Journal of the Neurological Sciences最新文献_第2页

Corrigendum to “Tissue plasminogen activator for acute branch atheromatous disease exhibits transient improvement and worsening” [Journal of the Neurological Sciences Volume 465 (2024) 123201] 对 "组织浆蛋白酶原激活剂治疗急性动脉粥样硬化性疾病表现出短暂的改善和恶化 "的更正[《神经科学杂志》第 465 卷（2024 年）123201]

IF 3.6 3区医学

Journal of the Neurological Sciences Pub Date : 2024-09-20 DOI: 10.1016/j.jns.2024.123241

引用次数: 0

Diagnostic importance of disproportionately enlarged subarachnoid space hydrocephalus and Callosal Angle measurements in the context of normal pressure hydrocephalus: A useful tool for clinicians 蛛网膜下腔不成比例扩大的脑积水和正常压力脑积水胼胝体角测量的诊断重要性：临床医生的有用工具

IF 3.6 3区医学

Journal of the Neurological Sciences Pub Date : 2024-09-19 DOI: 10.1016/j.jns.2024.123250

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Response to Aanwat et al. on chow et al. Tricaprilin (CER-0001) for the preventive treatment of migraine: A phase 2 randomised, double-blind, placebo-controlled pilot study JONS July 22, 2024. 对 Aanwat 等人关于 Chow 等人的三氯胰岛素（CER-0001）用于偏头痛预防性治疗的回应：第 2 期随机、双盲、安慰剂对照试验研究 JONS 2024 年 7 月 22 日。

IF 3.6 3区医学

Journal of the Neurological Sciences Pub Date : 2024-09-18 DOI: 10.1016/j.jns.2024.123239

Marc Cantillon

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Psychiatric symptoms and TDP-43 pathology in amyotrophic lateral sclerosis 肌萎缩性脊髓侧索硬化症的精神症状和 TDP-43 病理变化

IF 3.6 3区医学

Journal of the Neurological Sciences Pub Date : 2024-09-18 DOI: 10.1016/j.jns.2024.123249

{"title":"Psychiatric symptoms and TDP-43 pathology in amyotrophic lateral sclerosis","authors":"","doi":"10.1016/j.jns.2024.123249","DOIUrl":"10.1016/j.jns.2024.123249","url":null,"abstract":"<div><h3>Background</h3><div>ALS is not a pure motor neuron disease but co-occurs with cognitive impairment and psychiatric symptoms. The neuropathological origin of the psychiatric symptoms is unclear. This study examined the association between the psychiatric symptoms and neuropathology of ALS.</div></div><div><h3>Methods</h3><div>We investigated the clinicopathological characteristics of 15 autopsy cases of ALS, including neuronal loss, gliosis, and the burden of TDP-43 pathology. We divided TDP-43–positive structures by morphology into four categories (neuronal cytoplasmic inclusion, dystrophic neurite, dot, and glial cytoplasmic inclusion) and gave each a semiquantitative score in nine brain regions. Braak neurofibrillary tangle stage, Thal amyloid phase, Lewy-related pathology, and argyrophilic grains were also assessed.</div></div><div><h3>Results</h3><div>Of the 15 ALS patients, seven had presented with psychiatric symptoms and eight had not. Significantly higher TDP-43 pathology scores were found in the group with psychiatric symptoms in the temporal tip, transentorhinal cortex, entorhinal cortex, subiculum, and the hippocampal CA1 region and dentate gyrus. Cognitive impairment was not significantly associated with the degree of TDP-43 pathology. There were no significant differences in the degree of neuronal loss/gliosis or in other concurrent pathologies between patients with and without psychiatric symptoms. Morphological evaluation showed that neuronal cytoplasmic inclusions, dystrophic neurites, and dots tended to be more common in the group with psychiatric symptoms.</div></div><div><h3>Conclusion</h3><div>Psychiatric symptoms in ALS may be related to TDP-43 pathology in the perforant pathway. (224 words).</div></div>","PeriodicalId":17417,"journal":{"name":"Journal of the Neurological Sciences","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142319266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychiatric predictors of quality of life in Parkinson's disease: A three-year longitudinal study 帕金森病患者生活质量的精神病学预测因素：为期三年的纵向研究

IF 3.6 3区医学

Journal of the Neurological Sciences Pub Date : 2024-09-18 DOI: 10.1016/j.jns.2024.123248

{"title":"Psychiatric predictors of quality of life in Parkinson's disease: A three-year longitudinal study","authors":"","doi":"10.1016/j.jns.2024.123248","DOIUrl":"10.1016/j.jns.2024.123248","url":null,"abstract":"<div><h3>Introduction</h3><p>Parkinson's disease (PD) is associated with worsened quality of life (QOL) over time. Few longitudinal studies exist investigating the relationship of psychiatric comorbidities with QOL in people with PD (PwP). We sought to determine specific psychiatric symptoms associated with decreasing QOL in PwP over time.</p></div><div><h3>Methods</h3><p>We recruited PwP without dementia from a movement disorders clinic at an academic medical center. Participants were evaluated annually with motor and neuropsychological assessments at each visit. QOL was measured using the Parkinson's Disease Questionnaire-39 (PDQ-39). We assessed psychiatric symptoms, including depression (Beck Depression Inventory II, BDI-II), anxiety (Beck Anxiety Index, BAI), and apathy (Apathy Scale). Psychosis and impulse control disorders (ICDs) were recorded as present or absent. Using random coefficient regression, we analyzed psychiatric features associated with worsened QOL in PwP over three years.</p></div><div><h3>Results</h3><p>From the 105 participants enrolled at baseline, 67 completed three years of follow up. Mean PDQ-39 scores increased from 16.0 at baseline to 19.8 at year three. In multivariate analysis, higher BDI-II scores, BAI scores, and apathy scores were uniquely associated with worsened QOL over time (<em>p</em> < 0.001 for all measures), while presence of ICDs (<em>p</em> = 0.18) or psychosis (<em>p</em> = 0.10) were not. Changes in the BAI score and the BDI-II score exerted similar effects on the overall PDQ-39 score.</p></div><div><h3>Conclusion</h3><p>Depression, anxiety, and apathy are all associated with worsening quality of life over time in PwP, while presence of ICDs and psychosis are not. Treatment of these symptoms may lead to improved QOL in PwP.</p></div>","PeriodicalId":17417,"journal":{"name":"Journal of the Neurological Sciences","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics and prognostic impact of unsuccessful recanalization after endovascular therapy for acute ischemic stroke 急性缺血性脑卒中血管内治疗后未成功再通畅的特征和对预后的影响

IF 3.6 3区医学

Journal of the Neurological Sciences Pub Date : 2024-09-18 DOI: 10.1016/j.jns.2024.123247

{"title":"Characteristics and prognostic impact of unsuccessful recanalization after endovascular therapy for acute ischemic stroke","authors":"","doi":"10.1016/j.jns.2024.123247","DOIUrl":"10.1016/j.jns.2024.123247","url":null,"abstract":"<div><h3>Background</h3><div>Endovascular therapy (EVT) has shown high therapeutic efficacy for acute large vessel occlusion (LVO); however, recanalization is unsuccessful in some cases. This study aimed to examine the characteristics and prognostic impact of unsuccessful recanalization after EVT compared with medical treatment alone.</div></div><div><h3>Methods</h3><div>We conducted a post hoc analysis of RESCUE-Japan Registry 2, a nationwide registry of 2408 consecutive patients with acute LVO. Patients without successful recanalization after EVT (thrombolysis in cerebral infarction grade ≤ 2a) were classified into the Unsuccessful EVT group, and compared with the No-EVT group. To account for selection bias, the outcomes were compared in a propensity score-matched cohort. The outcomes included the modified Rankin Scale (mRS) score at 90 days and intracranial hemorrhage within 72 h after the LVO onset.</div></div><div><h3>Results</h3><div>Among 188 (14.7 %) patients in the Unsuccessful EVT group out of 1281 who underwent EVT, 147 were matched with the No-EVT group, with comparable baseline characteristics. Patients in the Unsuccessful EVT group had a higher distribution of mRS score at 90 days and were less likely to achieve mRS 0–2 compared to those in the No-EVT group (23 % vs. 34 %, OR:0.58, 95 % CI:0.35–0.98). All-cause mortality was higher in the Unsuccessful EVT group (16 % vs. 6.8 %, OR: 2.54, 95 % CIs: 1.16–5.55). Symptomatic intracranial hemorrhage was more frequently observed in the Unsuccessful EVT group (5.4 % vs. 0.7 %, OR: 8.40, 95 % CIs: 1.04–68.1).</div></div><div><h3>Conclusions</h3><div>The clinical outcomes of patients without successful recanalization after EVT were worse than those who did not undergo EVT.</div></div>","PeriodicalId":17417,"journal":{"name":"Journal of the Neurological Sciences","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142319267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-traumatic parkinsonism: The intricate twist between trauma, inflammation and neurodegeneration. A narrative review 创伤后帕金森病：创伤、炎症和神经变性之间错综复杂的关系。叙述性综述

IF 3.6 3区医学

Journal of the Neurological Sciences Pub Date : 2024-09-17 DOI: 10.1016/j.jns.2024.123242

引用次数: 0

The association between serum cholesterol levels and mild-to-moderate cognitive impairment in the Suita Study and evidence from other epidemiological studies 水田研究中血清胆固醇水平与轻度至中度认知障碍之间的关系以及其他流行病学研究的证据

IF 3.6 3区医学

Journal of the Neurological Sciences Pub Date : 2024-09-17 DOI: 10.1016/j.jns.2024.123244

{"title":"The association between serum cholesterol levels and mild-to-moderate cognitive impairment in the Suita Study and evidence from other epidemiological studies","authors":"","doi":"10.1016/j.jns.2024.123244","DOIUrl":"10.1016/j.jns.2024.123244","url":null,"abstract":"<div><h3>Background</h3><p>Serum cholesterols are well-documented markers of cardiovascular diseases; however, their association with cognitive well-being is uncertain. This study investigated the association between serum cholesterol levels and mild-to-moderate cognitive impairment.</p></div><div><h3>Methods</h3><p>Epidemiological evidence on the role of total cholesterol (TC), high-density lipoprotein cholesterol (HDL<img>C), non-HDL-C, and low-density lipoprotein cholesterol (LDL-C) in cognitive impairment was highlighted. Then, data from 6216 Japanese individuals, aged ≥50 years, from the Suita Study were analyzed. Mini-Mental State Examination (MMSE) scores <27 and < 24 were used to define cognitive impairment. Logistic regression was used to calculate the odds ratios (ORs) and 95 % confidence intervals (95 % CIs) for cognitive impairment.</p></div><div><h3>Results</h3><p>Epidemiological studies investigating the association between serum cholesterol and cognitive impairment have shown conflicting findings: elevated risk with certain lipid components in some studies and no association in others. In the Suita Study, HDL-C < 40 mg/dL was associated with cognitive impairment: ORs (95 % CIs) = 1.36 (1.08, 1.72) for MMSE <27 and 1.61 (1.00, 2.60) for MMSE <24. Non-HDL-C ≥ 200 mg/dL was also associated with cognitive impairment: ORs (95 % CIs) = 1.53 (1.02, 2.31) for MMSE <27 and 1.80 (1.16, 2.79) for MMSE <24. No such associations were detected with TC.</p></div><div><h3>Conclusion</h3><p>While epidemiological evidence remains inconsistent, the Suita Study showed that decreased HDL-C and increased non-HDL-C, but not increased TC, were associated with mild-to-moderate cognitive impairment. Management of serum cholesterol levels should be considered to prevent cognitive impairment.</p></div>","PeriodicalId":17417,"journal":{"name":"Journal of the Neurological Sciences","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Addressing the barrier of transport costs in accessing headache care in sub-Saharan Africa. 解决撒哈拉以南非洲地区因交通费用而无法获得头痛治疗的问题。

IF 3.6 3区医学

Journal of the Neurological Sciences Pub Date : 2024-09-17 DOI: 10.1016/j.jns.2024.123236

Massimo Leone, Luca Giani, Monica Mwazangati, Derya Uluduz, Tayyar Şaşmaz, Victor Tamba Tolno, Giovanni Guidotti, Timothy J Steiner

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Efficacy of a mitochondrial drug cocktail in preventing acute encephalopathy with biphasic seizures and late reduced diffusion 线粒体药物鸡尾酒对预防伴有双相癫痫发作和晚期弥散功能减退的急性脑病的疗效

IF 3.6 3区医学

Journal of the Neurological Sciences Pub Date : 2024-09-17 DOI: 10.1016/j.jns.2024.123245

{"title":"Efficacy of a mitochondrial drug cocktail in preventing acute encephalopathy with biphasic seizures and late reduced diffusion","authors":"","doi":"10.1016/j.jns.2024.123245","DOIUrl":"10.1016/j.jns.2024.123245","url":null,"abstract":"<div><p>Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is difficult to differentiate from prolonged febrile seizures during the acute phase. Mitochondrial dysfunction-induced energy depletion is among the key mechanisms underlying acute encephalopathy. Therefore, this study aimed to examine the efficacy of a “mitochondrial cocktail” in preventing AESD. We retrospectively studied children experiencing status epilepticus associated with fever lasting more than 30 min, focusing on those who received the mitochondrial cocktail between February 2016 and December 2020, and those who did not receive it within 24 h between February 2012 and January 2014. The mitochondrial cocktail contained vitamins B1, C, and E; biotin; coenzyme Q10; and <span>l</span>-carnitine. AESD occurred in 1 of 41 (2.4 %) patients in the administration group and 7 of 39 (17.9 %) patients in the non-administration group. The incidence of AESD was lower in the administration group than in the non-administration group, with a significant difference (<em>p</em> = 0.027). The incidence of encephalopathy, including cases classified as AESD and unclassified, was 7/41 (17.1 %) and 7/39 (17.9 %) in the administration and non-administration groups, respectively, with no significant difference. However, the number of cases with worsening pediatric cerebral performance category scores was significantly lower in the administration group compared to the non-administration group (<em>p</em> = 0.015). In conclusion, early administration of the mitochondrial cocktail may help prevent AESD. Some encephalopathy cases do not progress to a biphasic state or develop AESD. Thus, the mitochondrial cocktail should be administered as early as possible to prevent AESD.</p></div>","PeriodicalId":17417,"journal":{"name":"Journal of the Neurological Sciences","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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