Journal of thermal biology最新文献

{"title":"Poroelastic modeling of magnetic nanoparticle hyperthermia: Effects of infusion-induced tissue deformation on drug distribution and thermal damage","authors":"Aishik Dinda,&nbsp;Sujit Nath","doi":"10.1016/j.jtherbio.2025.104235","DOIUrl":"10.1016/j.jtherbio.2025.104235","url":null,"abstract":"<div><div>This study presents a comprehensive poroelastic modeling approach to investigate the effects of infusion-induced tissue deformation on drug distribution and thermal damage during magnetic nanoparticle (MNP) hyperthermia treatment. A three-dimensional computational model of a breast tumor nodule was developed, which incorporated interstitial fluid flow, nanoparticle transport, and heat transfer. The model accounted for the elastic deformation of the soft tissue caused by the infusion pressure at the needle tip. Comparative analyses were performed using a simplified Darcy model to highlight the significance of poroelasticity in capturing complex fluid-structure interactions within the tumor microenvironment. The results revealed that tissue deformation led to the formation of fluid pockets near the infusion site, reducing interstitial fluid pressure (IFP) and altering nanoparticle concentration profiles. Pharmacokinetic assessments using the area under the curve (AUC) indicated that larger nanoparticles with higher initial concentration, enhanced the drug-tissue contact duration, particularly in the tumor region. However, the clustering of nanoparticles within the fluid pockets hinders their magnetic relaxation, leading to a decrease in the specific absorption rate and a delay in thermal damage. This study emphasizes the importance of considering infusion-induced tissue mechanics in the design and optimization of magnetic nanoparticle hyperthermia treatments. These findings provide valuable insights into the complex interplay between drug delivery, tissue deformation, and thermal therapy, paving the way for more effective and precise cancer treatment strategies.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104235"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dehydration effects on the thermal biology and locomotor performance of the South American White-lipped Grassfrog, Leptodactylus fuscus","authors":"Georgia K. Kosmala,&nbsp;Luis M. Senzano,&nbsp;Mariana Routh,&nbsp;Nycolle A.O. Silva,&nbsp;Luis F. Montes,&nbsp;Denis V. Andrade","doi":"10.1016/j.jtherbio.2025.104232","DOIUrl":"10.1016/j.jtherbio.2025.104232","url":null,"abstract":"<div><div>Amphibians must constantly balance two vital physiological demands: maintaining adequate hydration and regulating body temperature. The behavioral adjustments required to support these needs often conflict, especially for terrestrial species, where performance-enhancing body temperatures typically increase the risk of dehydration. The complex interplay among these factors affects all aspects of amphibians’ biology and is thought to be highly sensitive to changes in climate and environment. Herein, we investigated how dehydration affects aspects of the thermal biology of the ground-dwelling frog <em>Leptodactylus fuscus,</em> a species tightly associated with terrestrial habitats. We investigated the frog's locomotor performance across different combinations of temperatures (10, 15, 20, 25, 30 and 35 °C) and hydration levels (100, 90 and 80 %), focusing on traits such as optimal temperature, maximal performance, and thermal performance breadth. We also investigated how dehydration affected their preferred body temperature, critical thermal maximum and minimum, and the thermal tolerance breadth. We found that dehydration reduced maximal performance capacity but did not affect optimal temperature or thermal performance breadth. Dehydrated frogs reduced their critical thermal maximum but not the critical thermal minimum, and as a result, narrowed their thermal tolerance breadth. Dehydration did not affect the frog's preferred body temperature, a response thought to be convenient to water conservation, since it reduces the potential for evaporative water loss. In general, the interplay between performance, temperature, and hydration state in <em>L. fuscus</em> seems to reflect the more terrestrial habit of this species and the climatic features of its habitat. The deleterious effects of combined hot and dehydrating conditions on the absolute levels of maximal performance may bear important consequences to the fitness and persistence of the species, and predicted scenarios of extreme heat and intense drought events bear more concern in the light of these findings.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104232"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cold tolerance of European populations of Drosophila suzukii varies among seasonal phenotypes","authors":"Madelena De Ro ,&nbsp;Tom Devos ,&nbsp;Nick Berkvens ,&nbsp;Hans Casteels ,&nbsp;Jochem Bonte ,&nbsp;Hervé Colinet ,&nbsp;Patrick De Clercq","doi":"10.1016/j.jtherbio.2025.104251","DOIUrl":"10.1016/j.jtherbio.2025.104251","url":null,"abstract":"<div><div>The invasive Asian fruit fly <em>Drosophila suzukii</em> is a significant pest of soft and stone fruits in large parts of the world, including Europe. Understanding its performance at low temperatures is crucial for establishing sustainable management programs. In this paper, we compared the cold tolerance of summer-acclimated (developed at 25 °C, 16:8 h (L:D)) and winter-acclimated (developed at 10 °C, 8:16 h (L:D)) males and females of one Southern European (Spanish) and two northern European (Belgian) populations by means of two common indices: (1) the lower lethal temperature (LLTemp) and (2) the lower lethal time (LLtime). Winter-acclimated <em>D. suzukii</em> adults proved to be substantially more cold tolerant than summer-acclimated adults. Their LLtime₅₀ values were significantly longer than those of summer-acclimated flies and this was the case for all tested temperatures. Winter-like acclimation also resulted in more negative LLTemp values. Non-uniform differences in cold susceptibility between males and females were found, depending on the exposure conditions and the treatment groups. Variations in cold tolerance among Belgian and Spanish populations were observed too, albeit these were more likely ascribed to variations among individuals than to variations due to geographic origin and adaption. Overall, our results indicate that phenotypic plasticity in the field can strongly increase the low temperature performance of <em>D. suzukii</em>, thereby facilitating its overwintering success in temperate climates.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104251"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Susceptibility of acute sleep deprivation to cerebral cortex depolarization assisted by conductive nanoparticles based on medical thermography” [J. Thermal Biol. 131 (2025) 104193]","authors":"Hao Wu ,&nbsp;Dan Wu ,&nbsp;Xudong Luo ,&nbsp;Congli Jin","doi":"10.1016/j.jtherbio.2025.104250","DOIUrl":"10.1016/j.jtherbio.2025.104250","url":null,"abstract":"","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104250"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporating thermoreceptor responses in a local sensation model to account for setpoint adaptation during cold-to-warm transition","authors":"Gineesh Gopi ,&nbsp;Jung Kyung Kim","doi":"10.1016/j.jtherbio.2025.104170","DOIUrl":"10.1016/j.jtherbio.2025.104170","url":null,"abstract":"<div><div>The Berkeley comfort models are well-suited for addressing nonuniform, transient, and cold conditions owing to their comprehensible model structures. Integrating these models with thermoregulation models can aid in formulating energy-efficient local warming and heating, ventilation, and air conditioning (HVAC) operational strategies for occupant-centric winter conditioning in battery electric vehicles (BEVs)—a critical step toward their widespread adoption. However, the Berkeley local sensation (LS) model requires accurate consideration of setpoint and setpoint adaptation to ensure reliable predictions. Since the dynamic responses and excitatory–inhibitory interactions between the cold- and warm-sensitive thermoreceptors may inherently entail setpoint adaptation, expressing the LS model in terms of the receptor responses offers a promising alternative. This study evaluates a thermoreceptor-response-based LS model by incorporatingnet cold- and warm-sensitive receptor responses into the existing framework. Model coefficients were regressed and tested on two independent datasets from experiments simulating routine cabin environments during outdoor winter conditions. The results showed a reasonable fit for the development dataset A, with root mean-squared error (<em>RMSE</em>) values in the range of 0.29–0.59 and coefficient of determination (<em>R</em>^<em>2</em>) values of 0.65–0.92. Validation on the test dataset B yielded <em>RMSE</em> values of 0.5–0.92 and moderate-to-strong <em>R</em>^<em>2</em> values of 0.53–0.78. Compared to the original Berkeley LS model, the proposed receptor-response-based model demonstrated improved performances across all body segments. Moreover, this new framework has the potential to eliminate the need for explicit setpoint and setpoint adaptation definitions while offering a viable solution for optimizing local warmer and HVAC operating strategies in BEVs operating under outdoor winter conditions.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104170"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of pyroptosis by sodium butyrate supplementation mitigates cold stress-induced intestinal damage in Danzhou chicken","authors":"Biao Jiang ,&nbsp;Limin Wei ,&nbsp;Wenjie Lu ,&nbsp;Xueqi Tian ,&nbsp;Yanyu Sun ,&nbsp;Hui Peng ,&nbsp;Diqi Yang","doi":"10.1016/j.jtherbio.2025.104239","DOIUrl":"10.1016/j.jtherbio.2025.104239","url":null,"abstract":"<div><div>Cold stress poses a significant threat to intestinal health in young broilers, contributing to economic losses and welfare concerns; however, the underlying mechanisms and effective interventions remain unclear. To investigate these aspects, this study examined the effects of cold stress on intestinal barrier integrity and explored the protective potential of sodium butyrate supplementation. Forty-five-day-old broilers were randomly assigned to either a control group (CON, thermoneutral at 30 ± 1 °C) or a cold stress group (CS, exposed to 10 ± 1 °C) for 48 h. Intestinal tissues were analyzed for histopathology, tight junction protein expression, oxidative stress markers (CAT, MDA, T-SOD, T-AOC), inflammatory cytokines (LITAF, TNF-α, IL-1β, IL-6, IL-8, IL-10), and pyroptosis-related indicators (Caspase-1, NLRP3). Cold stress significantly disrupted intestinal barrier function, as evidenced by histopathological damage and altered expression of tight junction proteins. The CS group exhibited increased oxidative stress, elevated inflammatory cytokines, and enhanced pyroptosis activation. Given sodium butyrate's role as a crucial energy source for intestinal cells and its reported anti-inflammatory properties, we hypothesized it could mitigate cold stress-induced damage. To test this, an in vitro model using chicken macrophage HD11 cells subjected to cold stress was treated with sodium butyrate (1 mM). Sodium butyrate effectively alleviated oxidative stress and suppressed pyroptosis in cold-stressed HD11 cells. Mechanistic analysis revealed that this protection was associated with the inhibition of the NLRP3/Caspase-1 signaling pathway. These findings demonstrate that sodium butyrate supplementation attenuates cold stress-induced intestinal damage in broilers, likely through mitigating oxidative stress and inhibiting NLRP3 inflammasome-mediated pyroptosis, highlighting its potential as a protective dietary intervention.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104239"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of algal β- glucan on stress, humoral immunity, plasma biomarkers, and carcass traits of broiler chickens reared during hot season","authors":"Sadiq Nabila Fathima ,&nbsp;Rajendra Moorthy Rajendran ,&nbsp;Srinivasan Balaji ,&nbsp;Ravichandran Mani ,&nbsp;Santosh Ramvilas Vyas ,&nbsp;Selvaraj Chandrasekar","doi":"10.1016/j.jtherbio.2025.104227","DOIUrl":"10.1016/j.jtherbio.2025.104227","url":null,"abstract":"","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104227"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial scale influences relationships between indices of organisms’ thermal tolerance","authors":"Beatrice S. Dewenter ,&nbsp;Jane Hughes ,&nbsp;Alisha A. Shah ,&nbsp;Stephanie Bristow ,&nbsp;N. LeRoy Poff ,&nbsp;Ross Thompson ,&nbsp;Ben J. Kefford","doi":"10.1016/j.jtherbio.2025.104226","DOIUrl":"10.1016/j.jtherbio.2025.104226","url":null,"abstract":"<div><div>Many thermal vulnerability indices potentially describe organismal responses to climate. However, the inter-relationships among indices and the effects of body size and spatial scale are mostly unknown. Existing literature on relationships between indices remains unclear, e.g. different hypotheses predict no, positive or negative relationship between critical thermal minimum and maximum (CT_min and CT_max). We used phylogenetic corrected analysis to determine relationships between CT_min, CT_max, thermal breadth (=CT_max-CT_min), warming tolerance (=CT_max-annual mean habitat temperature), warming capacity (=CT_max-annual maximum habitat temperature) and organism size in 121 species of freshwater insects (Ephemeroptera, Plecoptera and Trichoptera) from temperate and tropical streams distributed along elevation gradients in eastern Australia. When data were collated across all sites (i.e. both elevation gradients), CT_min and CT_max were positively related, indicating a trade-off between tolerating high and low temperatures at this multi-region spatial scale. However, within each gradient, these indices were uncorrelated, indicating that tolerance to high temperatures had no effect on tolerance to low temperatures and <em>vice versa</em> at this within-region scale. All pairs of variables, except CT_max and body size, were related (either positively or negatively) in one or more of the three datasets. Inconsistent relationships across sites in both the temperate and the tropical gradients occurred in 43 % of variable pairs. Hypotheses about the direction of relationships between pairs of variables were supported consistently in 50 % of the contrasts. While the variables examined are mostly related to each other, spatial scale is important in determining the nature of that relationship.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104226"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144894873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of heat stress on plasminogen activator related in milk protein in bovine mammary epithelial cells and mid lactating Holstein cow milk","authors":"Min-Kyeong Choi ,&nbsp;Jang-Hoon Jo ,&nbsp;Jung-Woo Lim ,&nbsp;Jalil Ghassemi Nejad ,&nbsp;Hong-Gu Lee","doi":"10.1016/j.jtherbio.2025.104236","DOIUrl":"10.1016/j.jtherbio.2025.104236","url":null,"abstract":"<div><div>Heat stress (HS) is a significant factor in reducing milk yield and protein in dairy cows. However, studies on the mechanisms underlying HS-induced reductions in milk protein are limited. This study investigated the effects of HS on the plasminogen activator (PA) in bovine mammary alveolar cells (MAC-T) and cow milk to investigate milk protein reduction under hyperthermia. In an in vivo study, milk samples were collected from thirty mid-lactating Holstein cows in different seasons with varying temperature–humidity index (severe–moderate, SM; moderate–mild, MM; and mild–comfortable, MC). The average daily milk yield of cows was 33.93 ± 0.98 kg; cows were fed a TMR diet, delivered twice daily, and ad libitum access to water. The SM group had the highest (<em>P</em> &lt; 0.05) milk uPA concentrations (1.48 ng/mL), followed by the MM group (0.43 ng/mL). Milk protein levels were lower (<em>P</em> &lt; 0.05) in the SM group (3.1 %), which was exposed to more HS than the MM (3.35 %) and MC (3.46 %) groups. To determine whether HS also alters PA expression in MAC-T cells, cells were subjected to HS at 41 °C for 2 h, with recovery at 37 °C for 8 h. HS increased (<em>P</em> &lt; 0.05) mRNA expression levels of heat shock protein 70 (HSP70), urokinase-PA (uPA), and tissue-PA (tPA). HS upregulated HSP70 expression (<em>P</em> &lt; 0.05) and tended to raise uPA protein expression (<em>P</em> = 0.096). Although HS did not affect protein synthesis in MAC-T cells, cortisol, insulin, and prolactin did not affect uPA or tPA expressions in MAC-T cells. These results suggest that HS contributes to decreased milk protein content through elevated PA in the alveolar lumen rather than impaired protein synthesis in MAC-T cells. Additionally, these HS-induced mechanisms in PA provide an additional clue explaining dairy cows' decreased milk protein levels.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104236"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemo-/sonodynamic/photothermal triune therapy in 2D and 3D models of MCF-7 cells using paclitaxel-loaded gold nanoparticles","authors":"N. Zahraie ,&nbsp;H. Haghighi ,&nbsp;H. Heli ,&nbsp;R. Dehdari Vais ,&nbsp;N. Sattarahmady","doi":"10.1016/j.jtherbio.2025.104259","DOIUrl":"10.1016/j.jtherbio.2025.104259","url":null,"abstract":"<div><h3>Objective</h3><div>Breast cancer remains the most prevalent cancer among females globally, with an alarming rise in incidence. Conventional treatments like chemotherapy face several limitations, necessitating innovative approaches. In this study, the efficacy of a novel chemo-/sonodynamic/photothermal triune therapy utilizing paclitaxel-loaded gold nanoparticles (PTX@GNPs) for MCF-7 breast cancer cells treatment was explored.</div></div><div><h3>Methods</h3><div>PTX@GNPs were synthesized and characterized followed by measurements of 808-nm photothermal conversion efficiency and drug loading capacity. The combined dual therapies of chemotherapy/photothermal therapy (chemo/PTT), chemotherapy/sonodynamic therapy (chemo/SDT), and combined triune therapies of chemotherapy/sonodynamic therapy/photothermal therapy (chemo/SDPTT) and chemotherapy/photothermal therapy/sonodynamic therapy (chemo/PTSDT) of both 2D monolayer and 3D spheroid MCF-7 cells were evaluated using the MTT and resazurin assays, and reactive oxygen species detection. The impact of laser light and ultrasound radiations (light followed by ultrasound and vice versa radiations) was also investigated.</div></div><div><h3>Results</h3><div>PTX@GNPs exhibited a high loading capacity of 60 % and a photothermal conversion efficiency of 28.7 %. In the 2D culture model, chemo/SDPTT demonstrated superior cytotoxicity and ROS generation, compared to the monotherapies and other dual and triune therapies. In the 3D culture spheroids, while overall cytotoxicity was lower due to slower growth rates and limited oxygen diffusion, chemo/PTSDT again provided the highest efficacy.</div></div><div><h3>Conclusion</h3><div>The synchronized chemo/PTSDT modality employing PTX@GNPs exhibited significant synergistic effects against both 2D and 3D MCF-7 cell culture models. This approach outperformed free paclitaxel and monotherapies, emphasizing the potential of gold nanoparticles as an effective drug carrier and dual photo/sonosensitizer. Importance of treatment sequence during multimodal cancer therapies for better therapeutic outcomes was highlighted.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104259"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}