Journal of the Neurological Sciences最新文献

{"title":"Corrigendum to 'Enhanced diagnosis accuracy of tuberculous meningitis using mycolic and tuberculostearic acid via advanced mass spectrometry' [Journal of the Neurological Sciences, 479 (2025) 123748].","authors":"Mridu Singh, Vikram Singh, Juhi Verma, Manish Raj Kulshrestha, Vandana Tiwari, Anumesh K Pathak, Tushant Kumar, Jaya Garg","doi":"10.1016/j.jns.2026.125921","DOIUrl":"10.1016/j.jns.2026.125921","url":null,"abstract":"","PeriodicalId":17417,"journal":{"name":"Journal of the Neurological Sciences","volume":" ","pages":"125921"},"PeriodicalIF":3.2,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' Response to \"Comment on 'Improving Care for Amyotrophic Lateral Sclerosis with Artificial Intelligence and Affective Computing'\".","authors":"Marc Garbey, Quentin Lesport, Gülşen Öztosun, Veda Ghodasara, Henry J Kaminski, Elham Bayat","doi":"10.1016/j.jns.2026.125885","DOIUrl":"https://doi.org/10.1016/j.jns.2026.125885","url":null,"abstract":"","PeriodicalId":17417,"journal":{"name":"Journal of the Neurological Sciences","volume":" ","pages":"125885"},"PeriodicalIF":3.2,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Improving care for amyotrophic lateral sclerosis with artificial intelligence and affective computing\".","authors":"Sadhana U Adhyapak, Priyanka Mishra, Mahesh Basavaraj","doi":"10.1016/j.jns.2026.125886","DOIUrl":"https://doi.org/10.1016/j.jns.2026.125886","url":null,"abstract":"","PeriodicalId":17417,"journal":{"name":"Journal of the Neurological Sciences","volume":" ","pages":"125886"},"PeriodicalIF":3.2,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viral load and pathophysiology-based framework in varicella-zoster virus meningitis: Focus on altered consciousness and outcomes","authors":"Taiki Yabumoto ,&nbsp;Shintaro Sugiyama ,&nbsp;Akiko Hosokawa ,&nbsp;Hiroshi Sakiyama ,&nbsp;Junya Kobayashi ,&nbsp;Kazuo Kitagawa ,&nbsp;Misa Nakano","doi":"10.1016/j.jns.2026.125810","DOIUrl":"10.1016/j.jns.2026.125810","url":null,"abstract":"<div><h3>Background</h3><div>Although varicella-zoster virus (VZV) meningitis is generally benign, some patients experience severe disability. Previous studies have lacked integration of host, viral, and clinical factors. The present study aimed to identify factors associated with poor outcomes, explore a descriptive, pathophysiology-informed framework and assess the feasibility of a simple, illustrative prognostic approach.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 41 adults with polymerase chain reaction (PCR)-confirmed VZV meningitis from two Japanese centers (2013–2025), including 30 with quantitative PCR data. Baseline variables included age, immunosuppression, altered level of consciousness (LOC), rash, cerebrospinal fluid (CSF) findings, and timing of acyclovir initiation. Outcomes were discharge modified Rankin Scale (mRS) scores. Logistic regression and serial mediation analyses were performed. Predictive performance was evaluated using the area under the curve and internal–external cross-validation (IECV).</div></div><div><h3>Results</h3><div>The median age was 63 years; 22.0% of patients were immunosuppressed, and 29.3% presented with LOC. LOC, age, and CSF viral load were associated with poor outcomes (mRS ≥ 3). Mediation analysis suggested an indirect pattern of association linking immunosuppression, higher viral load, LOC, and disability. A sequential rule—Rules 1 (LOC → mRS ≥ 3), 2 (age ≥ 69 years→mRS ≥ 2), and 3 (VZV ≥ 7000 copies/mL → mRS ≥ 2)— demonstrated high apparent discrimination and acceptable consistency in IECV. Early acyclovir initiation was associated with better outcomes only in patients without LOC at presentation.</div></div><div><h3>Conclusions</h3><div>Immunosuppression may be associated with viral replication, preceding LOC, strongly associated with short-term functional outcome. This descriptive, hypothesis-generating framework helps contextualize previously inconsistent findings and supports a clinically accessible, pathophysiology-informed approach to summarizing short-term risk in VZV meningitis.</div></div>","PeriodicalId":17417,"journal":{"name":"Journal of the Neurological Sciences","volume":"482 ","pages":"Article 125810"},"PeriodicalIF":3.2,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146190966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CSF and plasma GFAP and VEGF in adult type 3 spinal muscular atrophy patients treated with nusinersen","authors":"Ana Catarina Pronto-Laborinho ,&nbsp;Teresa Freitas ,&nbsp;Sara Domingues ,&nbsp;Michele Gomes Rosa ,&nbsp;Mamede de Carvalho ,&nbsp;Miguel Oliveira Santos","doi":"10.1016/j.jns.2026.125795","DOIUrl":"10.1016/j.jns.2026.125795","url":null,"abstract":"<div><h3>Introduction</h3><div>Nusinersen improves motor outcomes in SMA, but reliable biomarkers for treatment monitoring, especially in adults, are still lacking. We investigated cerebrospinal fluid (CSF) and plasma levels of glial fibrillary acidic protein (GFAP) and vascular endothelial growth factor (VEGF), exploring their potential as biomarkers in disease progression.</div></div><div><h3>Methods</h3><div>This single-centre observational study included adults with type 3 SMA treated with nusinersen over 30 months. GFAP and VEGF levels in CSF and plasma were measured using ELISA at baseline, 14 and 30 months. Functional evaluation included Hammersmith Functional Motor Scale Expanded (HFMSE), Revised Upper Limb Module (RULM), and respiratory tests. Longitudinal data were evaluated using generalized linear mixed-effects models. A significance level of α = 0.05 was used in all analyses.</div></div><div><h3>Results</h3><div>Eleven patients were included (63.6% male, aged 19–60 at baseline). Improvements were observed in motor function, with an estimated non-linear increase of 9.02% (CI95%: 5.13–8.79) for RULM and an estimated average increase of 6.96 points (CI95%: 5.44–8.48) for HFMSE over 30 months of treatment. However, both CSF and plasma GFAP and VEGF levels changes at 14 and 30 months did not reach statistical significance, respectively (all <em>p</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>CSF and plasma GFAP and VEGF trajectories over a 30-month period under nusinersen treatment were nonsignificant. This study confirms sustained motor function improvements in adult type 3 SMA patients treated with nusinersen. Future research in larger, multicentric, and internationally collaborative cohorts are essential to fully understand the role of these potential biomarkers in SMA pathogenesis.</div></div>","PeriodicalId":17417,"journal":{"name":"Journal of the Neurological Sciences","volume":"482 ","pages":"Article 125795"},"PeriodicalIF":3.2,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146142853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent parvovirus B19 DNAemia in B-cell depletion: Implications for family planning in multiple sclerosis and related disorders","authors":"Lorenz Karnbrock ,&nbsp;Marina Herwerth ,&nbsp;Guido Vincent Bloemberg ,&nbsp;Michael Huber ,&nbsp;Patrick Roth ,&nbsp;Irene Alma Abela ,&nbsp;Veronika Kana","doi":"10.1016/j.jns.2026.125796","DOIUrl":"10.1016/j.jns.2026.125796","url":null,"abstract":"<div><h3>Background</h3><div>B-cell depletion has transformed the management of multiple sclerosis (MS) and can be a treatment option in other neuroimmunological disorders, such as neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein-associated disease (MOGAD). However, its immunosuppressive effects increase susceptibility to viral and bacterial infections. During a recent parvovirus B19 (B19V) outbreak across Europe, we noted cases of persistent B19V infections in B-cell depleted patients.</div></div><div><h3>Aim</h3><div>To determine the clinical implications of persistent B19V for the management of B-cell-depleted individuals with MS and related neuroimmunological disorders.</div></div><div><h3>Methods</h3><div>In this retrospective observational study, patients with neuroimmunological disorders followed between 2013 and 2023 and during a B19V outbreak in 2024 undergoing B-cell depletion and diagnosed with B19V infection were included. Clinical presentation, laboratory findings and treatment response were reviewed.</div></div><div><h3>Results</h3><div>We identified three B-cell depleted individuals with confirmed B19V infection (two with relapse-remitting MS (RRMS) on ocrelizumab, one with MOGAD on rituximab), all female and of childbearing age. Two patients presented with symptomatic acute viral infection consistent with Fifth Disease, including neutropenia, anemia, and elevated liver enzymes. The third patient contracted B19V during early pregnancy, presented with mild flu-like symptoms not specific to B19V, however, her fetus developed signs of fetal anemia. Intravenous immunoglobulin treatment led to rapid clinical and laboratory improvement, yet all patients showed persistent B19V DNAemia.</div></div><div><h3>Conclusions</h3><div>Given the demographic characteristics of people with MS and related disorders, exposure to communicable childhood diseases may represent a relevant risk factor for potentially severe complications, including adverse pregnancy outcomes, during B-cell depletion therapy.</div></div>","PeriodicalId":17417,"journal":{"name":"Journal of the Neurological Sciences","volume":"482 ","pages":"Article 125796"},"PeriodicalIF":3.2,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146180665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations on comorbidity, chronic intravenous immunoglobulins, and methodological clarifications on ZILU25 study","authors":"Vincenzo Di Stefano ,&nbsp;Nicasio Rini ,&nbsp;Claudia Vinciguerra ,&nbsp;Rita Frangiamore","doi":"10.1016/j.jns.2026.125769","DOIUrl":"10.1016/j.jns.2026.125769","url":null,"abstract":"","PeriodicalId":17417,"journal":{"name":"Journal of the Neurological Sciences","volume":"482 ","pages":"Article 125769"},"PeriodicalIF":3.2,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OSA Treatment Lowers the Risk of Declining Daily Activities","authors":"Jaana K. Huhtakangas ,&nbsp;Juha Huhtakangas ,&nbsp;Marianne Haapea ,&nbsp;Tarja Saaresranta","doi":"10.1016/j.jns.2026.125784","DOIUrl":"10.1016/j.jns.2026.125784","url":null,"abstract":"<div><h3>Background</h3><div>The aim of the study was to investigate whether severe obstructive sleep apnea (OSA) had association with quality of life (QOL), fatigue and functional ability seven years after ischemic stroke.</div></div><div><h3>Methods</h3><div>A total of 204 ischemic stroke patients were included in the study during 2013‐2015. After seven years the 136 survivors had a structured interview by telephone focusing on subjective QOL, functional ability, fatigue, depression, and insomnia.</div></div><div><h3>Results</h3><div>Of alive patients, 136/99.3% answered the questionnaires. The mean age was 64.2 years, 41.9 % were men, and 54/40% had respiratory event index (REI) ≥30/h. Those with REI ≥ 30 were more obese (29.2% vs 26.6%, <em>p</em> &lt; 0.001), and coronary artery disease (25.9% vs 12.2%, <em>p</em> = 0.04), had lower Barthel Index (BI) (88.3 vs 92.3, <em>p</em> = 0.014), higher modified Rankin Scale (mRS) (2 vs 1, <em>p</em> = 0.025), and more need of medical aids (18.4 vs 13.2, <em>p</em> = 0.004). The QOL was good, but lower (6.98 vs 6.48, <em>p</em> = 0.056) and mobility domain was significantly worse (1.5 vs 1.3, <em>p</em> = 0.019) among severe OSA (REI) ≥30/h) patients. The CPAP treatment associated with an impaired risk of decreased usual activities (OR 0.190, 95% CI 0.042‐0.857, <em>p</em> = 0.031). Though severe OSA was not an independent risk factor for functional ability, whereas higher BMI was an independent risk factor for impaired QOL (<em>p</em> = 0.006, 95%CI 1.047‐1.315).</div></div><div><h3>Conclusions</h3><div>Seven years post-stroke the QOL was in good level, although it tended to be lower in stroke patients with severe OSA. The CPAP treatment associated with better usual activities in patients with severe OSA.</div></div>","PeriodicalId":17417,"journal":{"name":"Journal of the Neurological Sciences","volume":"482 ","pages":"Article 125784"},"PeriodicalIF":3.2,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146157677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Early real-life experience on Zilucoplan for generalized myasthenia gravis: ZILU25 multicenter observational study","authors":"Yao Yang ,&nbsp;Ye Hu","doi":"10.1016/j.jns.2026.125768","DOIUrl":"10.1016/j.jns.2026.125768","url":null,"abstract":"","PeriodicalId":17417,"journal":{"name":"Journal of the Neurological Sciences","volume":"482 ","pages":"Article 125768"},"PeriodicalIF":3.2,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pretreatment physical function as a risk factor for movement and neurocognitive treatment-emergent events (MNTs) in multiple myeloma (MM) patients treated with cilta-cel","authors":"Megan M. Herr ,&nbsp;Nisha M. Nair ,&nbsp;Theresa Hahn ,&nbsp;Chelsea Peterson ,&nbsp;Jens Hillengass ,&nbsp;Hillary Jacobson ,&nbsp;Grant Schofield ,&nbsp;Philip L. McCarthy ,&nbsp;Ehsan Malek ,&nbsp;Renee McKenzie ,&nbsp;Hamza Hassan ,&nbsp;Joseph D. Tario Jr ,&nbsp;Maureen Ross ,&nbsp;Marco L. Davila ,&nbsp;Brian C. Betts ,&nbsp;Shernan Holtan","doi":"10.1016/j.jns.2026.125771","DOIUrl":"10.1016/j.jns.2026.125771","url":null,"abstract":"","PeriodicalId":17417,"journal":{"name":"Journal of the Neurological Sciences","volume":"482 ","pages":"Article 125771"},"PeriodicalIF":3.2,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146090430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}