Journal of Toxicology and Risk Assessment最新文献_第2页

Meta-Analyses of Glyphosate and Non-Hodgkin's Lymphoma: Expert Panel Conclusions and Recommendations 草甘膦和非霍奇金淋巴瘤的荟萃分析:专家小组结论和建议

Journal of Toxicology and Risk Assessment Pub Date : 2022-03-31 DOI: 10.23937/2572-4061.1510044

C. Kirman, P. Cocco, G. Eslick, PJ Villeneuve, S. Hays

引用次数: 0

Evaluation of Effect of Ethanol Extraction of Graptophyllum pictum on Zebrafish (Danio rerio) Embryo Model through Toxicity Assay Assessment 通过毒性试验评价乙醇提取物对斑马鱼胚胎模型的影响

Journal of Toxicology and Risk Assessment Pub Date : 2021-12-31 DOI: 10.23937/2572-4061.1510040

Abidin Azrina Zainal, Visepomaran Subashini, Balan Santhra Segaran, B. Hasnah

{"title":"Evaluation of Effect of Ethanol Extraction of Graptophyllum pictum on Zebrafish (Danio rerio) Embryo Model through Toxicity Assay Assessment","authors":"Abidin Azrina Zainal, Visepomaran Subashini, Balan Santhra Segaran, B. Hasnah","doi":"10.23937/2572-4061.1510040","DOIUrl":"https://doi.org/10.23937/2572-4061.1510040","url":null,"abstract":"Graptophyllum pictum is a medicinal plant that helps to cure different forms of disease due to the availability of beneficial phytochemicals such as flavonoids, steroids, alkaloids, saponins and glycosides. The purpose of this research was to evaluate the toxicity effect of G. pictum extract on zebrafish embryos (Danio rerio) at different concentrations. G. pictum was extracted using the ethanol method. A toxicity test was done by exposing the Danio rerio embryo to the G. pictum extraction at different concentrations (0.2441000 μg/ml) for 24, 48, 72 and 96 hours. The survival rate, hatching rate, heartbeat rate, scoliosis rate and melanin pigmentation were observed. Data were analyzed using SPSS version 27. The value of LC50 was calculated. Result showed that the LC50, value of G. pictum is 7.662 μg/ml. No hatching was observed at higher concentrations (31.25-1000 μg/ml) while the hatch ability of Danio rerio embryos was observed at lower concentrations (0.2441.953 μg/ml). Scoliosis of zebrafish larvae was not present at all concentrations. The heartbeat of the zebrafish larvae treated with G. pictum extract was within a normal range from 120-180 beats per minute at a lower concentration. Melanin pigmentation was detected at 48, 72 and 96 hours post-fertilization and is normally absent at 24 hours postfertilization. As a conclusion, G. pictum extract stills exhibit a mild toxicity effect in higher concentrations when it was evaluated on zebrafish embryos.","PeriodicalId":174677,"journal":{"name":"Journal of Toxicology and Risk Assessment","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133305007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Biochemical Changes in Hematological and Liver Parameters in Albino Rats Exposed to Azo Dye Adulterated Palm Oil 偶氮染料掺假棕榈油对白化大鼠血液学和肝脏生化指标的影响

Journal of Toxicology and Risk Assessment Pub Date : 2021-12-31 DOI: 10.23937/2572-4061.1510042

R. Kola-Ajibade Ibukun, J. Jegede Rotimi, O. Olusola Augustine

引用次数: 0

Effects of Azo Dye Adulterated Palm Oil on the Expression of Inflammatory, Functional, Antioxidant Markers and Body Weights in Albino Rats 偶氮染料掺假棕榈油对白化大鼠炎症、功能、抗氧化标志物表达及体重的影响

Journal of Toxicology and Risk Assessment Pub Date : 2021-12-31 DOI: 10.23937/2572-4061.1510041

R. Kola-Ajibade Ibukun, Grace Atere, O. Olusola Augustine

{"title":"Effects of Azo Dye Adulterated Palm Oil on the Expression of Inflammatory, Functional, Antioxidant Markers and Body Weights in Albino Rats","authors":"R. Kola-Ajibade Ibukun, Grace Atere, O. Olusola Augustine","doi":"10.23937/2572-4061.1510041","DOIUrl":"https://doi.org/10.23937/2572-4061.1510041","url":null,"abstract":"Food is important to life and the continuous exposure to food throughout an individual’s lifetime renders diet the most important environmental factor challenging the biological system. Only few studies exist for evaluations of the toxicological effects of adulterated palm oil on biochemical parameters. This study was undertaken to evaluate the expression of the activity of inflammatory enzymes (TNF-α, MCP-1), antioxidant enzymes (GPx-1, CAT) and functional markers (EPO, ALB, CRIM) in liver, kidney and testicular tissues of albino Rats and to check for probable weight difference in treated animals before and after treatment. 25 albino rats were divided into 5 groups and treated as thus; group I (control), groups II and III (1 ml/kg of unadulterated and adulterated palm oil respectively), groups IV and V (50 mg/kg Sudan III and IV respectively) for 28 days. Gene expression levels were evaluated using reverse transcriptase and polymerase chain reaction protocols. The expression of inflammatory markers: Tumor necrosis factor α (TNFα), monocyte chemoattractant protein-1 (MCP-1) and oxidative stress markers catalase: (CAT), glutathione peroxidase-1 (GPx-1) were significantly up regulated (p < 0.05) in the liver, kidney and testes with the expression of functional markers: Albumin (ALB), erythropoietin (EPO), calcium responsive transcription factor (CRIM) significantly (p < 0.05) down regulated in groups III, IV and IV when compared to control groups. No weight gain was observed in treated animals before and after treatment. Ultimately, Sudan dyes are able to induce production of ROS which has been implicated in several disease conditions thus not safe for consumption.","PeriodicalId":174677,"journal":{"name":"Journal of Toxicology and Risk Assessment","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131167920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Science Advisory Panels: Results of a Survey of Panel Participants 科学顾问小组:小组成员调查结果

Journal of Toxicology and Risk Assessment Pub Date : 2021-05-10 DOI: 10.23937/2572-4061.1510038

S. Hays, R. Becker, Nelson Dm, Kirman Cr

{"title":"Science Advisory Panels: Results of a Survey of Panel Participants","authors":"S. Hays, R. Becker, Nelson Dm, Kirman Cr","doi":"10.23937/2572-4061.1510038","DOIUrl":"https://doi.org/10.23937/2572-4061.1510038","url":null,"abstract":"Science panel deliberations serve as an important step in policy and regulatory decision making, ideally providing independent validation that the decisions under consideration are based on sound scientific evidence and interpretation. To be useful, the findings from a science panel should be trusted by all parties involved (e.g., regulatory decision makers, participating scientists, general public, regulated industries). A survey was conducted of scientists who had participated in science advisory panels for regulatory agencies to gain a better understanding of their experiences. The purpose of the survey was to gain insight on science panel design with respect to: 1) Science panel recruitment and selection; 2) Science panel deliberations; and 3) Science panel reporting. We received input from more than 100 scientists, who reported both positive and negative experiences with science panels, and recommended a number of improvements. These recommendations included the need for greater transparency and the necessity to better manage internal and external sources of pressure that can adversely impact panel deliberations. The results of this survey are presented, and design elements that should be considered for improving science panel deliberations are discussed.","PeriodicalId":174677,"journal":{"name":"Journal of Toxicology and Risk Assessment","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125401575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Assessment and Communication in Pharmaceuticals: Recognizing the Differences in Occupational Health and Medication Safety 药品风险评估与沟通:认识职业健康与用药安全的差异

Journal of Toxicology and Risk Assessment Pub Date : 2019-12-31 DOI: 10.23937/2572-4061.1510019

Fung Vivian Sw Chan

{"title":"Risk Assessment and Communication in Pharmaceuticals: Recognizing the Differences in Occupational Health and Medication Safety","authors":"Fung Vivian Sw Chan","doi":"10.23937/2572-4061.1510019","DOIUrl":"https://doi.org/10.23937/2572-4061.1510019","url":null,"abstract":"Pharmaceuticals are the most common medical interven-tion. Ensuring workers and members of the public get the most benefits from advances in modern medicine is a criti cal component of improving the health care system. Pharmaceuticals bring healing to patients but increased risk of illness have been reported among workers manufacturing, handling and administering pharmaceutical products with inadequate attention to personal safety. Their potential for both helping and harming human health can be predicted based on health-based risk assessment. This assessment process for occupation and medication (product/patient) safety is similar yet provides different sets of information. Understanding the hazards and risks of pharmaceuticals and conveying appropriate safety messages to workers is essential. Workplace training in differentiating the use of safety data sheets (SDS) from drug product information (DPI) sheets, effectively communicating the difference between safe work practices (SWP) and good manufacturing, laboratory and clinical practice (GMP, GLP and GCP) quality guidelines will direct workers’ attention to the essential chemical hazard and risk information. The increase in knowledge on the proper use of SDS and SWP will encour-age appropriate self-protective behavior in reducing chemical exposure amongst workers and improve safety at work.","PeriodicalId":174677,"journal":{"name":"Journal of Toxicology and Risk Assessment","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130637484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Toxicity Evaluation of Cellulose Nanofibers (Cnfs) for Cosmetic Industry Application 化妆品工业用纤维素纳米纤维的毒性评价

Journal of Toxicology and Risk Assessment Pub Date : 2019-09-16 DOI: 10.23937/2572-4061.1510029

Kim Soo Min, Gwak Eun Ji, Jeong Seung Hwan, Lee Sang Mock, Sim Woo Jong, Kim Jin Sik

{"title":"Toxicity Evaluation of Cellulose Nanofibers (Cnfs) for Cosmetic Industry Application","authors":"Kim Soo Min, Gwak Eun Ji, Jeong Seung Hwan, Lee Sang Mock, Sim Woo Jong, Kim Jin Sik","doi":"10.23937/2572-4061.1510029","DOIUrl":"https://doi.org/10.23937/2572-4061.1510029","url":null,"abstract":"Nanocellulose is possessing the unique physical/structural properties, low product cost, renewable, biodegradable, and biocompatible material. For these characteristics, nanocellulose is applicable the many industrial fields such as energy, medical, packing and so on. Nanocellulose from wood and other higher plants is typically isolated as cellulose nanofibers (CNFs) and cellulose nanocrystals (CNCs). Specially, CNFs have strong water absorption capacity and thickening effect, which enhances the viscosity and apply to cosmetic applications. However, CNFs raise the safety concern because they have the high aspect ratio and fibrous morphology. For these reason, this study carried to cytotoxicity, skin irritation test and eye irritation test to find the cosmetic application of CNFs. As a result of this study, CNFs significantly induced cytotoxicity to HaCaT cells (≥ 156 μg/ ml) and HDF-α cells (≥ 313 μg/ml). But, CNFs did not induce the skin and eye irritation on 3D models. Taken together, this study suggested that appropriate concentration setting is needed to usage of CNFs as the cosmetic material.","PeriodicalId":174677,"journal":{"name":"Journal of Toxicology and Risk Assessment","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127351016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Heath Risk Assessment of Heavy Metals in Shrimp Acetes sp. and Cincalok Collected in 2007 from Pantai Klebang, Peninsular Malaysia 2007年马来西亚半岛班台克邦捕虾类和虾肉中重金属的健康风险评估

Journal of Toxicology and Risk Assessment Pub Date : 2019-08-31 DOI: 10.23937/2572-4061.1510028

Y. C. Kong, C. Hee, Ali Mohd Hafetz, N. Rosimah, Peng Shih Hao Tony, Ismail Mohamad Saupi, L. Seng, Yap Chee Wah

引用次数: 0

Health Risk Assessment of Heavy Metals in Fish (Chrysichthys Nigrodigitatus) from Two Lagoons in Southwestern Nigeria 尼日利亚西南部两个泻湖鱼类重金属健康风险评价

Journal of Toxicology and Risk Assessment Pub Date : 2019-08-10 DOI: 10.23937/2572-4061.1510027

OB Bassey, A. Chukwu

引用次数: 7

Role of Oxidative Stress and Apoptosis in the Hepatic Toxicity Induced by Cerium Oxide Nanoparticles Following Intratracheal Instillation in Male Sprague-Dawley Rats 氧化应激和细胞凋亡在氧化铈纳米颗粒气管内注入雄性sd大鼠肝毒性中的作用

Journal of Toxicology and Risk Assessment Pub Date : 2019-07-04 DOI: 10.23937/2572-4061.1510026

K NalabotuSiva, Manne Nandini Dpk, B KolliMadhukar, Nandyala Geeta, K ParaRadha, M RiceKevin, B JonesCynthia, R BloughEric

{"title":"Role of Oxidative Stress and Apoptosis in the Hepatic Toxicity Induced by Cerium Oxide Nanoparticles Following Intratracheal Instillation in Male Sprague-Dawley Rats","authors":"K NalabotuSiva, Manne Nandini Dpk, B KolliMadhukar, Nandyala Geeta, K ParaRadha, M RiceKevin, B JonesCynthia, R BloughEric","doi":"10.23937/2572-4061.1510026","DOIUrl":"https://doi.org/10.23937/2572-4061.1510026","url":null,"abstract":"Inhaled cerium oxide (CeO2) nanoparticles have been shown to be capable of translocation to the liver where they can cause dose dependent toxic effects [1]. Herein, we investigate if the deposition of cerium in the liver is linked to increased oxidative stress and cellular apoptosis. Specific pathogen free male Sprague-Dawley rats were instilled with either vehicle (saline) or CeO2 nanoparticles (7.0 mg/kg) and euthanized 1, 3, 14, 28, 56, or 90 days post exposure. Liver samples were evaluated for evidence of ceria deposition, oxidative stress and apoptosis. Inductively coupled plasma mass spectroscopy demonstrated that ceria deposition increased over time. Analysis of lipid peroxidation, superoxide levels and the number of TUNEL positive cells revealed evidence of increased oxidative stress and apoptosis at 1, 3 and 90 days post exposure. Immunoblotting showed that each of these time points were characterized by increases in the Bax/Bcl-2 ratio, elevations in caspase-9 protein levels and increases in caspase-3 protein expression. Interestingly, we found no evidence of oxidative stress or apoptosis at day 14, 28, or 56 post exposure. Taken together, these data demonstrate intratracheal instillation of CeO2 nanoparticles is associated with increased liver ceria deposition, whic causes biphasic oxidative stress and apoptotic response.","PeriodicalId":174677,"journal":{"name":"Journal of Toxicology and Risk Assessment","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133633470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3