Journal of Toxicologic Pathology最新文献_第9页

Malignant pinealoma observed in the deep cerebral parenchyma of a male Wistar rat 雄性Wistar大鼠脑深部实质中恶性松果体瘤的观察

IF 1.2 4区医学

Journal of Toxicologic Pathology Pub Date : 2021-11-25 DOI: 10.1293/tox.2021-0047

Mizuho Takagi, Y. Yamaguchi, S. Yamakawa, K. Tamura

引用次数: 0

Luteal toxicity evaluation in rats 大鼠黄体毒性评价

IF 1.2 4区医学

Journal of Toxicologic Pathology Pub Date : 2021-11-18 DOI: 10.1293/tox.2021-0058

Yoshikazu Taketa

{"title":"Luteal toxicity evaluation in rats","authors":"Yoshikazu Taketa","doi":"10.1293/tox.2021-0058","DOIUrl":"https://doi.org/10.1293/tox.2021-0058","url":null,"abstract":"The corpora lutea (CL) are endocrine glands that form in the ovary after ovulation and secrete the steroid hormone, progesterone (P4). P4 plays a critical role in estrous and menstrual cycles, implantation, and pregnancy. The incomplete rodent estrous cycle stably lasts 4–5 days and its morphological features can be distinguished during each estrous cycle stage. In rat ovaries, there are two main types of CL: newly formed ones due to the current ovulation (new CL), and CL remaining from prior estrous cycles (old CL). In the luteal regression process, CL were almost fully regressed after four estrous cycles in Sprague-Dawley rats. P4 secretion from CL in rodents is regulated by the balance between synthesis and catabolism. In general, luteal toxicity should be evaluated by considering antemortem and postmortem data. Daily vaginal smear observations provided useful information on luteal toxicity. In histopathological examinations, not only the ovaries and CL but also other related tissues and organs including the uterus, vagina, mammary gland, and adrenal glands, must be carefully examined for exploring luteal changes. In this review, histological and functional characteristics of CL in rats are summarized, and representative luteal toxicity changes are presented for improved luteal toxicity evaluation in preclinical toxicity research.","PeriodicalId":17437,"journal":{"name":"Journal of Toxicologic Pathology","volume":"35 1","pages":"7 - 17"},"PeriodicalIF":1.2,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43907471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Lipomatosis of axillary lymph nodes in a cynomolgus monkey (Macaca fascicularis) 食蟹猴腋窝淋巴结脂肪瘤病的研究

IF 1.2 4区医学

Journal of Toxicologic Pathology Pub Date : 2021-11-15 DOI: 10.1293/tox.2021-0054

M. Nakagawa, S. Hayashi, S. Matsuo, Masaki Yamazaki, A. Kato

引用次数: 1

Porencephaly with an optic organ abnormality in a beagle dog 比格犬伴有视觉器官异常的脑孔畸形

IF 1.2 4区医学

Journal of Toxicologic Pathology Pub Date : 2021-10-25 DOI: 10.1293/tox.2021-0039

Osamu Hashiguchi, Yuko Yamaguchi, S. Ikezaki, Tsubasa Saito, Saori Igura, Ryo Hirai, N. Horiuchi, K. Tamura

引用次数: 1

A case of spontaneous autoimmune skin disease in a cynomolgus monkey (Macaca fascicularis) 食蟹猴自发性自身免疫性皮肤病1例

IF 1.2 4区医学

Journal of Toxicologic Pathology Pub Date : 2021-10-16 DOI: 10.1293/tox.2021-0048

Shinichi Onishi, M. Nakagawa, S. Matsuo, J. Shinozuka, Mio Hiramatsu, Takehito Isobe, Toshihiko Watanabe, A. Kato

{"title":"A case of spontaneous autoimmune skin disease in a cynomolgus monkey (Macaca fascicularis)","authors":"Shinichi Onishi, M. Nakagawa, S. Matsuo, J. Shinozuka, Mio Hiramatsu, Takehito Isobe, Toshihiko Watanabe, A. Kato","doi":"10.1293/tox.2021-0048","DOIUrl":"https://doi.org/10.1293/tox.2021-0048","url":null,"abstract":"Pemphigus is an autoimmune blistering disease characterized by lesions on the skin and mucous membranes. To date, no spontaneous cases of this disease have been reported in cynomolgus monkeys. This report describes the histopathological characteristics of spontaneous pemphigus in a cynomolgus monkey. Macroscopically, redness and scaling with pruritus were observed on the skin of the entire body. Histopathologically, the epidermis showed intercellular edema, and eosinophils and mononuclear cells infiltrated the epidermis. There was no obvious acantholysis in the epidermis. The perivascular area showed edema, and eosinophils and mononuclear cells infiltrated the vessels in the dermis. Immunohistochemically, the intercellular area in the epidermis was positive for Immunoglobulin G and Complement component 3. Serologically, anti-desmoglein 1 and desmoglein 3 antibodies in the serum were negative. From these findings, this case was diagnosed as an autoimmune skin disease, suspected to be pemphigus, and concluded as lesions being similar to those in human “pemphigus herpetiformis”.","PeriodicalId":17437,"journal":{"name":"Journal of Toxicologic Pathology","volume":"35 1","pages":"103 - 106"},"PeriodicalIF":1.2,"publicationDate":"2021-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45278986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Confounders for kidney carcinogenesis in rodent cancer bioassays 啮齿动物癌症生物检测中肾癌发生的混杂因素

IF 1.2 4区医学

Journal of Toxicologic Pathology Pub Date : 2021-10-14 DOI: 10.1293/tox.2021-0000

G. Hard

引用次数: 1

Evaluation of Caspase-3 and Ki-67 expression in squamous cell hyperplasia of the stomach induced by Platycodi radix water extract in Sprague–Dawley rats 桔梗水提物诱导大鼠胃鳞状细胞增生过程中Caspase-3和Ki-67的表达

IF 1.2 4区医学

Journal of Toxicologic Pathology Pub Date : 2021-10-09 DOI: 10.1293/tox.2021-0003

Yinghua Li, Seung-Beom Cha, Youngil Park, Bo-Ho Gong, Inae Jeong, H. Kim, Min-Soo Kang, Young-Suk Kim, Chang Hoon Han, Hyun-Kul Lee, Si-Whan Song, C. Park, B. Kang

{"title":"Evaluation of Caspase-3 and Ki-67 expression in squamous cell hyperplasia of the stomach induced by Platycodi radix water extract in Sprague–Dawley rats","authors":"Yinghua Li, Seung-Beom Cha, Youngil Park, Bo-Ho Gong, Inae Jeong, H. Kim, Min-Soo Kang, Young-Suk Kim, Chang Hoon Han, Hyun-Kul Lee, Si-Whan Song, C. Park, B. Kang","doi":"10.1293/tox.2021-0003","DOIUrl":"https://doi.org/10.1293/tox.2021-0003","url":null,"abstract":"Platycodi radix is widely used in traditional herbal medicine for the treatment of bronchitis, asthma, pulmonary tuberculosis, hypertension, hyperlipidemia, and diabetes. This study aimed to investigate cell proliferation (Ki-67) and apoptosis (Caspase-3) potential in squamous cell hyperplasia of the stomach induced by a Platycodi radix water extract in a subchronic toxicity study. One hundred formalin-fixed, paraffin-embedded stomach tissues of rats treated with Platycodi radix at doses of 0, 500, 1,000, and 3,000 mg/kg body weight/day were used for the analysis. They were conventionally stained using hematoxylin and eosin (H&E) and immunohistochemically (IHC) stained using caspase-3 and Ki-67 antibodies. The incidence of squamous cell hyperplasia was significantly increased in the 3,000 mg/kg b.w./day treatment group in both sexes (p<0.01). However, the hyperplastic change was completely repaired after 4 weeks of recovery period. Ki-67 expression was similar in all groups, with no statistically significant differences among the groups. Caspase-3 expression was significantly increased in both sexes in the 3,000 mg/kg b.w./day treatment group (p<0.01), compared with the vehicle control groups, and then reduced to normal levels in the recovery groups in both sexes. In conclusion, this study showed that squamous cell hyperplasia induced by the Platycodi radix water extract in the limiting ridge of the stomach is not considered to be abnormal proliferative change; as a result, squamous cell hyperplasia is considered to be a non-adverse effect when induced by the oral administration of the Platycodi radix water extract once daily for 13 weeks in rats.","PeriodicalId":17437,"journal":{"name":"Journal of Toxicologic Pathology","volume":"35 1","pages":"45 - 52"},"PeriodicalIF":1.2,"publicationDate":"2021-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46245948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Spontaneous well-differentiated pancreatic islet cell carcinoma with vascular invasion in a male F344 rat 雄性F344大鼠自发性高分化胰岛细胞癌伴血管浸润

IF 1.2 4区医学

Journal of Toxicologic Pathology Pub Date : 2021-10-08 DOI: 10.1293/tox.2021-0037

Shiori Fujiwara, Y. Yamaguchi, Tsubasa Saito, T. Nakazawa, K. Tamura

引用次数: 0

A 13-week subchronic toxicity study of 2-(l-menthoxy)ethanol in F344 rats. 2-(l-薄荷氧基)乙醇对F344大鼠13周的亚慢性毒性研究。

IF 1.2 4区医学

Journal of Toxicologic Pathology Pub Date : 2021-10-01 Epub Date: 2021-06-03 DOI: 10.1293/tox.2020-0091

Takeshi Toyoda, Kohei Matsushita, Hirotoshi Akane, Tomomi Morikawa, Kumiko Ogawa

{"title":"A 13-week subchronic toxicity study of 2-(l-menthoxy)ethanol in F344 rats.","authors":"Takeshi Toyoda, Kohei Matsushita, Hirotoshi Akane, Tomomi Morikawa, Kumiko Ogawa","doi":"10.1293/tox.2020-0091","DOIUrl":"https://doi.org/10.1293/tox.2020-0091","url":null,"abstract":"2-(l-Menthoxy)ethanol has been frequently employed as a flavoring agent; however, data regarding 2-(l-menthoxy)ethanol toxicity remain limited. We performed a 13-week subchronic toxicity study of 2-(l-menthoxy)ethanol in male and female F344 rats, with doses of 0, 15, 60, or 250 mg/kg body weight (BW)/day orally administered by gavage using corn oil as the vehicle. No significant toxicological changes in general condition, body weight, or food intake were observed in any groups. The hematological assessment showed decreased hemoglobin, hematocrit, mean corpuscular volume, and mean corpuscular hemoglobin and increased platelet count in the male 250 mg/kg group. Serum biochemistry revealed elevated total cholesterol in the 250 mg/kg group of male and female rats, reduced triglyceride in the female 250 mg/kg group, and increased total protein in the male 250 mg/kg group, indicating effects on lipid metabolism and protein synthesis. For organ weights, absolute and relative weights of the liver and adrenal glands were increased in the 250 mg/kg group of both sexes and the male 250 mg/kg group, respectively. Histopathological analysis showed chronic nephropathy in the male 15 mg/kg or higher groups, with increased absolute and relative kidney weights, as well as elevated serum creatinine, in the male 60 and 250 mg/kg groups. However, eosinophilic granules containing α2u-globulin were identified in proximal tubules, suggesting α2u-globulin nephropathy specific to male rats and without toxicological significance. These results indicated that the no-observed-adverse-effect level of 2-(l-menthoxy)ethanol was 60 mg/kg BW/day for both sexes.","PeriodicalId":17437,"journal":{"name":"Journal of Toxicologic Pathology","volume":"34 4","pages":"309-317"},"PeriodicalIF":1.2,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/f2/tox-34-309.PMC8484932.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39526548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Safety and efficacy of sFilm-FS, a novel biodegradable fibrin sealant, in Göttingen minipigs. 新型可生物降解纤维蛋白密封剂sFilm-FS在Göttingen微型猪中的安全性和有效性。

IF 1.2 4区医学

Journal of Toxicologic Pathology Pub Date : 2021-10-01 Epub Date: 2021-07-10 DOI: 10.1293/tox.2021-0030

Yuval Ramot, Michal Steiner, Yossi Lavie, Nati Ezov, Orgad Laub, Eran Cohen, Yotam Schwartz, Abraham Nyska

{"title":"Safety and efficacy of sFilm-FS, a novel biodegradable fibrin sealant, in Göttingen minipigs.","authors":"Yuval Ramot, Michal Steiner, Yossi Lavie, Nati Ezov, Orgad Laub, Eran Cohen, Yotam Schwartz, Abraham Nyska","doi":"10.1293/tox.2021-0030","DOIUrl":"https://doi.org/10.1293/tox.2021-0030","url":null,"abstract":"Bleeding during surgical procedures is a common complication. Therefore, hemostatic agents have been developed to control bleeding, and fibrin sealants have several benefits. sFilm-FS is a novel fibrin sealant that comprises a biodegradable co-polymeric film embedded with human fibrinogen and thrombin. Herein, the safety and efficacy of sFilm-FS were compared using a liver and spleen puncture model of Göttingen minipigs with those of the standard hemostatic techniques (control animals) and EVARREST®, a reference fibrin sealant. Hemostasis and reduced blood loss were more effectively achieved with sFilm-FS than with the standard techniques in the control animals and comparable to those achieved with EVARREST®. No treatment-related adverse effects were observed in any of the groups. Histopathological evaluation indicated that sFilm-FS was slightly and moderately reactive at the liver puncture site and spleen, respectively, compared with the standard techniques in the control animals. These changes are expected degradation reactions of the co-polymeric film and are not considered as adverse events. No treatment-related abnormalities were noted in the other evaluated organs. Additionally, no evidence of local or systemic thromboses was noted. These results support the use of sFilm-FS for hemostasis in humans.","PeriodicalId":17437,"journal":{"name":"Journal of Toxicologic Pathology","volume":"34 4","pages":"319-330"},"PeriodicalIF":1.2,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6c/f4/tox-34-319.PMC8484930.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39526999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3