Konuralp Tıp Dergisi最新文献_第7页

Diyabetik Periferik Polinöropatili Hastalarda İnterlökin-23R Gen Polimofizmleri

Konuralp Tıp Dergisi Pub Date : 2022-06-21 DOI: 10.18521/ktd.1097853

Ö. Ocak, Fatma Silan

{"title":"Diyabetik Periferik Polinöropatili Hastalarda İnterlökin-23R Gen Polimofizmleri","authors":"Ö. Ocak, Fatma Silan","doi":"10.18521/ktd.1097853","DOIUrl":"https://doi.org/10.18521/ktd.1097853","url":null,"abstract":"Amaç: Diyabetik nöropatinin patogenezinde proinflamatuar ve nörovasküler değişiklikler suçlanmaktadır. Diyabetin vasküler inflamasyonu tetiklediği kabul edilse de inflamasyonun da diyabeti tetikleyebileceği öne sürülmüştür. İnterlökin-23 (IL-23) aktive makrofajlar ve dendritik hücreler tarafından salgılanan proinflamatuar bir sitokindir. Interleukin-23R'nin kronik inflamatuar hastalıklarda kritik bir rolü olduğu bilinmektedir. Bu çalışmanın amacı, IL-23R polimorfizmi ile diyabetik periferik nöropati arasındaki ilişkiyi incelemektir. \u0000Yöntem: Nöroloji polikliniğine başvuran 50 diyabetik periferik nöropati hastası ve hasta grubuna yaş ve cinsiyet açısından uyumlu 52 sağlıklı kontrol çalışmaya dahil edildi. Çalışmaya katılmayı kabul eden gönüllülerin tamamına elektromiyografi uygulandı ve EDTA'lı tüplere 2 ml kan örneği alındı. Pyrosequencing yöntemi ile IL-23R gen polimorfizmi analiz edildi. \u0000Bulgular: IL-23R gen varyantları rs2201841, rs199542433, rs201052419, rs11209026 diyabetik periferik nöropati (DPN) hastalarında ve kontrol grubunda analiz edildi. IL23R polimorfizmleri sıklıkları açısından hasta ve kontrol grupları arasında anlamlı bir fark saptanmadı. Ancak, odd’s oranlarına bakıldığında, rs2201841'in koruyucu rolü var gibi görünmekte, rs199542433 hem baskın hem de çekinik modellerde ve rs11209026 sadece çekinik modelde, DPN için 10 kata kadar daha yüksek risklerle ilişkili olabileceği görünmektedir. \u0000Sonuç: IL-23R gen polimorfizminin birçok otoimmün ve inflamatuar hastalık ile ilişkili olduğu gösterilmiştir. İnflamasyonun diyabet üzerinde önemli bir etkisi olduğu bilinmektedir. Diyabetik periferik nöropatide IL-23R gen polimorfizminin sıklığı anlamlı değildi. Çalışmamız diyabetik periferik nöropatide IL-23R gen polimorfizminin rolünü araştıran tek ve ilk çalışmadır. Etnik köken, genetik çalışmalarda çok önemlidir ve bu çalışmanın başka etnik kökene sahip hastalarda yapılması ve daha geniş çalışma gruplarının alınması, bize ilerisi için daha net bilgiler verecektir.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"417 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122850806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bir yoğun bakım ünitesinde sık görülen enfeksiyonların önlenmesi için bir bakım paketinin etkinlik ve maliyetinin analizi: Yarı deneysel bir öntest-sontest tasarım çalışması

Konuralp Tıp Dergisi Pub Date : 2022-06-20 DOI: 10.18521/ktd.1109974

Gülay Yazici, Hülya Bulut, Burcu BAYRAK KAHRAMAN, Tuncay Palteki̇

{"title":"Bir yoğun bakım ünitesinde sık görülen enfeksiyonların önlenmesi için bir bakım paketinin etkinlik ve maliyetinin analizi: Yarı deneysel bir öntest-sontest tasarım çalışması","authors":"Gülay Yazici, Hülya Bulut, Burcu BAYRAK KAHRAMAN, Tuncay Palteki̇","doi":"10.18521/ktd.1109974","DOIUrl":"https://doi.org/10.18521/ktd.1109974","url":null,"abstract":"Amaç \u0000Sağlık hizmeti ilişkili enfeksiyonlar hasta güvenliğini tehdit etmekte, hastanede yatış süresinin uzamasına, morbidite, mortalite ve maliyetlerin artmasına neden olmaktadır. Bu çalışma, sağlık hizmeti ilişkili enfeksiyonları önlemeye yönelik müdahalelerin etkinliğini ve bu müdahalelerin maliyete etkisini değerlendirmek amacıyla yapılmıştır. \u0000Metod \u0000Bu araştırma bir yoğun bakım ünitesinde 1 Ocak – 30 Haziran 2018 ile 1 Ekim 2018 – 31 Mart 2019 tarihleri arasında 27 eğitim öncesi ve 27 eğitim sonrası olmak üzere toplam 54 hasta ile yarı deneysel ön test-son test tasarım çalışması olarak yapılmıştır. \u0000Bulgular \u0000Çalışmada enfeksiyon oranları Ocak-Mart 2018'de 20.34, Nisan-Haziran 2018'de 25.7, Ekim-Aralık 2018'de 20.97 ve Ocak-Mart 2019'da 17.77 olarak bulunmuştur. Dört farklı dönemin enfeksiyon oranları karşılaştırıldığında, eğitim öncesine göre eğitim sonrasında enfeksiyon oranlarında azalma olduğu ancak bu düşüşün istatistiksel olarak anlamlı olmadığı saptanmıştır (p>0.05). Eğitim öncesi ortalama maliyet 11361.35₺, eğitim sonrası ortalama maliyet 9149.87₺ olarak belirlenmiştir. Tüm maliyetlerin en önemlisi olan ortalama yatak maliyeti eğitim öncesine göre %95 güven aralığında %25,7 oranında azalmıştır. (5241.86₺-13251.50₺, sırasıyla 3489.03₺-10257.41₺). \u0000Sonuç \u0000Sonuç olarak, çalışmada eğitimin yoğun bakım hemşirelerinin sağlık hizmeti ilişkili enfeksiyonlara ilişkin puanlarında anlamlı bir artış sağladığı, sağlık hizmeti ilişkili enfeksiyon oranlarında, hastanede kalış sürelerinde ve eğitim sonrası maliyette istatistiksel olarak anlamlı olmasa da azalma sağladığı belirlenmiştir.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129138053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Evaluation of Relationship Between Monocyte/High-Density Lipoprotein Ratio (MHR) and COVID-19 单核细胞/高密度脂蛋白比值(MHR)与COVID-19关系的评价

Konuralp Tıp Dergisi Pub Date : 2022-06-19 DOI: 10.18521/ktd.1099432

Belgin Coşkun, M. Ayhan, E. M. Saricaoğlu, Rahmet Güner, E. Akıncı, T. Buzgan, B. Kayaaslan, A. Aypak, Ayşe Yasemin Tezer Tekçe, I. Hasanoğlu, A. Kaya Kalem, F. Eser, Y. Aybar Bilir, B. Özdemir

{"title":"The Evaluation of Relationship Between Monocyte/High-Density Lipoprotein Ratio (MHR) and COVID-19","authors":"Belgin Coşkun, M. Ayhan, E. M. Saricaoğlu, Rahmet Güner, E. Akıncı, T. Buzgan, B. Kayaaslan, A. Aypak, Ayşe Yasemin Tezer Tekçe, I. Hasanoğlu, A. Kaya Kalem, F. Eser, Y. Aybar Bilir, B. Özdemir","doi":"10.18521/ktd.1099432","DOIUrl":"https://doi.org/10.18521/ktd.1099432","url":null,"abstract":"Objective: Early diagnosis is important for severe diseases in COVID-19. Monocyte/high dansity lipoprotein ratio (MHR) is a new prognostic marker indicating inflammation. We aimed to investigate the relationship between MHR and diseases severity in COVID-19. \u0000Materials and Methods: Patients with laboratory confirmed COVID-19, were retrospectively analyzed. Clinical symptoms, signs and laboratory data on the first day of hospitalization were obtained from medical records of hospital. The clinical data of 301 patients were included in study. Cases were diagnosed on the basis of interim guidance of World Health Organization (WHO). Patients were classified into two groups as non-severe COVID-19 and severe COVID-19. MHR were calculated with laboratory data on the first day of hospitalization. The relationship between MHR level and COVID-19 severity was evaluated. Statistical analysis of the data was performed by using SPSS 25 (SPSS Inc., Chicago, IL, USA) package program. Statistical significance level was accepted as p","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134116636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathological features of Gastrointestinal Stromal Tumors and review of the literature 胃肠道间质瘤的临床病理特点及文献复习

Konuralp Tıp Dergisi Pub Date : 2022-06-16 DOI: 10.18521/ktd.1094503

Sinem Kantarcioglu Coskun

{"title":"Clinicopathological features of Gastrointestinal Stromal Tumors and review of the literature","authors":"Sinem Kantarcioglu Coskun","doi":"10.18521/ktd.1094503","DOIUrl":"https://doi.org/10.18521/ktd.1094503","url":null,"abstract":"Objective: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasias of the gastrointestinal system (GIS). The malignancy potential of GISTs may vary ranging from indolent tumors to progressive malignant tumors. This study aims to define clinicopathological and immunohistochemical features of GISTs diagnosed in our institute with a review of the literature. \u0000Method: A total of 28 GIST cases were included in the study. The Hematoxylin&Eosin stained slides of surgical resection materials and cell blocks and immunohistochemistry performed slides were reviewed by a pathologist. The immunohistochemical expression with CD117, DOG-1, CD34, SMA, and S100 was scored between 0 and 3 points according to staining intensity. Descriptive statistics were used in the study. The demographic data, prognostic histopathological, and immunohistochemical findings are evaluated with the literature indications. \u0000Result: Eleven of the cases were male and seventeen were female. The age range was 18-88. The most common site of GISTs was the stomach, followed by the small intestine, colorectal region, and, esophagus. Twenty of the tumors were resected surgically, four were endoscopic biopsy material and four were fine-needle aspiration biopsies. The tumor size in measurable materials ranged from 0,2 to 22 cm. The mitotic count in 50 HPF ranges from 0 to 10. Seven of the GISTs were high grade and the remaining 21 were low grade. The majority of the cases were composed of spindle cells, 3 were epithelioid and 3 were the mixed type with spindle and epitheloid cells. \u0000Conclusion: A variety of criteria has been proposed to estimate the malignancy potential of GISTs and predict prognosis but definite prognostic criteria remain uncertain. Further studies with larger series of GISTs consisting of different types of biopsy materials may help define criteria to predict prognosis precisely.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"9 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124423101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological and Clinical Characteristics of Shoulder Dislocations in Emergency Care Settings in Turkey: A Single-Center Experience 土耳其急诊护理中肩部脱位的流行病学和临床特征:单中心经验

Konuralp Tıp Dergisi Pub Date : 2022-06-16 DOI: 10.18521/ktd.1105501

Murat Çeti̇n, Nurcan Biçakçi, S. Bicakci, Neil J Cunningham

{"title":"Epidemiological and Clinical Characteristics of Shoulder Dislocations in Emergency Care Settings in Turkey: A Single-Center Experience","authors":"Murat Çeti̇n, Nurcan Biçakçi, S. Bicakci, Neil J Cunningham","doi":"10.18521/ktd.1105501","DOIUrl":"https://doi.org/10.18521/ktd.1105501","url":null,"abstract":"Objective: This study evaluated the general epidemiological and clinical characteristics of patients admitted to the emergency department with shoulder dislocations. \u0000Methods: This is a retrospective cross-sectional study, conducted as a chart review at the Emergency Department of the *** State Hospital between 01 January 2018 to 31 December 2019. \u0000Results: A total of 165 patients (median age 50 years and 60% of males) with anterior shoulder dislocations were included. The most common mechanism was traumatic dislocation (65.5%), the primary maneuver of treatment was traction/countertraction (80.6%), and 22.4% were recurrent dislocations. Males were younger and had more spontaneous dislocations. Also, patients with spontaneous dislocations were younger and predominantly males, and tended to be recurrent dislocations than traumatic ones. \u0000Conclusions: Epidemiological characteristics of our patients were similar to a previous study conducted in Turkey, but slightly different from the studies in other populations. Further studies evaluating the incidence and long-term follow-up data are also needed to better elucidate the epidemiological features of shoulder dislocations.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117064708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paraneoplastic Severe Sensorimotor Axonal Polyneuropathy in Pancreatic Neuroendocrine Carcinoma: A Case Report and Review Of The Literature 胰腺神经内分泌癌伴发严重感觉运动轴索多神经病变1例报告及文献复习

Konuralp Tıp Dergisi Pub Date : 2022-06-10 DOI: 10.18521/ktd.1019045

Türkay Akbaş, Sinem Coşkun Kantarcioğlu, Serkan Torun, Ayhan Öztürk, O. Eşbah, Ömer Önbaş

引用次数: 0

Kronik Obstrüktif Akciğer Hastalığı Olan Hastalarda Komorbid Bronşektazinin Yaşam Kalitesine Etkisinin Değerlendirilmesi

Konuralp Tıp Dergisi Pub Date : 2022-06-01 DOI: 10.18521/ktd.997761

Cansu Yılmaz, M. Acat, Serkan Öner, Habibe İnci, Didem Adahan

{"title":"Kronik Obstrüktif Akciğer Hastalığı Olan Hastalarda Komorbid Bronşektazinin Yaşam Kalitesine Etkisinin Değerlendirilmesi","authors":"Cansu Yılmaz, M. Acat, Serkan Öner, Habibe İnci, Didem Adahan","doi":"10.18521/ktd.997761","DOIUrl":"https://doi.org/10.18521/ktd.997761","url":null,"abstract":"Objective: The objective of this study was to evaluate the effect of comorbid bronchiectasis on quality-of-life in patients with Chronic Obstructive Pulmonary Disease (COPD). \u0000Method: 103 patients were diagnosed with COPD were included in our study. Spirometric measurements were made. The following measurement tools were used to collect data: 6-Minute Walk Test (6MWT), Modified Medical Research Council (mMRC) dyspnea scale, COPD Assessment Test (CAT), St. George Respiratory Questionnaire (SGRQ), and Short Form 36 (SF-36) quality-of-life questionnaire. Furthermore, all the patients’ high Resolution Computed Tomography (HRCT) images for the last three years were included in the study. \u0000Result: 93.2% of the patients were male, with a mean age of 64.79±9.35 years. It was found that SGRQ and SF-36 quality-of-life scores decreased by half in all the patients compared to normal ones. The volume/forced vital capacity (FEV1/FVC) values in the first second of forced expiration were significantly lower in the group with bronchiectasis. A significant correlation was found to exist between the patients’ mMRC dyspnea scale and CAT scores, 6MWT distances, and all subscales of SGRQ and SF-36. In addition, a significant correlation was also found to exist between FEV1 values and all subscales of SGRQ, and between subscales of SF-36. \u0000Conclusion: In our study, when we compared the quality-of-life scores of the patients with COPD and bronchiectasis with those with COPD alone, we found that the quality-of-life of both groups was impaired, but there was no significant difference between them.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"343 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115451737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using smartphone to evaluate Cranial Computed Tomography videos: an inter-observer study 使用智能手机评估颅脑计算机断层扫描视频:一项观察者间研究

Konuralp Tıp Dergisi Pub Date : 2022-06-01 DOI: 10.18521/ktd.1080194

I. F. Naldemir, A. Karaman, M. Boğan, H. B. Altınsoy, M. Karadağ

引用次数: 0

Akademisyenlerin Sosyal Medya Bağımlılık Düzeylerinin Belirlenmesine Yönelik Bir Saha Araştırması: Geçerlilik ve Güvenilirlik Çalışması

Konuralp Tıp Dergisi Pub Date : 2022-06-01 DOI: 10.18521/ktd.1088492

H. Mutlu, Rengim SİNE NAZLI, Gülşah Sarı

{"title":"Akademisyenlerin Sosyal Medya Bağımlılık Düzeylerinin Belirlenmesine Yönelik Bir Saha Araştırması: Geçerlilik ve Güvenilirlik Çalışması","authors":"H. Mutlu, Rengim SİNE NAZLI, Gülşah Sarı","doi":"10.18521/ktd.1088492","DOIUrl":"https://doi.org/10.18521/ktd.1088492","url":null,"abstract":"Objective: The main purpose of this research was to find out the social media addiction levels of academicians and to reveal whether the scale used is a valid and reliable scale. In addition, it is another aim of the study to determine which variables differ in terms of social media addictions of academics whose social media addiction levels are determined. \u0000Methods: A total of 430 academicians, 199 of whom were females and 231 males, participated in this study. The validity and reliability of the scale were tested by performing exploratory and confirmatory factor analyzes and reliability analyzes on the data collected from the academicians reached by the online survey method. Then, the differences of the factors, whose validity and reliability were ensured by using parametric techniques, according to demographic variables were examined. \u0000Results: The exploratory factor analysis done on the data collected from academicians reached by online survey method, showed that the scale had four sub-factors called Virtual Tolerance (Slacking), Virtual Interaction, Virtual Communication, and Emotional State. Obtained sub-factors were subjected to confirmatory factor analysis and it was seen that the fit indices gave good results. Since the Cronbach's alpha value, which was used to measure the reliability of the scale, was also high, the scale used to measure the social media addiction levels of academicians was found to be valid and reliable. The differences of the factors that were found to be valid and reliable according to demographic variables were examined. \u0000Conclusions: The result of the analysis demonstrated that addiction levels of single academicians were more than that of the married academicians; young or old academicians’ social media addiction levels were more than that of middle-aged academicians. Clearly, this study revealed that as the academic title increases, social media addiction levels of academicians decreases.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"2016 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128066415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of a Mobile Phone Application on Smoking Cessation 手机应用程序对戒烟的影响

Konuralp Tıp Dergisi Pub Date : 2022-05-12 DOI: 10.18521/ktd.1064357

S. Mıstık, Cemalinur Uzun, İnci Gülmez

引用次数: 0