Journal of thermal biology最新文献

{"title":"Integration of multi-omics resources reveals genetic features associated with environmental adaptation in the Wuzhishan pig genome","authors":"Ziqi Zhong ,&nbsp;Feng Wang ,&nbsp;Xinfeng Xie ,&nbsp;Ziyi Wang ,&nbsp;Deyou Pan ,&nbsp;Zhen Wang ,&nbsp;Qian Xiao","doi":"10.1016/j.jtherbio.2025.104264","DOIUrl":"10.1016/j.jtherbio.2025.104264","url":null,"abstract":"<div><div>In light of the challenges posed by global climate change, the environmental adaptability of organisms is becoming increasingly important. The Wuzhishan (WZS) pig, tolerant to high heat and humidity, is an ideal model for genomic study. By characterizing its genome and assessing its genetic diversity and runs of homozygosity (ROH), we can gain insights into its current conservation status and genomic architecture. To this end, we analyzed whole-genome resequencing data from WZS pigs, identifying a comprehensive set of genetic variations: 12,844,858 single nucleotide polymorphisms (SNPs), 4,723,303 insertions and deletions (InDels), 39,311 copy number variations (CNVs), and 70,392 structural variations (SVs). ROH analysis revealed mostly short segments, indicating limited recent admixture and relatively low inbreeding, reflecting high genetic diversity. Linkage disequilibrium decay and effective population size analyses supported these findings, consistent with previous studies. Population genetic analyses of pig populations from Asia, Europe, and the Americas were conducted using SNPs, InDels, and SVs. The results obtained from different variant types were largely concordant, suggesting that the constructed genomic variation database is robust. Notably, the WZS pig displayed relatively unique genetic characteristics compared to other breeds. By intersecting the top 5 % of genes under selection signatures, we identified key pathways and candidate genes associated with important traits in WZS pigs, including reproduction (<em>ABCC9, APC2, CABS1, CSNK1G1</em>), immunity (<em>ARPIN, CMAS, ITPR1, SLC25A13</em>), meat quality (<em>GANC, OBSCN, SLC5A4</em>), environmental adaptability (<em>MAGI1, PHF3</em>), and heat tolerance (<em>GABPB1, LRRC25</em>). Further integrative analyses based on transcriptomic, single-cell transcriptomic, and epigenomic data were conducted to explore the regulatory mechanisms of key genes such as <em>LRRC25</em> and <em>ITPR1</em>. We identified relevant expression quantitative trait loci (eQTLs), associated tissues, and distal regulatory elements that potentially influence gene expression. These findings suggest that epigenetic modifications may contribute to the enhanced heat tolerance and immune function observed in WZS pigs. In conclusion, WZS pigs represent a valuable genetic resource. Further research on this breed will deepen our understanding of mechanisms underlying environmental adaptability, and provide important insights into evolutionary biology and breeding strategies for improved resilience in livestock.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104264"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ventilatory and perceptual habituation achieved with twice-daily, six total brief 12 °C head-out water immersions","authors":"Afton D. Seeley ,&nbsp;Thomas A. Mayer ,&nbsp;Shaun C. Brazelton ,&nbsp;David H. Gonzalez Rojas ,&nbsp;Kathryn G. McCarthy ,&nbsp;Phillip O. Bodurtha ,&nbsp;Molly E. Heikkinen ,&nbsp;Gabrielle E.W. Giersch ,&nbsp;MariaLena A. Shaw ,&nbsp;Andrew M. Greenfield ,&nbsp;Karleigh E. Bradbury ,&nbsp;Koby C. Conz ,&nbsp;Benjamin J. Ryan ,&nbsp;Aaron R. Caldwell ,&nbsp;K. Riley Connor ,&nbsp;Billie K. Alba ,&nbsp;John W. Castellani","doi":"10.1016/j.jtherbio.2025.104216","DOIUrl":"10.1016/j.jtherbio.2025.104216","url":null,"abstract":"<div><div>Repetitive cold exposure can evoke habituation capable of reducing physiological stress, energy expenditure and improving comfort in the cold. This study sought to evaluate physiological responses to repeated 10-min 12 °C head-out cold immersions to determine whether metabolic habituation with lower temporal burden could be achieved. Fourteen males (25 ± 7 years, 23.8 ± 5.8% body fat) completed two water immersion sequences consisting of twice daily, six total 10-min head-out immersions, one in cold water (CWI, 12.0 ± 0.1 °C) and the other in thermoneutral water (TN, 35.0 ± 0.2 °C). Water immersion was completed twice per day, separated by at least 4 h, for three consecutive days wearing only compression shorts. CWI was unable to induce metabolic habituation evidenced by unchanged oxygen consumption (<em>p</em> = 0.281) across immersions. Six 12 °C CWIs were sufficient to reduce average 10-min V_E after just three immersions (IMM4: 22.12 ± 4.68 vs. IMM1: 30.90 ± 14.15 L min⁻¹, <em>p</em> &lt; 0.001), via reduced tidal volume (−0.252 [-0.446 to −0.058] L). Perceptual habituation was achieved, with cold exposure inducing shivering sensation habituation after 2 immersions (<em>p</em> = 0.002), thermal comfort improvement after 4 (<em>p</em> = 0.017), and thermal sensation elevation (<em>p</em> = 0.029) after the completion of 5 head-out immersions. Heart rate, mean arterial blood pressure, change in core temperature, and mean weighted skin temperature did not demonstrate evidence of cold-water habituation. In summary, a total of six 12 °C water head-out immersions provided an adaptive stimulus capable of inducing both ventilatory and perceptual habituation but unable to habituate cardiovascular, metabolic, or thermoregulatory cold response.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104216"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144828702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of transcriptomic and proteomic changes in bovine myocytes subject to temporal heat stress","authors":"Erika Eckhardt ,&nbsp;Andrea Luttman ,&nbsp;Jayasimha R. Daddam ,&nbsp;Boon Hong Keng ,&nbsp;Wonseob Kim ,&nbsp;Cedric Gondro ,&nbsp;Jongkyoo Kim","doi":"10.1016/j.jtherbio.2025.104246","DOIUrl":"10.1016/j.jtherbio.2025.104246","url":null,"abstract":"<div><div>This study elucidated the degree of molecular response to heat stress (HS) in bovine myocytes by measuring changes in the transcriptome and proteome. Bovine satellite cells (BSCs) were extracted from holstein bull calves (n = 3, BW: 77.10 ± 2.02 kg). Following myogenic differentiation, myocytes were exposed to one of three treatment groups for 3 h: 38 °C (control; <strong>CON</strong>; n = 3), 39.5 °C (moderate heat stress; <strong>MHS</strong>; n = 3), and 41 °C (extreme heat stress; <strong>EHS</strong>; n = 3). RNA and protein were extracted for transcriptomic and proteomic sequencing analyses, respectively. Differentially expressed genes (DEGs) for the contrasts MHS vs. CON and EHS vs. CON were selected using an FDR adjusted significance threshold of <em>P</em> &lt; 0.05, regardless of Log₂ fold change, with differentially abundant proteins (DAPs) selected at an FDR adjusted significance threshold of <em>P</em> &lt; 0.05 and absolute fold change ± 1.2. DEGs were then subjected to gene set enrichment analysis. A total of 888 DEGs were detected for MHS and 2590 for EHS, with 590 DEGs shared between MHS and EHS. EHS resulted in elevated expression of multiple heat shock protein (HSP) isoforms especially those related to <em>HSP70</em>, in addition to increased expression of <em>FOXO6</em> and <em>PPARGC1A</em>. Alteration of key anabolic pathways associated with protein synthesis, modulation of myogenic regulatory factors, and the large number of DEGs detected in HS-myocytes demonstrates the speculation of phenotypic alterations to myotube size and protein synthesis.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104246"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitory effect of SMAD2 on myogenesis in heat-stressed Hu sheep myoblasts","authors":"Jiawei Lu,&nbsp;Yilan Liu,&nbsp;Huixia Li","doi":"10.1016/j.jtherbio.2025.104223","DOIUrl":"10.1016/j.jtherbio.2025.104223","url":null,"abstract":"<div><div>Heat stress can cause muscle damage and affect myogenesis. Myogenesis is a complicated process modulated by numerous genes. While SMAD2 has been implicated in various biological processes, its specific role in the myogenesis of heat-stressed Hu sheep myoblasts remains unclear. To explore the function of <em>SMAD2</em> in myogenesis, si-SMAD2-446 and pcDNA3.1-SMAD2 were transfected into heat-stressed Hu sheep myoblasts. The results indicated that heat stress increased the SMAD2 expression in Hu sheep myoblasts. Furthermore, <em>SMAD2</em> was found to suppress proliferation in heat-stressed Hu sheep myoblasts by downregulating the expression of proliferation-related genes, including proliferating cell nuclear antigen (PCNA), cyclin D1 (CCND1) and cyclin-dependent kinase 2 (CDK2). Additionally, <em>SMAD2</em> inhibited differentiation by downregulating the expression of myogenic differentiation factor (MYOD) and myogenin (MYOG). Moreover, <em>SMAD2</em> promoted apoptosis by activating BCL-associated X protein (BAX), B-cell CLL/lymphoma 2 (BCL-2), Caspase3 and Caspase9 in heat-stressed Hu sheep myoblasts. In conclusion, these findings suggest that <em>SMAD2</em> functions as an inhibitory factor in the myogenesis of heat-stressed Hu sheep myoblasts.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104223"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermoregulation strategies differ for large macropods during high temperatures","authors":"Loic Q. Juillard,&nbsp;Lisa M. Ashby,&nbsp;Taylor J. McEvoy,&nbsp;Daniel Ramp","doi":"10.1016/j.jtherbio.2025.104245","DOIUrl":"10.1016/j.jtherbio.2025.104245","url":null,"abstract":"<div><div>In semi-arid drylands, landscape features such as water and trees are vital for individuals when reducing heat stress. In Australia, such landscapes have witnessed widespread canopy loss and considerable shifts in water availability due to anthropogenic processes, and are subject to greater frequencies of extreme temperatures. We explored the use of dammed watercourses and excavated earth tanks, and tree shade in two large macropod species, eastern grey kangaroos (<em>Macropus giganteus</em>) and red kangaroos (<em>Osphranter rufus</em>) in the semi-arid drylands of south-western Queensland. Using a thermal drone, camera traps, and temperature sensors, we examined the relationship between temperature, and water and canopy shade use by both species. The likelihood of kangaroos being observed in the sun was negatively correlated with temperature, with the likelihood of observing eastern grey kangaroos in the sun dropping below 50 % when temperatures exceeded 28 °C, and 17 °C for red kangaroos. Probability of detecting kangaroos in the shade was positively correlated with temperature, with red kangaroos more strongly selecting shade than eastern grey kangaroos. For eastern grey kangaroos, we observed greatly increased activity at waterpoints when daily maximum temperatures exceeded 28 °C, with a preference for dammed watercourses over excavated earth tanks. Only a weak trend of using dammed watercourses at high temperatures (&gt;36 °C) was detected for red kangaroos. As higher temperatures become more frequent due to climate change, our results suggest that the capacity of wildlife to persist may increasingly depend on the provision and maintenance of landscape features such as water and canopy shade.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104245"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “A phenological shift to save the boys? Current and projected trends of hatchling sex ratio of the loggerhead turtle Caretta caretta at Dalyan Beach, Türkiye” [J. Therm. Biol. 129 (2025) 104091]","authors":"Jay Kirkham ,&nbsp;Dogan Sözbilen ,&nbsp;Arzu Kaska ,&nbsp;Çisem Sezgin ,&nbsp;Yakup Kaska","doi":"10.1016/j.jtherbio.2025.104129","DOIUrl":"10.1016/j.jtherbio.2025.104129","url":null,"abstract":"","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104129"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144847176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embryonic temperature shapes morphology, physiology, and survival across life stages for an ectotherm threatened by global change","authors":"Julia M. Thulander ,&nbsp;Joshua M. Hall","doi":"10.1016/j.jtherbio.2025.104215","DOIUrl":"10.1016/j.jtherbio.2025.104215","url":null,"abstract":"<div><div>Climate change and urbanization expose organisms to novel thermal regimes. These changes are particularly impactful for embryonic development of ectotherms due to a lack of parental care, thermal sensitivity of development, and inability to behaviorally thermoregulate. Although the effects of shifting thermal regimes have been studied extensively using a few vertebrate models, little is known about impacts on species with multiple, distinct life stages such as amphibians. We measured nest temperatures of the Streamside Salamander (<em>Ambystoma barbouri</em>) in both disturbed and undisturbed habitats to determine how urbanization affects embryonic temperature. We incubated eggs across a range of temperatures to understand the effects of temperature on survival and larval and juvenile phenotypes. Resultant larvae and metamorphs were maintained in a common garden to isolate the effects of embryonic temperature, illuminating the effect of nest temperature on each life stage (egg, larvae, juvenile). Maximum nest temperatures were warmer in disturbed than undisturbed sites. Warmer incubation temperatures enhanced developmental rate but decreased survival and body size. These effects persisted into larval and metamorph stages, demonstrating that the effects of embryonic temperature persist across life stages. Our results illustrate the need for a deeper understanding of the long-term effects of nest temperature on ectotherms. Moreover, this work indicates that studies which use egg survival and hatchling phenotypes alone to forecast species responses to global change are conservative, and future work must incorporate the full life cycle.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104215"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heat stroke-induced central nervous system injury: Mechanisms and therapeutic perspectives","authors":"Wenjun Yang ,&nbsp;Zhen Gao ,&nbsp;Chengjin Wang ,&nbsp;Min Wang ,&nbsp;Yuan Cao ,&nbsp;Yun Li ,&nbsp;Shaoqing Shi ,&nbsp;Yiqi Wu ,&nbsp;Lu Wang ,&nbsp;Hongjun Kang","doi":"10.1016/j.jtherbio.2025.104263","DOIUrl":"10.1016/j.jtherbio.2025.104263","url":null,"abstract":"<div><div>Heat stroke (HS), a life-threatening heat-related disorder, is characterized by a rapid elevation of core body temperature exceeding 40 °C, accompanied by central nervous system (CNS) dysfunction and multiple organ dysfunction syndrome (MODS). With the escalating impact of global warming, the incidence of HS has risen progressively, posing a significant threat to global health. The CNS is one of the primary target organs in HS, and its injury mechanisms involve intricate interactions among inflammatory cascades, oxidative stress, programmed cell death, and blood-brain barrier (BBB) disruption. These pathological processes synergistically contribute to neuronal damage, functional impairment, potential long-term cognitive and motor deficits. This review synthesizes current evidence on the molecular and cellular mechanisms underlying HS-induced CNS injury, explores the current progress in therapeutic strategies, and proposes future research directions to address critical knowledge gaps.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104263"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermal stability of pigment- and structurally based body coloration in a polymorphic lizard","authors":"Cristina Romero-Diaz ,&nbsp;Enrique Font ,&nbsp;Guillem Pérez i de Lanuza","doi":"10.1016/j.jtherbio.2025.104262","DOIUrl":"10.1016/j.jtherbio.2025.104262","url":null,"abstract":"<div><div>Animal coloration plays a fundamental role in communication, camouflage, aposematism, mimicry and thermoregulation, and has strong implications for adaptation and diversification. Phenotypic plasticity of color traits can thus affect social, reproductive, antipredator, or thermoregulatory behavior and determining the causes and consequences of color change helps us understand evolution. In contrast to seasonal or ontogenetic color changes, physiological color change in response to fine-scale changes in environmental conditions has received less attention. Temperature-driven, rapid changes in coloration can have profound implications for ecophysiology, particularly in ectotherms. Here, using a widespread color polymorphic lacertid, <em>Podarcis muralis</em>, we study the impact of temperature on the chromatic properties and perception of pigment- and structurally based coloration of different body regions. We subjected male and female adult lizards from different color morphs to two different temperature regimes: cold (25 °C) and hot (≥34 °C) temperature, and quantified color change in the dorsum, belly, throat and ultraviolet (UV)-blue ventrolateral patches using a spectrophotometer. We then applied visual modeling to assess color variation from the perspective of a conspecific and two visual predators. We show that despite minor differences in spectral reflectance metrics, temperature had no significant effect on how color patches are perceived by receivers. Moreover, temperature did not affect existing sex and morph differences in color properties, suggesting that the minor changes we observed have little functional/adaptive consequences in this context. Contrary to results reported in other lizard taxa (iguanians and geckos), our findings suggest that temperature-induced rapid visual color change is unlikely in this lacertid species.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104262"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracerebroventricular injection of taurine affords thermotolerance and regulates mitochondrial thermogenic gene expression in pectoralis muscle in neonatal chicks exposed to high ambient temperature","authors":"Mohamed Z. Elhussiny ,&nbsp;Haruka Nishimura ,&nbsp;Shogo Haraguchi ,&nbsp;Elizabeth R. Gilbert ,&nbsp;Mark A. Cline ,&nbsp;John F. Cockrem ,&nbsp;Eiki Takahashi ,&nbsp;Yoshimitsu Ouchi ,&nbsp;Takashi Bungo ,&nbsp;Vishwajit S. Chowdhury","doi":"10.1016/j.jtherbio.2025.104238","DOIUrl":"10.1016/j.jtherbio.2025.104238","url":null,"abstract":"<div><div>Intracerebroventricular (ICV) injection of taurine can induce hypothermia and attenuate stress behaviors in neonatal chicks under control thermoneutral temperature (CT) conditions. While, its ability to withstand heat stress (thermotolerance) has not identified yet. Thus, the objective of this study was to examine the effects of ICV taurine effects on thermoregulation, mitochondrial thermogenic gene expression, and amino acid metabolism in 5-day-old Julia male chick exposed to either high ambient temperature <strong>(</strong>HT<strong>)</strong> or CT conditions. Procedures were performed in the absence of food with water available after injections. The results showed that ICV injection of taurine reduced the magnitude of temperature rises in heat-exposed chicks (afforded thermotolerance). Central taurine increased gene expression of avian uncoupling protein mRNA in pectoral muscle under CT and HT. However, avian peroxisome proliferator-activated receptor γ coactivator-1α, avian adenine nucleotide translocase and carnitine palmitoyltransferase-I mRNA were decreased in chicks that were administered taurine under CT and HT. Diencephalic tryptophan, taurine and 3-methylhistidine were increased, while glutamic acid was decreased following taurine treatment under both CT and HT. Moreover, central taurine caused to reduce plasma triacylglycerol and uric acid concentrations. In conclusion, central taurine administration reduced temperature rises and was associated with changes in gene expression of mitochondrial thermogenic factors in heat-exposed fasted chicks. The changes in the mitochondrial thermogenic genes in muscle and amino acid concentrations in the brain suggest that skeletal muscle and central nervous system metabolism may be involved in the effects of taurine on thermoregulation in chicks under both CT and HT.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"132 ","pages":"Article 104238"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}