Journal of thermal biology最新文献

{"title":"The influence of cold temperature exposure on markers of bone health in humans: A scoping review","authors":"R. Allan ,&nbsp;H.T. Hurst ,&nbsp;B. Akin ,&nbsp;N. Liles ,&nbsp;J. Dickson ,&nbsp;J. Knill-Jones ,&nbsp;J. Sinclair ,&nbsp;S. Dillon ,&nbsp;S.J. Hesketh ,&nbsp;C. Mawhinney","doi":"10.1016/j.jtherbio.2026.104401","DOIUrl":"10.1016/j.jtherbio.2026.104401","url":null,"abstract":"<div><h3>Background</h3><div>Studies of cold-dwelling humans show lower bone mineral density (BMD) and greater age-related bone loss. While cold exposure is regularly used for analgesic purposes, prolonged use may unintentionally exacerbate symptoms it aims to treat.</div></div><div><h3>Objective</h3><div>To evaluate human evidence on the effects of cold exposure upon markers of bone health.</div></div><div><h3>Methods</h3><div>This scoping review followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. OVID (MEDLINE, EMBASE), Elsevier (ScienceDirect, Scopus), and PubMED databases were searched using the terms (“Cold temperature” OR “cryotherapy” OR “Hydrotherapy” OR “Cold stress”) AND (“Bone Matrix” OR “Bone mineral density” OR “bone formation” OR “bone remodelling” OR Osteogenesis). Inclusion criteria were: (1) cold exposure or application in humans; (2) measurement of bone health or turnover markers; and (3) original research or case reports.</div></div><div><h3>Results</h3><div>Searches resulted in 2372 articles, yielding a final pool of 13 articles for inclusion after screening. Several cooling methods were used, predominantly cold air (n = 6), cooling vests (n = 4), sleeping in cold rooms (n = 1), β3 agonist coupled with cooling pads (n = 1) and ice water swimming (n = 3). Markers of bone health were assessed, with BMD shown to increase following cryotherapy, and having a positive correlation with brown adipose tissue. Papers returned suggest a neutral or positive response in factors that enhance osteoblast differentiation (irisin, insulin-like growth factor-1 [IGF-1], meteorin-like protein [METRNL]), which fails to translate directly into improved bone formation (procollagen 1 N-terminal propeptide [P1NP], osteocalcin).</div></div><div><h3>Conclusion</h3><div>Cold exposure might dampen bone resorption mechanisms (beta isomerised C terminal telopeptide of type 1 collagen [β-CTX]) but not others (receptor activator of nuclear factor <em>κ</em> B [RANK], RANK ligand [RANKL], interleukin-6 [IL-6]). Hormonal markers of bone remodelling (thyroid stimulating hormone [TSH], parathyroid hormone [PTH], triiodothyronine [T3]) also showed contrasting effects. As such, the limited data does not allow for clear conclusions.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"136 ","pages":"Article 104401"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hard to measure Lilliputians: Error in the measurement of body temperature of small amphibians and a method to avoid it","authors":"Georgia K. Kosmala,&nbsp;Enore A. Massoni,&nbsp;Denis V. Andrade","doi":"10.1016/j.jtherbio.2026.104391","DOIUrl":"10.1016/j.jtherbio.2026.104391","url":null,"abstract":"<div><div>Accurate measurement of body temperature (T_b) is essential for understanding the physiological ecology of ectothermic organisms. However, in small-bodied amphibians, heat exchange during handling and intrinsic limitations of measuring devices and/or protocols can introduce substantial error in T_b measurements. Here, we first estimated the magnitude of such an error for methodological approaches commonly adopted in the measurement of T_b in small ectothermic organisms in the field. We then propose a novel, low-cost restraint method, using a modified Foerster forceps, aimed at reducing heat transfer during handling. Accordingly, we compared the short-term changes (&lt;2 min) in the T_b of frogs restrained with bare or gloved hands with those measured under the new proposed restraint method. We performed all tests using the Hylidae treefrog <em>Dendropsophus nanus</em>, whose small size made it perfectly suited to our goals, and we also repeated the experiments at three ambient temperatures (15 °C, 25 °C, and 35 °C), which allowed us to evaluate the influence of this variable on the measurement error. Our results clearly demonstrate that heat transfer from the researcher's hand to a small-bodied frog causes large deviations in the measured T_b and that those changes happen at an amazingly fast pace (within seconds) and are most prominent at lower ambient temperatures. The largely preconized use of gloves during measurements indeed reduced the error in T_b measurements to a moderate extent; however, the novel Foerster method herein proposed resulted in minimal change in frog's T_b and proved to be a superior and viable alternative to improve the accuracy of T_b measurement in small-bodied ectotherms.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"136 ","pages":"Article 104391"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygen uptake in two temporary pond ostracods (Crustacea: Ostracoda) in response to different temperatures and salt contents: testing the Metabolic Cold Adaptation hypothesis","authors":"Julio Cruz-Vila ,&nbsp;Alexandre Mestre ,&nbsp;Lucía Villarroya-Villalba ,&nbsp;Alex Martínez ,&nbsp;Francesc Mesquita-Joanes","doi":"10.1016/j.jtherbio.2026.104414","DOIUrl":"10.1016/j.jtherbio.2026.104414","url":null,"abstract":"<div><div>Temporary ponds experience wide variation in their physical and chemical conditions, including changes in temperature and salinity, two critical factors strongly affecting aquatic life metabolism. Although ostracods are common in these habitats, little is known on the combined effects of temperature and salt content on their metabolic rates. Here, we compared the oxygen consumption rates of two cosmopolitan ostracods common in temporary ponds: <em>Eucypris virens</em>, which mostly grows dense populations during winter-spring in temperate climates, and <em>Heterocypris incongruens</em>, mostly considered a spring-summer inhabitant in the same habitats. We performed respirometry experiments combining five different temperatures (5-25 °C) and six salinities (0.1-10 PSU), and quantified their combined effects on mass-specific oxygen consumption rates of both species. According to the Metabolic Cold Adaptation (MCA) hypothesis, we expected differences in metabolic rate associated with their different phenologies, with the winter species showing a higher rate at the same temperature. We observed significant effects of temperature and salinity with no interaction between them on the oxygen consumption rates of both species, and confirmed that the winter species had higher energetic demands at all the temperatures tested, as predicted by MCA. Furthermore, significant interaction effects between species and salinity were consistent with their different salinity tolerances. These results provide support for MCA in ostracods and call for further experimental work with a wider range of conditions to better evaluate variation in ostracod metabolic responses at more extreme values of salinity and temperature.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"136 ","pages":"Article 104414"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic fluid hyperthermia for different breast categories: Effect of nanoparticle distribution patterns and temperature-dependent perfusion models on thermal transport","authors":"Pratik Roy ,&nbsp;Ranjan Ganguly ,&nbsp;Nirmalendu Biswas","doi":"10.1016/j.jtherbio.2026.104417","DOIUrl":"10.1016/j.jtherbio.2026.104417","url":null,"abstract":"<div><div>Magnetic fluid hyperthermia (MFH) offers a targeted means of thermally degrading malignant tissue by impregnating superparamagnetic nanoparticles (SPMNPs) within a tumor and exciting them with an alternating magnetic field. Although numerical modeling has been attempted before to guide MFH treatment optimization, systematic studies jointly integrating specific tissue categories, clinically realistic nanoparticle distributions, and dynamic perfusion evolution remain absent from the literature, leaving a critical gap in personalized MFH treatment planning. To address this, we develop a finite-element framework that integrates realistic SPMNPs distribution functions, along with a perfusion model whose magnitude varies with thermally induced tissue damage, all embedded within the Pennes bioheat formulation. Using representative breast compositions and tumor types, we investigate five spatial SPMNP-distributions under magnetic field conditions constrained by the magnetic field-frequency/Hergt–Dutz (<em>Hf</em>) threshold. The simulations resolve transient temperature fields, quantify thermal injury, and assess treatment quality across fatty to highly dense breast categories. The results indicate that fat-rich tumors exhibit a faster temperature rise than muscle-dominant tumors, and that the relative ease of heating mirrors the proportion of adipose to fibroglandular tissue in the surrounding breast. For deeply situated lesions, the extent of healthy-tissue injury is governed more strongly by the duration of heating than by the peak temperature attained, underscoring the importance of temporal control in MFH. Among the investigated spatial SPMNP-patterns, the radial Gaussian distribution consistently delivers the most advantageous balance − enhancing energy deposition within the tumor while restraining damage to adjacent tissue. These findings offer valuable insights for tailored, patient-specific hyperthermia therapy, thus lending to the successful clinical implementation of MFH as a promising tool for localized breast cancer treatment.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"136 ","pages":"Article 104417"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Entropy enhanced infrared thermography: A radiation free paradigm for precision screening of adolescent idiopathic scoliosis","authors":"Ning Du ,&nbsp;Songzi Cui ,&nbsp;Chenxi Hu ,&nbsp;Shengshu Wang ,&nbsp;Fanqi Hu ,&nbsp;Xiaoqing Yang ,&nbsp;Weibo Liu ,&nbsp;Ji Guo Yu ,&nbsp;Xuesong Zhang ,&nbsp;Yafeng Song","doi":"10.1016/j.jtherbio.2026.104430","DOIUrl":"10.1016/j.jtherbio.2026.104430","url":null,"abstract":"<div><div>Adolescent idiopathic scoliosis (AIS) is a significant challenge to global paediatric health. Early detection and longitudinal monitoring are critical for initiating non operative interventions and preventing irreversible skeletal complications. The aim of this study was to evaluate the efficacy of infrared thermography (IRT) entropy as a non invasive screening technique for adolescent idiopathic scoliosis. To this end, we recruited 203 patients with idiopathic scoliosis and 105 healthy controls, all aged 8 to 18 years. The analysis examined differences in back entropy and temperature values between the idiopathic scoliosis and control groups, whilst calculating the area under the receiver operating characteristic (ROC) curve to assess classification performance. Data analysis was conducted between February and July 2025. A significant disparity was identified between the idiopathic scoliosis group and the control group in both back entropy and temperature values (P &lt; 0.05), with idiopathic scoliosis patients exhibiting markedly reduced entropy and significantly elevated temperatures (for example, in the upper right (UR) region, entropy decreased from 2.63 ± 0.46 bits in the control group to 1.79 ± 0.41 bits in the left convex, while temperature increased from 36.1 ± 0.7 °C to 36.5 ± 0.1 °C). Intragroup analysis revealed good symmetry in both entropy and temperature between the left and right sides of the back in the control group (P &gt; 0.05). Conversely, both entropy and temperature values exhibited significant left right asymmetry in the idiopathic scoliosis group (P &lt; 0.05). ROC curve analysis demonstrated that entropy had good discriminatory ability in distinguishing AIS patients from controls, suggesting its potential utility as an adjunctive screening tool. This approach, being radiation free, effectively addresses the limitation of cumulative radiation exposure inherent in current X ray dependent detection protocols.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"136 ","pages":"Article 104430"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146776376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of hibernation temperature and duration on oxidative status in the common wall lizard (Podarcis muralis)","authors":"Jelena P. Gavrić-Čampar ,&nbsp;Marko Anđelković ,&nbsp;Branka R. Gavrilović ,&nbsp;Tijana B. Radovanović ,&nbsp;Mihailo Milićević ,&nbsp;Tamara G. Petrović ,&nbsp;Marko D. Prokić ,&nbsp;Svetlana G. Despotović","doi":"10.1016/j.jtherbio.2026.104416","DOIUrl":"10.1016/j.jtherbio.2026.104416","url":null,"abstract":"<div><div>Global warming is expected to alter phenology in temperate ectotherms by advancing spring arousal and delaying autumn entry into hibernation. However, the physiological consequences of such shifts remain poorly understood in reptiles, particularly with respect to oxidative balance. We investigated the effects of hibernation temperature and duration on oxidative status in the common wall lizard (<em>Podarcis muralis</em>). Oxidative markers were measured in the liver and tail during the pre-hibernation period and after exposure to laboratory-simulated winter regimes differing in temperature (∼2.5 °C vs. 5.5 °C) and duration (three vs. four months), representing short-cold, short-mild, long-cold, and long-mild winter scenarios. Hibernation duration exerted generally inconsistent effects on antioxidant defenses, with changes detected in liver superoxide dismutase, catalase, and glutathione, as well as in tail superoxide dismutase and glutathione. Temperature effects were modest, manifesting as upward trends in liver glutathione content and tail catalase activity, without significant interactions with hibernation duration. Cold-winter regimes were associated with increased lipid oxidative damage in the liver, although this response was not consistent across all treatments. Importantly, most oxidative parameters remained comparable to pre-hibernation values, with a significant reduction in glutathione levels observed only under short-cold conditions. Overall, the maintenance of redox homeostasis across contrasting thermal and temporal winter regimes indicates substantial physiological plasticity and resilience of <em>P. muralis</em> to altered thermal environments during hibernation, highlighting the capacity of reptiles to buffer oxidative challenges imposed by climate-driven changes in winter conditions.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"136 ","pages":"Article 104416"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using infrared thermography to understand the thermal ecology of wild bumblebees","authors":"Mei L. McFeely ,&nbsp;Jessica R.K. Forrest ,&nbsp;Ilona Naujokaitis-Lewis","doi":"10.1016/j.jtherbio.2026.104423","DOIUrl":"10.1016/j.jtherbio.2026.104423","url":null,"abstract":"<div><div>As global warming intensifies, pollinators such as bumblebees may experience increasing exposure to temperatures near their thermal limits. Heat stress impairs foraging and survival, making it essential to understand bumblebee body temperature in natural conditions. This study tested the feasibility of using infrared (IR) thermography as a non-invasive technique to measure the thoracic temperature of wild, foraging bumblebees and to evaluate how body temperature relates to environmental variables, including ambient air and floral surface temperatures. Thermographic measurements were validated against internal thoracic temperatures recorded by thermocouples in static bees, revealing a strong correlation (<em>r</em> = 0.98) with an average absolute difference of &lt;1 °C. We analysed thermal images of live <em>Bombus</em> individuals (<em>n</em> = 98) collected over five observation days in late summer. Bee body temperatures routinely exceeded both ambient and floral temperatures and approached the critical thermal maximum (CT_max) during midday foraging. A linear mixed-effects model revealed that bee temperature increased significantly with both ambient air and floral temperature, and a significant interaction term indicated that warmer floral surfaces amplified the effect of high ambient temperatures. These findings demonstrate that IR thermography can reliably measure bumblebee body temperature <em>in-situ</em>, bridging the gap between laboratory-derived thermal limits and field conditions. By capturing the combined effects of microclimate and physiology, this method offers new insight into pollinator heat stress at the organismal level and highlights the importance of fine-scale thermal data for assessing species’ responses to climate change.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"136 ","pages":"Article 104423"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heat hardening enhances mosquito heat tolerance in a species-specific and assay-specific manner","authors":"Apeksha L. Warusawithana,&nbsp;Belinda van Heerwaarden,&nbsp;Ary A. Hoffmann,&nbsp;Perran A. Ross","doi":"10.1016/j.jtherbio.2026.104394","DOIUrl":"10.1016/j.jtherbio.2026.104394","url":null,"abstract":"<div><div>Models predict that the distribution of many mosquito species will shift with climate change, but few incorporate adaptive capacity. Acclimation is one mechanism that allows mosquitoes previously exposed to sub-lethal stress to better tolerate subsequent stress. In this study we evaluated the heat tolerance of three vector mosquitoes, <em>Aedes aegypti</em>, <em>Ae. notoscriptus</em> and <em>Culex quinquefasciatus,</em> after prior exposure to heat hardening. Adults from all species were heat-hardened by exposure to 41 °C for 1 h, subsequently tested for (1) heat survival and knockdown responses following 1-h heat shocks across a range of temperatures up to the lethal limit, (2) ramping CTmax assays and (3) static temperature knockdown time assays. Females from all three species were more heat tolerant than males in the 1-h heat shock assays, but effects of sex were absent or inconsistent for CTmax and heat knockdown time assays. A beneficial impact of heat hardening on subsequent heat shock knockdown was evident in both sexes of all three species. However, hardening effects differed substantially for survival 24 h later, ranging from no effect of hardening in <em>Cx. quinquefasciatus</em> to a ∼1 °C increase in LT₅₀ in <em>Ae. notoscriptus</em>. In contrast, no effects of heat hardening were detected for CTmax or static knockdown time assays. An additional experiment in <em>Ae. aegypti</em> detected no benefits of parental heat shock exposure on the thermal tolerance of offspring. Our findings emphasize the need to consider effects of acclimation including heat hardening in models to predict the response of mosquitoes to climate warming. They also have implications for measuring thermal tolerance more generally, as sex and hardening effects depend on the type of assay used and trait measured.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"136 ","pages":"Article 104394"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between cognitive and thermoregulatory performance in the common wall lizard","authors":"Ioanna Gavriilidi ,&nbsp;Elina Trafali ,&nbsp;Panayiotis Pafilis ,&nbsp;Raoul Van Damme","doi":"10.1016/j.jtherbio.2026.104393","DOIUrl":"10.1016/j.jtherbio.2026.104393","url":null,"abstract":"<div><div>Behavioural thermoregulation is critical for reptiles, because it allows them to maintain their body temperatures within a range that optimizes physiological functions. Behavioural thermoregulation requires sensing, processing, and retaining information on the thermal environment, potentially involving several cognitive processes. Surprisingly, the relationship between cognitive performance and thermoregulatory behaviour and accuracy has hitherto remained virtually unstudied. Here we examined whether enhanced spatial cognition is correlated with more efficient thermoregulation, while also taking into account the possible confounding role of personality. To do that, we first assessed the spatial cognitive abilities of male common wall lizards in two different spatial learning tasks, as well as three personality traits (boldness, explorativeness, and sociability). We then recorded lizards' preferred body temperature range in a thermal gradient. We assessed the lizards’ thermoregulatory performance by recording their body surface temperatures and heat source use in a large enclosure with different types of heat sources (lamps, heating stones, thermal mats), mimicking a spatiotemporally heterogeneous thermal environment. We found that individuals that performed well in the spatial cognition tests switched more often between different heat sources and tended to use them more evenly, but maintained lower overall body temperatures and tended to thermoregulate less accurately than their slow learning conspecifics. Social, shy, and more explorative lizards were more often observed near activated heat sources than lizards with opposite personalities, but personality profiles did not affect body temperature or thermoregulatory accuracy. Overall, spatial cognition and personality may play a role in better exploiting the thermal heterogeneity of the environment, but interestingly this did not translate into more accurate thermoregulation.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"136 ","pages":"Article 104393"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Online decoupled estimation of temperature field in biological tissue during invasive laser thermal therapy","authors":"Zhaohui Mao ,&nbsp;Hong Chen ,&nbsp;Guangjun Wang ,&nbsp;Zhenbiao Li","doi":"10.1016/j.jtherbio.2026.104413","DOIUrl":"10.1016/j.jtherbio.2026.104413","url":null,"abstract":"<div><div>Invasive laser-induced thermal therapy (LITT) is an emerging minimally invasive technique for treating deep-seated tumors. Online estimation of the transient temperature field in target biological tissue is crucial for the research and development of LITT technology. Existing state estimation theories, which employ the state-space model to describe the system, essentially belong to coupled estimation methods. They cannot achieve decoupled estimation of system states, leading to numerous challenges in applying current state estimation methods to temperature field estimation during LITT procedures. This paper focuses on the online decoupled estimation of the temperature field in biological tissue during invasive LITT. By constructing an optimal estimation model and a spatiotemporal correlation model, it achieves online decoupled estimation of temperatures at critical discrete points throughout the invasive LITT process. This scheme effectively overcomes the difficulties inherent in existing temperature field estimation techniques based on state-space models. The reliability of the constructed biological model is validated using existing experimental data. Through numerical simulations, the impacts of the influence time domain, measurement noise, and model mismatch are analyzed. Comparison with the standard Kalman filter demonstrates that when only real-time temperature estimation of specific regions (such as tumor regions) is required, the decoupled estimation scheme proposed in this paper exhibits significant advantages in computational efficiency. This research provides reliable technical support for the online estimation of tissue temperature fields.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"136 ","pages":"Article 104413"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146170324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}