Walter Ojok, William Edema, Betty Akwongo, Asbjørn Haaning Nielsen, Morgan Andama
{"title":"Evaluation of drinking water suitability in rural primary school environments: linking hydrochemistry, multivariate analysis, and water quality indices in Northern Uganda.","authors":"Walter Ojok, William Edema, Betty Akwongo, Asbjørn Haaning Nielsen, Morgan Andama","doi":"10.2166/wh.2026.263","DOIUrl":"https://doi.org/10.2166/wh.2026.263","url":null,"abstract":"<p><p>Groundwater is the dominant source of drinking water in rural Sub-Saharan Africa, yet its suitability in school environments is rarely evaluated using process-based approaches. This study assesses groundwater sources used by government aided primary schools in Vurra Subcounty, Northern Uganda, integrating hydrochemical analysis with principal component analysis (PCA), hierarchical cluster analysis (HCA), and Water Quality Index (WQI) assessment. Water sources exhibited slightly acidic to near-neutral conditions (pH 5.59-7.17) and low mineralization (TDS: 4-356 mg L<sup>-1</sup>), consistent with dilute basement aquifers. PCA indicates that hydrochemical variability is primarily controlled by carbonate-mediated water-rock interaction (PC1: 41.0%), while redox-sensitive mobilization of iron and manganese accounts for secondary variability (PC2: 22.8%). WQI values ranged from 27.07 to 219.96, with 55% of sites classified as poor to very poor. Sites with elevated WQI values correspond to higher Fe and Mn concentrations rather than total dissolved solids. These results indicate that groundwater suitability in the study area is constrained by trace metal dynamics within an otherwise low-mineralization system. The findings highlight the need for targeted monitoring and treatment strategies that explicitly address redox-driven contaminants in rural water supply systems.</p>","PeriodicalId":17436,"journal":{"name":"Journal of water and health","volume":"24 8","pages":"1174-1186"},"PeriodicalIF":2.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara Morales, Diana Catalina Rodríguez, J Natalia Jimenez, Gustavo A Peñuela, Nancy J Pino
{"title":"Wastewater treatment configuration shapes ESBL- and KPC-producing gram-negative bacteria in effluents from a Colombian city: a one health perspective.","authors":"Sara Morales, Diana Catalina Rodríguez, J Natalia Jimenez, Gustavo A Peñuela, Nancy J Pino","doi":"10.2166/wh.2026.253","DOIUrl":"https://doi.org/10.2166/wh.2026.253","url":null,"abstract":"<p><p>Wastewater-based surveillance is increasingly used to track antimicrobial resistance (AMR), yet evidence from treatment configurations common in small and mid-sized cities, particularly upflow anaerobic sludge blanket (UASB) reactors and stabilization ponds, remains limited. We conducted culture-based surveillance in two full-scale municipal wastewater treatment systems in Colombia: a UASB-trickling filter line and a stabilization pond system. Influent, biological-stage, and effluent samples were analyzed for extended-spectrum <i>β</i>-lactamase (ESBL)-associated and carbapenem-resistant Gram-negative bacilli, antimicrobial susceptibility profiles, and <i>β</i>-lactamase genes, including <i>bla</i><sub>TEM</sub>, <i>bla</i><sub>SHV</sub>, <i>bla</i><sub>CTX-M</sub> groups, AmpC-related determinants, and carbapenemase genes. Total heterotrophic bacteria declined in both systems, but attenuation of resistant Gram-negative bacilli differed by configuration. The UASB-trickling filter system did not reduce carbapenem-resistant Gram-negative bacilli and showed higher ESBL and multidrug-resistant (MDR) frequencies in effluent than in influent. In contrast, stabilization ponds achieved >1-log reductions in carbapenem-resistant Gram-negative bacilli and lower ESBL and MDR frequencies. <i>bla</i>CTX-M group 1 predominated across isolates, and <i>bla</i>KPC was detected in both systems in Enterobacterales and <i>Aeromonas</i> spp. Conventional organic-load indicators did not predict AMR-related outcomes, whereas treatment configuration was more closely associated with resistant-bacteria persistence and attenuation.</p>","PeriodicalId":17436,"journal":{"name":"Journal of water and health","volume":"24 8","pages":"1141-1156"},"PeriodicalIF":2.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Integrated risk assessment of industrial wastewater in a Bangladeshi export processing zone.","authors":"Muhammad Saidur Rahman, Abdul Jalil, Sabbir Ahmed","doi":"10.2166/wh.2026.069","DOIUrl":"https://doi.org/10.2166/wh.2026.069","url":null,"abstract":"<p><p>Industrial wastewater from export processing zones may comply with regulatory standards while concealing ecological risks not captured by routine monitoring. This study aimed to (1) evaluate effluent quality and regulatory compliance in the Chattogram Export Processing Zone (CEPZ), Bangladesh; (2) develop an integrated risk assessment framework integrating the Effluent Quality Index (EQI), ecotoxicity, metal speciation, and geographic information system (GIS) analysis; and (3) identify high-risk discharge corridors. Treated effluents (n = 6) and drinking water were analyzed for physicochemical parameters, Pb and Cr, acute ecotoxicity using Daphnia magna (EC<sub>50</sub>), metal speciation (Visual MINTEQ), and spatial distribution against ECR 2023 and WHO guidelines. Although pH and metal concentrations complied with regulatory limits, 5-day biochemical oxygen demand (95-180 mg L<sup>-1</sup>) exceeded the ECR limit (30 mg L<sup>-1</sup>) by up to 600%, while chemical oxygen demand (240-326 mg L<sup>-1</sup>) exceeded the 200 mg L<sup>-1</sup> limit by 63%. The washing-finishing sector exhibited the highest pollution burden (EQI = 3.10) and toxicity (EC<sub>50</sub> = 18.5%). Metal speciation showed that 45-88% of regulated heavy metals occurred as bioavailable organic complexes. EQI correlated with EC<sub>50</sub> (R² = 0.84, p < 0.01); GIS identified a 2-km high-risk corridor, potentially exposing 50,000-75,000 residents.</p>","PeriodicalId":17436,"journal":{"name":"Journal of water and health","volume":"24 8","pages":"1187-1204"},"PeriodicalIF":2.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Spatial-temporal variability of metals and organic carbon in the upper awash and implications for TOC removal at Koka Water Treatment Plant (Ethiopia).","authors":"Emeru Assefa, Tesema Kebede, Meseret Dessalegne, Seyoum Bezabih","doi":"10.2166/wh.2026.258","DOIUrl":"https://doi.org/10.2166/wh.2026.258","url":null,"abstract":"<p><p>This study assessed spatial and temporal variations of metals and TOC in the Upper Awash Basin and their effects on TOC removal efficiency at the Koka Water Treatment Plant. Water samples were collected from river sites and the treatment plant influent during three dry and three wet months (May 2023-September 2024) to assess seasonal and spatial variations in water quality. Metal concentrations were quantified using inductively coupled plasma optical emission spectrometry (ICP-OES), while TOC was measured using a TOC analyzer. Spatial distribution patterns and pollution hotspots were identified using Ordinary Kriging in QGIS. Average total measured metal concentrations and influent TOC were approximately 1,546 μg/L and 29.63 mg/L, respectively, yielding a mean TOC removal efficiency of 57.52%. At the Koka Water Treatment Plant, higher concentrations of total measured metals and influent TOC were associated with lower TOC removal efficiency, indicating that elevated contaminant loading may adversely affect treatment performance. Dry-season concentrations generally exceeded wet-season levels. Spatial analysis identified the Akaki and Mojo Rivers as major metal hotspots, while Koka Lake and upstream hydropower reservoirs were key contributors to TOC. These findings highlight critical source areas that require targeted watershed management interventions to sustain drinking water treatment performance.</p>","PeriodicalId":17436,"journal":{"name":"Journal of water and health","volume":"24 8","pages":"1157-1173"},"PeriodicalIF":2.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Macroplastic and microplastic presence in riverbank, surface water, and sediment of a Japan agricultural river.","authors":"Widyastuti Kusuma Wardhani, Kuriko Yokota, Takanobu Inoue, Hardianti Alimuddin, Nguyen Minh Ngoc","doi":"10.2166/wh.2026.214","DOIUrl":"https://doi.org/10.2166/wh.2026.214","url":null,"abstract":"<p><p>Macroplastics and microplastics are increasingly being documented in riverine systems, yet their pathways remain poorly understood, especially in agricultural catchments. In this study, macroplastics along riverbanks and microplastics in surface water and sediments of the Hamada River in Toyohashi, Japan, were examined, complemented by a survey of mulch sheet and sewage sludge usage. Sampling and analyses were conducted based on the Japanese Guidelines of Riverine Microplastic Survey and were determined using attenuated total reflectance Fourier transform infrared spectroscopy. The abundance of macroplastics was 2.06 ± 0.56 pieces/m<sup>2</sup>. Almost half the macroplastics found were mulch sheets with polyethylene of varying colors, such as white, black, transparent, and gray, corresponding to an estimated leakage rate of 0.013% from tobacco mulch sheet applications. Mesoplastics averaged 0.01 ± 0.001 particles/m<sup>3</sup> in surface water and 20 ± 15 particles/kg in sediment, while microplastics averaged 0.038 ± 0.02 particles/m<sup>3</sup> and 75 ± 87 particles/kg, respectively. Films were the dominant type in water, and coated fertilizers were the major type in sediment. The polymer composition was dominated by polyethylene and polypropylene. The dominance of film-shaped plastics in both macroplastic and microplastic fractions suggests that agriculture is a major source of plastic pollution, which may help to inform mitigation strategies and proper waste management in agricultural catchments.</p>","PeriodicalId":17436,"journal":{"name":"Journal of water and health","volume":"24 8","pages":"1121-1140"},"PeriodicalIF":2.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrick M D'Aoust, Elisabeth Mercier, Tram B Nguyen, Shen Wan, Chandler H Wong, Nada Hegazy, Elizabeth M Renouf, Tyson E Graber, Robert Delatolla
{"title":"From plant pathogen to public health tool: A review of tobamoviruses and their role in wastewater & environmental surveillance.","authors":"Patrick M D'Aoust, Elisabeth Mercier, Tram B Nguyen, Shen Wan, Chandler H Wong, Nada Hegazy, Elizabeth M Renouf, Tyson E Graber, Robert Delatolla","doi":"10.2166/wh.2026.261","DOIUrl":"https://doi.org/10.2166/wh.2026.261","url":null,"abstract":"<p><p>Since the pandemic, interest in Wastewater and environmental surveillance (WES) has expanded rapidly, alongside advances in PCR-based detection and the need for reliable normalization strategies. One widely adopted approach to quantification in WES involves normalizing pathogen measurements using human-associated fecal biomarkers such as tobamoviruses. While pepper mild mottle virus and tomato brown rugose fruit virus have been extensively studied and utilized in hundreds of WES studies, the broader <i>tobamovirus</i> genus remains relatively underexplored. We reviewed over 270 published studies, assessed the suitability of 43 tobamoviruses for application as indicators of human fecal contamination or for normalization biomarkers for WES applications. Tobamoviruses were systematically evaluated based on host range, likelihood of human dietary exposure and gastrointestinal passage, environmental persistence, and evidence of detection in wastewater. This analysis identifies 11 tobamoviruses with significant potential as current or emerging biomarkers across diverse geographic and dietary contexts. Our analyses identify 11 tobamoviruses with significant potential as biomarkers across global wastewater contexts. Tobamoviruses have proven suitable for wastewater and environmental surveillance normalization due to their frequent and high-volume introduction into the human food chain through staple crops, in which they induce only mild or asymptomatic infections. This results in reliable, high-abundance measurements in municipal wastewater.</p>","PeriodicalId":17436,"journal":{"name":"Journal of water and health","volume":"24 6","pages":"844-866"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Socioeconomic and attitudinal predictors of bottled water use among lower-income households in Southwest Virginia.","authors":"Bethesda O'Connell, Md Rasheduzzaman, Chidiebube Ugwu, Phillip Scheuerman, Alasdair Cohen","doi":"10.2166/wh.2026.036","DOIUrl":"https://doi.org/10.2166/wh.2026.036","url":null,"abstract":"<p><p>Bottled water consumption is rising, influenced by perceptions of taste, convenience, safety, and concerns about other drinking water sources. However, bottled water use raises quality, environmental, and economic concerns. Despite poorer economic and health outcomes in Central Appalachia, there is a severe lack of research about drinking water in the region. This small-scale study explored predictors of bottled water usage among 27 households with utility-supplied water in Virginia. Logistic regression analyses considered the following as potential predictors of bottled water use: income, level of education, marital status, and tap water quality perceptions. About 78% of households reported using bottled water as a primary or secondary source, for reasons including perceptions of taste (43%), convenience (29%), safety (15%), and other reasons (13%). In this study, socioeconomic indicators were not significantly associated with bottled water use, but the perceived quality of households' tap water was a significant predictor of primary bottled water use. This study contributes to our understanding drivers of bottled water use with a focus on the under-studied region of central Appalachia.</p>","PeriodicalId":17436,"journal":{"name":"Journal of water and health","volume":"24 6","pages":"896-904"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Detection and removal methods of antibiotic-resistance genes in drinking water sources: a review.","authors":"Meng Du, Yan Yan, Xin Kang, Yuchen Zhang","doi":"10.2166/wh.2026.236","DOIUrl":"https://doi.org/10.2166/wh.2026.236","url":null,"abstract":"<p><p>The natural evolutionary process of bacterial resistance has been catastrophically amplified into a planetary health crisis through anthropogenic antibiotic pollution. Antibiotic accumulation in the environment has become a key driver of antimicrobial resistance (AMR) proliferation. This is particularly critical in wastewater and drinking water systems (DWSs). The presence of antibiotics selects for resistant strains and facilitates horizontal gene transfer of antibiotic resistance genes (ARGs). This phenomenon arises from excessive antibiotic usage coupled with inefficient removal through conventional water treatments, which fail to eliminate residual antibiotics or impede ARG dissemination. This review systematically summarizes current knowledge on bacterial resistance mechanisms in DWSs and recent advancements in detection methodologies of ARGs. Furthermore, we discussed the efficiency of conventional water treatment processes against antimicrobial containment and the emerging solutions to help curb the menace of AMR effectively. Overall, this study aims to establish a theoretical foundation for accurately assessing health risks posed by ARGs in DWSs and implementing effective prevention and control measures. This review can serve as a foundational resource for guiding policy recommendations to protect drinking water sources and public health.</p>","PeriodicalId":17436,"journal":{"name":"Journal of water and health","volume":"24 6","pages":"800-829"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edgar Tumwesigye, Chika Felicitas Nnadozie, Frank C Akamagwuna, Xavier Siwe Noundou, George William Nyakairu, Oghenekaro Nelson Odume
{"title":"Relationship between land use, seasonality, hydrological conditions, and the adsorption of sulfamethoxazole, ciprofloxacin, and 17<i>β</i>-estradiol onto polyethylene terephthalate microplastics in a small urban river system, Eastern Cape, South Africa.","authors":"Edgar Tumwesigye, Chika Felicitas Nnadozie, Frank C Akamagwuna, Xavier Siwe Noundou, George William Nyakairu, Oghenekaro Nelson Odume","doi":"10.2166/wh.2026.194","DOIUrl":"https://doi.org/10.2166/wh.2026.194","url":null,"abstract":"<p><p>Microplastics (MPs) are increasingly identified as contaminant vectors in aquatic systems. However, the role of land use, seasonality, and hydrological conditions in contaminant- microplastic (MP) interactions remains underexplored. This study investigated the adsorption of sulfamethoxazole (SMX), ciprofloxacin (CIP), and 17<i>β</i>-estradiol (E2) onto polyethylene terephthalate (PET) MPs in the Bloukrans River, South Africa, across four land use sites (municipal, wastewater, agriculture, and control) during summer and autumn. PET MPs were deployed <i>in situ</i>, retrieved, and analysed for adsorbed contaminants using LC-MS/MS. Sulfamethoxazole adsorption differed significantly by site (F(3,16) = 4.161, <i>p</i> = 0.0234) and season F(1,16) = 7.202, <i>p</i> = 0.016), with adsorption highest at wastewater and agriculture impacted sites, and autumn concentrations exceeding summer by 176.5 ng L<sup>-1</sup>. CIP adsorption varied significantly only by site (<i>p</i> = 0.0231) but not between seasons. E2 adsorption was non-significant (<i>p</i> > 0.05) for both sites and seasons. The hydrological analysis indicated that river width significantly influenced CIP, while SMX and E2 showed no hydrological dependence. By addressing the paucity of <i>in situ</i> evidence in small urban rivers of Africa, this study demonstrates that land use, seasonality, and hydrological conditions play an important role in influencing the adsorption of the selected compounds by PET MPs.</p>","PeriodicalId":17436,"journal":{"name":"Journal of water and health","volume":"24 6","pages":"744-758"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frances N N Nathan-Mensah, Emmanuel U Osisiogu, Abubakari Issaka, Genevive A Afia Agyapong, Raphael Eyram Amemo, Godknows Afenya, Richard Alipio
{"title":"Aquatic bacterial and antimicrobial resistance profile at different fish farms in Accra.","authors":"Frances N N Nathan-Mensah, Emmanuel U Osisiogu, Abubakari Issaka, Genevive A Afia Agyapong, Raphael Eyram Amemo, Godknows Afenya, Richard Alipio","doi":"10.2166/wh.2026.190","DOIUrl":"https://doi.org/10.2166/wh.2026.190","url":null,"abstract":"<p><p>Aquaculture expansion in Ghana has been accompanied by increased antimicrobial use, raising concerns about antimicrobial-resistant bacteria emergence. This study determined bacterial prevalence and antimicrobial resistance profiles across fish farms in Accra. A cross-sectional study was conducted at 45 fish farms in Accra. Water samples (<i>n</i> = 135), stool samples from farm workers (<i>n</i> = 42), and biological samples from fish (<i>n</i> = 89) were collected. Bacterial identification used standard microbiological techniques. Antimicrobial susceptibility testing followed Clinical and Laboratory Standards Institute guidelines for nine antimicrobials. Multidrug resistance (MDR) was defined as resistance to ≥3 antimicrobial classes. Diverse bacterial populations were identified across sample types. Resistance rates exceeded 70% for tetracycline, ampicillin, and penicillin. MDR prevalence was highest in water samples (68.9%), followed by biological samples (61.8%) and stool samples (57.1%). Hierarchical clustering analysis using Euclidean distance revealed distinct resistance patterns indicating common selective pressures. Similar resistance profiles across water, fish, and human samples suggested active resistance circulation within farm ecosystems. Significant antimicrobial resistance exists in Accra fish farms, with evidence of resistance dissemination across the aquaculture ecosystem. These findings suggest the need for antimicrobial stewardship programs with veterinary oversight and routine resistance surveillance to mitigate public health risks.</p>","PeriodicalId":17436,"journal":{"name":"Journal of water and health","volume":"24 6","pages":"729-743"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}