 and SW480 cell lines. The tumoricidal effect of 2 was realized mainly through caspase-mediated apoptosis.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135748626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of derivatives of 2,3-dihydroquinazolin-4(1H)-one as inhibitors of cholinesterases and their antioxidant activity: In vitro, in silico, and kinetics studies 评价2,3-二氢喹唑啉-4(1H)- 1衍生物作为胆碱酯酶抑制剂及其抗氧化活性:体外、硅和动力学研究

IF 1 4区化学

Journal of The Serbian Chemical Society Pub Date : 2023-01-01 DOI: 10.2298/jsc211106005b

O. Babatunde, S. Hameed, Kingsley A. Mbachu, F. Saleem, S. Chigurupati, A. Wadood, Rehman Ur, V. Venugopal, Khalid M Khan, M. Taha, O. Ekundayo, M. Khan

引用次数: 0