Journal of Urology最新文献

{"title":"Infection and Inflammation of the Genitourinary Tract.","authors":"J Quentin Clemens","doi":"10.1097/JU.0000000000004424","DOIUrl":"10.1097/JU.0000000000004424","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"668-669"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uro-Science.","authors":"Anthony Atala","doi":"10.1097/JU.0000000000004366","DOIUrl":"10.1097/JU.0000000000004366","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"665-666"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment.","authors":"Benjamin Borgert, Mary E Westerman","doi":"10.1097/JU.0000000000004467","DOIUrl":"10.1097/JU.0000000000004467","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"567"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment.","authors":"Niels V Johnsen","doi":"10.1097/JU.0000000000004449","DOIUrl":"10.1097/JU.0000000000004449","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"635-636"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Artificial Intelligence-Digital Pathology Algorithm Predicts Survival After Radical Prostatectomy From the Prostate, Lung, Colorectal, and Ovarian Cancer Trial.","authors":"Eric V Li, Yi Ren, Jacqueline Griffin, Jialin Han, Rikiya Yamashita, Akinori Mitani, Ruoji Zhou, Huei-Chung Huang, Ximing Yang, Felix Y Feng, Andre Esteva, Hiten D Patel, Edward M Schaeffer, Lee A D Cooper, Ashley E Ross","doi":"10.1097/JU.0000000000004435","DOIUrl":"10.1097/JU.0000000000004435","url":null,"abstract":"<p><strong>Purpose: </strong>Clinical variables alone have limited ability to determine which patients will have recurrence after radical prostatectomy (RP). We evaluated the ability of locked multimodal artificial intelligence (MMAI) algorithms trained on prostate biopsy specimens to predict prostate cancer-specific mortality (PCSM) and overall survival (OS) among patients undergoing RP with digitized RP specimens.</p><p><strong>Materials and methods: </strong>The Prostate, Lung, Colorectal, and Ovarian Cancer Screening Randomized Controlled Trial randomized subjects from 1993 to 2001 to cancer screening or control. A subset of patients who underwent RP with available digitized histopathological images and subsequent survival data were identified. Distant metastasis (DM) and PCSM MMAIs originally trained on biopsy slides for patients undergoing radiation were evaluated for prediction of PCSM and OS. Cox proportional hazards modeling and Kaplan-Meier survival curve analysis were used.</p><p><strong>Results: </strong>In total, 1032 patients who underwent RP with median follow-up of 17 years (IQR, 14.3, 19.3 years) were identified. MMAI algorithms for PCSM and DM both predicted PCSM (HR, 2.31, 95% CI, 1.6-3.35, <i>P</i> < .001 and HR, 1.96, 95% CI, 1.35-2.85, <i>P</i> < .001, respectively). Similarly, DM and PCSM MMAI predicted OS (HR, 1.22, 95% CI, 1.01-1.47, <i>P</i> = .04 and HR, 1.19, 95% CI, 1.02-1.4, <i>P</i> = .03).</p><p><strong>Conclusions: </strong>Locked MMAI algorithms previously developed and validated on biopsy specimens from patients undergoing radiation for prostate cancer successfully predicted clinical outcomes when applied to RP specimens from patients treated with surgery. MMAI models and other biomarkers may help select patients who may benefit from postoperative treatment intensification with androgen deprivation therapy or radiation.</p>","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"600-608"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urologic Oncology: Bladder, Penis, and Urethral Cancer and Basic Principles of Oncology.","authors":"Sam S Chang","doi":"10.1097/JU.0000000000004349","DOIUrl":"10.1097/JU.0000000000004349","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"666-668"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Contemporary Estimate of Vasectomy Failure in the United States: Analysis of US Claims Data.","authors":"Albert Ha, Chiyuan Amy Zhang, Shufeng Li, Ashkan Pourabhari Langroudi, Satvir Basran, Michael Scott, Frank Glover, Francesco Del Giudice, Michael L Eisenberg","doi":"10.1097/JU.0000000000004405","DOIUrl":"10.1097/JU.0000000000004405","url":null,"abstract":"<p><strong>Purpose: </strong>We characterize trends in vasectomy utilization, delivery, and failure in a large administrative database.</p><p><strong>Materials and methods: </strong>We used the Merative MarketScan (2007-2021) Commercial Database to identify vasectomized men. Vasectomy failure (VF) was defined as documented pregnancy ≥ 6 months post procedure. Additional outcomes include the need for repeat vasectomy within 1 year and birth rates. Logistic and Cox proportional hazard regression were used to analyze factors associated with failure.</p><p><strong>Results: </strong>In a cohort of 489,277 vasectomized men, the mean (SD) age was 38 (6) years, with most of the procedures performed by urologists (n = 344,319). Overall postvasectomy pregnancy rate 6 months post procedure was 1.97 cases per 1000 persons per year, representing a pregnancy rate of 0.58%. Annual declines-particularly in recent years-in postvasectomy pregnancy (p_trend = 0.03) and birth (p_trend = 0.04) rates were observed. Older age and recent vasectomy years were associated with reduced odds of VF, while the absence of a postvasectomy semen analysis was associated with increased VF (adjusted odds ratio [aOR]: 1.14; 95% CI: 1.03-1.25; <i>P</i> < .001). Importantly, vasectomies performed by nonurologists (aOR: 1.56; 95% CI: 1.40-1.74; <i>P</i> < .0001) and vasectomies occurring in office-based settings (aOR: 1.25; 95% CI: 1.08-1.44; <i>P</i> < .01) were associated with higher odds of repeat procedures.</p><p><strong>Conclusions: </strong>VF is a rare phenomenon. Older age and vasectomies performed in later years correlate with decreased odds of failure, whereas the lack of postvasectomy semen analysis increases odds of failure. A higher pregnancy rate shortly after the procedure underscores the need to improve patient counseling.</p>","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"638-647"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Clinician-Reported Management Recommendations in Response to Universal Germline Genetic Testing in Patients With Prostate Cancer.","authors":"Neal Shore","doi":"10.1097/JU.0000000000004439","DOIUrl":"10.1097/JU.0000000000004439","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"649-650"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply by Authors.","authors":"I Rivero Belenchón, C B Congregado Ruíz, G Gómez Ciriza, V Gómez Dos Santos, F J Burgos Revilla, R A Medina López","doi":"10.1097/JU.0000000000004469","DOIUrl":"10.1097/JU.0000000000004469","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"579"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparison of Stockholm3, Serum Biomarkers, and Risk Calculators to Predict Prostate Cancer in a Racially and Ethnically Diverse Cohort: Evaluation of the Stockholm3 Multiethnic SEPTA Trial.","authors":"Alon Lazarovich, Hari Vigneswaran, Thorgerdur Palsdottir, Martin Eklund, Andrea Discacciati, Tobias Nordström, Rebecca A Hubbard, Nathan Perlis, Michael R Abern, Daniel M Moreira, Paul Yonover, Alexander K Chow, Kara Watts, Michael A Liss, Gregory R Thoreson, Andre L Abreu, Geoffrey A Sonn, Anna Plym, Fredrik Wiklund, Henrik Grönberg, Adam B Murphy, Scott Eggener","doi":"10.1097/JU.0000000000004437","DOIUrl":"10.1097/JU.0000000000004437","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to compare performance of Stockholm3 in an external validation with commonly used prostate cancer biomarkers and risk calculators.</p><p><strong>Materials and methods: </strong>SEPTA was a multicenter trial validating Stockholm3 in a racially/ethnically diverse population of men meeting local care guidelines for prostate biopsy (2019-2023). In total, 2115 (98%) men with complete data for risk calculators and biomarkers were included. The primary outcome was detection of Grade Group ≥ 2 (GG ≥ 2) cancer. Predictors included Stockholm3, free/total PSA ratio, PSA density, European Randomized Study of Screening for Prostate Cancer-4, Prostate Biopsy Collaborative Group, and Prostate Cancer Prevention Trial version 2 risk calculators. Performance characteristics were computed at clinically used thresholds for each risk score. ROC analysis, graphical calibration assessment, and decision curve analysis were performed.</p><p><strong>Results: </strong>Among 2115 men, median age was 63 years (IQR: 58-68), median PSA was 6.1 ng/mL (IQR: 4.5-9.0), 415 (20%) had a prior negative prostate biopsy, and 356 (17%) had an MRI performed before biopsy. There were 1200 (56.7%) benign biopsies performed, 307 (14.5%) GG1 cancers detected, and 608 (28.8%) GG ≥ 2 cancers detected. The Stockholm3 test had superior discrimination (all <i>P</i> < .001) compared with all evaluated biomarkers and risk calculators with an AUC of 0.82 vs 0.72 for free/total PSA, 0.76 for PSA density, 0.77 for European Randomized Study of Screening for Prostate Cancer-4, 0.74 for Prostate Biopsy Collaborative Group, and 0.78 for Prostate Cancer Prevention Trial version 2. Decision curve analysis demonstrated superior performance of Stockholm3, showing the highest positive net benefit. Compared with free/total PSA, Stockholm3 could reduce unnecessary biopsies by 44% while maintaining a 0.95 sensitivity.</p><p><strong>Conclusions: </strong>Stockholm3 outperforms other commonly used biomarkers and risk calculators for detecting GG ≥ 2 cancer in a diverse population.</p>","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":"213 5","pages":"590-599"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}