Journal of The Serbian Chemical Society最新文献

{"title":"The Practice of Prescribing Antidepressants During Pregnancy and Breastfeeding Among Mental Health Practitioners in Tertiary Care Centers in Oman.","authors":"Salim Al Kasbi, Yousif Obaid, Samir Al Adawi, Sanjay Jaju","doi":"10.5001/omj.2023.123","DOIUrl":"10.5001/omj.2023.123","url":null,"abstract":"<p><strong>Objectives: </strong>This study sought to determine the confidence level of mental health practitioners in Oman regarding the use of antidepressants during pregnancy and breastfeeding, assess their knowledge and need for further training in this area, and examine their current prescribing patterns and preferences.</p><p><strong>Methods: </strong>A questionnaire-based survey was conducted from May to June 2017 among all practitioners in the psychiatry specialty, including medical officers authorized to prescribe medications, at the Behavioral Medicine Department of Sultan Qaboos University Hospital and Al Masarra Hospital.</p><p><strong>Results: </strong>Forty-two practitioners (response rate = 89.4%) responded to the questionnaire. Of them, 10 (23.8%) had no experience, while 30 (71.4%) had experience in prescribing antidepressants during both pregnancy and breastfeeding periods. Twenty-seven (64.3%) respondents felt that they were confident in prescribing antidepressants for women during their perinatal period, while 30.0% were neutral. Moreover, 35 (83.3%) participants expressed the need for more training in this area. Furthermore, 34 (81.0%) believed that more training in perinatal psychiatry should be included in the psychiatry curriculum. There was no consistent prescribing pattern (either prescribing or avoiding) among our participating practitioners during the first trimester of pregnancy and breastfeeding periods. The drug of choice in the first trimester of pregnancy was fluoxetine preferred by approximately 85.0% of the practitioners, but avoided by 10.0% of practitioners in the same period. This was followed by amitriptyline (50.0% vs. 23.0%), sertraline (50.0% vs. 9.0%), imipramine (28.0% vs. 84.0%). During breastfeeding, the drug of choice for approximately 74.0% of the practitioners was paroxetine, but avoided by 15.0% of practitioners. This was followed by sertraline (50.0% vs. 8.0%). The most common reasons for prescription during pregnancy were safety, evidence-based practice, and low teratogenicity. For breastfeeding, the main reasons for prescription were low levels of the drug in breast milk, safety, and evidence-based practice. On the other hand, high teratogenicity, neonatal side effects, limited data, and lack of evidence were among the most common reasons behind avoiding prescribing during pregnancy, while high levels of breast milk, neonatal side effects, limited evidence, and safety concerns were the most common reasons during the breastfeeding period.</p><p><strong>Conclusions: </strong>There was inconsistency among mental health practitioners in making prescription decisions and in their prescribing patterns.</p>","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"85 1","pages":"e572"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10801695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70682986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes after curatively intended treatment of limited peritoneal metastases and thermal ablation for liver metastases from colorectal cancer.","authors":"Rogini Balachandran, Mette Møller Sørensen, Jonas Amstrup Funder, Anders Riegels Knudsen, Lene Hjerrild Iversen","doi":"10.1515/pp-2023-0015","DOIUrl":"10.1515/pp-2023-0015","url":null,"abstract":"<p><strong>Objectives: </strong>Peritoneal metastases (PM) and liver metastases (LM) are present simultaneously in up to 2 % of patients at the time of their colorectal cancer (CRC) diagnosis. Curatively intended treatment includes cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) combined with LM resection. A less invasive treatment for LM is ablation. We aimed to estimate overall survival (OS), disease-free survival (DFS) and postoperative data in patients managed simultaneously with CRS, HIPEC and radiofrequency ablation (RFA) as first choice.</p><p><strong>Methods: </strong>This was a retrospective national cohort study. All patients were treated at Aarhus University Hospital; the only CRS+HIPEC centre in Denmark. We included CRC patients managed with curative intent for simultaneously diagnosed PM and LM in the period January 2016 - December 2021. LM was treated with RFA as first choice, if possible. Survival was calculated by the Kaplan-Meier method.</p><p><strong>Results: </strong>A total of 25 patients were included, the median age was 60 years (range 43-75 years) and 15 (60 %) were females. The median peritoneal cancer index was 7 (range 0-12), the median number of LM was 1 (range 1-3). Ablation was performed as the only treatment for LM in 18 (72 %) patients. After a median follow-up time of 17.1 months (range 4-36 months), the median OS was 28.6 months (95 % confidence interval (Cl) 15.8;36.1), 1-year OS was 84.0 % (95 % Cl 62.8;93.7). Median DFS was 6.1 months (95 % Cl 4.0;10.3). Median LOS was ten days (range 5-26 days). Both 30-day and 90-day mortality were 0 %.</p><p><strong>Conclusions: </strong>The selected treatment modality (RFA) for CRC patients with both LM and PM was safe. However, DFS was low. Further research is warranted to investigate if RFA is as effective as LM resection.</p>","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"78 1","pages":"167-174"},"PeriodicalIF":1.8,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10739284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90459696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure and thermal stability of phosphochlorinated polybutadiene/carbon black composite synthesized via oxidative chlorophosphorylation reaction","authors":"Nada Edres, Irada Buniyat-Zadeh, Solmaz Aliyeva, Sinan Turp, Rasim Alosmanov","doi":"10.2298/jsc230731080e","DOIUrl":"https://doi.org/10.2298/jsc230731080e","url":null,"abstract":"The aim of the presented work was to obtain a new type of homogeneous composite based on an industrial polymer (polybutadiene, PB) and a well-known inexpensive filler (carbon black P-234, CB). For this purpose, the reaction of oxidative chlorophosphorylation (OxCh) was used. This makes it possible to introduce CB into the cross-linked structure of the modified polymer and ensure optimal distribution of the filler in it. The structure and thermal stability of the composite synthesized by the OxCh reaction were studied. Analysis of the composite by Fourier-transform infrared spectroscopy indicates a uniform distribution of carbon black in the network structure of the matrix and the physical interaction of the phases of the composite. Ultraviolet-visible spectrum data confirmed the improvement in light absorption in a wide range of the electromagnetic spectrum and the decrease in the optical band gap energy of the phosphochlorinated PB (PhPB) matrix with the addition of CB (Eg of PhPB=3.25 eV; Eg of PhPB/CB composite=2.28 eV). The influence of CB on the thermal stability of the PhPB matrix was studied using thermogravimetric and differential thermogravimetric analysis. After thermal analysis, the char yield for PhPB was 41 wt%, and for PhPB/CB composite was 35.2 wt%. Compared to PhPB, the increase in char yield, the decrease in maximum thermal decomposition temperature, and the high-integrated thermal decomposition temperature for the PhPB/CB composite show the improvement in the thermal stability of PhPB due to CB.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135107138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A DFT study of the chemical bonding properties, aromaticity indexes and molecular docking study of some phenylureas herbicides","authors":"Souhila Laib, Saad Bouchekioua, Rafik Menacer","doi":"10.2298/jsc230712085l","DOIUrl":"https://doi.org/10.2298/jsc230712085l","url":null,"abstract":"Herbicides have implied disastrous consequences towards the environment and human health. This practice urges scientists to investigate the physical, chemical and biological properties of these substances, hence avoiding the use of the most harmful pesticides. For this purpose, the molecular structure and chemical bonding properties of phenylurea herbicides namely: Fenuron (L1), Monuron (L2), Diuron (L3) and Chlorotoluron (L4), were calculated in water using density functional theory (DFT). The energy decomposition analysis (EDA) and the extended transition state natural orbitals for chemical Valence (ETS-NOCV) reveal the dominant ionic character in Carbon-Nitrogen bond between dimethylurea fragment and benzene ring. Besides, the interaction of these herbicides with the Human Serum Albumin (HSA) was undertaken by molecular modeling. The calculation of HOMA and FLU indexes indicate that the electronic delocalization is stronger in Diuron than the other compounds, mainly caused by the two chloro substituents effects on benzene. Good correlations are found between the calculated parameters such as structural parameters, Mulliken atomic charge, topological and bonding properties and aromaticity indexes. The Vinardo molecular docking results suggest that, the binding energies of the complexes formed between HSA target and investigated compounds have the following order: L3 (-27.57 kJ/mol) < L2 (-25.56 kJ/mol) < L4 (-24.94 kJ/mol) < L1 (-24.10 kJ/mol), which confirmed that the Fenuron is the less harmful option between the studied herbicides especially against HSA.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135263013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron(III) complexes with ditopic macrocycles bearing crown-ether and bis(salicylidene) isothiosemicarbazide moieties","authors":"Vladimir Arion, Oleg Palamarciuc, Sergiu Shova, Ghenadie Novitchi, Peter Rapta","doi":"10.2298/jsc230607065a","DOIUrl":"https://doi.org/10.2298/jsc230607065a","url":null,"abstract":"The main aims of this work were the synthesis and characterization of iron(III) complexes with with a ditopic ligand H2L consisting of a bis(salicylidene)isothiosemicarbazide moiety with a N2O2 binding site and a crown-ether (O6) moiety. A series of high-spin iron(III) complexes, i.e. [FeIIILClBa(CH3OH)(H2O)0.5(ZnCl4)] (1), [FeIIILCl] (2), [FeIIIL(N3)] (3) and [(FeIIIL)2O] (4), were synthesized. The complexes were characterized by mass spectrometry, IR and UV-vis spectroscopy, variable temperature (VT) magnetic susceptibility measurements, M?ssbauer spectroscopy, single crystal X-ray diffraction and cyclic voltammetry.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135550600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidation of 1,5-benzodiazepine oximes catalysed by peroxidases","authors":"Lidija Kosychova, Lina Rekovic, Irina Bratkovskaja, Ingrida Radveikiene, Regina Vidziūnaitė","doi":"10.2298/jsc230520068k","DOIUrl":"https://doi.org/10.2298/jsc230520068k","url":null,"abstract":"Oxidation of 1,3,4,5-tetrahydro-2H-1,5-benzodiazepine oximes catalysed by horseradish peroxidase (HRP) and recombinant Coprinus cinereus peroxidase (rCiP) was studied spectrophotometrically. The reaction rate dependences on the substrate and hydrogen peroxide concentrations were investigated; the values of apparent KM and Vmax, catalytic, oxidation and reduction constants (kcat, kox and kred, respectively) were calculated. The reactivity constants for the reactions catalysed by rCiP were higher than those for the HRP. Since oximes can have different structures depending on pH, the influence of pH on the rate of oxidation of compounds was studied. The dependences of the oxidation rate of the investigated oximes on the pH of the buffer solution were determined, and the pKa values of the amino acids of peroxidases responsible for the rate of catalysis were obtained. The HRP activity dependence on pH has a classical bell-shaped character, while rCiP dependence has a complex character.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135595758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the properties of uranyl nicotinate: Synthesis, characterization, and thermal analysis","authors":"Assis de, Carvalho de, Colman Denck","doi":"10.2298/jsc230817071a","DOIUrl":"https://doi.org/10.2298/jsc230817071a","url":null,"abstract":"This study reports the successful synthesis and characterization of a uranyl nicotinate compound, UO2(C6H4NO2)2?0.25H2O. The compound was synthesized using a Metal 1:2 Ligand ratio and water as the solvent. The average yield of the compound was found to be 67%. Thermogravimetric analysis revealed multiple stages of mass loss, including dehydration, nitrogen decomposition, and UO22+ reduction. Fourier-transform infrared spectroscopy confirmed the coordination of the carboxylate group in the compound. Field emission gun scanning electron microscope analysis showed particles with a regular oval shape. Energy-dispersive X-ray spectroscopy provided semi-quantitative data on the elemental composition of the compound. The major elements identified were uranium, carbon, oxygen, and nitrogen. These results contribute to understanding the compound's synthesis, thermal behavior, molecular composition, particle morphology, and elemental composition. Further research can build upon these findings to explore potential applications and develop new compounds with tailored properties","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135700837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of Jamun seed (Syzyum Cumini) biochar for removal of Fuchsin dye from aqueous solution","authors":"Divya Kosale, C. Thakur, Vinod Singh","doi":"10.2298/jsc220830021k","DOIUrl":"https://doi.org/10.2298/jsc220830021k","url":null,"abstract":"The textile, leather, paint and other industries discharge lots of dyes in their effluent which can cause major impact to environment and human life. Therefore, it becomes necessary to eliminate the dye from the effluent before its discharge and reuse. Several procedures for the removal and inactivation of dyes have been proposed over past but the adsorption has gained popularity due to its efficiency and operational ease. Use of the biochars as an adsorbent is gaining attention due to their low cost, availability and high adsorption capability. The current study focuses on the removal of Basic Fuchsin (BF) dye through adsorption using Jamun (Syzyum Cumini) seed powder biochar as an adsorbent. The biochar was characterized through various analyses such as: XRD, EDS, FTIR, TGA and SEM. Adsorption was studied by varying the parameters such as pH, contact duration, temperature, adsorbent dose, and temperature. Further, the isotherm, kinetic, and thermodynamic studies were also performed to understand the adsorption mechanism. The maximum adsorption capacity for BF dye was found with Jamun seed biochar produced at 500?C. The study reveals that the biochar manufactured from Jamun seed power has significant potential for elimination of BF dye from wastewater.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68515407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of sodium silicate crystals from rice husk ash","authors":"S. Emmanuel, A. Sallau, O. Adedirin, H. Ibrahim, M. Buga, Anthony Okereke, G. Ozonyia, Fortune Alabi","doi":"10.2298/jsc221126040e","DOIUrl":"https://doi.org/10.2298/jsc221126040e","url":null,"abstract":"The rich husk is an agricultural waste of rice cultivation worldwide, which is highly rich in amorphous silica. Rice husk obtained from Dagiri was pyrolysed at 750 ? to give white ash (RHA) which was further treated with acid (ARHA). The ash was reacted with sodium hydroxide at 90 ? for 2 hours 30 min to produce Sodium silicate crystals. Sodium silicates synthesized in the study were characterized with some physicochemical parameters. Their structural and morphological properties were assessed using a Fourier Transform Infra-red spectrophotometer (FTIR), X-ray Diffractometer (XRD) and Scanning Electrode Microscope (SEM). The mineralogical composition of the ash and sodium silicate was investigated with Energy-dispersive X-ray fluorescence (EDXRF) spectrometer. The sodium silicate produced has a melting point of 61 ?, a pH of 12.03 and appeared as brownish-white to clear-white in colour. The RHA and ARHA from XRD investigation showed patterns which match the mineral phase cristobalite, while that of the sodium silicate XRD patterns match the mineral heptahydrate disodiumtrioxosilicate as the most dominant phase. Rietveld refinement of the XRD pattern for the sodium silicate gave Rwp = 12.81, Rexp = 5.55, ?2 = 5.3274 and GoF = 2.3081 against a dual phase analysis. The sodium crystal-synthesized is suitable for use in cosmetic formulations.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68516201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of aliphatic thiols for on-site derivatization and gas chromatographic identification of Adamsite","authors":"T. Rozsypal","doi":"10.2298/jsc221207025r","DOIUrl":"https://doi.org/10.2298/jsc221207025r","url":null,"abstract":"The report describes the development of methods for rapid and simple identification of Adamsite in mobile laboratory conditions using a field gas chromatograph coupled with mass spectrometer. Adamsite is a chemical warfare agent with unique properties that cannot be analyzed without conversion to a volatile derivative. Derivatization procedures with 5 aliphatic thiols (ethanethiol, 1-propanethiol, 2-propanethiol, 1-butanethiol and 1-hexanethiol) were developed and compared. The retention characteristics of the derivatization products, peak characteristics and the formation of unwanted artifacts in the chromatograms were monitored. The influence of the reaction media and the time dependence of the reaction were also objects of interest. Other investigated parameters were the optimal reaction temperature and the volume of the derivatization agent. Mass spectra of newly created substances that are not yet included in the chemical weapons related databases were recorded. With optimal reagents (1-butanethiol and 1-hexanethiol), calibration procedures for analyte determination were subsequently developed, and the methods were verified during the Adamsite identification test in selected environmental and urban matrices.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68516333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}